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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

15:39 EST 6th February 2016 | BioPortfolio

PubMed Articles [10987 Associated PubMed Articles listed on BioPortfolio]

A multi-subband Monte Carlo study on dominance of scattering mechanisms over carrier transport in sub-10-nm Si nanowire FETs.

Dominance of various scattering mechanisms in determination of the carrier mobility is examined for silicon (Si) nanowires of sub-10-nm cross-sections. With a focus on p-type channels, the steady-stat...

The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules.

The encapsulation by spray drying method of coriander essential oil (CEO) in various materials (chitosan, alginate, chitosan/alginate, chitosan/inulin) was studied. The viscoelastic properties of the ...

O-003 Understanding the Relevance of Whole Exome Sequencing Identified Variants in Patients with Very Early-Onset-IBD.

Very early onset inflammatory bowel disease (VEO-IBD) is frequently considered a different disease process than older onset IBD. The severe phenotype and young age of onset suggest a more pronounced g...

O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD.

Rare mutations in IL-10 or its receptors (IL10R) lead to severe very early onset (VEO)/infantile IBD in humans suggesting that the IL10/IL10R pathway is indispensable for mucosal immune homeostasis in...

O-009 Lymphotoxin Links Microbiota and Group 3 Innate Lymphoid Cells to Protect Against Intestinal Inflammation.

The balance between immune defense and inflammation in the gut is a highly regulated process that requires interactions between intestinal epithelial cells and the underlying immune system. RORgt+ gro...

O-011 Paneth Cell Phenotypes Define a Subtype of Pediatric Crohn's Disease Through Alterations in Host-Microbial Interactions.

To identify and develop novel targeted therapies for complex diseases such as Crohn's disease (CD), functional subtypes rooted in pathogenesis must be defined. One candidate method to subtype CD is to...

O-018 New Evidence for Structural Brain Differences in Pediatric Crohn's Disease: Impact of Underlying Disease Factors.

Structural brain changes in gray matter volume, cortical thickness, and white matter density have been recently found in adults with Crohn's disease (CD), with the potential to affect cognitive and em...

Health Benefits of Exposure to Low-dose Radiation.

Although there is no doubt that exposure to high doses of radiation (delivered at a high dose-rate) induces harmful effects, the health risks and benefits of exposure to low levels (delivered at a low...

Is Ionizing Radiation Harmful at any Exposure? An Echo That Continues to Vibrate.

The health risks to humans and non-human biota exposed to low dose ionizing radiation remain ambiguous and are the subject of intense debate. The need to establish risk assessment standards based on t...

Ghrelin attenuates the growth of HO-8910 ovarian cancer cells through the ERK pathway.

Ovarian cancer is one of the most common causes of death from gynecologic tumors and is an important public health issue. Ghrelin is a recently discovered bioactive peptide that acts as a natural endo...

News Articles [2685 Associated News Articles listed on BioPortfolio]

Tau and IGF1 in Alzheimer’s Disease

Tau and IGF1 in Alzheimer’s Disease Larry H. Bernstein, MD, FCAP, Curator LPBI TAU links growth factor to development of Alzheimer’s disease https://english.tau.ac.il/sites/default/files/s...

Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer

Background: Drug resistance in breast cancer is the major obstacle to effective treatment with chemotherapy. While upregulation of multidrug resistance genes is an important component of drug resistan...

Schneiderman’s Furniture, University of Minnesota Foundation and National Parkinson Foundation Minnesota to Host Triumph Over Parkinson’s Event

Larry Schneiderman, CEO of Schneiderman’s Furniture, is proud to announce his collaboration with the University of Minnesota Foundation and the National Parkinson Foundation Minnesota (NPFM) to host...

New Exoskeleton Suit from UC Berkeley Helps Paraplegics Walk

It’s been an over a 10-year journey. In 2000, Univ. of California, Berkeley Prof. Homayoon Kazerooni began working with a team to develop a series of exoskeletons. The research was funded by the Def...

Study Explores the Role of Medical Affairs in Supporting a New Product Launch in the Oncology Therapeutic Area

CHAPEL HILL, N.C., Feb. 5, 2016 /PRNewswire/ -- In the pharmaceutical industry the medical affairs function plays a key role for a host of launch activities including the identification and e...

Bionow and Baker Tilly co-host R&D Tax Credit Event

Baker Tilly kindly sponsored and co-hosted an R&D Tax Credit Seminar with Bionow Ltd on Wednesday 28 September. HM Revenue and Customs also presented at the event, which discussed the changes to t...

