Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

21:47 EST 21st December 2014 | BioPortfolio

PubMed Articles [9826 Associated PubMed Articles listed on BioPortfolio]

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin - Implication to their genotoxic mechanism.

The aim of this study was to investigate the possible protective effect of sodium copper chlorophyllin (CHL) against cytotoxicity and DNA damage induced by mycotoxins ochratoxin A (OTA) and fumonisin ...

Pound the alarm: danger signals in rheumatic diseases.

Damage-associated molecular patterns (DAMPs) are chemically heterogeneous endogenous host molecules rapidly released from damaged or dying cells that incite a sterile inflammatory response mediated vi...

Impact of Anti-Peroxynitrite-Damaged-Thymidine- Monophosphate Antibodies on Disease Activity in Patients with Systemic Lupus Erythematosus.

Present study probes the role of peroxynitrite (ONOO(-))-modified thymidine-5'-monophosphate (TMP) in SLE patients with different disease activity scores according to the SLE Disease Activity Index (S...

Genome-wide detection of selection and other evolutionary forces.

As is well known, pathogenic microbes evolve rapidly to escape from the host immune system and antibiotics. Genetic variations among microbial populations occur frequently during the long-term pathoge...

Regulation of Skeletal Muscle Development and Disease by microRNAs.

The identification of microRNAs (miRNA) in vertebrates has uncovered new mechanisms regulating skeletal muscle development and disease. miRNAs are inhibitors and act by silencing specific mRNAs or by ...

Dormancy and Quiescence of Skeletal Muscle Stem Cells.

The skeletal muscle of vertebrates has a huge regenerative capacity. When destroyed after different types of injury, this organ can regenerate very quickly (less than 20 days following myotoxin inject...

Multilocus Sequence Typing (MLST): Markers for the Traceability of Pathogenic Leptospira Strains.

Leptospirosis is a major zoonosis with worldwide distribution. Conventional serological typing is arduous and time consuming. Genotyping is increasingly applied for the typing and identification of le...

Next-Generation Sequencing in Veterinary Medicine: How Can the Massive Amount of Information Arising from High-Throughput Technologies Improve Diagnosis, Control, and Management of Infectious Diseases?

The development of high-throughput molecular technologies and associated bioinformatics has dramatically changed the capacities of scientists to produce, handle, and analyze large amounts of genomic, ...

SYMBIOTIC FACTORS IN Burkholderia ESSENTIAL FOR ESTABLISHING AN ASSOCIATION WITH THE BEAN BUG, Riptortus pedestris.

Symbiotic bacteria are common in insects and intimately affect the various aspects of insect host biology. In a number of insect symbiosis models, it has been possible to elucidate the effects of the ...

PARALYTIC PEPTIDE: AN INSECT CYTOKINE THAT MEDIATES INNATE IMMUNITY.

Host animals combat invading pathogens by activating various immune responses. Modulation of the immune pathways by cytokines is critical for efficient pathogen elimination. Insects and mammals posses...

News Articles [2915 Associated News Articles listed on BioPortfolio]

"In America", with host James Earl Jones, set to produce new content on Chiropractic Care

New content will be produced for upcoming program on chiropractic health... (PRWEB) December 19, 2014 Many people suffer from back and body pain, often living for years attempting to self-manage thei...

Health Net Federal Services Receives Full URAC Health Utilization Management and Case Management Reaccreditation

Effective management of health care services demonstrated by compliance with rigorous health care standards Health Net Federal Services, LLC, a wholly owned subsidiary ...

Fifth Third Private Bank Donates More Than $115,000 to National Charities in Honor of Clients

Contributions Made to Selected Organizations as Part of Annual Client Experience Survey As part of its annual client experience survey, Fifth Third Private Bank, a divi...

Learn How to Capitalize on the Industry's Shifting Patient Engagement Model---Register Now for PM360's “The New Healthcare Trifecta” Webcast

Webcast will be held on January 20th at 3 PM EST New York, NY (PRWEB) December 19, 2014 The patient engagement model is dramatically shifting. Historically, the relationship between drug developers a...

Neuroscientists identify brain mechanisms that predict generosity in children

Developmental neuroscientists have found specific brain markers that predict generosity in children. Those neural markers appear to be linked to both social and moral evaluation processes. Although yo...

Two-armed control of ATR, a master regulator of the DNA damage checkpoint

Our genomes encounter DNA damaging events continuously. As damage accumulates, our cells react and stop the cell division process, giving repair mechanisms time to act. To achieve this, two master pro...

