Hyaluronic acid Sanofi - Biotech, Pharma and Life Science Channel

15:18 EDT 18th April 2015 | BioPortfolio

PubMed Articles [7198 Associated PubMed Articles listed on BioPortfolio]

Enhancement of a Novel Extracellular Uricase Production by Media Optimization and Partial Purification by Aqueous Three-Phase System.

Uricase (urate: oxygen oxidoreductase, EC 1.7.3.3), an enzyme belonging to the class of oxidoreductases, catalyzes the enzymatic oxidation of uric acid to allantoin and finds a wide variety of applica...

Semi-synthesis of new antimicrobial esters from the natural oleanolic and maslinic acids.

In this article, we report an effective procedure for the selective isolation of oleanolic acid 1 and maslinic acid 2 (3.4 and 8.5mg/g DW, respectively) from pomace olive (Olea europaea L.) using an u...

Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity.

The antiproliferative effects of a purified white grape pomace extract (PWGPE), as well as of some phenolic standards on colon cancer cells were examined. The phenolic composition of the PWGPE was det...

Physical features, phenolic compounds, betalains and total antioxidant capacity of coloured quinoa seeds (Chenopodium quinoa Willd.) from Peruvian Altiplano.

Physical features, bioactive compounds and total antioxidant capacity (TAC) of coloured quinoa varieties (Chenopodium quinoa Willd.) from Peruvian Altiplano were studied. Quinoa seeds did not show a p...

Variation in nutritional compositions, antioxidant activity and microstructure of Lycopus lucidus Turcz. root at different harvest times.

The objective of this study was to investigate the variation in nutritional compositions, antioxidant activity and microstructure of Lycopus lucidus Turcz. root at different harvest times. L. lucidus ...

Three differently generated salmon protein hydrolysates reveal opposite effects on hepatic lipid metabolism in mice fed a high-fat diet.

This study investigates the effects of salmon peptide fractions, generated using different enzymatic hydrolyzation methods, on hepatic lipid metabolism. Four groups of mice were fed a high-fat diet wi...

Influence of dried Hokkaido pumpkin and ascorbic acid addition on chemical properties and colour of corn extrudates.

The influence of Hokkaido pumpkin powder (PP) addition to corn grits at levels 4%, 6%, and 8% and ascorbic acid (AA) addition at levels 0.5% and 1% was evaluated. Extrusion was done using a single-scr...

Chemical composition of red, brown and green macroalgae from Buarcos bay in Central West Coast of Portugal.

Six representative edible seaweeds from the Central West Portuguese Coast, including the less studied Osmundea pinnatifida, were harvested from Buarcos bay, Portugal and their chemical characterizatio...

Ion-exchange equilibrium of N-acetyl-d-neuraminic acid on a strong anionic exchanger.

N-acetyl-d-neuraminic acid (Neu5Ac) is a high value-added product widely applied in the food industry. A suitable equilibrium model is required for purification of Neu5Ac based on ion-exchange chromat...

Comparative in vitro fermentations of cranberry and grape seed polyphenols with colonic microbiota.

In this study, we have assessed the phenolic metabolism of a cranberry extract by microbiota obtained from the ascending colon and descending colon compartments of a dynamic gastrointestinal simulator...

News Articles [2054 Associated News Articles listed on BioPortfolio]

FDA to ALS biotech Genervon: Show us the data

The FDA said the full data from Pasadena, California-based Genervon Biopharmaceuticals' Phase IIa trial of GM604, a 6-amino acid endogenous peptide, are needed "to allow a more informed discussion of ...

Bioconjugation: How to pick a single amine?

Single-step site-specific labeling of native proteins is one of the holy grails in the chemical biology field. 2-Pyridinecarboxyaldehyde derivatives are shown to react selectively at the N terminus of...

Anika Therapeutics Reports on Cingal® 13-01 Study Clinical Trial Top Line Data and Announces the Completion of Cingal 13-02 Study’s Patient Enrollment

Anika Therapeutics, Inc. (Nasdaq: ANIK), a leader in products for tissue protection, healing, and repair based on hyaluronic acid (HA) technology, today announced the compl...

Lucigen – isothermal nucleic acid amplification

Lucigen is a biotech company applying novel nucleic acid detection technology to the leading challenges of human and animal infectious disease. Lucigen – isothermal nucleic acid amplification  ...

The European Stroke Organisation (ESO) Unveils Clinical Trials With Ground-Breaking Results at the Inaugural European Stroke Organisation Conference (ESOC 2015), Glasgow

GLASGOW, April 17, 2015 /PRNewswire/ -- The European Stroke Organisation (ESO), at the first annual European Stroke Organisation Conference (ESOC 2015), in Glasgow, April 17-19, is pleased to announc...

Deutsche Bank hebt Ziel für Sanofi auf 94 Euro - 'Hold'

Die Deutsche Bank hat das Kursziel für Sanofi vor Zahlen von 77 auf 94 Euro angehoben und die Einstufung auf "Hold" belassen. Das verschlechterte Geschäft mit Diabetes-Medikamenten dürfte das erst....

Active Pin1 is a target for all-trans retinoic acid in leukaemia and breast cancer

by ecancer reporter Clare Sansom Targeted cancer therapy offers significant advantages over chemotherapy, but it can be ineffective in treating some aggressive tumours because pathways that are block...

PRN's Omega-3 Hits Major Endpoints Against Placebo in a Study of Dry Eye Symptoms

IRVINE, Calif., April 17, 2015 /PRNewswire/ -- ALPHAEON Corporation and its subsidiary company PRN Physician Recommended Nutriceuticals, a leading provider of nutritional supplements, announced t...

