Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

02:53 EST 30th January 2015 | BioPortfolio

PubMed Articles [9819 Associated PubMed Articles listed on BioPortfolio]

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin - Implication to their genotoxic mechanism.

The aim of this study was to investigate the possible protective effect of sodium copper chlorophyllin (CHL) against cytotoxicity and DNA damage induced by mycotoxins ochratoxin A (OTA) and fumonisin ...

Pound the alarm: danger signals in rheumatic diseases.

Damage-associated molecular patterns (DAMPs) are chemically heterogeneous endogenous host molecules rapidly released from damaged or dying cells that incite a sterile inflammatory response mediated vi...

Improving Outcome of Aplastic Anaemia with HLA-Matched Sibling Donor Hematopoietic Stem Cell Transplantation: An Experience of Gujarat Cancer and Research Institute (GCRI).

Fifteen patients, with a median age of 19 years having severe aplastic anaemia (SAA) underwent human leucocyte antigen (HLA) identical sibling donor hematopoietic stem cell transplantation (HSCT) usi...

Does red undermine individuals' intellectual performance? A test in China.

Previous research shows that red impairs individuals' performance on challenging intellectual tasks in achievement situations. However, no research to date has examined this issue in Chinese society. ...

Novel approaches to minimize ventilator-induced lung injury.

To discuss the mechanisms of ventilator-induced lung injury and the pro and cons of the different approaches proposed by literature to minimize its impact in patients with acute respiratory distress s...

Hypercapnia: clinical relevance and mechanisms of action.

Multiple clinical and laboratory studies have been conducted to illustrate the effects of hypercapnia in a range of injuries, and to understand the mechanisms underlying these effects. The aim of this...

Bovine Genome-wide Association Study for Genetic Elements to Resist the Infection of Foot-and-mouth Disease in the Field.

Foot-and-mouth disease (FMD) is a highly contagious disease affecting cloven-hoofed animals and causes severe economic loss and devastating effect on international trade of animal or animal products. ...

Melatonin potentiates cisplatin-induced apoptosis and cell cycle arrest in human lung adenocarcinoma cells.

Melatonin produces anti-cancer effects via several mechanisms, including by induction of apoptosis. In this way, it has been shown to be of use, in combination with chemotherapeutic drugs, for cancer ...

Entitativity and intergroup bias: How belonging to a cohesive group allows people to express their prejudices.

We propose that people treat prejudice as more legitimate when it seems rationalistic-that is, linked to a group's pursuit of collective interests. Groups that appear to be coherent and unified wholes...

Committee Opinion No. 623: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period.

Acute-onset, severe systolic hypertension; severe diastolic hypertension; or both can occur in pregnant women or women in the postpartum period. Introducing standardized, evidence-based clinical guide...

News Articles [2901 Associated News Articles listed on BioPortfolio]

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications

Ironwood Pharmaceuticals to Host Fourth Quarter 2014 Investor Update Call

Ironwood Pharmaceuticals, Inc. (NASDAQ: IRWD) today announced it will host its fourth quarter 2014 investor update conference call and webcast at 4:30 p.m. Eastern Time on ...

CORRECTING and REPLACING Registration for the 2015 BIO International Convention Now Open

A New York Times’ Top 5 Global Tourist Destination – Philadelphia to Host 2015 BIO International Convention First paragraph, second sentence of release should read:...

Public-Private Sector Partners Launch $2 Million Open Innovation Challenge to Find Advanced Energy Absorbing Materials

NFL, GE & Under Armour collaborate with U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) on Head Health Challenge III The NFL, ...

Super Bowl alert after measles outbreak warning in Arizona

Health authorities in Arizona are on alert after warning 1,000 people may have been exposed to a measles outbreak as the US state prepares to host this weekend's Super Bowl.

VTI Vacuum Technologies, Inc. Attending MD&M West Tradeshow on Feb. 10th - 12th Anaheim, Calif.

REEDSBURG, Wis., Jan. 29, 2015 /PRNewswire/ — VTI Vacuum Technologies, Inc. is attending the MD&M West tradeshow in Anaheim, California. MD&M West will be held at the Anaheim Convent...

VLOC to Integrate with II-VI Optical Systems

II-VI Optical Systems, a California-based, wholly-owned subsidiary of II-VI Incorporated (Nasdaq: IIVI) and leading vertically integrated producer of high precision imaging and la...

JULABO USA Releases Company Video

JULABO USA Inc. has just released a company video summarizing their facilities and capabilities out of their Allentown, Pennsylvania location. Allentown, PA (PRWEB) January 29, 2015 German-crafted wi...

