Hematologic paraneoplastic syndromes - Biotech, Pharma and Life Science Channel
PubMed Articles
Over-expression of integrin αvβ6 and increased numbers of cancer-associated fibroblasts (CAFs) play an important role in the development and progression of cancers. The aim of this study is to inves...
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematologic neoplasms, and the pathophysiology of these disorders is still unclear. Previous studies investigating the association b...
A number of mutated genes that code for proteins concerned with brain synapse function and circuit formation have been identified in patients affected by intellectual disability syndromes over the las...
BACKGROUND: Guided by decades-old reports of hantaviral antigens in the Eurasian common shrew (Sorex araneus) and the Eurasian water shrew (Neomys fodiens) in European Russia, we employed RT-PCR to an...
Aplastic anemia is a bone marrow failure syndrome that causes pancytopenia and can lead to life-threatening complications. Bone marrow transplantation remains the standard of care for younger patients...
OBJECTIVE: The calcified stylohyoid ligament and the elongated styloid process (SP) are identified radiographically, are associated with several syndromes and symptoms. The aim of this study was to cl...
Cytogenetic classification by the revised international prognostic scoring system (IPSS-R) and the prognostic value of monosomal karyotype (MK) were assessed in 783 patients with primary myelodysplast...
Aim:To investigate the roles of P21-activated kinase 5 (PAK5) in proliferation and tumorigenicity of human hepatocellular carcinoma (HCC).Methods:HCC and matched paraneoplastictis tissue samples were...
Leveraging Cancer Genome Information in Hematologic Malignancies.
The use of candidate gene and genome-wide discovery studies in the last several years has led to an expansion of our knowledge of the spectrum of recurrent, somatic disease alleles, which contribute t...
News Articles
European, US NSTE-ACS guidelines recommend bivalirudin alone in patients undergoing PCI
Results from a large observational study reported at EuroPCR 2013 today question whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, showing similar 30-day mortality in p...
Synageva BioPharma™ to Present at the Jefferies 2013 Global Healthcare Conference
Synageva BioPharma Corp. (“Synageva”) (NASDAQ:GEVA), a biopharmaceutical company developing therapeutic products for rare disorders, today announced that Sanj K. Patel,...
Results from a large observational study reported at EuroPCR 2013 (the official annual meeting of the European Association for Percutaneous Cardiovascular Interventions; EAPCI) this week question whet...
Nordion, Navidea Biopharmaceuticals ink contract manufacturing agreement
Nordion, a provider of products and services to the global health science market, has signed a contract manufacturing agreement with Navidea Biopharmaceuticals, a biopharmaceutical company focused on...
Portola Announces Pricing of Initial Public Offering
SOUTH SAN FRANCISCO, CA -- (Marketwired) -- 05/22/13 -- Portola Pharmaceuticals, Inc. announced today the pricing of its initial public offering of 8,422,758 shares of its common stock at a price to...
Registry questions superiority of bivalirudin over heparin
(European Society of Cardiology) Results from a large observational study reported at EuroPCR 2013 today question whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, show...
Pfizer to Continue Evaluation of Inotuzumab Ozogamicin in Other Hematologic Malignancies Pfizer Inc. announced today the discontinuation of a Phase 3 randomized, open-l...
Karyopharm raises $48.2 million in series B
Cancer company Karyopharm Therapeutics Inc. (Natick, Mass.) raised $48.2 million in a series B round led by an undisclosed private investor. New investor Delphi Ventures and additional undisclosed inv...
The Detroit Institute for Children Needs Your Vote To Win $25,000
The Organization is Competing in Art Van Furniture’s Third Annual Million Dollar Charity Challenge Bonus Challenge The Detroit Institute for Children (DIC) needs your help...
Antifungal Pharmacoeconomics in Hematologic Cancer and HSCT
Is antifungal therapy cost-effective for empirical treatment of invasive fungal infections? Expert Review of Pharmacoeconomics & Outcomes Research
Events
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Companies
Cancer Genetics, Inc. (CGI) is an emerging leader in the field of personalized medicine, offering products and services that enable cancer diagnostics as well as treatments that are tailored to the...
Physician Therapeutics is a division of Targeted Medical Pharma, Inc., a specialty pharmaceutical company that develops and sells prescription medical foods to physi...
Physician Therapeuticsâ medical foods are amino acid based, FDA-regulated medications specially formulated to meet the bodyâs increased nutritional requirements of disea...