Sanofi partners with Innate Pharma on antibody-drug conjugates

Sanofi and Innate Pharma agreed to collaborate to develop novel antibody drug conjugates using Innate's technology for the co -More- 

Innate, Sanofi Collaborate on Next Generation Antibody-drug Conjugates

Innate Pharma has entered into a collaboration agreement with Sanofi to apply Innate Pharma's site-specific conjugation technology to the development of new Antibody Drug Conjugates.

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Companies [69 Associated Companies listed on BioPortfolio]

ImmunoGen, Inc.

ImmunoGen, Inc. develops targeted anticancer therapeutics using its expertise in cancer biology, monoclonal antibodies and the creation and attachment of potent cell-killing agent...

Anika Therapeutics Incorporated

Anika Therapeutics, Inc. develops, manufactures and commercializes therapeutic products and devices intended to repair, protect and heal bone, cartilage and soft tissues. These products are currently ...

CanBiocin Inc

CanBiocin was formed in 1998 as a University of Alberta spin-off company to commercialize novel technologies developed from research conducted by professors Michael Stiles, Lynn M...

WaVe Life Sciences

WaVe Life Sciences is leading a revolution in nucleic acid therapeutics and was founded on the core principle that medicines should possess precisely controlled molecular structur...

QIAGEN

QIAGEN is one of the world’s leading providers of innovative enabling technologies and products for separating and purifying nucleic acids (DNA and RNA). Since 1986, the Company has developed and ma...

TapImmune Inc.

TapImmune Inc. is an immunotherapy company specializing in the development of innovative vaccine technologies for the treatment of cancer and infectious disease. The Company’...

Creative Biogene

Creative Biogene provides kits, reagents, and services that help researchers explore questions about gene discovery, regulation, and function. Creative Biogene holds a leadership position in the glo...

Reinnervate Ltd

Reinnervate is a market leading company in the fast growing 3D cell culture market. The Alvetex® family of 3D cell culture products provide a flexible platform that allows scientists in any life...

Oasis Diagnostics Corporation

Oasis Diagnostics® is an emerging Vancouver, WA based company focused on the design, development and commercialization of salivary diagnostic tools with applications at the poi...

ImmunID

ImmunID is pioneering the field of molecular immune diagnostics since 2005, offering two commercial products. Its proprietary CE-marked flagship product ImmunTraCkeR evaluates the...

Clinical Trials [1352 Associated Clinical Trials listed on BioPortfolio]

Comparative Pharmacodynamics and Pharmacokinetics Study of Generic and Reference Clopidogrel Products

The purpose of this study is to compare the pharmacodynamic effect of clopidogrel on the platelet inhibition and the pharmacokinetic profiles of clopidogrel carboxylic acid metabolite betw...

Study of Treatment With the Combination of Drospirenone Plus Ethinyl Estradiol Plus Levomefolate Calcium in Mexican Women Seeking Contraception

The objective of this study is to compare the red blood cell (RBC) and plasma concentrations of folate in subjects treated with drospirenone (DRSP)/ethinyl estradiol (EE) plus levomefolate...

Zoledronic Acid in Rheumatoid Arthritis

The progression of structural joint damage is the leading cause of disability and socioeconomic costs associated with rheumatoid arthritis (RA). Remission and low clinical activity not alw...

Pharmacokinetics and Bioavailability of Pomegranate Phenolics and Urolithins in Healthy Subjects.

Pomegranate phenolics (such as the ellagitannin punicalagin and ellagic acid) are metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A)....

Blood-sparing During Hip Prosthesis Surgery With Exacyl® in Patients Treated With Rivaroxaban

This study evaluates the efficiency of tranexamic acid versus placebo on blood perioperative losses in two modes of administration (standard and extended) after a surgery which is a total ...

3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk Neuroblastoma

The purpose of this study is to find out what effects, good and/or bad, the combination of 3F8 and GM-CSF has on the patient and the cancer. Antibodies are made by the body to attack tumo...

Lysosomal Acid Lipase (LAL) Deficiency Registry

This is an observational, multi-center, international disease registry designed to collect longitudinal data and create a knowledge base that will be utilized to improve the care and treat...

Hemostatic and Anti-Inflammatory Effects of Ulinastatin and Tranexamic Acid in Cardiopulmonary Bypass Cardiac Surgery

Antifibrinolytic drugs are used to decrease perioperative bleeding and allogeneic transfusions. The extensively studied antifibrinolytic drug aprotinin is efficacious but expensive, and ha...

Oxidative Stress Links Aging, Activity and Mobility Limitation

The purpose of this study is to understand why and how oxidative stress negatively impacts mobility in the elderly, and to determine whether antioxidant supplements can increase vascular h...

Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors

This randomized phase II trial studies how well docosahexaenoic acid works in preventing recurrence in breast cancer survivors. Docosahexaenoic acid supplement may prevent recurrence in br...

Medical and Biotech [MESH] Definitions

A group of high molecular weight chondroitin sulfate proteoglycans that form aggregates with HYALURONIC ACID.

Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

A therapeutic treatment typically involving INTRA-ARTICULAR INJECTIONS of HYALURONIC ACID and related compounds. The procedure is commonly used in the treatment of OSTEOARTHRITIS with the therapeutic goal to restore the viscoelasticity of SYNOVIAL FLUID, decrease pain, improve mobility and restore the natural protective functions of hyaluronan in the joint.

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.

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