Hematologic manifestations - Biotech, Pharma and Life Science Channel
PubMed Articles
Tumor lysis syndrome and malignant melanoma.
Tumor lysis syndrome (TLS) is an oncological emergency that results from massive cytolysis of malignant cells with a sudden release of their contents into the systemic circulation. TLS was rarely desc...
Ocular manifestations of Churg-Strauss syndrome : Review article and case report.
This paper summarizes the possible ocular manifestations of Churg-Straus syndrome (CCS) from the literature and presents an unusual case report from routine clinical practice with conjunctival granulo...
Although intestinal microbiota are essential for the development of T cell-mediated colitis, it remains undetermined whether they enhance or suppress the chronic extraintestinal inflammation that ofte...
Insights into thermoregulation: a clinico-radiological description of Shapiro syndrome.
Shapiro syndrome is a rare entity, comprising a triad of recurrent hypothermia, hyperhidrosis and congenital agenesis of the corpus callosum. Fewer than 50 cases have been described, almost invariably...
Statement on the use of mycophenolate mofetil for systemic lupus erythematosus.
Mycophenolate mofetil (MMF) is among the few immunosuppressive drugs with sufficient data from controlled studies on the therapy of systemic lupus erythematosus (SLE). In the light of results from rec...
Risk of recurrence of unusual site venous thromboembolism.
The term unusual site venous thrombosis defines uncommon clinical manifestations of venous thromboembolism occurring in sites different from the lower limbs or the lungs, with peculiar pathophysiologi...
Chanarin-Dorfman syndrome (CDS) is a rare nonlysosomal neutral lipid storage disorder characterized by congenital ichthyosis, lipid vacuoles in leukocytes (Jordan's anomaly), and hepatomegaly. The aut...
Primary Cutaneous CD4+ Small to Medium-Size Pleomorphic T-Cell Lymphoma in a 12-Year-Old Girl.
Primary cutaneous CD4+ small to medium-size pleomorphic T-cell lymphoma (PCSM-TCL) is a rare disease that has been added as a provisional entity to the World Health Organization European Organization...
Primary antiphospholipid syndrome: newly developed leg ulcer and history of stroke.
Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and...
Vaccine review: "Staphyloccocus aureus vaccines: Problems and prospects".
Staphylococcus aureus is a leading cause of both healthcare- and community-associated infections globally. S. aureus exhibits diverse clinical presentations, ranging from benign carriage and superfici...
News Articles
Sarepta Therapeutics Remains A Strong Buy
ByCarl Cachia:On April 6th, 2013, I presented an article about Acadia Pharmaceuticals (ACAD) as one can read here. ACAD has risen from $7 to the current price of $19. My latest buy that I think can sh...
SAN DIEGO, June 18, 2013 /PRNewswire/ -- MEI Pharma, Inc. (Nasdaq: MEIP), an oncology company focused on the clinical development of novel therapies for cancer, announced today that the first patients...
North Carolina Pioneering Care for Huntington's Disease Patients
WINSTON-SALEM, N.C., June 18, 2013 /PRNewswire/ -- North Carolina has emerged as a leader in providing care for patients of Huntington's disease, an inherited brain disorder that affects control...
Huntington Study Group Researchers Combat Huntington's Disease
Dr. Francis Walker of Wake Forest Baptist Medical Center discusses Huntington's disease, HSG research, and NC nonprofit HD Reach Winston-Salem, NC (PRWEB) June 18, 2013 North Carolina has emerged...
SEATTLE, June 17, 2013 /PRNewswire/ -- Cell Therapeutics, Inc. (CTI) (NASDAQ and MTA: CTIC) today announced results from a pooled analysis of data from completed Phase 1 and 2 studies of pacriti...
Data from an Additional Six Months of Imetelstat Treatment and Follow-Up since ASH 2012 Imetelstat Continues to be Well Tolerated with No New Safety Signals Reported; No Patients Have Discontinued...
A new study presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, shows that rapid evaluation for Giant Cell Arteritis (GCA) by Color Doppler Ultrasound (CDUS) follow...
Israel's Teva Pharmaceutical Industries (NYSE: TEVA) and Swedish partner Active Biotech (OMX NORDIC: ACTI) have released positive results of a Phase IIa study of oral laquinimod designed to assess saf...
SPRING HOUSE, Pa., June 13, 2013 /PRNewswire/ -- Results from a Janssen Research & Development, LLC (Janssen)-sponsored Phase 3 study published today in The Lancet showed patients with active psor...
