Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

02:53 EDT 1st November 2014 | BioPortfolio

PubMed Articles [9623 Associated PubMed Articles listed on BioPortfolio]

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin - Implication to their genotoxic mechanism.

The aim of this study was to investigate the possible protective effect of sodium copper chlorophyllin (CHL) against cytotoxicity and DNA damage induced by mycotoxins ochratoxin A (OTA) and fumonisin ...

Genome-wide detection of selection and other evolutionary forces.

As is well known, pathogenic microbes evolve rapidly to escape from the host immune system and antibiotics. Genetic variations among microbial populations occur frequently during the long-term pathoge...

Regulation of Skeletal Muscle Development and Disease by microRNAs.

The identification of microRNAs (miRNA) in vertebrates has uncovered new mechanisms regulating skeletal muscle development and disease. miRNAs are inhibitors and act by silencing specific mRNAs or by ...

Dormancy and Quiescence of Skeletal Muscle Stem Cells.

The skeletal muscle of vertebrates has a huge regenerative capacity. When destroyed after different types of injury, this organ can regenerate very quickly (less than 20 days following myotoxin inject...

Mouse models of rhinovirus infection and airways disease.

Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infecti...

Reverse genetics system for studying human rhinovirus infections.

Human rhinovirus (HRV) contains a 7.2 kb messenger-sense RNA genome which is the template for reproducing progeny viruses after it enters the cytoplasm of a host cell. Reverse genetics refers to the r...

Proteases of human rhinovirus: role in infection.

Human rhinoviruses (HRV) are the major etiological agents of the common cold and asthma exacerbations, with significant worldwide health and economic impact. Although large-scale population vaccinatio...

Peptidomics study of anthocyanin-rich juice of elderberry.

Biologically active peptides play a role in plant signaling and defense. Elderberry juice is known to contain a variety of anthocyanin compounds, a sub-set of polyphenols, which are responsible for th...

Resonance Rayleigh scattering method for determination of ethion using silver nanoparticles as probe.

A simple, novel and sensitive method was developed to determine ethion insecticide in water samples. This method was based on the interaction of ethion with silver nanoparticles (AgNPs) and quenching ...

A vapor response mechanism study of surface-modified single-walled carbon nanotubes coated chemiresistors and quartz crystal microbalance sensor arrays.

This paper compares the selectivity and discusses the response mechanisms of various surface-modified, single-walled carbon nanotube (SWCNT)-coated sensor arrays for the detection of volatile organic ...

News Articles [3028 Associated News Articles listed on BioPortfolio]

Autoinhibition and cooperative activation mechanisms of cytoplasmic dynein

Furuta and colleagues report that single dynein molecules are kept in an autoinhibited state through the stacking of their two head domains. This autoinhibition is relieved when dynein molecules assem...

Ignyta to Report 2014 Third Quarter Company Highlights and Financial Results and Host Conference Call on November 7, 2014

Ignyta, Inc. (Nasdaq: RXDX), an precision oncology biotechnology company, announced today that it will release its third quarter 2014 financial results after the market closes on...

Pentagon civilians leaving Ebola zones may choose monitoring regimen

WASHINGTON, Oct 31 (Reuters) - Civilian U.S. defense employees returning from Ebola relief work in West Africa must undergo monitoring to ensure they are free of disease but can choose between followi...

DLA Energy ships fuel storage containers for Operation United Assistance

FORT BELVOIR, Va., Oct. 31, 2014 /PRNewswire-USNewswire/ -- Storage containers to hold Defense Logistics Agency Energy-procured fuel for the government's effort to combat Ebola in West Africa arr...

Veloxis Pharmaceuticals A/S: Veloxis Pharmaceuticals A/S to Host Conference Call discussing the FDA tentative approval of Envarsus® XR

Investor service announcement no. 6/2014 To: NASDAQ OMX Copenhagen Hørsholm, Denmark, 31 October, 2014 Veloxis Pharmaceuticals A/S to Host Conference Call discussing the FDA tentative approval of E.....

Department of Defense contracts Profectus to develop its VesiculoVax Zaire-Ebola virus vaccine

The US Department of Defense has contracted the manufacture and IND-enabling preclinical testing of the trivalent vaccine developed by clinical-stage viral disease vaccine company Profectus BioScience...

Beyond the Movember Mustache: Dr. Karol, Medical Director of Natural Health Products Online Marketplace Vitarock.com, Takes on Men’s Health on The Natural Health Show

In honor of Prostate Cancer Health Awareness Month, a.k.a., Movember, Dr. Karol Wojewnik will be tackling natural health prevention and detection strategies this weekend (Nov. 1st & 2nd) on The Na...

Scientists develop new system to treat a host of genetic conditions

As potential next-generation therapeutics and research tools, few life sciences technologies hold more promise than genome-editing proteins – molecules that can be programmed to alter specific genes...

