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Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

10:40 EDT 23rd May 2017 | BioPortfolio

PubMed Articles [11603 Associated PubMed Articles listed on BioPortfolio]

Neck Muscle EMG-Force Relationship and Its Reliability During Isometric Contractions.

Susceptible to injury, the neck is subject to scientific investigations, frequently aiming to elucidate possible injury mechanisms via surface electromyography (EMG) by indirectly estimating cervical ...

Human perinatal immunity in physiological conditions and during infection.

The intrauterine environment was long considered sterile. However, several infectious threats are already present during fetal life. This review focuses on the postnatal immunological consequences of ...

Structure-activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor.

Fraxamoside, a macrocyclic secoiridoid glucoside featuring a hydroxytyrosol group, was recently identified as a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout...

Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients.

Cystic fibrosis (CF) is a genetic disease in which bacterial infections of the airways play a major role in the long-term clinical outcome. In recent years, a number of next-generation sequencing (NGS...

Pregnancy-associated transient osteoporosis of the hip: results of a case-control study.

The etiology and underlying mechanisms of transient of osteoporosis of the hip (TOH) during pregnancy are still unclear, since no systematic analyses exist. Our results support the hypothesis that TOH...

Simulated airplane headache: a proxy towards identification of underlying mechanisms.

Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrenc...

The effect of repetitive flexion and extension fatigue loading on the young porcine lumbar spine, a feasibility study of MRI and histological analyses.

The biomechanical mechanisms of failure of FSUs have been studied but the correlation of repetitive flexion and extension loadings to the initial phase of fatigue in young FSUs are still not known. Th...

Microarray meta-analysis to explore abiotic stress-specific gene expression patterns in Arabidopsis.

Abiotic stresses are the major limiting factors that affect plant growth, development, yield and final quality. Deciphering the underlying mechanisms of plants' adaptations to stresses using few datas...

Assimilates mobilization, stable canopy temperature and expression of expansin stabilizes grain weight in wheat cultivar LOK-1 under different soil moisture conditions.

Grain yield of wheat is primarily determined by both grain number and grain weight, which often influence each other in response to environmental stimuli. Some of the genotypes are capable of maintain...

Multiple regulatory roles of AP2/ERF transcription factor in angiosperm.

APETALA2/ethylene response factor (AP2/ERF) transcription factor (TF) is a superfamily in plant kingdom, which has been reported to be involved in regulation of plant growth and development, fruit rip...

News Articles [2886 Associated News Articles listed on BioPortfolio]

OSI Systems to Present at the B. Riley & Co. 18th Annual Investor Conference

OSI Systems, Inc. (NASDAQ: OSIS) today announced that it will be presenting at the B. Riley & Co. 18th Annual Investor Conference on Wednesday, May 24, 2017 at 11:30AM ...

Scholar Rock Announces Drug Development Leaders, Michael Gilman and Shelia Violette, to Join Scientific Advisory Board

New members bring deep knowledge of fibrosis and the TGFβ growth factor family to advance Company’s therapeutic pipeline Scholar Rock, a biotechnology company focused on di...

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Joanna Howson and colleagues perform a genome-wide association study and meta-analysis for coronary artery disease in large, trans-ancestry cohorts. They identify 15 new loci and correlate these regio...

Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms

TP Therapeutics Closes $45M Series C Financing

TP Therapeutics, Inc., a clinical-stage biopharmaceutical company focusing on addressing oncology drug resistance, announced today that the company raised $45 million in a Serie...

Ballistic Composites Market by Fiber Type Aramid, UHMWPE, SGlass, Matrix Type Polymer, PolymerCeramic, Metal, Application Vehicle Armor, Body Armor, Helmet Face Protection, and Region Global Forecast to 2021 [Updated: 18052017] Prices from USD $5650

Ballistic composites market projected to grow at a CAGR of 7.12%The global ballistic composites market is projected to reach USD 1.80 billion by 2021, at a CAGR of 7.12% from 2016 to 2021. The major d...

Deloitte Debuts ConvergeHEALTH Evidence Lifecycle Management Solutions that Support Shift to Value Based, Personalized Health Care at 2017 Bio-IT World Conference

BOSTON, May 23, 2017 /PRNewswire/ -- This year at the 2017 Bio-IT World Conference & Expo, Deloitte will be showcasing the latest updates to its ConvergeHEALTH suite of life sciences end...

Where money and the law intersect, truth can sometimes be the victim

Afterword from a story entitled “Litigation Lane,” excerpted from Beyond Bedlam’s Door: True Tales from the Couch and Courtroom (Thunder Lake Press).  Forensic psychiatry involves the interface...

'Pregnant' housefly males demonstrate the evolution of sex determination

(University of Zurich) An international team headed up by researchers from the University of Zurich has discovered the gene that determines the male sex in houseflies. Surprisingly, the sex-determinin...

