Host Defense Mechanisms - Biotech, Pharma and Life Science Channel

16:47 EDT 29th March 2015 | BioPortfolio

PubMed Articles [9975 Associated PubMed Articles listed on BioPortfolio]

A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes.

Granulomas play a centric role in tuberculosis (TB) infection progression. Multiple granulomas usually develop within a single host. These granulomas are not synchronized in size or bacteria load, and...

The effect of time delay in plant--pathogen interactions with host demography.

Botanical epidemic models are very important tools to study invasion, persistence and control of diseases. It is well known that limitations arise from considering constant infection rates. We replace...

Network-level reproduction number and extinction threshold for vector-borne diseases.

The basic reproduction number of deterministic models is an essential quantity to predict whether an epidemic will spread or not. Thresholds for disease extinction contribute crucial knowledge of dise...

Phagocyte NADPH oxidase and specific immunity.

The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptiv...

The bright side of migration: Hedonic, psychological, and social well-being in immigrants in Spain.

The aim of this study was to examine the multi-dimensional structure of well-being in immigrant population, as well as to explore the complexity of well-being disparities between immigrants and host n...

Hallucinations and inhibitory functioning in healthy young adults with high and low levels of hypomanic personality traits.

Hallucinations in schizophrenia and hallucination proneness in healthy young adults are associated with a common cognitive mechanism, namely impaired inhibitory control. Hallucinatory-like experiences...

Effect of Hormonal Contraception on the Function of Plasmacytoid Dendritic Cells and Distribution of Immune Cell Populations in the Female Reproductive Tract.

Epidemiological evidence suggests an association between the use of hormonal contraception and an increased risk of acquiring sexually transmitted diseases including HIV-1. We sought to elucidate the ...

Towards the fabrication of artificial 3D microdevices for neural cell networks.

This work reports first steps towards the development of artificial neural stem cell microenvironments for the control and assessment of neural stem cell behaviour. Stem cells have been shown to be fo...

Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

Implantation of a medical implant within the body inevitably triggers a host inflammatory response that negatively impacts its function and longevity. Nevertheless, the degree and severity of this res...

Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.

We have generated a bioinspired tunable system of hyaluronic acid (HyA)-based hydrogels for Matrix-Assisted Cell Transplantation (MACT). With this material, we have independently evaluated matrix para...

News Articles [2493 Associated News Articles listed on BioPortfolio]

UnitedHealthcare Community Plan of Ohio and Youngstown Office on Minority Health Host Citywide Baby Shower and Health Fair

Mom and moms-to-be took steps to improve their health and the health of their babies today by participating in a health fair and baby shower organized by the city of Youngstown an...

Second Genome – microbiome modulators

Second Genome is a biotech company developing product candidates that modulate microbe-host and microbe-microbe interactions across multiple disease areas. Second Genome – microbiome modulators ...

How music improves brain function

Chuck Bednar for redOrbit.com - @BednarChuck While previous studies have found that listening to music (especially classical music) has a positive impact on a person’s cognitive ability and brain f...

A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015

(PRWEB) March 28, 2015 "Necrorun" was featured on NewsWatch as part of its monthly AppWatch, which takes a look at the latest and coolest applications on the market for iOS, Android, and ...

MYOS Corporation to Host Conference Call to Discuss Quarterly Update and Management Highlights / Conference Call Scheduled for Monday March 30th, 2015 at 10:00 a.m. ET; Interested Parties May Access This Conference Call by Dialing 877-407-7186 (U.S./Cana

CEDAR KNOLLS, NJ -- (Marketwired) -- 03/27/15 -- MYOS Corporation ("MYOS" or the "Company") (NASDAQ: MYOS), an emerging biotherapeutics and bionutrition company focused on the discovery, developme...

Hamburg’s Public Farewell Includes Rallying Cry For FDA Power

Outgoing commissioner gives forceful defense of the agency’s regulatory authority and warns that lowering drug approval standards would damage both patients and industry.

White House Antibiotic Plan Takes Top-Down Approach To Boosting Research

Federal agencies, including the Defense Department, are instructed to create a biopharmaceutical incubator and get at least two new treatments into clinical trials by 2020.

Report: Transparency, cooperation help reduce high prices for new medicines

As the number of new medicines introduced in Europe rises, governments are finding it increasingly difficult to afford them, according to a comprehensive study released today by the WHO Regional Offi...

Host Cell Protein Impurities Come Under the Regulatory Microscope

Have host cell proteins replaced subvisible particles as the new hot topic for biologics manufacture? Some say that FDA is now rightly focusing its attention on HCPs and the analytical tests that meas...

Tumour immunology: A triple blow for cancer

Dual immune checkpoint blockade combined with radiation promotes effective antitumour immunity through distinct mechanisms.

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Companies [191 Associated Companies listed on BioPortfolio]

Hofstra North Shore-LIJ School of Graduate Nursing and Health Professions

Hofstra University is nationally ranked and recognized private university in Hempstead, NY that is one of only two universities chosen to host consecutive presidential debates (20...

