Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

03:47 EDT 19th September 2014 | BioPortfolio

PubMed Articles [9488 Associated PubMed Articles listed on BioPortfolio]

Genetic heterogeneity in Alzheimer disease and implications for treatment strategies.

Since the original publication describing the illness in 1907, the genetic understanding of Alzheimer's disease (AD) has advanced such that it is now clear that it is a genetically heterogeneous condi...

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies.

Neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the abnormal aggregation of a small number of intracellular proteins, with tau and α-synuclein ...

Effect of fermentation on the antioxidant activity in plant-based foods.

This study provides an overview of the factors that influence the effect of fermentation on the antioxidant activity and the mechanisms that augment antioxidative activities in fermented plant-based f...

In vitro total antioxidant capacity and anti-inflammatory activity of three common oat-derived avenanthramides.

To better understand mechanisms underlying the health benefits of oats, the free radical scavenging capacities of oat avenanthramides 2c, 2f, and 2p and their ability to inhibit NF-κB activation were...

Role of the potassium channel KCa3.1 in diabetic nephropathy.

There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointe...

Infectious Diseases and Tropical Disease Pathology: SY16-2B PEDIATRIC CEREBRAL MALARIA PATHOLOGY.

Malaria kills more than half a million children a year in sub-Saharan Africa despite the availability of effective combination drug therapy, efficacy of bed nets, and environmental control measures. C...

Endothelial dysfunction: the role of sterol regulatory element-binding protein-induced NOD-like receptor family pyrin domain-containing protein 3 inflammasome in atherosclerosis.

Great effort has been devoted to elucidate the molecular mechanisms by which inflammasome in macrophages contributes to atherosclerosis. Inflammasome in vascular endothelial cells and its causal relat...

Macrophage polarization: the epigenetic point of view.

The first functions of macrophages to be identified by Metchnikoff were phagocytosis and microbial killing. Although these are important features, macrophages are functionally very complex and involve...

Micronutrient deficiencies and celiac disease in Pediatrics.

Celiac disease (CD) is apparently changing in its clinical presentation, from chronic diarrhea and malnutrition to a silent clinic at older ages. The basal enteropathy of CD induces macro-and micronut...

The ABCD of malaria prevention in pediatric travelers.

The development and spread of drug resistant Malaria parasites, population and travelers movements to Malaria zones have led to the resurgence of Malaria as a global health problem. Estimates suggest ...

News Articles [3020 Associated News Articles listed on BioPortfolio]

China shares trim weekly losses as military-related stocks rise

HONG KONG, Sept 19 (Reuters) - China shares rose for a third straight day on Friday, bolstered by strength in shipbuilders and aviation firms, which are expected to benefit from plans to let private c...

A.M. Best “A” Rated Medical Malpractice Insurance Carrier Lowers Rates – Coverage Available Through Diederich Healthcare

An admitted and A.M. Best “A” (Excellent) rated professional liability insurance carrier has recently announced available discounts of up to 40% for qualified physicians. Carbondale, IL (PRWEB) Se...

Pro-Dex's (PDEX) CEO Hal Hurwitz on Q4 2014 Results - Earnings Call Transcript

By SA Transcripts:Pro-Dex, Inc. (NASDAQ:PDEX) Q4 2014 Earnings Conference Call September 18, 2014 16:30 ET Executives Hal Hurwitz - Chief Executive Officer Analysts Presentation Operat...

Study Finds Genes in Corn Important in Defense Response

Researchers at North Carolina State University have identified candidate genes and cellular processes believed to control hypersensitive defense response (HR) in corn. Hypersensitive defense is a resp...

Small-molecule inhibitors: Viral fusion arrested

A newly discovered small molecule with broad reactivity against diverse HIV-1 strains prevents the surface envelope glycoprotein from fusing with host cells and offers a potential new anti–HIV-1 tar...

Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma

There has recently been a flurry of publications on the molecular and genetic basis of diffuse high-grade glioma, a devastating paediatric tumour. In this Review, Jones and Baker integrate these findi...

Signalling: Hippo signalling arrests tetraploid cell growth

Ganem et al. elucidate the mechanisms underlying cell cycle arrest in tetraploid cells in vitro and in vivo.

Infectious disease: Mosquitoes awaken malaria

Mosquitoes biting a malaria-carrying host coax the malaria parasite to come out of hiding, resulting in greater disease transmission.Sylvain Gandon at the National Centre of Scientific Research in Mon...

