Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

14:22 EDT 21st October 2014 | BioPortfolio

PubMed Articles [9633 Associated PubMed Articles listed on BioPortfolio]

In vitro genotoxicity of mycotoxins ochratoxin A and fumonisin B1 could be prevented by sodium copper chlorophyllin - Implication to their genotoxic mechanism.

The aim of this study was to investigate the possible protective effect of sodium copper chlorophyllin (CHL) against cytotoxicity and DNA damage induced by mycotoxins ochratoxin A (OTA) and fumonisin ...

Mouse models of rhinovirus infection and airways disease.

Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infecti...

Reverse genetics system for studying human rhinovirus infections.

Human rhinovirus (HRV) contains a 7.2 kb messenger-sense RNA genome which is the template for reproducing progeny viruses after it enters the cytoplasm of a host cell. Reverse genetics refers to the r...

Proteases of human rhinovirus: role in infection.

Human rhinoviruses (HRV) are the major etiological agents of the common cold and asthma exacerbations, with significant worldwide health and economic impact. Although large-scale population vaccinatio...

Peptidomics study of anthocyanin-rich juice of elderberry.

Biologically active peptides play a role in plant signaling and defense. Elderberry juice is known to contain a variety of anthocyanin compounds, a sub-set of polyphenols, which are responsible for th...

Resonance Rayleigh scattering method for determination of ethion using silver nanoparticles as probe.

A simple, novel and sensitive method was developed to determine ethion insecticide in water samples. This method was based on the interaction of ethion with silver nanoparticles (AgNPs) and quenching ...

A vapor response mechanism study of surface-modified single-walled carbon nanotubes coated chemiresistors and quartz crystal microbalance sensor arrays.

This paper compares the selectivity and discusses the response mechanisms of various surface-modified, single-walled carbon nanotube (SWCNT)-coated sensor arrays for the detection of volatile organic ...

β-Cyclodextrin coated CdSe/ZnS quantum dots for vanillin sensoring in food samples.

An optical sensor for vanillin in food samples using CdSe/ZnS quantum dots (QDs) modified with β-cyclodextrin (β-CD) was developed. This vanillin-sensor is based on the selective host-guest interact...

Analysis of human hyaluronan synthase gene transcriptional regulation and downstream hyaluronan cell surface receptor mobility in myofibroblast differentiation.

The ubiquitous extracellular glycosaminoglycan hyaluronan (HA) is a polymer composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alter...

Isolation and purification of versican and analysis of versican proteolysis.

Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its receptor CD44 and interac...

News Articles [3033 Associated News Articles listed on BioPortfolio]

The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor

Large semiconductor companies and sensor manufacturers drive the North American Crystal Oscillator market http://www.micromarketmonitor.com/market/north-america-crystal-oscillator-2899164194.html (PRW...

Psychological Stress Could Contribute to Developing Diabetes

It’s well known that a stress-filled lifestyle can lead to high blood pressure, insomnia and a host of other chronic health issues. Now, you can add type 2 diabetes to that list. Past studies have ...

Medicare, Health Care Getting Attention In Senate, Congressional Races

In Louisiana's Senate race, Medicare is grabbing the spotlight. The powerful issue is also popping up in North Carolina and Iowa. Meanwhile, Michigan's Senate race references to Medicare and the healt...

Fluidigm to Announce Q3 2014 Financial Results and Host Conference Call for Investors

Fluidigm Corporation (NASDAQ:FLDM) will report its third quarter 2014 financial results on October 30, 2014, after close of market. Gajus Worthington, Fluidigm president ...

Pall ForteBio Introduces Off-The-Shelf Dip And Read Anti-CHO HCP Detection Kit To Accelerate Drug Development

Pall ForteBio LLC, a division of Pall Corp. and a leading supplier of instrumentation and analytics for accelerated drug discovery and development, has announced commercial availability of a new Dip a...

Skilled Healthcare to Host Transaction Update Conference Call on November 4, 2014

FOOTHILL RANCH, Calif., Oct. 21, 2014 /PRNewswire/ -- Skilled Healthcare Group, Inc. (NYSE:SKH) announced today that it will host a conference call and webcast on Tuesday, November 4 at 10:00 a.m...

Contemporary concepts in the aetiopathogenesis of detrusor underactivity

Detrusor underactivity (DUA) is a poorly understood bladder dysfunction without effective pharmacological treatments. This Review summarizes the available evidence relating to the aetiology and pathop...

iCAD to Host Third Quarter 2014 Financial Results Conference Call on Tuesday, October 28, 2014

NASHUA, N.H., Oct. 21, 2014 /PRNewswire/ -- iCAD, Inc. (Nasdaq: ICAD), an industry-leading provider of advanced image analysis, workflow solutions and radiation therapy for the early identification an...