Tokai Pharmaceuticals

Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The company’s lead drug candidate, TOK-001, is the first i...

Bulova Technologies Group, Inc.

Headquartered in Clearwater, FL, Growth Technologies International, Inc. focuses on disruptive technologies in the fields of defense, alternative energy, alternative healthcare, h...

Nutter McClennen & Fish LLP

Nutter McClennen & Fish LLP represents an international roster of innovative clients involved in a range of sophisticated technologies in the medical device, biotechnology and pha...

Pannone Lopes Devereaux & West LLC

The attorneys and staff at Pannone Lopes Devereaux & West LLC (PLDW) are committed to developing practical and cost-effective solutions while also being supportive of the communit...

Acceleron Pharma and Celgene Corporation

Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel protein therapeutics for cancer and rare diseases. The...

Exostar and Code-N

Exostar powers secure business-to-business information sharing, collaboration and business process integration throughout the value chain. Exostar supports the complex trading nee...

The Object Management Group

What: The Object Management Group® (OMG®) will host an all-day seminar entitled “Cross Domain Threat and Risk Information Exchange Day” on March 23 at the H...

Cambrian Innovation

Cambrian Innovation is a leader in developing biotechnology solutions that extract energy from water. Spun out of MIT in 2006, Cambrian has scaled and validated its proprie...

Newron Pharmaceuticals SpA

Newron Pharmaceuticals SpA is a clinical stage biopharmaceutical company focused on the discovery and development of small molecule drugs for the treatment of central nervous system (CNS) diseases. Ou...

Clinical Trials [1080 Associated Clinical Trials listed on BioPortfolio]

Phase II Trial for Large ER-Negative Breast Cancers

A primary objective of this study is to evaluate the in vivo response of tumor to chemotherapy through gene microarray analysis. Neoadjuvant treatment allows the unique opportunity to obse...

Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence

The purpose of the study is to learn more about tobacco dependence and nicotine metabolism in African-Americans and whites, by studying to see if how fast a person metabolizes nicotine (ho...

Trial to Incentivise Adherence for Diabetes

Type II diabetes is associated with a host of adverse and costly complications, including heart attacks, strokes, blindness, kidney failure, and severe neuropathy that may result in amputa...

Regulation of the Release of Inflammatory Mediators From Lung Macrophages.

The aim of this study is to investigate the mechanisms whereby specific white cells called macrophages found in the lung release inflammatory mediators or chemicals together with enzymes t...

Vismodegib in Treating Patients With Steroid-Refractory Chronic Graft-versus-Host Disease

This pilot clinical trial studies how well vismodegib works in treating patients with chronic graft-versus-host disease that did not respond to previous steroid treatment. Chronic graft-ve...

Influence of Patient/Ventilador Decoupling in Neurocognitive and Psychopathological Sequelae in ICU Patients

Mechanical ventilation (MV) is a vital support tool for critically ill patients. However, it may present several adverse effects, such as the development of cognitive and psychopathologica...

In Vivo Treg Expansion and Graft-Versus-Host Disease Prophylaxis

IL-2 add-back post allogeneic hematopoietic stem cell transplant (HSCT), combined with Sirolimus (SIR), Tacrolimus (TAC) will optimize Treg reconstitution and prevent graft versus host dis...

Characterization of the Motivational Deficit in Schizophrenia and Depression

This research focuses on disorders of motivation, responsible for a disability that patients experience daily. It is a disorder that affects behavior, especially social. Mechanisms, which ...

Effect of Teleprevir in Triple Therapy on Intrahepatic Immunological Mechanisms

Chronic hepatitis C infection (HCV) is a disease that affects worldwide about 170 million people. The previous standard of care therapy of chronic HCV patients consists of pegylated-IFN-α...

Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients

Fatigue is one of the most common and debilitating symptoms experienced in Parkinson's Disease (PD) and Multiple Sclerosis (MS). There are multiple proposed mechanisms of disorder-related...

Medical and Biotech [MESH] Definitions

The mechanisms by which a cell becomes internalized in another. The host cell may engulf another as do PHAGOCYTIC CELLS, or the host cell may be invaded by another cell (ENTOSIS), or internalization processes may involve the cooperation of both the host cell and the cell being internalized. Viable cells may remain in non-phagocytic cells (EMPERIPOLESIS), undergo cell division, pass through and then out of the host cell (TRANSCELLULAR CELL MIGRATION), or trigger APOPTOSIS of the invaded cell.

Unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.

Processes that translocate macromolecules across the cell envelope of gram negative bacteria, often directly into the host. These effectors modulate the defense response and thereby facilitate survival of the pathogen.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Defense mechanisms involving approach and avoidance responses to threatening stimuli. The sensitizing process involves intellectualization in approaching or controlling the stimulus whereas repression involves unconscious denial in avoiding the stimulus.

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