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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

00:28 EST 26th February 2017 | BioPortfolio

PubMed Articles [11295 Associated PubMed Articles listed on BioPortfolio]

Structure-activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor.

Fraxamoside, a macrocyclic secoiridoid glucoside featuring a hydroxytyrosol group, was recently identified as a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout...

Pregnancy-associated transient osteoporosis of the hip: results of a case-control study.

The etiology and underlying mechanisms of transient of osteoporosis of the hip (TOH) during pregnancy are still unclear, since no systematic analyses exist. Our results support the hypothesis that TOH...

Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients.

Cystic fibrosis (CF) is a genetic disease in which bacterial infections of the airways play a major role in the long-term clinical outcome. In recent years, a number of next-generation sequencing (NGS...

Simulated airplane headache: a proxy towards identification of underlying mechanisms.

Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrenc...

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available ...

Zika Virus RNA Replication and Persistence in Brain and Placental Tissue.

Zika virus is causally linked with congenital microcephaly and may be associated with pregnancy loss. However, the mechanisms of Zika virus intrauterine transmission and replication and its tropism an...

The nerve: A fragile balance between physiology and pathophysiology.

Regarding nerves as simple cables and electrical conduits is a gross error that does not allow us to understand the anomalies and disorders observed postoperatively. Instead, nerves should be seen as ...

Shoulder Synovial Fluid Lipoprotein Levels and Their Relationship to the Rotator Cuff.

Rotator cuff pathology has been proposed to occur through intrinsic and extrinsic mechanisms. Hyperlipidemia has been proposed as a mechanism of intrinsic rotator cuff pathology. This prospective obse...

Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial.

Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America. Although the pathogenesis ...

Intra and inter species genetic variability of transferrin receptor gene regions in Trypanosoma evansi isolates of different livestock and geographical regions of India.

Trypanosoma evansi, the aetiological agent of Surra affects a wide range of livestock and wild animals in India. In the present study, we studied intra- and inter species genetic variability in the tr...

News Articles [2558 Associated News Articles listed on BioPortfolio]

Doctors Consider a Last Best Hope for Obese Teenagers: Surgery

Parents and doctors have a host of concerns about the procedure, but some are wondering if teenage patients are waiting too long for what may be their best option.

The cellular and molecular bases of leptin and ghrelin resistance in obesity

In obesity, individuals develop resistance to leptin and ghrelin, which have important functions in the neuroendocrine control of energy homeostasis. Here, Cui and colleagues discuss the mechanisms th...

OncoSec to Host KOL Event Focused on New ASCO-SITC Melanoma Data and Clinical Strategy on ...

Sharron Gargosky, PhD, OncoSec's Chief Clinical and Regulatory Officer, and Chris Twitty, PhD, OncoSec's Director of Clinical Science, will provide an overview of the Read more...

Through Development, Some Brain Cells May Favor Mom’s Genes, or Dad’s

If we look at a child’s face, we may feel moved to say that she has her mother’s eyes, or her father’s nose. But if we consider an individual cell, we’re less discriminating. Our usual baselin...

Startup Wins $400K from Foundations to Develop DMD Candidate

Startup Duchenne muscular dystrophy (DMD) drug developer DMD Therapeutics said today it will advance its first candidate into the clinic after winning a commitment of $400,000 from three foundations. ...

The National Inventors Hall Of Fame To Induct 15 Luminaries Who Are Driving Innovation Forward

ALEXANDRIA, Va., Feb. 24, 2017 /PRNewswire/ -- The National Inventors Hall of Fame®, in partnership with the United States Patent and Trademark Office (USPTO), will host the Greatest Celebration...

Disruption of genes involved in CORVET complex leads to enhanced secretion of heterologous carboxylesterase only in protease deficient Pichia pastoris

The methylotrophic yeast Pichia pastoris (Komagataella spp.) is a popular microbial host for the production of recombinant proteins. Previous studies have shown that mis‐sorting to the vacuole can b...

OncoSec to Host KOL Event Focused on New ASCO-SITC Melanoma Data and Clinical Strategy on Tuesday, February 28 in New York City

SAN DIEGO, Feb. 24, 2017 /PRNewswire/ -- OncoSec Medical Incorporated ("OncoSec") (NASDAQ: ONCS), a company developing DNA-based intratumoral cancer immunotherapies, will host a Key Opinion Leade...

T cells in babies give clues to who will develop type 1 diabetes

The research group of Prof. Ezio Bonifacio, group leader and Director at the DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence at TU Dresden, and group leader at DZD-Paul La...

[Comment] Solving the conundrum of insoluble protein aggregates

A pathological hallmark of many neurodegenerative diseases is the aggregation of misfolded proteins.1 To prevent accumulation of misfolded protein, constant intracellular clearance through the proteas...

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Companies [224 Associated Companies listed on BioPortfolio]

Lumany, LLC

Established in 2011 in Costa Mesa, CA, Lumany designs and manufactures next-generation laser and illumination products for industrial, biomedical and defense & security applicatio...

Bulova Technologies Group, Inc.

Headquartered in Clearwater, FL, Growth Technologies International, Inc. focuses on disruptive technologies in the fields of defense, alternative energy, alternative healthcare, h...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Unity Biotechnology

Unity Biotechnology is designing therapeutics that prevent, halt or reverse numerous diseases of aging. The Company is targeting biological mechanisms that unify many afflictions,...

CMMI Institute

CMMI Institute (CMMIinstitute.com) is the organization behind Capability Maturity Model Integration (CMMI®), the globally adopted capability improvement framework that g...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Armor

The leader in active cyber defense, Armor offers customer-centric security outcomes for retail and eCommerce enterprises, healthcare organizations, payment leaders and financial i...

Histide AG

Histide™ is a biotech intellectual property platform company pioneering a new class of nonmutagenic extracellular therapeutic agents called Cell Recoding Molecules™ (CRM...

Lieber Institute for Brain Development

The mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of basic genetic and molecular mechanisms of schizo...

Clinical Trials [1733 Associated Clinical Trials listed on BioPortfolio]

Mechanisms of Weight Loss in Patients Diagnosed With Achalasia

Currently there are no existing data to determine why some achalasia patients lose weight while others do not. The purpose of this study is to gather data from patients diagnosed with acha...

The White Blood Cell Reactivity Following Surgical Trauma and Associated Regulatory Mechanisms.

The purpose of this study is to describe numerical and functional changes in the white blood cell efter surgical trauma. Further, observed immune cell changes correlate to heart rate varia...

Biomarkers in Dyspnea

To explore biological mechanisms in human model of induced dyspnea, in order to remove the source of dyspnoea, to modify cerebral impact and to allow the development of targeted therapies.

Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

This randomized clinical trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus...

Effects of Intranasal Oxytocin on Emotion Regulation

The aim is to examine whether intranasal oxytocin will influence the individuals' emotion regulation ability and related neural mechanisms.

Post-surgery Systemic Inflammation and Neuro-immune Interactions

The aim is to map the inflammatory response after surgery and further investigate the mechanisms by which inflammation is regulated. The inflammatory cascade is pivotal in protecting organ...

Canola Oil Multi-center Intervention Trial II

Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DE...

Immune Response Evaluation to Curative Conventional Therapy

The IRECT trial is a non-interventional, prospective clinical trial using modern immune monitoring techniques over the course of the standard of care for HNSCC. The dynamics of host/tumor ...

Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.

In this study, the investigators will investigate and characterize acute medical patients in order to optimize patient courses in the acute care departments, especially with regard to poly...

Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty

Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis. Despite its ...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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