Improving clinical pain management practices

Oncologists treat cancer, neurologists specialise in brain disorders, immunologists diagnose infectious diseases, and a host of other specialists tackle ailments from broken bones to ruptured arteries...

US Environmental Group Sues EPA Over Herbicide Approval

Close on the heels of the Environmental Protection Agency's (EPA) approval of Dow Chemical's controversial new weed killer Enlist Duo, the Natural Resource Defense Council (NRDC) is suing the US autho...

Events [1 Associated Events listed on BioPortfolio]

Free webinar: DNA Methylation Changes during Cell Differentiation

This one hour webinar provides an overall perspective on the connections between DNA methylation and other epigenetic marks and the interplay with transcription factors.

Companies [179 Associated Companies listed on BioPortfolio]

Barco N.V.

Barco is a world leader in professional markets, in which it offers display and visualization solutions. Based upon in-depth market knowledge, the company designs and develops solutions for large-scre...

Tenable Network Security Inc.

Tenable Network Security provides continuous network monitoring to identify vulnerabilities, reduce risk and ensure compliance. Our family of products includes SecurityCenter Cont...

ImmuneXcite, Inc.

ImmuneXcite is a privately held biotech company located in Lexington, Massachusetts that is developing the next generation of immune-activating therapies for oncology utilizing a ...

II-VI Optical Systems

II-VI Optical Systems is a leading producer of high precision optical assemblies, objectives, infrared optics and components, windows, domes, thin film coatings, and optical mater...

Tokai Pharmaceuticals, Inc.

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, galeterone (TOK-001), i...

CherylLeeMD® Sensitive Skin Care

CherylLeeMD® Sensitive Skin Care products are the first skin care products to work with the skin to obtain its optimal equilibrium by simultaneously addressing skin lipid defic...

Navitor Pharmaceuticals, Inc.

Navitor Pharmaceuticals, Inc., is a biopharmaceutical company developing novel medicines by targeting cellular nutrient signaling pathways. The company’s proprietary drug dis...

Pelican Products, Inc.

Pelican Products, Inc. is the global leader in design and manufacture of both high-performance protective case solutions and advanced portable LED lighting systems. Their produ...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

HealthFleet, Inc.

HealthFleet is the first platform-as-a-service (PaaS) provider for healthcare. HealthFleet’s technology allows providers to deliver their health programs and services online,...

Clinical Trials [1013 Associated Clinical Trials listed on BioPortfolio]

Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (NST) for Patients With Refractory Crohn's Disease

Allogeneic transplantation has been a high-risk procedure, although non-myeloablative conditioning regimens (mini-transplantation) minimizes regimen related toxicity. The investigators, th...

MLN9708 for the Prophylaxis of Chronic Graft-versus-host Disease in Patient Undergoing Allogeneic Transplantation

This is a phase I/II study of MLN9708 for the prophylaxis of chronic graft-versus-host-disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Duri...

Trial to Evaluate Palifermin in the Reduction of Acute Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Allogeneic Marrow/Peripheral Blood Progenitor Cell (PBPC) Transplantation

The main purpose of this study is to evaluate the effect of palifermin versus placebo in the reduction of severe acute graft versus host disease (GVHD) and severe oral mucositis.

A Phase 2a Study of ALXN1007 in Subjects With Newly Diagnosed Acute GI GVHD

The objectives of this trial are to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics (PK/PD) and efficacy of intravenous (IV) ALXN1007 in subjects with acute graft-vers...

Bacterial and Host Genetic Risk Factors in Acute Pyelonephritis

No single host or pathogen trait identified by previous research can be correlated with all cases of childhood acute pyelonephritis or APN (i.e., kidney/upper urinary tract infections) and...

Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke

The purpose of this study will evaluate the long-term benefits, optimal dose and mechanisms of mirror therapy and its effects on physiological markers.

The Influence of Information Sources on Knowledge and Anxiety in Inflammatory Bowel Disease Patients

Inflammatory Bowel Diseases (IBD) are life-long, incurable illnesses that can have a profound effect on the patients quality of life. Disease education is a corner stone of IBD care to ena...

Natural Killer (NK) Cells in Cord Blood Transplantation

The goal of this clinical research study is to learn if giving cells called natural killer (NK) cells after receiving fludarabine, melphalan, lenalidomide, and a UCB transplant can improve...

Safety Study of Gene Modified Donor T-cells Following TCR Alpha Beta Depleted Stem Cell Transplant

This study will evaluate pediatric patients with malignant or non-malignant blood cell disorders who are having a blood stem cell transplant depleted of T cell receptor (TCR) alfa and beta...

Electronic Algorithms Based on Host Biomarkers Point of Care Tests to Decide on Admission and Antibiotic Prescription in Tanzanian Febrile Children

Health professionals in developing countries have limited ability to identify children at risk of dying and those in need of antibiotics. The main reasons are limited clinical skills and t...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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