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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

03:47 EDT 27th June 2016 | BioPortfolio

PubMed Articles [11068 Associated PubMed Articles listed on BioPortfolio]

Is Neurotoxicity of Metallic Nanoparticles the Cascades of Oxidative Stress?

With the rapid development of nanotechnology, metallic (metal or metal oxide) nanoparticles (NPs) are widely used in many fields such as cosmetics, the food and building industries, and bio-medical in...

A multi-subband Monte Carlo study on dominance of scattering mechanisms over carrier transport in sub-10-nm Si nanowire FETs.

Dominance of various scattering mechanisms in determination of the carrier mobility is examined for silicon (Si) nanowires of sub-10-nm cross-sections. With a focus on p-type channels, the steady-stat...

Recent progress on the genetics and molecular breeding of brown planthopper resistance in rice.

Brown planthopper (BPH) is the most devastating pest of rice. Host-plant resistance is the most desirable and economic strategy in the management of BPH. To date, 29 major BPH resistance genes have be...

Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models.

Toll-like receptor (TLR) 4 is an important polysaccharide receptor; however, the relationships between the structures and biological activities of TLR4 and polysaccharides remain unknown. Many recent ...

Mechanically flexible and optically transparent three-dimensional nanofibrous amorphous aerocellulose.

Aerocelluloses are considered as "third generation" aerogels after the silica and synthetic polymer-based ones. However, their brittleness and low optical translucency keep quite narrow their fields o...

Bone disorders: Mechanisms and targets.

Surface patterned pH-sensitive fluorescence using β-cyclodextrin functionalized poly(ethylene glycol).

This paper reports the development of a pH-responsive molecular pattern that shows specific and selective affinity for particular host-guest interactions, and its use as a pH fluorescent sensor. The p...

APOE and aging-related cognitive change in a longitudinal cohort of men.

We examined associations between APOE major isoforms, rs405509 promoter and rs440446 intron-1 polymorphisms, and nonpathologic cognitive aging. Men from the Helsinki Birth Cohort Study took the Finnis...

Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice.

Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these...

Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease.

The posterior cingulate cortex (PCC) is a key hub of the default mode network, a resting-state network involved in episodic memory, showing functional connectivity (FC) changes in Alzheimer's disease ...

News Articles [2642 Associated News Articles listed on BioPortfolio]

Funding to help improve quality and quantity of donor limbs, tissues for transplant

(Case Western Reserve University) A Case Western Reserve University School of Medicine faculty member has received $998,500 from the US Department of Defense to develop a new approach to improve the q...

How Telemedicine Is Transforming Health Care

The revolution is finally here—raising a host of questions for regulators, providers, insurers and patients.

Reversible Process Forms Supramolecular Polymers For Fibers, Molecular-Transport Mechanisms

Nori Yamaguchi, a chemistry graduate student at Virginia Tech (Blacksburg, VA; nyamaguc@vt.edu), and her professor, Harry Gibson, have used hydrogen bonding self-assembly to create large aggregate str...

CONSTIPATION chronique: Et si c'était une infection virale? - Cell Host & Microbe

Cette étude de chercheurs de Yale révèle un processus pathologique jusque-là inconnu et qui peut expliquer de nombreux cas de constipation chronique inexpliqués. Une...

Vice President Biden to host Cancer Moonshot Summit in Washington, D.C.

Vice President Biden and Dr. Jill Biden will host a Cancer Moonshot Summit in Washington, D.C. at the White House. Cheryl Willman, MD, Director and CEO of The University of New Mexico Comprehensive Ca...

Florida Library Closes Due to Head Lice; Lice Troopers Takes Steps to Keep Facilities Bug Free

Miami, FL (PRWEB) June 25, 2016 The temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as r...

Re-engineering cardiac scarring process could improve clinical outcomes for heart disease patients

Literal heartbreak, from illness or injury, triggers the body's natural healing mechanisms.