Ecology: Sneaky ants steal in plain sight

A recently discovered parasitic ant species steals food from colonies of another ant by disguising itself as the host.Scott Powell at George Washington University in Washington DC and his co-workers d...

Orexigen Therapeutics (OREX) Presents at Bank of America Merrill Lynch Global Healthcare Conference (Transcript)

By SA Transcripts:Orexigen Therapeutics, Inc. (NASDAQ:OREX) Bank of America Merrill Lynch Global Healthcare Conference September 18, 2014 11:10 AM ET Executives Mark Booth - CCO McDavid Stilwell -...

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Companies [173 Associated Companies listed on BioPortfolio]

Pelican Products, Inc.

Pelican Products, Inc. is the global leader in design and manufacture of both high-performance protective case solutions and advanced portable LED lighting systems. Their produ...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

HealthFleet, Inc.

HealthFleet is the first platform-as-a-service (PaaS) provider for healthcare. HealthFleet’s technology allows providers to deliver their health programs and services online,...

Premier Biomedical Inc.

Premier Biomedical, Inc. is a research-based company that intends to discover and develop medical treatments for humans, in collaboration with the University of Texas at El Paso a...

Sephos Biotherapeutics

Sephos Biotherapeutics is a privately owned company focused on designing drugs for the treatment of cancer stem cells where the structure and biological activity of the drugs have...

Parx Casino Philly Cycling Classic

The Parx Casino Philly Cycling Classic is operated by a community-based non-profit organization formed to organize and host the new world-class professional cycling race in Philad...

FORUM Pharmaceuticals Inc.

FORUM Pharmaceuticals Inc. and its subsidiaries (“FORUM Pharmaceuticals” or “FORUM”) are dedicated to developing groundbreaking medicines in support of all tho...

True North Therapeutics, Inc.

True North Therapeutics is a biotechnology company developing novel therapies that selectively target the Complement pathway of the immune system to address fundamental mechanisms...

Natera Inc.

Natera Inc. is a genetic testing company that specializes in analyzing microscopic quantities of DNA for reproductive health indications. The mission of the company is to help fam...

Cambrian Innovation

Cambrian Innovation is a leader in developing biotechnology solutions that extract energy from water. Spun out of MIT in 2006, Cambrian has scaled and validated its proprie...

Clinical Trials [999 Associated Clinical Trials listed on BioPortfolio]

Pilot Peg-Interferon-a2b in Decreasing Viral DNA in HIV

We propose to test our primary hypothesis that treatment with Peg-IFN-α-2b will result in a decrease in integrated HIV DNA in peripheral blood and tissue in chronically HIV-infected immun...

ALL-SCT BFM International- HSCT in Children and Adolescents With ALL

With this protocol the ALL-SCT BFM international study group wants - to evaluate whether hematopoietic stem cell transplantation (HSCT) from matched family or unrelated donors (MD...

Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling

Obesity, with its associated co-morbidities, is a major public health challenge. It is estimated that by 2050, 60% of men and 50% of women will be clinically obese. Obesity is associated w...

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

This study is a research study involving subjects who are diagnosed with a malignant disease, that has either failed standard therapy or is unlikely to be cured with standard non-transplan...

Assessing the Fit of Motivational Interviewing by Cultures With Adolescents

Hispanic adolescents experience more severe alcohol-related consequences due to their alcohol abuse and yet significantly fewer Hispanic adolescents receive alcohol treatment, particularly...

Methylphenidate to Improve Balance and Walking in MS

Methylphenidate is an amphetamine-like psychomotor stimulant drug currently approved for the treatment of attention-deficit hyperactivity disorder (ADHD), postural orthostasis tachycardia ...

Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients

The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...

Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)

This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant a...

Tacrolimus, Sirolimus and Ustekinumab vs. Tacrolimus and Sirolimus for the Prevention of Acute Graft-Versus-Host Disease

To determine whether treatment with ustekinumab will alter the ratio of Treg/total CD4+ cells in peripheral blood at day 30 post-hematopoietic cell transplantation (HCT).

Study of OFATUMUMAB as Part of the Scheme of Reduced Intensity Conditioning in High Risk Non-Hodgkin Lymphoma B Patients

The aim of this study is rate of acute graft-versus-host disease II-IV measured at day +365according to conventional criteria (Przepiorka et al. 1995) in patients with high risk non-Hodgki...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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