Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

23:06 EST 25th November 2014 | BioPortfolio

PubMed Articles [9726 Associated PubMed Articles listed on BioPortfolio]

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin - Implication to their genotoxic mechanism.

The aim of this study was to investigate the possible protective effect of sodium copper chlorophyllin (CHL) against cytotoxicity and DNA damage induced by mycotoxins ochratoxin A (OTA) and fumonisin ...

Pound the alarm: danger signals in rheumatic diseases.

Damage-associated molecular patterns (DAMPs) are chemically heterogeneous endogenous host molecules rapidly released from damaged or dying cells that incite a sterile inflammatory response mediated vi...

Genome-wide detection of selection and other evolutionary forces.

As is well known, pathogenic microbes evolve rapidly to escape from the host immune system and antibiotics. Genetic variations among microbial populations occur frequently during the long-term pathoge...

Regulation of Skeletal Muscle Development and Disease by microRNAs.

The identification of microRNAs (miRNA) in vertebrates has uncovered new mechanisms regulating skeletal muscle development and disease. miRNAs are inhibitors and act by silencing specific mRNAs or by ...

Dormancy and Quiescence of Skeletal Muscle Stem Cells.

The skeletal muscle of vertebrates has a huge regenerative capacity. When destroyed after different types of injury, this organ can regenerate very quickly (less than 20 days following myotoxin inject...

Multilocus Sequence Typing (MLST): Markers for the Traceability of Pathogenic Leptospira Strains.

Leptospirosis is a major zoonosis with worldwide distribution. Conventional serological typing is arduous and time consuming. Genotyping is increasingly applied for the typing and identification of le...

Next-Generation Sequencing in Veterinary Medicine: How Can the Massive Amount of Information Arising from High-Throughput Technologies Improve Diagnosis, Control, and Management of Infectious Diseases?

The development of high-throughput molecular technologies and associated bioinformatics has dramatically changed the capacities of scientists to produce, handle, and analyze large amounts of genomic, ...

Mouse models of rhinovirus infection and airways disease.

Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infecti...

Reverse genetics system for studying human rhinovirus infections.

Human rhinovirus (HRV) contains a 7.2 kb messenger-sense RNA genome which is the template for reproducing progeny viruses after it enters the cytoplasm of a host cell. Reverse genetics refers to the r...

Proteases of human rhinovirus: role in infection.

Human rhinoviruses (HRV) are the major etiological agents of the common cold and asthma exacerbations, with significant worldwide health and economic impact. Although large-scale population vaccinatio...

News Articles [2937 Associated News Articles listed on BioPortfolio]

MicroRNAs and atrial fibrillation: mechanisms and translational potential

Available treatments for atrial fibrillation (AF) often lack sufficient efficacy or have considerable complications, but novel therapies based on the underlying molecular mechanisms of AF can provide ...

Mortality Threefold Higher in Epilepsy

A new meta-analysis has found mortality rates to be three times higher in epilepsy than in the general population. Future research must look beyond mortality to risk factors and mechanisms. Medscape...

Stratasys Joins PTC PartnerAdvantage Program to Increase Accessibility and Enhance Design for Additive Manufacturing

Stratasys Ltd. (Nasdaq:SSYS), a leading global provider of 3D printing and additive manufacturing solutions, today announced the company has joined the PTC® PartnerAdvanta...

EuroMold 2014: Stratasys Showcases Additive Manufacturing Ecosystem, Creating "Your Way" 3D Printing Experience with New Partnerships, Professional Services and Solutions

Company announces largest presence ever at EuroMold 2014 with three exhibits spanning 20 customer applications Stratasys unveils new Professional Services program and new...

Piper Jaffray to Host 26th Annual Healthcare Conference

Piper Jaffray (NYSE:PJC), a leading investment bank and asset management firm, will host its 26th annual Healthcare Conference in New York on December 2-3, 2014. ...

Fingerprint Sensors Market by Type (Swipe And Area), Material (Optical Prism, Pizeoelectric, Capacitive,and Adhesives), Application (Mobile Devices, Government, Defense, Healthcare, Commercial Security and Banking & Finance), and Geography - Global

LONDON, Nov. 25, 2014 /PRNewswire/ -- In 2013, the introduction of the first fingerprint sensor by Apple (U.S.) in the iPhone 5s triggered the growth of the fingerprint sensors market immensely. Soon ...

Deadly Superbug in Southeast Michigan Shows Recent Decline

A new study finds a decrease in an emergent strain of the superbug methicillin-resistant S. aureus (MRSA) that is resistant to last line defense antibiotics. Researchers examined the prevalence of van...