Registration for the 2015 BIO International Convention Now Open

A New York Times’ Top 5 Global Tourist Destination – Philadelphia to Host 2015 BIO International Convention The Biotechnology Industry Organization (BIO) announced ...

FLC Announces 2015 Award Winners: Honoring the Best of Technology Transfer

Washington, DC, January 29, 2015 --(PR.com)-- The Federal Laboratory Consortium for Technology Transfer (FLC), a nationwide network of federal laboratories that cultivates best practice strategies fo...

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Companies [184 Associated Companies listed on BioPortfolio]

Acceleron Pharma and Celgene Corporation

Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel protein therapeutics for cancer and rare diseases. The...

Surface Oncology

Surface Oncology was created to advance next-generation approaches to cancer immunotherapy based on proprietary insights about novel immunotherapy targets and emerging areas of ca...

DigitalGlobe

DigitalGlobe (NYSE: DGI) is a leading provider of commercial high-resolution earth observation and advanced geospatial solutions that help decision makers better understand our ch...

Eyelit Inc.

Eyelit Inc. is the leader in Manufacturing Execution and Quality Management (MES and QMS) solutions for visibility, control, and coordination of manufacturing operations for the a...

PaR Systems, Inc.

PaR Systems, a portfolio company of MML Capital Partners (www.mmlcapital.com), is a world leader in providing advanced intelligent solutions for critical material handling, automa...

Barco N.V.

Barco is a world leader in professional markets, in which it offers display and visualization solutions. Based upon in-depth market knowledge, the company designs and develops solutions for large-scre...

Tenable Network Security Inc.

Tenable Network Security provides continuous network monitoring to identify vulnerabilities, reduce risk and ensure compliance. Our family of products includes SecurityCenter Cont...

ImmuneXcite, Inc.

ImmuneXcite is a privately held biotech company located in Lexington, Massachusetts that is developing the next generation of immune-activating therapies for oncology utilizing a ...

II-VI Optical Systems

II-VI Optical Systems is a leading producer of high precision optical assemblies, objectives, infrared optics and components, windows, domes, thin film coatings, and optical mater...

Tokai Pharmaceuticals, Inc.

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, galeterone (TOK-001), i...

Clinical Trials [1047 Associated Clinical Trials listed on BioPortfolio]

Mechanisms of Intradialytic Hypertension

Patients with end-stage renal disease (ESRD) are at significantly higher risk for death due to cardiovascular disease. Those with paradoxical increases in blood pressure (BP) during hemodi...

Saturated Fat Versus Monounsaturated Fat and Insulin Action

High intakes of saturated fat are associated with diabetes. Our work has shown that the two most common fatty acids in the North American diet, palmitic acid (saturated fat) and oleic aci...

Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes

The study will be focused on determining the integrated in-vivo mechanisms responsible for Ramipril's effects on delaying type 2 diabetes and restoring normal (blood sugar levels) glycemia...

Pilot Study of Functional and Morphometric Brain Abnormalities Related to Adolescent Idiopathic Scoliosis (MOR-FO-SIA)

Adolescent idiopathic scoliosis (AIS) is a complex deformity with different curves. These different curves may be distinguished by different physiopathologic mechanisms. Without fully con...

A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

Eosinophils are a type of white blood cell. Elevated eosinophil levels can damage the heart, nerves, and other organs, in the syndrome known as hypereosinophilic syndrome (HES). Some indiv...

Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Background: - National Institutes of Health (NIH) researchers have been studying immune cells (white blood cells) to better understand how the human body s defense system works ...

Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali

Malaria caused by Plasmodium falciparum continues to be a global problem with devastating consequences. A greater understanding of the immunologic and parasitologic factors associated wit...

Long-term Effect of Fingolimod on Circulating Immunocompetent Mononuclear Cells in Patients With Multiple Sclerosis

The purpose of this study is to explore immunomodulatory and immunosuppressive mechanisms of action of fingolimod in patients with Relapsing remitting multiple Sclerosis to collect data on...

Observational Study of the Combination of Post-transplant High Dose Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Acute Graft-versus-Host Disease in Patients Eligible to Allogeneic Hematopoietic Stem Cell Transplant

This observational study is proposed to observe the effect of high-dose, post-transplantation cyclophosphamide after a T cell-replete, HLA-matched PBSC graft from an HLA-identical or mism...

Hemodynamic Instability Index: The Impact to Care With a New Predictive Indicator

Philips has developed a new algorithm, called Hemodynamic Instability Rules Based Advisor (HIRBA 2.0) system, for the prediction of hemodynamic instability in critically ill patients, who ...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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