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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

12:23 EDT 28th July 2014 | BioPortfolio

PubMed Articles [9394 Associated PubMed Articles listed on BioPortfolio]

Effect of fermentation on the antioxidant activity in plant-based foods.

This study provides an overview of the factors that influence the effect of fermentation on the antioxidant activity and the mechanisms that augment antioxidative activities in fermented plant-based f...

In vitro total antioxidant capacity and anti-inflammatory activity of three common oat-derived avenanthramides.

To better understand mechanisms underlying the health benefits of oats, the free radical scavenging capacities of oat avenanthramides 2c, 2f, and 2p and their ability to inhibit NF-κB activation were...

Role of the potassium channel KCa3.1 in diabetic nephropathy.

There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointe...

Cyclodextrin-coated denim fabrics as novel carriers for ingredient deliveries to the skin.

Garments with coverage of a large part of the body generate an exceptional opportunity for transferring active ingredient to the skin. A fabric finished with β-cyclodextrin derivatives can play a rol...

Effect and mechanisms of curdlan sulfate on inhibiting HBV infection and acting as an HB vaccine adjuvant.

In this study, the effect and mechanisms of curdlan sulfate (CS3) on hepatitis B virus (HBV) infection and promoting immune response of the mice immunized with recombinant hepatitis B surface protein...

Impact of ghosts on the viscoelastic response of gelatinized corn starch dispersions subjected to small strain deformations.

Corn starch dispersions (5.0% w/w) were gelatinized by heating at 90°C for 20min using gentle stirring. Under these conditions, ghosts, which are insoluble material with high amylopectin content, wer...

Potentiometry up to 275°C: Example of pH titrations of cobalt ferrite particles.

High temperature potentiometry (or pH-metry) is needed for specific hydrothermal applications such as acid-base titration of metallic oxides particles to predict their reactivity toward dissolved spec...

Role of the BaeSR two-component regulatory system in resistance of Escherichia coli O157:H7 to allyl isothiocyanate.

Allyl isothiocyanate (AITC) is an essential oil with antimicrobial activity against Escherichia coli O157:H7. The ability of E. coli O157:H7 to withstand inhibitory AITC concentrations and the role o...

Listeria ivanovii ATCC 19119 strain behaviour is modulated by iron and acid stress.

It has been suggested that the rarity of human listeriosis due to Listeria ivanovii reflects not only host tropism factors but also the rare occurrence of this species in the environment, compared wit...

Emerging Roles of MicroRNA in the Embryo-Endometrium Cross Talk.

Embryo implantation requires a reciprocal interaction between the blastocyst and endometrium and is associated with complex regulatory mechanisms. Since their discovery, microRNAs have become prominen...

News Articles [2939 Associated News Articles listed on BioPortfolio]

Cubist to Present at August Investor Conference

Cubist Pharmaceuticals, Inc. (NASDAQ: CBST) today announced that company management will discuss Cubist’s business activities and financial outlook at investor conference...

Chiesi USA, Inc. (CRTX) - Strategic SWOT Analysis Review

Recently added to the BioPortfolio report store, Chiesi USA, Inc. (CRTX) - Strategic SWOT Analysis Review is a new report from GlobalData published on 2014-07-14. This 28-page report is available in...

Forte Research Systems to Host Inaugural Industry Conference, Clinical Research Operations Forum

Forte Research Systems, Inc. will host its inaugural industry-wide conference, the Clinical Research Operations Forum, in Madison, WI from September 9-10, 2014. Madison, Wis. (PRWEB) July 28, 2014 Fo...

The Neural Development of Trust and Cooperation

This study explored the brain mechanisms underlying trust and cooperation in subjects ranging from adolescence to mid-adulthood. Did age matter? Social Cognitive and Affective Neuroscience

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS–RAF–MEK–ERK mitogen-activated protein kinase (MAPK) s...

Antifungal drug resistance evoked via RNAi-dependent epimutations

Microorganisms evolve via a range of mechanisms that may include or involve sexual/parasexual reproduction, mutators, aneuploidy, Hsp90 and even prions. Mechanisms that may seem detrimental can be rep...

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self rene...

Pax-8–PPAR-γ fusion protein in thyroid carcinoma

Approximately one-third of follicular thyroid carcinomas contain PAX8–PPARG gene fusions, which result in the production of an oncogenic Pax 8–PPAR γ fusion protein (PPFP). Here, Raman and Koenig...

Scientists throw light on the mechanism of plants' ticking clock

Scientists from the University of York are part of an international team of researchers who have made a significant step in discovering the genetic mechanisms that plants use to fight for light.

Mark Crislip's Tales of an Infectious Disease Doctor, "Puswhisperer," Available in Review Format from Bitingduck Press in Advance of Its November 3 Release

"Puswhisperer" is a compilation of clinical tales from an Oregon infectious disease specialist. Revised and edited for a lay audience, the book will be released in November by Bitingduck Pre...

