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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

17:45 EDT 25th March 2017 | BioPortfolio

PubMed Articles [11289 Associated PubMed Articles listed on BioPortfolio]

Structure-activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor.

Fraxamoside, a macrocyclic secoiridoid glucoside featuring a hydroxytyrosol group, was recently identified as a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout...

Pregnancy-associated transient osteoporosis of the hip: results of a case-control study.

The etiology and underlying mechanisms of transient of osteoporosis of the hip (TOH) during pregnancy are still unclear, since no systematic analyses exist. Our results support the hypothesis that TOH...

Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients.

Cystic fibrosis (CF) is a genetic disease in which bacterial infections of the airways play a major role in the long-term clinical outcome. In recent years, a number of next-generation sequencing (NGS...

Simulated airplane headache: a proxy towards identification of underlying mechanisms.

Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrenc...

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available ...

Vasopressors induce passive pulmonary hypertension by blood redistribution from systemic to pulmonary circulation.

Vasopressors are widely used in resuscitation, ventricular failure, and sepsis, and often induce pulmonary hypertension with undefined mechanisms. We hypothesize that vasopressor-induced pulmonary hyp...

Inhibition of acrolein-induced autophagy and apoptosis by a glycosaminoglycan from Sepia esculenta ink in mouse Leydig cells.

In our recent reports, a squid ink polysaccharide (SIP) was found having preventive activity against cyclophosphamide induced damage in mouse testis and ovary. Here we further reveal the regulative me...

Engineering a humanized bone organ model in mice to study bone metastases.

Current in vivo models for investigating human primary bone tumors and cancer metastasis to the bone rely on the injection of human cancer cells into the mouse skeleton. This approach does not mimic s...

Sedentary Behavior and Mechanisms of Cardiovascular Disease-Getting to the Heart of the Matter.

RNA-Seq reveals the molecular mechanism of trapping and killing of root-knot nematodes by nematode-trapping fungi.

Nematode-trapping fungi are well known for their inherent potential to trap and kill nematodes using specialized trapping devices. However, the molecular mechanisms underlying the trapping and subsequ...

News Articles [2621 Associated News Articles listed on BioPortfolio]

eHealth, Inc. Announces Completion of Strategic Alternatives Review

Company Plans to Host an Investor Day on May 10, 2017 eHealth, Inc. (NASDAQ: EHTH), a leading private online health insurance exchange, announced today the completion of its p...

Neurons shown to regulate reproduction in fruit flies during infection.

It is known that all living organisms adapt their behaviour in response to infection, however, the mechanisms behind this are less understood. Recent studies in fruit flies have begun to unravel these...

Mechanisms of resistance in triple negative breast cancer

Prof Loi speaks with ecancer at 2017 St. Gallen International Breast Cancer Conference about the oncogenic pathways upregulated in triple negative breast cancer, which can be highly resistant to che...

EyeGate Pharmaceuticals Inc EYEG Medical Equipment Deals and Alliances Profile [Updated: 23012017] Prices from USD $250

SummaryEyeGate Pharmaceuticals Inc EyeGate is a pharmaceutical and drug delivery company that develops and commercialize therapeutics and drug delivery mechanisms. The company offers macular edema and...

Summer Sanders And Coolibar Partner Against Sun Damage With UPF 50+ Sun Protective Apparel On HSN

MINNEAPOLIS, March 24, 2017 /PRNewswire/ -- Two-time Olympic Gold Medalist and three-time melanoma survivor Summer Sanders will appear on HSN as Coolibar brand ambassador with host, Lesley Machado.&nb...

Rally Health Names Maria Menounos Its Newest Health Ambassador

E! News co-host joins actor/comedian Kevin Hart and NFL player Melvin Gordon to inspire people to take an active role in their health Menounos to co-host...

Running for Charity is One of the Upcoming Episodes of "Informed", with Host Rob Lowe

(PRWEB) March 24, 2017 Viewers who like to educate themselves on current issues and who enjoy gaining knowledge on a variety of crit...

Prepping crops for climate change: Understanding genetics of blooming time may be key

Plants possess molecular mechanisms that prevent them from blooming in winter. Once the cold of winter has passed, they are deactivated. However, if it is still too cold in spring, plants adapt their...