Trevi Therapeutics, Inc. is a drug development company founded in 2011 focused on developing T111 for the severe chronic itching condition known as pruritus. Pruritus is ma...
KaloBios Pharmaceuticals, Inc.
KaloBios Pharmaceuticals, Inc., a U.S. based, private monoclonal company, uses its biologic capabilities and its proprietary platform technology to develop first-in-class human an...
Nodality develops and commercializes the next generation of personal diagnostic tests by characterizing cell signaling pathways in defined cellular sub-populations of malig...
The Myelodysplastic Syndromes Foundation, Inc. is a multi-disciplinary, international organization devoted to the prevention, treatment, and study of the myelodysplastic syndromes...
Gloucester Pharmaceuticals acquires clinical-stage oncology drug candidates and advances them through regulatory approval and commercialization. The Companyâs first candidate...
Physicians’ Education Resource
Physiciansâ Education Resource is dedicated to advancing cancer care through professional education for the health care team. Physiciansâ Education Resource is accredite...
TONIX Pharmaceuticals is developing new treatments for challenging disorders of the central nervous system. The Companyâs most advanced program targets fibromyalgia syndrome...
Clinical Trials
This randomized phase II trial is studying how well giving tacrolimus and mycophenolate mofetil (MMF) together with or without sirolimus works in preventing acute graft-versus-host disease...
Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts
The primary objective of this study is to compare overall survival (OS) in patients receiving ON 01910.Na + best supportive care (BSC) to OS of patients receiving BSC in a population of pa...
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...
RATIONALE: Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. PURPOSE: This randomized phase I...
Botox as a Treatment for Interstitial Cystitis in Women
Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pel...
Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies
Blood and marrow stem cell transplant has improved the outcome for patients with high-risk hematologic malignancies. However, most patients do not have an appropriate HLA (immune type) ma...
PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions
PROSPECT is a multi-center prospective registry of Acute Coronary Syndromes (ACS) patients with single or double vessel coronary artery disease. Approximately 700 patients with ACS will be...
Supporting Effect of Dronabinol on Behavioral Therapy in Fibromyalgia and Chronic Back Pain
It is known, that a so called "pain memory" usually evolves in chronic pain syndromes which both aggravates the disorder and modifies the patients pain perception. Thus, the principal obje...
The Study of Human Atherosclerosis by Polarization-Sensitive Optical Coherence Tomography
Atherosclerosis is unquestionably the leading cause of morbidity and mortality in developed countries, and the world-wide importance of acute vascular syndromes is increasing. Rupture of a...
Stem Cell Transplantation for Patients With Hematologic Malignancies
Childhood leukemias which cannot be cured by chemotherapy alone may be effectively treated by allogeneic bone marrow transplantation. Moreover, for patients with chronic myelogenous leuke...
Videos
100. Paraneoplastic Syndromes: Endocrinologic/Hematologic [Harrison's Internal Medicine Audiobook]
Other chapters here- http://goo.gl/LGnwL (Chapters 61 to 223) Check out our channel for other sections- http://youtube.com/MedAudioBooks This is an audio ver...
Medical and Biotech [MESH] Definitions
Piscirickettsiaceae Infections
Infections with bacteria of the family PISCIRICKETTSIACEAE, causing septicemic disease of salmonid fish (SALMONIDAE). Piscirickettsia-like bacteria are also associated with disease syndromes in non-salmonid fish.
Therapeutic Uses
Uses of chemicals which affect the course of conditions, diseases, syndromes or pathology to benefit the health of an individual.
Cyclin-dependent Kinase Inhibitor P15
An INK4 cyclin-dependent kinase inhibitor containing four ANKYRIN-LIKE REPEATS. INK4B is often inactivated by deletions, mutations, or hypermethylation in HEMATOLOGIC NEOPLASMS.
Hu Paraneoplastic Encephalomyelitis Antigens
A family of RNA-binding proteins that are homologues of ELAV protein, Drosophila. They were initially identified in humans as the targets of autoantibodies in patients with PARANEOPLASTIC ENCEPHALOMYELITIS. They are thought to regulate GENE EXPRESSION at the post-transcriptional level.
Usher Syndromes
Autosomal recessive hereditary disorders characterized by congenital SENSORINEURAL HEARING LOSS and RETINITIS PIGMENTOSA. Genetically and symptomatically heterogeneous, clinical classes include type I, type II, and type III. Their severity, age of onset of retinitis pigmentosa and the degree of vestibular dysfunction are variable.
