Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

00:15 EDT 2nd September 2014 | BioPortfolio

PubMed Articles [9393 Associated PubMed Articles listed on BioPortfolio]

Effect of fermentation on the antioxidant activity in plant-based foods.

This study provides an overview of the factors that influence the effect of fermentation on the antioxidant activity and the mechanisms that augment antioxidative activities in fermented plant-based f...

In vitro total antioxidant capacity and anti-inflammatory activity of three common oat-derived avenanthramides.

To better understand mechanisms underlying the health benefits of oats, the free radical scavenging capacities of oat avenanthramides 2c, 2f, and 2p and their ability to inhibit NF-κB activation were...

Role of the potassium channel KCa3.1 in diabetic nephropathy.

There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointe...

Cyclodextrin-coated denim fabrics as novel carriers for ingredient deliveries to the skin.

Garments with coverage of a large part of the body generate an exceptional opportunity for transferring active ingredient to the skin. A fabric finished with β-cyclodextrin derivatives can play a rol...

Effect and mechanisms of curdlan sulfate on inhibiting HBV infection and acting as an HB vaccine adjuvant.

In this study, the effect and mechanisms of curdlan sulfate (CS3) on hepatitis B virus (HBV) infection and promoting immune response of the mice immunized with recombinant hepatitis B surface protein ...

Impact of ghosts on the viscoelastic response of gelatinized corn starch dispersions subjected to small strain deformations.

Corn starch dispersions (5.0% w/w) were gelatinized by heating at 90°C for 20min using gentle stirring. Under these conditions, ghosts, which are insoluble material with high amylopectin content, wer...

Potentiometry up to 275°C: Example of pH titrations of cobalt ferrite particles.

High temperature potentiometry (or pH-metry) is needed for specific hydrothermal applications such as acid-base titration of metallic oxides particles to predict their reactivity toward dissolved spec...

Long non-coding RNAs: emerging players in gastric cancer.

Gastric cancer (GC) remains a major public health issue as the second leading cause of cancer-related death and the fourth most common cancer worldwide. Although much progress has been achieved in rec...

Role of the BaeSR two-component regulatory system in resistance of Escherichia coli O157:H7 to allyl isothiocyanate.

Allyl isothiocyanate (AITC) is an essential oil with antimicrobial activity against Escherichia coli O157:H7. The ability of E. coli O157:H7 to withstand inhibitory AITC concentrations and the role o...

Listeria ivanovii ATCC 19119 strain behaviour is modulated by iron and acid stress.

It has been suggested that the rarity of human listeriosis due to Listeria ivanovii reflects not only host tropism factors but also the rare occurrence of this species in the environment, compared wit...

News Articles [3005 Associated News Articles listed on BioPortfolio]

[Comment] How deadly is meticillin-resistant Staphylococcus aureus?

Staphylococcus aureus bloodstream infection is a common infectious disorder with a broad clinical spectrum ranging from mild to devastating disease. Overall mortality in patients with S aureus bloodst...

TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis

Compartmentalization of Toll-like receptors (TLRs) in intestinal epithelial cells (IECs) regulates distinct immune responses to microbes; however, the specific cellular machinery that controls this me...

Dok1 and Dok2 proteins regulate natural killer cell development and function

Natural killer (NK) cells are involved in immune responses against tumors and microbes. NK-cell activation is regulated by intrinsic and extrinsic mechanisms that ensure NK tolerance and efficacy. Her...

DICER1: mutations, microRNAs and mechanisms

Germline mutations in DICER1 can lead to DICER1 syndrome, which is characterised by the predisposition of various types of cancer in childhood and during early adulthood. Additionally, specific DICER1...

Study for better understanding of neural circuitry and dynamic mechanisms controlling memory

A study just published in the prestigious Nature Neuroscience journal by, Sylvain Williams, PhD, and his team, of the Research Centre of the Douglas Mental Health University Institute and McGill Unive...

Why Top10BestSEOHosting.com Calls Them Great Web Hosting Suppliers

(PRWEB) September 01, 2014 Top10BestSEOHosting.com has recently compared many web hosting companies. After evaluating many web host suppliers carefully, Top10BestSEOHosting.com is here to announce ...

Daiichi Sankyo Further Expands TaNeDS Collaborative Drug Discovery Program in Europe

TOKYO, Sept. 1, 2014 /PRNewswire/ -- Daiichi Sankyo Company, Limited (Tokyo Stock Exchange: 4568; hereafter Daiichi Sankyo) announced on September 1 details of the application for its Take a New Chall...

