Humoral Immunity - Biotech, Pharma and Life Science Channel
PubMed Articles
Recently, novel molecular targeted agents markedly changed the treatment of renal cell carcinoma (RCC), with promising results. However, there is little understanding of how these agents affect immune...
JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-Î...
Tomato MAPK kinase SlMKK2 is a key protein regulating immunity-associated programmed cell death (PCD) in plants. We examined the role of the N-terminal MAPK-docking site (or D-site) of SlMKK2 in PCD e...
Macrophage derived foam cells are actively involved in the initial phase of atherosclerosis. Uptake of modified lipoprotein such as oxidized LDL (oxLDL) is a critical step for foam cell formation. CD3...
Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy.
Salutary responses to adeno-associated viral (AAV) gene therapy have been reported in the mouse model of Sandhoff disease (SD), a neurodegenerative lysosomal storage disease caused by deficiency of β...
RhoGTPases - NODes for effector-triggered immunity in animals.
A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which m...
SUMMARY Hepatitis B virus (HBV) can be eliminated by effective universal vaccination. In Belgium, a free-of-charge HBV vaccination programme in infants with catch-up in adolescents was introduced in 1...
A well-functioning immune system is key to providing good defence against pathogenic organisms and to providing tolerance to non-threatening organisms, to food components and to self. The immune syste...
Friendly pathogens: prevent or provoke autoimmunity.
Abstract The gut microflora is an immense health asset for human beings. The mammalian gut harbors trillions of commensals. These microbes not only modulate local but also systemic immunity. Recently,...
Intestinal infection with Trichinella spiralis induces distinct, regional immune responses.
The aim of this study was to evaluate differences between the small and large intestines (SI and LI) with regard to colonization and immunity during infection with Trichinella spiralis. In orally infe...
News Articles
Take a look at the newest Image of the Week ! - Hilda Bastian - Dissecting the controversy about early psychological response to disasters and trauma [More]
New Insight Into How Pathogens Break Through A Host's Defenses
Parasitic wasps switch off the immune systems of fruit flies by draining calcium from the flies' blood cells, a finding that offers new insight into how pathogens break through a host's defenses. "We...
Epigenetic Regulators And NF-Kappa B May One Day Be Targeted For The Treatment Of Cancer
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor grow...
Swine flu pandemic of 2009 more deadly for younger adults, UCI study finds
(University of California - Irvine) As the world prepares for what may be the next pandemic strain of influenza virus, in the H7N9 bird flu, a new UC Irvine study reveals that the 2009 H1N1 swine flu...
Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy
RhoGTPases — NODes for effector-triggered immunity in animals
Low population immunity to new bird flu virus H7N9 in humans
The level of immunity to the recently circulating H7N9 influenza virus in an urban and rural population in Vietnam is very low, according to the first population level study to examine human immunity...
Will Influenza A H7N9 Generate Opportunities For Pharma?
ByJean-Christophe Larsimont:It has been hard not to hear about the H7N9 flu virus. Everybody bears in mind the H1N1 scandal. Briefly, the H1N1 virus quickly received an exaggerated status, in a first...
Estimates reveal low population immunity to new bird flu virus H7N9 in humans
(Wellcome Trust) The level of immunity to the recently circulating H7N9 influenza virus in an urban and rural population in Vietnam is very low, according to the first population level study to examin...
Yellow fever booster not needed, says WHO
A single dose of yellow fever vaccine is enough to protect against infection for life, according to updated advice from the World Health Organization. The WHO’s Strategic Advisory Group of Expe...
Events
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Companies
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Hycult Biotech is a leader in the fields of immunology and cell biology, we develop, produce and market antibodies, antibody based products and more specifically immunoassays for...
BridgeWave Communications is the leading supplier of high-capacity 4G millimeter wave backhaul and gigabit wireless connectivity solutions. BridgeWave's carrier-grade, point-to-po...
Innate Immunotherapeutics Limited
Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...
Vaxxas is a privately-held biotechnology company focused on enhancing the performance of existing and next generation vaccines with its proprietary Nanopatch™ technology plat...