Chemistry on Android

A reader sends along an organic chemistry mechanisms game that he's released on Google Play. I don't have an android device, so I haven't tried it out myself, but those of you who teaching organic (or...

Profectus BioSciences gets funding to develop VesiculoVax Zaire-Ebola virus vaccine

Profectus BioSciences, Inc., a clinical-stage vaccine company developing novel vaccines for the treatment and prevention of infectious diseases, announced today that the Department of Defense through ...

Events [1 Associated Events listed on BioPortfolio]

Free webinar: DNA Methylation Changes during Cell Differentiation

This one hour webinar provides an overall perspective on the connections between DNA methylation and other epigenetic marks and the interplay with transcription factors.

Companies [179 Associated Companies listed on BioPortfolio]

Barco N.V.

Barco is a world leader in professional markets, in which it offers display and visualization solutions. Based upon in-depth market knowledge, the company designs and develops solutions for large-scre...

Tenable Network Security Inc.

Tenable Network Security provides continuous network monitoring to identify vulnerabilities, reduce risk and ensure compliance. Our family of products includes SecurityCenter Cont...

ImmuneXcite, Inc.

ImmuneXcite is a privately held biotech company located in Lexington, Massachusetts that is developing the next generation of immune-activating therapies for oncology utilizing a ...

II-VI Optical Systems

II-VI Optical Systems is a leading producer of high precision optical assemblies, objectives, infrared optics and components, windows, domes, thin film coatings, and optical mater...

Tokai Pharmaceuticals, Inc.

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, galeterone (TOK-001), i...

CherylLeeMD® Sensitive Skin Care

CherylLeeMD® Sensitive Skin Care products are the first skin care products to work with the skin to obtain its optimal equilibrium by simultaneously addressing skin lipid defic...

Navitor Pharmaceuticals, Inc.

Navitor Pharmaceuticals, Inc., is a biopharmaceutical company developing novel medicines by targeting cellular nutrient signaling pathways. The company’s proprietary drug dis...

Pelican Products, Inc.

Pelican Products, Inc. is the global leader in design and manufacture of both high-performance protective case solutions and advanced portable LED lighting systems. Their produ...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

HealthFleet, Inc.

HealthFleet is the first platform-as-a-service (PaaS) provider for healthcare. HealthFleet’s technology allows providers to deliver their health programs and services online,...

Clinical Trials [1021 Associated Clinical Trials listed on BioPortfolio]

Identification the Cause of Cerebral Infarction in Patients With Cancer

Although there has been increasing interest in the association between cancer and cerebrovascular disease, the underlying pathophysiology of stroke in cancer patients is still not fully un...

An Open Label Phase II Trial of Topical Sirolimus for the Treatment of Refractory Oral Chronic Graft-versus-Host-Disease

This research study is evaluating the effectiveness of topical sirolimus combined with topical steroid therapy, as a possible treatment for oral cGVHD.

Nasal Potential Difference (NPD) Protocol in Chronic Rhinosinusitis

The purpose of this study is to determine if acquired (partial) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) deficiency contributes substantially to the pathogenic mechanisms...

Allogeneic Stem Cell Transplantation for Patients With Severe Aplastic Anemia

For patients with severe aplastic anemia (SAA) who have failed to respond to immunosuppressive therapy and lack an HLA identical family member, our objectives are to make an initial assess...

Abdominal CT to Predict the Risk of Acute Graft-versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

Contrast-enhanced abdominal CT will be performed 1-2 weeks after allogeneic stem cell transplant, and radiographic evidence of mucosal inflammation will be correlated with the subsequent d...

Natural Killer (NK) Cells in Cord Blood Transplantation

The goal of this clinical research study is to learn if giving cells called natural killer (NK) cells after receiving fludarabine, melphalan, lenalidomide, and a UCB transplant can improve...

The Effects of Repetitive Transcranial Magnetic Stimulation in Obese People With BED

The presence of binge eating (BE) is a core feature of bulimic syndromes. Binge eating disorder (BED) is a new category in DSM-5 highly associated with higher body mass index (BMI). The ne...

Plerixafor for Stem Cell Mobilization in Normal Donors

The goal of this clinical research study is to learn if treating stem cell donors with filgrastim (G-CSF) and plerixafor (Mozobil®) can cause them to produce a higher number of blood stem...

Developing Novel Microbiota-Targeted Therapies for Irritable Bowel Syndrome

This longitudinal study is being done to understand mechanisms underlying development of irritable bowel syndrome (IBS) and the role of the gut bacteria in development of symptoms. This in...

DLBS2411 Treatment for Ulcer Healing in Non-Bleeding Peptic Ulcers

This is a 2-arm, prospective, double-blind, double-dummy, randomized-controlled study using DLBS2411 at a dose of 250 mg twice daily (before morning and evening meals), or omeprazole at a ...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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