Science Foundation Ireland appoints Profesor Mark Ferguson as New Director General

The Board of Science Foundation Ireland (SFI) has appointed Professor Mark Ferguson as Director General of the organisation. Professor Ferguson, a native of Northern Ireland, will take up the position...

Gentronix Wins Research Grant

Biotech firm Gentronix, a Manchester University spin-out, has been awarded a grant of £147,552 by the Medical Research Council (MRC) and the Technology Strategy Board.The Manchester company wi...

Euprotec Looking to Double in Size

Euprotec, the ambitious biotech company, has announced plans to raise external finance for the first time to help it double in size over the next two to three years.The firm, which is based at Manch...

Nuffield Research Placements

Nuffield Research Placements (previously Nuffield Science Bursaries) provide over 1,000 students each year with the opportunity to work alongside professional scientists, technologists, engineers and ...

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Companies [223 Associated Companies listed on BioPortfolio]

Unity Biotechnology

Unity Biotechnology is designing therapeutics that prevent, halt or reverse numerous diseases of aging. The Company is targeting biological mechanisms that unify many afflictions,...

CMMI Institute

CMMI Institute (CMMIinstitute.com) is the organization behind Capability Maturity Model Integration (CMMI®), the globally adopted capability improvement framework that g...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Armor

The leader in active cyber defense, Armor offers customer-centric security outcomes for retail and eCommerce enterprises, healthcare organizations, payment leaders and financial i...

Histide AG

Histide™ is a biotech intellectual property platform company pioneering a new class of nonmutagenic extracellular therapeutic agents called Cell Recoding Molecules™ (CRM...

Lieber Institute for Brain Development

The mission of the Lieber Institute for Brain Development and the Maltz Research Laboratories is to translate the understanding of basic genetic and molecular mechanisms of schizo...

Cambrian Innovation

Cambrian Innovation is a leader in developing biotechnology solutions that extract energy from water. Spun out of MIT in 2006, Cambrian has scaled and validated its proprie...

NantKwest, Inc.

NantKwest (Nasdaq:NK) is a pioneering, next generation, clinical-stage immunotherapy company focused on harnessing the unique power of our immune system using natural killer (NK) ...

NantKwest Inc.

NantKwest (Nasdaq:NK) is a pioneering, next generation, clinical-stage immunotherapy company focused on harnessing the unique power of our immune system using natural killer (NK) ...

Acceleron Pharma & Celgene Corporation

Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel therapeutic candidates that regulate cellular growth a...

Clinical Trials [1353 Associated Clinical Trials listed on BioPortfolio]

Biological Aging of Skeletal Muscles in Humans

Aging affects almost all the tissues and physiological functions, and skeletal muscle is the most affected organ. The progressive decline of the weight and the muscular function linked to ...

Mechanisms of Action of Dimethyl Fumarate (Tecfidera) in Relapsing MS

This is a prospective study that will explore the mechanisms of efficacy of dimethyl fumarate (DMF) treatment in multiple sclerosis (MS). Investigators will enroll relapsing MS patients wh...

Air Pollution Study: The Effect of Ozone on the Lung

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. Subj...

The Efficacy of Maternal Sound for Pediatric Patients Undergoing Cardiac Surgery

A newborn's recognition and preference for their mother's voice occurs early in life, very likely during fetal development. Maternal voice stimuli undergo a unique form of cerebral process...

Activation of Brain Centers by Short-term Walnut Consumption in Obesity

The purposes of the study are: - Study Aim 1. To assess the mechanisms underlying the biological effects of short-term walnut consumption on appetite with functional magnetic reso...

Pilot Study on Metabolic Effects of Fish Peptides and Vitamin D

The overall goal of this study is to investigate the effects and the mechanisms of action of a fish peptide and vitamin D on glucose metabolism, insulin secretion, and cardiometabolic risk...

Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant

Allogeneic hematopoietic stem cell transplantation is a life-saving procedure in patients with blood cancers, but only 25% of transplant candidates have a sibling donor. A matched unrelate...

Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor

Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy i...

Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR)

Intermittent arm cuff inflation reduces the extent of heart muscle injury at the time of cardiovascular injury. The intervention is known as remote ischaemic conditioning (RIC) however the...

Effects of Fava Bean Fractions as Ingredients in Novel Food Products on Glycemia, Appetite and Metabolic Control

To describe the effect and mechanisms of action faba bean powder and fractions (protein, starch and fiber) on glucose and insulin homeostasis, food intake, satiety and metabolic regulation...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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