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Companies [169 Associated Companies listed on BioPortfolio]

Premier Biomedical Inc.

Premier Biomedical, Inc. is a research-based company that intends to discover and develop medical treatments for humans, in collaboration with the University of Texas at El Paso a...

Reinnervate Ltd

Reinnervate is a market leading company in the fast growing 3D cell culture market. The Alvetex® family of 3D cell culture products provide a flexible platform that allows scientists in any life...

Scholar Rock, Inc.

Scholar Rock, LLC, together with its wholly-owned operating subsidiary, Scholar Rock, Inc., is a biotechnology company discovering and developing a new class of biologic medicines...

True North Therapeutics

True North Therapeutics is a biotechnology company developing novel therapies that selectively target the Complement pathway of the immune system to address fundamental mechanisms...

HeartGift Austin

HeartGift Austin provides life-saving surgery to repair congenital heart defects in children who live in countries where this kind of medical care is not available. We provide our...

NanoLogix Inc.

NanoLogix is a biotechnology company focused primarily on rapid diagnostics. Its products offer accelerated detection and identification of microorganisms. In addition to national...

Aerie Pharmaceuticals, Inc.

Aerie Pharmaceuticals is a privately held pharmaceutical company in late Phase 2 dedicated to the discovery and development of novel small-molecule treatments for glaucoma. Aerie...

ProMining Therapeutics Ltd

ProMining Therapeutics, Ltd., based in Israel, is an early-stage biopharmaceutical research and development company engaged in the discovery and development of novel oral, small-molecule drugs for a...

Tokai Pharmaceuticals, Inc.

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, galeterone (TOK-001), i...

InTouch Technologies, Inc.

InTouch Health provides end-to-end telemedicine solutions and expertise that enable physicians to perform real-time consults with patients. Through a single portal, physici...

Clinical Trials [997 Associated Clinical Trials listed on BioPortfolio]

Methylphenidate to Improve Balance and Walking in MS

Methylphenidate is an amphetamine-like psychomotor stimulant drug currently approved for the treatment of attention-deficit hyperactivity disorder (ADHD), postural orthostasis tachycardia...

Early Clinical Results of Mobile-Bearing Revision Total Knee Arthroplasty

Long term follow-up is needed to determine whether current Mobile Bearing revision Total Knee Arthroplasty (TKA) designs will improve implant longevity. The potential advantages of mobile...

ALL-SCT BFM International- HSCT in Children and Adolescents With ALL

With this protocol the ALL-SCT BFM international study group wants - to evaluate whether hematopoietic stem cell transplantation (HSCT) from matched family or unrelated donors (MD...

Genetic Study of Peginterferon Treatment in Hepatitis B Patients: The GIANT-B Study

Background and rationale Chronic hepatitis B is the most common cause of liver cirrhosis and hepatocellular carcinoma worldwide.(1) Antiviral therapy with oral nucleoside analogs and inter...

Women's Angiographic Vitamin and Estrogen Trial (WAVE)

To assess whether hormonal replacement therapy and/or antioxidant treatment would stabilize or inhibit progression, and induce regression of coronary plaques. The mechanisms by which thes...

Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy

To evaluate the short-term effects of administering zidovudine ( AZT ) at the same time with increasing doses of aldesleukin ( interleukin-2; IL-2 ) in patients with persistent generalized...

Phase I/II Study of Recombinant Human Interferon-Gamma (rIFN-Gamma) in HIV-Infected Children

PRIMARY: To determine the safety and toxicity of recombinant interferon gamma-1b ( rIFN-gamma ) in HIV-infected children receiving ongoing zidovudine ( AZT ) or didanosine ( ddI ) therapy....

A Phase I Concentration-Controlled Trial to Assess the Safety, Tolerance, Pharmacokinetics and Development of Decreased HIV-1 Susceptibility to the Combination of Atevirdine Mesylate (U-87201E), Zidovudine (AZT), and Didanosine (ddI)

Part I: To determine the pharmacokinetic dose for atevirdine mesylate ( U-87201E ) when used in combination with zidovudine ( AZT ). To determine the pharmacokinetic profiles of U-87201E a...

A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to HAART Alone

To compare two different routes of intermittently administered rhIL-2 with a highly active antiretroviral regimen (HAART) to HAART alone. The comparison is based on the following: proporti...

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial to Compare the Safety and Immunogenicity of Recombinant Envelope Protein rgp120/HIV-1SF2 (BIOCINE) Combined With Seven Adjuvants in Healthy HIV-1 Uninfected Individuals

To determine in healthy HIV-negative volunteers the safety and immunogenicity of rgp120/HIV-1SF2 (BIOCINE) formulated with each of seven adjuvants. PER AMENDMENT 3/6/96: Purpose of the ex...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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