Hemangiomas - Biotech, Pharma and Life Science Channel
PubMed Articles
We examined whether mutation of the platelet-derived growth factor receptor protein tyrosine kinase (PDGFR)-α and PDGFR-β genes contributes to their overexpression in canine vascular tumours. Genomi...
Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence.
OBJECTIVE: To evaluate the efficacy, adverse effects, and recurrence of oral propranolol for treatment of infantile hemangioma. METHODS: Participants were treated with oral propranolol three times dai...
Complicated Infantile Hemangioma of the Lip: Outcomes of Early versus Late Resection.
: Lip hemangiomas have traditionally been approached with expectant management. However, intervention is warranted for associated complications, including facial disfigurement, feeding difficulties, s...
Infantile hemangiomas and retinopathy of prematurity: clues to the regulation of vasculogenesis.
Retinopathy of prematurity (ROP) and infantile hemangiomas are vascular disorders that may share common mechanisms. This study examined a potential clinical association between these disorders in popu...
Propranolol and Infantile Hemangiomas Four Years Later: A Systematic Review.
To systematically review the literature evaluating efficacy and adverse events of propranolol treatment for infantile hemangiomas, we searched the MEDLINE and Cochrane databases for all studies examin...
Objectives- The purpose of this study was to evaluate the sonographic features of angioleiomyomas with priority given to the vascular pattern to help in the differential diagnosis from other hypervasc...
Lack of Effect of Propranolol in the Treatment of Lymphangioma in Two Children.
Vascular lesions such as hemangiomas and lymphangiomas can cause significant mortality and morbidity, as well as amblyopia when located in the orbit. Oral propranolol can regress infantile hemangi...
Use of Systemic Corticosteroids in Management of a Large Congenital Haemangioma of the Scalp.
Congenital haemangiomas are rare and are estimated to have a combined incidence of less than 3% of all infantile haemangiomas. They are fully grown at birth, having undergone their proliferative p...
Intrinsic regulation of hemangioma involution by platelet-derived growth factor.
Infantile hemangioma is a vascular tumor that exhibits a unique natural cycle of rapid growth followed by involution. Previously, we have shown that hemangiomas arise from CD133+ stem cells that diffe...
This paper is aimed at developing and evaluating a content-based retrieval method for contrast-enhanced liver computed tomographic (CT) images using bag-of-visual-words (BoW) representations of single...
News Articles
Infantile Hemangiomas: Daily Timolol Maleate Slows Growth
The gel formulation of a medicine approved in 1978 to treat glaucoma slows the growth of potentially disfiguring infantile hemangiomas with few of the adverse effects that limit other treatments. Me...
New York Group for Plastic Surgery (NYGPS) Expands Practice to New York City
NEW YORK, March 14, 2013 /PRNewswire/ -- Plastic and reconstructive surgeons C. Andrew Salzberg, M.D. and Tae Ho Kim, M.D. of the New York Group for Plastic Surgery are now providing their surgical ex...
Proper Diagnosis Key to Successful Treatment of Facial Birthmark in Young Children
TARRYTOWN, N.Y., March 7, 2013 /PRNewswire/ -- A reddish birthmark that appears on a baby's skin in the first few weeks after birth is most often harmless, but should be brought to a phy...
Beta-Blocker Clears Infancy Hemangiomas
MIAMI BEACH (MedPage Today) -- A majority of infantile hemangiomas, sometimes known as strawberry mark, had complete or near-complete clearance within 6 months after treatment with propranolol, an int...
Understanding of infantile hemangiomas is improving
(HealthDay)—Improved understanding of the pathogenesis of infantile hemangiomas (IHs) is leading to better treatment options, according to a review published online Dec. 24 in Pediatrics.
Pharmaceutical Research: Evaluation of Skin Permeation of β-Blockers for Topical Drug Delivery
Type: Original PaperPurposeβ-Blockers have recently become the main form of treatment of infantile hemangiomas. Due to the potential systemic adverse effects of β-blockers, topical skin treatment of...