Neumedicines Inc. is developing protein therapeutics that address unmet clinical and societal needs in the fields of oncology, hematology and immunology. The company’s lead p...
US/Hungarian Genetic Immunity and US/Italian ViroStatics, both spin-offs of the non-profit Research Institute for Human and Genetic Therapy (RIGHT), are developing novel treatment...
Telormedix (www.telormedix.com), founded in October 2007, is a biopharmaceutical company focused on targeted immunity and modulation of the innate immune system for treatin...
Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...
San Francisco-based Attune Foods is dedicated to bringing innovation to the food business by creating convenient, great tasting natural digestive health products that make you fee...
Clinical Trials
Administration of Autologous Dendritic Cells (DCs) Infected With an Adenovirus Expressing Her-2
We, the researchers at Hamilton Health Sciences, have developed a novel approach to cancer therapy using transfected dendritic cells (DCs) to generate enhanced immunity to defined tumor an...
This is a study of a melanoma vaccine. Study participants will have melanoma that invaded deeply and spread to lymph nodes or another location. Although the participants' melanoma has be...
Hyperthermia With Chemotherapy for Locally Advanced or Metastatic Pancreas Cancer
Thermal therapy (hyperthermia, or heat) enhances the chemotherapy anti-tumor kill. Thermal therapy by itself also kills cancer cells. Whole-body thermotherapy is a systemic treatment th...
Antibody Response and Immune Memory 15-18 Years After HBV Vaccination
Taiwan is an endemic region for hepatitis B. Before the implementation of a nationwide vaccination program in 1984, the hepatitis B virus (HBV) carrier rate in the general population was 1...
Neoadjuvant Estradiol or Androgen Deprivation in Clinically Localized Prostate Cancer
Prostate cancer is the most commonly diagnosed cancer among males in the U.S. More than 220,000 men will be diagnosed with prostate cancer in the USA this year and more that 31,000 will...
Vaccine to Prevent West Nile Virus Disease
This study will test the safety of an experimental vaccine intended to prevent West Nile virus (WNV) infection and determine if it causes side effects. WNV symptoms may vary from fever and...
Phase I Study of a Vaccine for Severe Acute Respiratory Syndrome (SARS)
This study will test whether an experimental vaccine to protect against severe acute respiratory syndrome (SARS) is safe, causes any side effects, and causes an immune response. SARS affec...
The purpose of this study is to gather information on the safety and the effectiveness of an investigational vaccine for the prevention of smallpox disease. Smallpox was one of the major c...
Phase I/II Trial of Modified Vaccinia Virus Ankara (MVA) Vaccine Against Smallpox
This study will test the safety of an experimental vaccine called modified vaccinia virus ankara (MVA) and determine if it confers protection against the smallpox virus (variola). There is...
HIV-1 Vaccine Test in Uninfected Adult Volunteers
This study will test the safety of an experimental vaccine against HIV and examine whether it induces an immune response to HIV. A vaccine is a substance given to try to create resistance...
Videos
Types of immune responses: Innate and Adaptive. Humoral vs. Cell-Mediated
Learn more: http://www.khanacademy.org/video?v=rp7T4IItbtM Overview of types of immune responses. Difference between innate and adaptive immunity. Difference...
Medical and Biotech [MESH] Definitions
Immunity, Herd
The non-susceptibility to infection of a large group of individuals in a population. A variety of factors can be responsible for herd immunity and this gives rise to the different definitions used in the literature. Most commonly, herd immunity refers to the case when, if most of the population is immune, infection of a single individual will not cause an epidemic. Also, in such immunized populations, susceptible individuals are not likely to become infected. Herd immunity can also refer to the case when unprotected individuals fail to contract a disease because the infecting organism has been banished from the population.
Mass Vaccination
Administration of a vaccine to large populations in order to elicit IMMUNITY.
Thrombopoiesis
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.
Parathyroid Hormone-related Protein
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Vdj Recombinases
Recombinases involved in the rearrangement of immunity-related GENES such as IMMUNOGLOBULIN GENES and T-CELL RECEPTOR GENES.