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

A fundamental feature of immune systems is the ability to distinguish pathogenic from self and commensal elements, and to attack the former but tolerate the latter. Prokaryotic CRISPR-Cas immune syste...

Sensory-evoked LTP driven by dendritic plateau potentials in vivo

Long-term synaptic potentiation (LTP) is thought to be a key process in cortical synaptic network plasticity and memory formation. Hebbian forms of LTP depend on strong postsynaptic depolarization, wh...

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Several features common to a Western lifestyle, including obesity and low levels of physical activity, are known risk factors for gastrointestinal cancers. There is substantial evidence suggesting tha...

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Companies [171 Associated Companies listed on BioPortfolio]

HealthFleet, Inc.

HealthFleet is the first platform-as-a-service (PaaS) provider for healthcare. HealthFleet’s technology allows providers to deliver their health programs and services online,...

Premier Biomedical Inc.

Premier Biomedical, Inc. is a research-based company that intends to discover and develop medical treatments for humans, in collaboration with the University of Texas at El Paso a...

Sephos Biotherapeutics

Sephos Biotherapeutics is a privately owned company focused on designing drugs for the treatment of cancer stem cells where the structure and biological activity of the drugs have...

Parx Casino Philly Cycling Classic

The Parx Casino Philly Cycling Classic is operated by a community-based non-profit organization formed to organize and host the new world-class professional cycling race in Philad...

FORUM Pharmaceuticals Inc.

FORUM Pharmaceuticals Inc. and its subsidiaries (“FORUM Pharmaceuticals” or “FORUM”) are dedicated to developing groundbreaking medicines in support of all tho...

True North Therapeutics, Inc.

True North Therapeutics is a biotechnology company developing novel therapies that selectively target the Complement pathway of the immune system to address fundamental mechanisms...

Natera Inc.

Natera Inc. is a genetic testing company that specializes in analyzing microscopic quantities of DNA for reproductive health indications. The mission of the company is to help fam...

Cambrian Innovation

Cambrian Innovation is a leader in developing biotechnology solutions that extract energy from water. Spun out of MIT in 2006, Cambrian has scaled and validated its proprie...

Health Net Foundation, Inc.

Health Net, Inc. (NYSE: HNT) is a publicly traded managed care organization that delivers managed health care services through health plans and government-sponsored managed...

Reinnervate Ltd

Reinnervate is a market leading company in the fast growing 3D cell culture market. The Alvetex® family of 3D cell culture products provide a flexible platform that allows scientists in any life...

Clinical Trials [997 Associated Clinical Trials listed on BioPortfolio]

ALL-SCT BFM International- HSCT in Children and Adolescents With ALL

With this protocol the ALL-SCT BFM international study group wants - to evaluate whether hematopoietic stem cell transplantation (HSCT) from matched family or unrelated donors (MD...

CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant

This study is a research study involving subjects who are diagnosed with a malignant disease, that has either failed standard therapy or is unlikely to be cured with standard non-transplan...

Assessing the Fit of Motivational Interviewing by Cultures With Adolescents

Hispanic adolescents experience more severe alcohol-related consequences due to their alcohol abuse and yet significantly fewer Hispanic adolescents receive alcohol treatment, particularly...

Methylphenidate to Improve Balance and Walking in MS

Methylphenidate is an amphetamine-like psychomotor stimulant drug currently approved for the treatment of attention-deficit hyperactivity disorder (ADHD), postural orthostasis tachycardia ...

Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients

The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...

Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)

This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant a...

Tacrolimus, Sirolimus and Ustekinumab vs. Tacrolimus and Sirolimus for the Prevention of Acute Graft-Versus-Host Disease

To determine whether treatment with ustekinumab will alter the ratio of Treg/total CD4+ cells in peripheral blood at day 30 post-hematopoietic cell transplantation (HCT).

Study of OFATUMUMAB as Part of the Scheme of Reduced Intensity Conditioning in High Risk Non-Hodgkin Lymphoma B Patients

The aim of this study is rate of acute graft-versus-host disease II-IV measured at day +365according to conventional criteria (Przepiorka et al. 1995) in patients with high risk non-Hodgki...

Atorvastatin After Aneurysmal Subarachnoid Hemorrhage

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, known as statins, have recently been demonstrated to improve endothelial function. Additionally, numerous studies ...

Women's Angiographic Vitamin and Estrogen Trial (WAVE)

To assess whether hormonal replacement therapy and/or antioxidant treatment would stabilize or inhibit progression, and induce regression of coronary plaques. The mechanisms by which thes...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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