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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

00:14 EDT 1st May 2016 | BioPortfolio

PubMed Articles [11047 Associated PubMed Articles listed on BioPortfolio]

A multi-subband Monte Carlo study on dominance of scattering mechanisms over carrier transport in sub-10-nm Si nanowire FETs.

Dominance of various scattering mechanisms in determination of the carrier mobility is examined for silicon (Si) nanowires of sub-10-nm cross-sections. With a focus on p-type channels, the steady-stat...

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia.

The mitochondrion is a major site for the metabolism of the transition metal, iron, which is necessary for metabolic processes critical for cell vitality. The enigmatic mitochondrial protein, frataxin...

Early life exposure to obesogenic diets and learning and memory dysfunction.

Obesogenic dietary factors, such as simple sugars and saturated fatty acids, have been linked to memory impairments and hippocampal dysfunction. Recent evidence suggests that the brain may be particul...

An insect with a delta-12 desaturase, the jewel wasp Nasonia vitripennis, benefits from nutritional supply with linoleic acid.

The availability of linoleic acid (LA; C18:2(∆9,12)) is pivotal for animals. While vertebrates depend on a nutritional supply, some invertebrates, including the parasitic wasp Nasonia vitripennis, a...

The Role of Resilience in the Clinical Management of Chronic Pain.

Chronic pain affects more individuals than does cancer, heart disease, and diabetes combined. Yet, our treatment options remain remarkably limited. Often, highly effective psychotherapeutic approaches...

Toxoplasma gondii infection and schizophrenia: an inter-kingdom communication perspective.

The apicomplexan protozoan Toxoplasma gondii has a striking predilection for infecting the central nervous system and has been suggested as a risk factor for schizophrenia. Here, we address some of th...

More sensitivity of cortical GABAergic neurons than glutamatergic neurons in response to acidosis.

Acidosis impairs brain functions. Neuron-specific mechanisms underlying acidosis-induced brain dysfunction remain elusive. We studied the sensitivity of cortical GABAergic neurons and glutamatergic ne...

Epochs in the depressor/pressor balance of the renin-angiotensin system.

The renin-angiotensin system (RAS) plays a commanding role in the regulation of extracellular fluid homoeostasis. Tigerstadt and Bergman first identified the RAS more than two centuries ago. By the 19...

T-cell involvement in sex differences in blood pressure control.

Hypertension affects one-third of adults in the Western world and is the most common independent risk factor for cardiovascular disease, and the leading cause of premature death globally. Despite avai...

The rules for symbiont community assembly change along a mutualism-parasitism continuum.

Symbiont community assembly is driven by host-symbiont and symbiont-symbiont interactions. The effects that symbionts exert on their hosts are often context-dependent, and existing theoretical framewo...

News Articles [2707 Associated News Articles listed on BioPortfolio]

Pharmaceutical Research: Insights into Spray Development from Metered-Dose Inhalers Through Quantitative X-ray Radiography

Type: Original PaperPurposeTypical methods to study pMDI sprays employ particle sizing or visible light diagnostics, which suffer in regions of high spray density. X-ray techniques can be applied to p...

U.S. donates $5 million to Puerto Rico for Zika defense

The U.S. Department of Health and Human Services is giving $5 million to 20 health centers in Puerto Rico to fight the spread of Zika virus.Approximately 474 cases of Zika have been reported ...

Amedica Corporation to Release First Quarter 2016 Financial Results and Host Conference Call

SALT LAKE CITY, UT--(Marketwired - Apr 29, 2016) - Amedica Corporation ( NASDAQ : AMDA), a company that develops and commercializes silicon nitride ceramics Read more...

Paving the Road for Clinical Biomarkers

In time, the narrow, tortuous paths followed by pioneers become wider and straighter, whether the pioneers are looking to settle new land or bring new biomarkers to the clinic. In the case of biom...

New therapeutic target to treat bacterial infections may substitute antibiotics

Infections continue to threaten human health. With remarkable genetic flexibility, pathogenic organisms outsmart available therapies. Fortunately, microbial versatility is matched by the host immune s...

Researchers Calculate Risk of Dengue for Non-Immune Visitors to Olympic Games in Rio de Janeiro

Rio de Janeiro in Brazil will host the Summer Olympic Games this summer, with about 400,000 non-immune foreign tourists expected to attend. As Brazil is the country with the highest number of dengue c...