SOUTH SAN FRANCISCO, CA -- (Marketwired) -- 06/12/13 -- Portola Pharmaceuticals, Inc. (NASDAQ: PTLA) today announced that William Lis, chief executive officer, will present at the Wells Fargo Securit...
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Companies
Concert Pharmaceuticals is a clinical stage biotechnology company with a broad development pipeline targeting renal disease, CNS disorders, inflammation and hematologic disorders....
Cancer Genetics, Inc. (CGI) is an emerging leader in the field of personalized medicine, offering products and services that enable cancer diagnostics as well as treatments that are tailored to the...
Trevi Therapeutics, Inc. is a drug development company founded in 2011 focused on developing T111 for the severe chronic itching condition known as pruritus. Pruritus is ma...
KaloBios Pharmaceuticals, Inc.
KaloBios Pharmaceuticals, Inc., a U.S. based, private monoclonal company, uses its biologic capabilities and its proprietary platform technology to develop first-in-class human an...
Nodality develops and commercializes the next generation of personal diagnostic tests by characterizing cell signaling pathways in defined cellular sub-populations of malig...
Gloucester Pharmaceuticals acquires clinical-stage oncology drug candidates and advances them through regulatory approval and commercialization. The Companyâs first candidate...
Physicians’ Education Resource
Physiciansâ Education Resource is dedicated to advancing cancer care through professional education for the health care team. Physiciansâ Education Resource is accredite...
Cyterix Pharmaceutics, Inc., a privately held cancer therapeutics company, is engaged in the discovery and development of new classes of small molecule prodrugs with improved safe...
Pfizer Oncology is committed to the discovery, investigation and development of innovative treatment options to improve the outlook for cancer patients worldwide. Our strong pipeline, one of the most...
Cancer Genetics, Inc. (CGI) is an emerging leader in the field of personalized medicine, offering products and services that enable cancer diagnostics as well as treatments that a...
Clinical Trials
The purpose of this research study is to determine the effects of ProHema modulated umbilical cord blood units used in transplantation. ProHema modulated cord blood units are being tested...
This randomized phase II trial is studying how well giving tacrolimus and mycophenolate mofetil (MMF) together with or without sirolimus works in preventing acute graft-versus-host disease...
Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders
The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of,...
Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-Year Manometric Follow-Up
Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. In...
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency). It is unc...
Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies
Blood and marrow stem cell transplant has improved the outcome for patients with high-risk hematologic malignancies. However, most patients do not have an appropriate HLA (immune type) ma...
The exact mechanism of the pathogenesis of Graves’ ophthalmopathy is still unknown. Histopathologically, extraocular muscle inflammation and orbital fat inflammation are two prominent ch...
Current diagnostic criteria of schizophrenia are based on marked positive and negative symptoms. This definition may impede the exploration of basic phenomenological psychopathology or pat...
Stem Cell Transplantation for Patients With Hematologic Malignancies
Childhood leukemias which cannot be cured by chemotherapy alone may be effectively treated by allogeneic bone marrow transplantation. Moreover, for patients with chronic myelogenous leuke...
Enzyme Replacement Therapy in Fabry Disease
Fabry disease is an X-linked rare metabolic disease, caused by a deficient activity of the hydrolase α-Galactosidase A, and characterized by a progressive and systematic deposition of gly...
Videos
Hemochromatosis ¦ Treatment and Symptoms
http://www.mainmd.com/hemochromatosis/ ◅ Hemochromatosis treatment — Finding the right information about Hemochromatosis treatment & symptoms, is crucial to ...
Medical and Biotech [MESH] Definitions
Coffin-lowry Syndrome
A rare, X-linked mental retardation syndrome that results from mutations in the RIBOSOMAL PROTEIN S6 KINASE gene. Typical manifestations of the disease include an intelligence quotient of less than 50, facial anomalies, and other malformations.
Cyclin-dependent Kinase Inhibitor P15
An INK4 cyclin-dependent kinase inhibitor containing four ANKYRIN-LIKE REPEATS. INK4B is often inactivated by deletions, mutations, or hypermethylation in HEMATOLOGIC NEOPLASMS.
Granulomatosis, Orofacial
A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. There is no consensus on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.
Avastrovirus
A genus of ASTROVIRIDAE infecting avian species and often involving extra-intestinal manifestations. The type species is Turkey astrovirus.
National Institute Of Diabetes And Digestive And Kidney Diseases...
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research for a national program in diabetes, endocrinology, and metabolic diseases; digestive diseases and nutrition; and kidney, urologic, and hematologic diseases. It was established in 1948.