Inflammatory bowel disease, bone marrow transplant precision medicine clinical trial opens

(Seattle Children's) In an effort to find new strategies to personalize treatment for pediatric patients, Seattle Children's has opened the first clinical trial applying next-generation T-cell recepto...

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Companies [232 Associated Companies listed on BioPortfolio]

Futurpreneur Canada

Futurpreneur Canada has been fueling the entrepreneurial passions of enterprising young Canadians since 1996. We’re the only national, non-profit organization that provides f...

Logos Technologies LLC

Founded in 1996, Logos Technologies LLC is a diversified defense and energy company specializing in the fields of biofuel research, lasers, advanced nuclear engineering, cyber def...

Pelican BioThermal LLC

Pelican Products, Inc. is the global leader in the design and manufacture of high performance protective cases, temperature controlled packaging solutions, advanced portable light...

Barco N.V.

Barco is a world leader in professional markets, in which it offers display and visualization solutions. Based upon in-depth market knowledge, the company designs and develops solutions for large-scre...

Vaisala Inc.

Vaisala develops, manufactures and markets products and services for environmental and industrial measurement. Vaisala's markets are global. The mission is to provide basis for better quality of life,...

Mitsui Seiki USA, Inc.

Mitsui Seiki USA, Inc. is the North American subsidiary of Mitsui Seiki Kogyo Co., Ltd., headquartered just outside of Tokyo, Japan. According to the company, the appointments pos...

Tenet Diagnostics

Tenet Diagnostics offers fast, accurate, high-quality laboratory and genomic testing to hospitals, clinics and physicians’ offices to help them provide the best patient care....

Battelle is a global science and technology enterprise

Battelle is a global science and technology enterprise that develops and commercializes technology and manages laboratories for customers. Headquartered in Columbus, Ohio, Battelle has a vast science ...

Serenity Pharmaceuticals

Founded in 2007 and located in Milford, Pennsylvania, Serenity Pharmaceuticals is focused on developing products that address urinary conditions that impact the health and well-be...

Lumany, LLC

Established in 2011 in Costa Mesa, CA, Lumany designs and manufactures next-generation laser and illumination products for industrial, biomedical and defense & security applicatio...

Clinical Trials [1814 Associated Clinical Trials listed on BioPortfolio]

Comparison of Effectiveness of Ranolazine Plus Metoprolol Combination vs. FlecainidE pluS Metoprolol Combination in ATrial Fibrillation Recurrences FOllowing PhaRmacological or Electrical CardioverSion of AtRial Fibrillation

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice with a prevalence reaching 5% in patients older than 65 years and an incidence that increases progressively with...

Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve Adults

This study is designed to evaluate efficacy, immunogenicity and safety of various dose schedules of GSK Biologicals' candidate malaria vaccines RTS,S/AS01B (adult formulation) and RTS,S/AS...

Protective Factors Against Elderly Suicide

Suicidal intentionality is generally stronger among the elderly, suicidal acts are more violent and are combined with a greater physical fragility. The suicide of an older adult is a situa...

Azithromycin as Host-directed Therapy for Pulmonary Tuberculosis

Rationale: Treatment in tuberculosis (TB) is focused on eradication of the bacterial infection, however, after treatment approximately half of patients are left with a significant and ...

Role of IL-37 Genetic Variants in Modulating Innate Immune Response to Periodontal Pathogens

This study will provide mechanistic insight into the underlying causes and molecular level pathogenesis of periodontal diseases. We will identify key mechanisms that confer risk and protec...

Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients

.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired diastolic relaxation and contractility with electrophysiological abnormalities. .Cirrhotic patients...

Transcriptome Study of Acute Myocardial Infarction

This study aims to compare whole-blood microarray gene-expression profiling between patients with acute myocardial infarction and normal participants without cardiovascular diseases. First...

Evaluation of Umbilical Cord-Derived Wharton's Jelly Stem Cells for the Treatment of Acute Graft Versus Host Disease

This study evaluates the safety and effectiveness of two different doses of umbilical cord derived, ex-vivo cultured and expanded Wharton's jelly mesenchymal stem cells (MSCTC-0010) in the...

Analysis of Soluble Mediators, Cytokines, and Circulating Angiogenic Factors (FACs) as Potential Predictors / Prognostic Factors in Advanced Non-squamous Lung Carcinoma

Recent studies have shown that the assessment of a set of cytokines and / or circulating angiogenic factors (FACs) could be used to identify prognostic factors predictive of efficacy and /...

A Study to Determine the Abuse Potential of Single Oral Doses of Lemborexant Compared to Zolpidem, Suvorexant and Placebo in Healthy, Non-Dependent, Recreational Sedative Users

The primary purpose of this study is to evaluate the abuse potential of lemborexant (E2006) in comparison to placebo and 2 controls with known abuse potential (ie, zolpidem and suvorexant)...

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Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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