Sojourner Center BRAIN Program to research neurological care for survivors of domestic violence

Body: A recent feature story published by Yes! Magazine examined the rise in national interest in traumatic brain injury (TBI). As more people become aware of TBI, the story explained, some gro...

Cancer cells plasticity and drug resistance

Dr Rafaella Sordella speaks with ecancertv at AACR 2016 about cell plasticity affecting its susceptibility to therapies. With specific regard to non-genetic mechanisms of resistance in cancer cells, ...

Entomologists shed light on bizarre mating mechanisms of native twisted-winged parasites

Twisted-winged parasites of the species Stylops ovinae reproduce using so-called traumatic insemination. Entomologists of the Friedrich Schiller University Jena and the Christian Albrechts University ...

Barcelona to host second edition of Internet of Things Solutions World Congress

Barcelona to host second edition of Internet of Things Solutions World Congress

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Companies [223 Associated Companies listed on BioPortfolio]

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Unity Biotechnology

Unity Biotechnology is designing therapeutics that prevent, halt or reverse numerous diseases of aging. The Company is targeting biological mechanisms that unify many afflictions,...

CMMI Institute

CMMI Institute (CMMIinstitute.com) is the organization behind Capability Maturity Model Integration (CMMI®), the globally adopted capability improvement framework that g...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Armor

The leader in active cyber defense, Armor offers customer-centric security outcomes for retail and eCommerce enterprises, healthcare organizations, payment leaders and financial i...

Histide AG

Histide™ is a biotech intellectual property platform company pioneering a new class of nonmutagenic extracellular therapeutic agents called Cell Recoding Molecules™ (CRM...

Lieber Institute for Brain Development

The mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of basic genetic and molecular mechanisms of schizo...

Cambrian Innovation

Cambrian Innovation is a leader in developing biotechnology solutions that extract energy from water. Spun out of MIT in 2006, Cambrian has scaled and validated its proprie...

NantKwest, Inc.

NantKwest (Nasdaq:NK) is a pioneering, next generation, clinical-stage immunotherapy company focused on harnessing the unique power of our immune system using natural killer (NK) ...

Clinical Trials [1422 Associated Clinical Trials listed on BioPortfolio]

Impact of Allo- and Autoantibodies on Chronic Cardiac Allograft Function

This is a multi-center, prospective, single cohort, observational study of pediatric heart transplant recipients designed to determine the impact of preformed versus de novo human leukocyt...

Study on the Therapeutic Mechanisms of Dithranol Treatment in Patients With Chronic Plaque Psoriasis

Dithranol (known in the U.S.A. as anthralin and in Germany as cignolin) is one of the oldest and safest topical anti-psoriatic treatments. However, despite explorative investigations, the ...

Evaluation of a Kit for the Prediction of the Risk of Graft Versus Host Disease

This study is a proof of concept that will assess the Predictor's kit performances. The test will be performed by several technicians, in immunological laboratories of several sites in Fra...

Azacitidine in Haploidentical Donor Hematopoietic Cell Transplantation

Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for patients with hematologic malignancies including acute myeloid leukemia (AML), myelodysplasti...

Comparison of Aqueous and Plasma Glucose Level in Diabetic Patients

Comparison of aqueous and plasma glucose level in diabetic patients High glucose concentrations in aqueous humor are thought to be related of diabetic ocular injury, including cataract an...

Multiple Donor Treg DLI for Severe Refractory Chronic GVHD

This is a INTERVENTIONAL TRANSPLANTATION STUDY WITHOUT DRUGS. The INTERVENTION is represented by the INFUSION of DONOR T REGULATORY CELL-ENRICHED LYMPHOCYTES to PATIENTS suffering from RE...

Prevention of Acute Kidney Injury - Molecular Mechanisms of Dietary Pre-conditioning in Human

The key objective of this pilot study is to assess the molecular mechanisms of renal pre-conditioning by a one-week low-calorie diet in humans. The protective effect of the low-calorie di...

Dose Finding Study Evaluating Safety and Feasibility in Patients With Relapsed or Refractory Myeloid Neoplasms

This study will evaluate patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) or advanced hypomethylating agent-resistant myelodysplastic syndrome (MDS) who will have autologo...

Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition

The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and greate...

Anticoagulation in Cancer Related Stroke

Purpose: Cancer associated intravascular coagulopathy is the primary mechanism of cancer-related stroke, particularly in those without conventional stroke etiologies. Randomized clinical t...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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