New treatments for cancer – you may have a pig to thank

Genetically engineered pigs, minipigs, and microminipigs are valuable tools for biomedical research, as their lifespan, anatomy, physiology, genetic make-up, and disease mechanisms are more similar to...

No proof 5:2 diet prevents cancer

"Could 5:2 diet help to ward off cancer?" is the question posed by the Mail Online after the publication of a study into experimental diets. An honest and accurate answer to the question, b...

Superbug in SE Michigan shows recent decline

A new study finds a decrease in an emergent strain of methicillin-resistant S. aureus (MRSA) that is resistant to last line defense antibiotics. Researchers examined the prevalence of vancomycin-resis...

Events [1 Associated Events listed on BioPortfolio]

Free webinar: DNA Methylation Changes during Cell Differentiation

This one hour webinar provides an overall perspective on the connections between DNA methylation and other epigenetic marks and the interplay with transcription factors.

Companies [179 Associated Companies listed on BioPortfolio]

Barco N.V.

Barco is a world leader in professional markets, in which it offers display and visualization solutions. Based upon in-depth market knowledge, the company designs and develops solutions for large-scre...

Tenable Network Security Inc.

Tenable Network Security provides continuous network monitoring to identify vulnerabilities, reduce risk and ensure compliance. Our family of products includes SecurityCenter Cont...

ImmuneXcite, Inc.

ImmuneXcite is a privately held biotech company located in Lexington, Massachusetts that is developing the next generation of immune-activating therapies for oncology utilizing a ...

II-VI Optical Systems

II-VI Optical Systems is a leading producer of high precision optical assemblies, objectives, infrared optics and components, windows, domes, thin film coatings, and optical mater...

Tokai Pharmaceuticals, Inc.

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, galeterone (TOK-001), i...

CherylLeeMD® Sensitive Skin Care

CherylLeeMD® Sensitive Skin Care products are the first skin care products to work with the skin to obtain its optimal equilibrium by simultaneously addressing skin lipid defic...

Navitor Pharmaceuticals, Inc.

Navitor Pharmaceuticals, Inc., is a biopharmaceutical company developing novel medicines by targeting cellular nutrient signaling pathways. The company’s proprietary drug dis...

Pelican Products, Inc.

Pelican Products, Inc. is the global leader in design and manufacture of both high-performance protective case solutions and advanced portable LED lighting systems. Their produ...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

HealthFleet, Inc.

HealthFleet is the first platform-as-a-service (PaaS) provider for healthcare. HealthFleet’s technology allows providers to deliver their health programs and services online,...

Clinical Trials [1034 Associated Clinical Trials listed on BioPortfolio]

Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer

NSCLC tumors are appropriate targets for active immunotherapy, because they are non-immunogenic, which indicates that NSCLC does not stimulate a spontaneous immune response. NSCLC t...

Interdisciplinary Case-Control Study of Bladder Cancer in Spain

The incidence rate of bladder cancer in the Barcelona area of Spain is almost identical to that of the U.S. Cigarette smoking has been identified as the most significant risk factor for b...

The Healthy Elderly Longevity Cohort

With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; how...

Immunogenetic Mechanisms in Behcet's Disease

Background: - Uveitis, the inflammation of the interior of the eye, is responsible for numerous new cases of legal blindness every year. Uveitis can be caused by Beh(SqrRoot)(Beta)et s ...

Optimal Exercise Training and Nutrition Supplementation in Older Men

As we age we tend to lose muscle mass and strength. These losses contribute to the increased incidence of falls and fractures, metabolic diseases such as type 2 diabetes, loss of independ...

Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in th...

Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT

This study evaluates the efficacy of high-dose post-transplantation cyclophosphomide as graft-versus-host disease (GVHD) prophylaxis after allogeneic stem cell transplantation in patients ...

Randomized, Double Blind, Placebo-controlled Topical Resiquimod Adjuvant for NY-ESO-1 Protein Vaccination

The study is designed to see if a course of injections containing the NY-ESO-1 protein (a tumor antigen, marker expressed by tumors); in combination with an immune stimulant (adjuvant) Mon...

Busulfan, Melphalan, Fludarabine and T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Followed by Post Transplantation Donor Lymphocyte Infusions

The patients are being offered a stem cell transplant. Stem cells are very early blood cells. They have not yet matured to become red or white blood cells or platelets. They have already r...

Genetic Analysis of Immune Disorders

The purposes of this study are to 1) identify the genes responsible for certain immune disorders, 2) learn about the medical problems they cause, and 3) learn how to predict who is likely ...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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