Prepping crops for climate change: Genetics of bloom time may be key

Plants possess molecular mechanisms that prevent them from blooming in winter. Once the cold of winter has passed, they are deactivated. However, if it is still too cold in spring, plants adapt their...

Why it’s time to end the ‘farmers versus environmentalists’ fight and work together

[Editor’s note: Suzy Friedman is the senior director of agricultural sustainability at the Environmental Defense Fund.] On paper, I appear to be the picture perfect stereotype

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Companies [226 Associated Companies listed on BioPortfolio]

Battelle is a global science and technology enterprise

Battelle is a global science and technology enterprise that develops and commercializes technology and manages laboratories for customers. Headquartered in Columbus, Ohio, Battelle has a vast science ...

Serenity Pharmaceuticals

Founded in 2007 and located in Milford, Pennsylvania, Serenity Pharmaceuticals is focused on developing products that address urinary conditions that impact the health and well-be...

Lumany, LLC

Established in 2011 in Costa Mesa, CA, Lumany designs and manufactures next-generation laser and illumination products for industrial, biomedical and defense & security applicatio...

Bulova Technologies Group, Inc.

Headquartered in Clearwater, FL, Growth Technologies International, Inc. focuses on disruptive technologies in the fields of defense, alternative energy, alternative healthcare, h...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Unity Biotechnology

Unity Biotechnology is designing therapeutics that prevent, halt or reverse numerous diseases of aging. The Company is targeting biological mechanisms that unify many afflictions,...

CMMI Institute

CMMI Institute (CMMIinstitute.com) is the organization behind Capability Maturity Model Integration (CMMI®), the globally adopted capability improvement framework that g...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Armor

The leader in active cyber defense, Armor offers customer-centric security outcomes for retail and eCommerce enterprises, healthcare organizations, payment leaders and financial i...

Clinical Trials [1752 Associated Clinical Trials listed on BioPortfolio]

Personalising Anti-TNF Therapy in Crohns Disease (PANTS)

To develop a cost-effective, individualised anti-TNF treatment strategy for patients with Crohn's disease which maximizes benefit and minimises harm. The primary objective of this study i...

Post-natal Depression and Chronic Stress

The risk of emergence of a post natal depression is based on an interaction between a maternal psychic vulnerability and a chronic environmental context of stress. The PND appears as a rel...

Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide

Historically, the best results of allogeneic SCT have been obtained when the stem cell donor is a human leukocyte antigen (HLA)-matched sibling, however, this is only available for approxi...

Mechanisms of Active Music Engagement to Improve Health Outcomes of Children With Cancer and Parents

Music therapy, a frequently used arts-based therapy, has become standard palliative care in many pediatric and adult hospitals; however, few studies have examined the mechanisms by which m...

The Impact of Diabetes on REvascularization

The presence of foot symptoms at rest or tissue necrosis in patients with peripheral artery disease is a medical urgency and represents a state of critical limb ischemia (CLI) where the ri...

Extracorporeal Photopheresis Using Theraflex ECP™ for Patients With Refractory Chronic Graft Versus Host Disease (cGVHD)

The present project is a prospective, multicenter, non-randomized, phase II trial which aims to evaluate the clinical impact and the safety of extracorporeal photopheresis (ECP) using the ...

Study of Ixazomib to Prevent Recurrent or Late Acute and Chronic Graft-versus-Host Disease 1-year After Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Malignancies

This is a single arm open label phase 2 study evaluating the potential effect of ixazomib on the prevention of recurrent or late acute graft-versus-host disease (GVHD) and chronic GVHD at ...

Corynebacterium Spp Bone and Joint Infection: Retrospective Study of Microbiological, Diagnostic and Therapeutic Features

Corynebacterium spp have been considered as innocuous commensals of human skin, but are now accepted as important opportunistic pathogens responsible for various nosocomial infections, esp...

A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru

Tropical diseases are continuously on the rise throughout the world as they are spreading and manifesting in various locations globally. The more prominent vector tends to be the mosquito ...

Study on the Clinical Efficacy of Chinese Medicine Treatment of Sequelae of Apoplexy

This project is one multi-center, a prospective cohort study, based on 1660 cases of ischemic stroke patients with the treatment of 3 months, and 21 months of follow-up observation in orde...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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