Bet Low, Lose High: New Psychtests.com Study Reveals The Psychological Basis Of Low Self-Expectations

New study by Psychtests.com reveals that people who set low expectations for themselves are not just afraid of failure - they have a host of psychological blocks that are holding them back from succes...

Acute Care Needleless Connectors Market to Cross USD 1,036 Million by 2020

Maryland Heights, MO, June 25, 2016 --(PR.com)-- According to a market research report published by iHealthcareAnalyst, Inc., Acute Care Needleless Connectors Market – Global Designs, Mechanism...

Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

Several classes of glucose-lowering therapies are now available for treatment of type 2 diabetes mellitus. In this Review, the current knowledge relating to mechanisms of action, pharmacokinetics, pha...

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Companies [223 Associated Companies listed on BioPortfolio]

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Unity Biotechnology

Unity Biotechnology is designing therapeutics that prevent, halt or reverse numerous diseases of aging. The Company is targeting biological mechanisms that unify many afflictions,...

CMMI Institute

CMMI Institute (CMMIinstitute.com) is the organization behind Capability Maturity Model Integration (CMMI®), the globally adopted capability improvement framework that g...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Armor

The leader in active cyber defense, Armor offers customer-centric security outcomes for retail and eCommerce enterprises, healthcare organizations, payment leaders and financial i...

Histide AG

Histide™ is a biotech intellectual property platform company pioneering a new class of nonmutagenic extracellular therapeutic agents called Cell Recoding Molecules™ (CRM...

Lieber Institute for Brain Development

The mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of basic genetic and molecular mechanisms of schizo...

Cambrian Innovation

Cambrian Innovation is a leader in developing biotechnology solutions that extract energy from water. Spun out of MIT in 2006, Cambrian has scaled and validated its proprie...

NantKwest, Inc.

NantKwest (Nasdaq:NK) is a pioneering, next generation, clinical-stage immunotherapy company focused on harnessing the unique power of our immune system using natural killer (NK) ...

Clinical Trials [1487 Associated Clinical Trials listed on BioPortfolio]

Pathophysiology Analysis of "Costello Syndrome" on Cellular Models

The objective is to collect skin biopsies rom patients with Costello syndrome to analyze the molecular mechanisms responsible for this syndrome caused by a mutation in the HRAS gene and th...

Single-centre Study of Everolimus as GvHD Prophylaxis After Post-Transplantation Cyclophosphamide After Allogeneic SCT

A phase II clinical study to assess the efficacy of short-term everolimus as prophylaxis for Graft-versus-Host disease (GvHD) in addition to post-transplantation cyclophosphamide after all...

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I

The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.

Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults

I recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults...

The Influence Cirrhosis of the Liver on the Coronary Re-stenosis (LTX- Stent Study)

The aim of the study is to choose an optimal stent and to get further knowledge about the mechanisms of the engraftment of a stent. The occurrence of a hyperplasia of neointima can be min...

Early Interventions in Children With Attention Deficit/Hyperactivity Disorder

Introduction: Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent mental disorders in children and is associated with important negative functional outcomes throug...

Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging

This is a prospective, multicenter, randomized trial to determine the mechanisms of vascular healing. The study will evaluate subjects with peripheral artery disease (PAD) who require an e...

Brain Plasticity of Autism in Response to Early Behavioral Intervention: A Multimodal MRI Study

Autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. While the unclear neurobiological basis of autism and the lack of effective medication, t...

Salivary Cytokines as Biomarker for Oral Health

Oral complications during and after cancer treatment are common. A key role in maintaining oral health plays saliva. In the last decade numerous studies have investigated immunological bio...

Pharmacokinetics of Posaconazole (Noxafil®) as Prophylaxis for Invasive Fungal Infections

This study evaluates the the pharmacokinetics of posaconazole (new solid oral and IV) given as prophylaxis to patients who are at risk for developing fungal infections after receiving cond...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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