Timolol Gel Effective for Infantile Capillary Hemangiomas
Pediatric superficial capillary hemangiomas respond well to short-term treatment with timolol gel. Medscape Medical News
Propranolol tops corticosteroids for hemangiomas
Propranolol may be more effective than corticosteroids in treating infantile cutaneous hemangiomas, a new study suggests.
Early treatment vital for infantile hemangiomas
US research shows that infantile hemangiomas, otherwise known as “strawberry” birthmarks, grow faster and earlier than previously believed.
Rapid Growth Of 'Strawberry' Birthmarks When Babies Just Weeks Old
Strawberry-shaped birthmarks, called infantile hemangiomas, grow rapidly in infants much earlier than previously thought, Mayo Clinic and University of California, San Francisco, researchers found. Th...
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Clinical Trials
Randomized Study of Hormonal Regulation of Infantile Hemangioma
OBJECTIVES: I. Evaluate the clinical efficacy of leuprolide, a gonadotropin-releasing hormone agonist (GnRHa), in treating infants with vision-endangering or large, disfiguring hemangiom...
A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy
Hemangiomas of infancy, the most common benign tumors of infancy, are congenital or early infancy lesions characterized by a rapid postnatal growth, with high expression of angiogenic stim...
The purpose of this study is to investigate the pathogenesis of hemangiomas of infancy as they relate to normal pregnancies and those pregnancies complicated by placenta abnormalities. Wo...
Immune Suppression Of Infants Treated With Steroids
The goal of this study is to clarify the degree of immune suppression in infants requiring therapy and to create guidelines for evaluation and prevention of infection in infants on oral st...
Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas
This study will attempt to determine how common liver hemangiomas are in children with infantile hemangiomas by comparing liver ultrasound results in patients with 1-4 cutaneous hemangioma...
Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy
The purpose of the study is to determine if pulse steroids are more efficacious and safer than the standard treatment with oral corticosteroids.
Infantile Hemangioma (IH) is infancy's most common vascular tumor of infancy and most frequent benign neoplasm. Treatment of IHs is indicated for approximately 10 to 20% of the cases. Two...
Prospective controlled study evaluating cryocontact therapy of infantile hemangiomas of preterm infants Principal investigator: Rangmar Goelz, MD Coworkers: M Möhrle, M Moll, HM Häfner,...
Nadolol for Proliferating Infantile Hemangiomas
The purpose of this study is to explore the efficacy and safety of Nadolol in hemangiomas of infancy. The secondary objective is to assess the feasibility of conducting a randomized contr...
Propranolol Versus Prednisolone for Treatment of Symptomatic Hemangiomas
Hemangiomas are relatively common lesions in infants. Most go away spontaneously after one year of life and do not need treatment. Others require treatment because they cause significant...
Videos
Sydney's Hemangiomas Laser Treatments and Propranolol
Our daughter, Sydney, was born with segmental hemangiomas. We met with 10 doctors prior to meeting Dr. Waner, none of them knew what to do about the birthmar...
Medical and Biotech [MESH] Definitions
Proteus Syndrome
Hamartoneoplastic malformation syndrome of uncertain etiology characterized by partial GIGANTISM of the hands and/or feet, asymmetry of the limbs, plantar hyperplasia, hemangiomas (HEMANGIOMA), lipomas (LIPOMA), lymphangiomas (LYMPHANGIOMA), epidermal NEVI, macrocephaly, cranial HYPEROSTOSIS, and long-bone overgrowth. Joseph Merrick, the so-called "elephant man", apparently suffered from Proteus syndrome and not NEUROFIBROMATOSIS, a disorder with similar characteristics.
Histiocytoma, Benign Fibrous
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
Port-wine Stain
A vascular malformation of developmental origin characterized pathologically by ectasia of superficial dermal capillaries, and clinically by persistent macular erythema. In the past, port wine stains have frequently been termed capillary hemangiomas, which they are not; unfortunately this confusing practice persists: HEMANGIOMA, CAPILLARY is neoplastic, a port-wine stain is non-neoplastic. Port-wine stains vary in color from fairly pale pink to deep red or purple and in size from a few millimeters to many centimeters in diameter. The face is the most frequently affected site and they are most often unilateral. (From Rook et al., Textbook of Dermatology, 5th ed, p483)
Hemangioendothelioma
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