From Single Product to Booming Electrophoresis Portfolio

When Labnet International launched its Electrophoresis and Molecular Biology product line in 2002, it included a single Horizontal Gel Electrophoresis unit. Labnet has since expanded the product line ...

SPR Advanced Technologies receives funding from USAID to deploy solution to combat Ebola epidemic

SPR Advanced Technologies announced that it has been awarded a grant by the US Agency for International Development (USAID) to test, refine and deploy its patented technology to assist USAID and its p...

Healthcare Industry: The Top Target of Cyber Attacks

JD Sherry | Trend Micro It is not an overstatement to acknowledge that 2014 has solidified its position as the “year of the hack.” While most are familiar with high profile attacks against Ta...

FDA Approves INTERCEPT Blood System for Platelets

Second U.S. Approval for Cerus’ INTERCEPT Blood System Extends Pathogen Reduction to Platelet Components Cerus Corporation (NASDAQ:CERS) today announced that the ...

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Companies [181 Associated Companies listed on BioPortfolio]

Acceleron Pharma and Celgene Corporation

Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel protein therapeutics for cancer and rare diseases. The...

PaR Systems, Inc.

PaR Systems, a portfolio company of MML Capital Partners (www.mmlcapital.com), is a world leader in providing advanced intelligent solutions for critical material handling, automa...

Barco N.V.

Barco is a world leader in professional markets, in which it offers display and visualization solutions. Based upon in-depth market knowledge, the company designs and develops solutions for large-scre...

Tenable Network Security Inc.

Tenable Network Security provides continuous network monitoring to identify vulnerabilities, reduce risk and ensure compliance. Our family of products includes SecurityCenter Cont...

ImmuneXcite, Inc.

ImmuneXcite is a privately held biotech company located in Lexington, Massachusetts that is developing the next generation of immune-activating therapies for oncology utilizing a ...

II-VI Optical Systems

II-VI Optical Systems is a leading producer of high precision optical assemblies, objectives, infrared optics and components, windows, domes, thin film coatings, and optical mater...

Tokai Pharmaceuticals, Inc.

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, galeterone (TOK-001), i...

CherylLeeMD® Sensitive Skin Care

CherylLeeMD® Sensitive Skin Care products are the first skin care products to work with the skin to obtain its optimal equilibrium by simultaneously addressing skin lipid defic...

Navitor Pharmaceuticals, Inc.

Navitor Pharmaceuticals, Inc., is a biopharmaceutical company developing novel medicines by targeting cellular nutrient signaling pathways. The company’s proprietary drug dis...

Pelican Products, Inc.

Pelican Products, Inc. is the global leader in design and manufacture of both high-performance protective case solutions and advanced portable LED lighting systems. Their produ...

Clinical Trials [1047 Associated Clinical Trials listed on BioPortfolio]

Mechanisms of Intradialytic Hypertension

Patients with end-stage renal disease (ESRD) are at significantly higher risk for death due to cardiovascular disease. Those with paradoxical increases in blood pressure (BP) during hemodi...

Saturated Fat Versus Monounsaturated Fat and Insulin Action

High intakes of saturated fat are associated with diabetes. Our work has shown that the two most common fatty acids in the North American diet, palmitic acid (saturated fat) and oleic aci...

Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes

The study will be focused on determining the integrated in-vivo mechanisms responsible for Ramipril's effects on delaying type 2 diabetes and restoring normal (blood sugar levels) glycemia...

Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms. Without fully con...

A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some indiv...

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Background: - National Institutes of Health (NIH) researchers have been studying immune cells (white blood cells) to better understand how the human body s defense system works ...

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali

Malaria caused by Plasmodium falciparum continues to be a global problem with devastating consequences. A greater understanding of the immunologic and parasitologic factors associated wit...

Long-term Effect of Fingolimod on Circulating Immunocompetent Mononuclear Cells in Patients With Multiple Sclerosis

The purpose of this study is to explore immunomodulatory and immunosuppressive mechanisms of action of fingolimod in patients with Relapsing remitting multiple Sclerosis to collect data on...

Observational Study of the Combination of Post-transplant High Dose Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Acute Graft-versus-Host Disease in Patients Eligible to Allogeneic Hematopoietic Stem Cell Transplant

This observational study is proposed to observe the effect of high-dose, post-transplantation cyclophosphamide after a T cell-replete, HLA-matched PBSC graft from an HLA-identical or mism...

Hemodynamic Instability Index: The Impact to Care With a New Predictive Indicator

Philips has developed a new algorithm, called Hemodynamic Instability Rules Based Advisor (HIRBA 2.0) system, for the prediction of hemodynamic instability in critically ill patients, who ...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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