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Hyaluronic acid Sanofi - Biotech, Pharma and Life Science Channel

12:20 EDT 3rd May 2016 | BioPortfolio

PubMed Articles [7372 Associated PubMed Articles listed on BioPortfolio]

An insect with a delta-12 desaturase, the jewel wasp Nasonia vitripennis, benefits from nutritional supply with linoleic acid.

The availability of linoleic acid (LA; C18:2(∆9,12)) is pivotal for animals. While vertebrates depend on a nutritional supply, some invertebrates, including the parasitic wasp Nasonia vitripennis, a...

Theoretical study of the regioselective cyclization of enaminones in the construction of benzofurans and indoles.

A theoretical study was undertaken regarding the regioselective Lewis acid-promoted intramolecular cyclization of novel enaminones 1-3 leading to the corresponding benzofurans 4-5 and indoles 6. The d...

Omega-3 Fatty Acid-rich Parenteral Nutrition: Is It a Double-edged Sword?

Global Aesthetics Consensus: Hyaluronic Acid Fillers and Botulinum Toxin Type A-Recommendations for Combined Treatment and Optimizing Outcomes in Diverse Patient Populations.

Combination of fillers and botulinum toxin for aesthetic applications is increasingly popular. Patient demographics continue to diversify, and include an expanding population receiving maintenance tre...

Metal-Organic Frameworks: Bimetallic Metal-Organic Frameworks: Probing the Lewis Acid Site for CO2 Conversion (Small 17/2016).

On page 2334, R. Q. Zou, Y. L. Zhao, and co-workers present a porous metal-organic framework (MOF) that serves as a platform for studying the metal exchange effect on both CO2 adsorption and catalytic...

Characterization of Biosurfactant Produced by Bacillus licheniformis TT42 Having Potential for Enhanced Oil Recovery.

Bacillus licheniformis TT42 produced a low-molecular weight anionic biosurfactant that reduced the surface tension of water from 72 to 27 mN/m and the interfacial tension from 12 to 0.05 mN/m agains...

Biochemical characterization of a thermostable HNH endonuclease from deep-sea thermophilic bacteriophage GVE2.

His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity and are found in all kingdoms of life. Although HNH ...

Trans-nasal Zolmitriptan Novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency.

Migraine attack is a troublesome physiological condition associated with throbbing, intense headache, in one half of the head. Zolmitriptan is a potent second-generation triptan, prescribed for patien...

HPLC Methods for Quantitation of Exemestane-Luteolin and Exemestane-Resveratrol Mixtures in Nanoformulations.

Two HPLC-DAD assays for the simultaneous quantitation of exemestane (EXE) and resveratrol (RES)-Mix 1-and EXE and luteolin (LUT)-Mix 2-in novel breast cancer therapy nanoformulations were developed. C...

TLC Profiles of Selected Cirsium Species with Chemometrics in Construction of Their Fingerprints.

The dried aerial parts of 12 plants of Cirsium species were extracted with the Soxhlet apparatus using dichloromethane and methanol as solvents. Next, the extracts were separated by TLC methods to obt...

News Articles [2265 Associated News Articles listed on BioPortfolio]

Marina Biotech to Acquire Late-Stage Program From Turing Pharmaceuticals / Marina to Pursue Phase 3 Studies for Use of Intranasal Ketamine in Multiple Indications

BOTHELL, WA, and BAAR, SWITZERLAND -- (Marketwired) -- 05/03/16 -- Marina Biotech, Inc. (OTCQB: MRNA), a leading nucleic acid-based drug discovery and development company focused on rare diseases ...

Medivation unimpressed with Sanofi's offer

CEO says the offer “substantially undervalues” the oncology specialist

HSBC senkt Sanofi auf 'Hold' und Ziel auf 81 Euro

Die britische Investmentbank HSBC hat Sanofi nach Zahlen von "Buy" auf "Hold" abgestuft und das Kursziel von 89 auf 81 Euro gesenkt. Das erste Quartal des Pharmakonzerns habe enttäuscht, schrieb A...

Recursion Pharmaceuticals Announces Research Agreement With Sanofi Genzyme

Recursion Pharmaceuticals recently announced a research agreement with Sanofi Genzyme, the specialty care global business unit of Sanofi, to deploy its drug repurposing platform to identify new uses f...

Marina Biotech Terminates Negotiations for Sale of Its Nucleic Acid Therapeutic Assets

BOTHELL, WA -- (Marketwired) -- 05/03/16 -- Marina Biotech, Inc. (OTCQB: MRNA), a leading nucleic acid-based drug discovery and development company focused on rare diseases announced that they have t...

Marina Biotech to Acquire Late-Stage Program From Turing Pharmaceuticals

BOTHELL, WA, and BAAR, SWITZERLAND -- (Marketwired) -- 05/03/16 -- Marina Biotech, Inc. (OTCQB: MRNA), a leading nucleic acid-based drug discovery and development company focused on rare diseases an...

Architecture of the mitochondrial calcium uniporter

Mitochondria from many eukaryotic clades take up large amounts of calcium (Ca2+) via an inner membrane transporter called the uniporter. Transport by the uniporter is membrane potential dependent and ...

Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

Cachexia-inducing tumors release complex factors that promote the increased uptake and burning of fats by muscle, resulting in muscle atrophy—a process that can be blocked if fatty acid oxidation is...

#jobs #lifescience Senior Director, Infusion Support Manager

// MA-Cambridge, Senior Director, Infusion Support Manager-POS_70041986-1 Description Sanofi Genzyme has pioneered the development and delivery of transformative therapies for patients affected by rar...

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Companies [79 Associated Companies listed on BioPortfolio]

Sanofi Genzyme

WAVE Life Sciences Ltd.

WAVE Life Sciences is utilizing its innovative and proprietary synthetic chemistry drug development platform to design, develop and commercialize stereopure nucleic acid therapeut...

Pronutria Biosciences

Pronutria Biosciences is pioneering new nutritional and therapeutic modalities: amino acid biologics. Amino acids (AA) are known as the “building blocks of life,” and ar...

Alexion Pharmaceuticals Inc.

Alexion is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare disorders. Alexion developed ...

MabSpace Biosciences Co., Ltd.

MabSpace Biosciences Co., Ltd. is a biotechnology company focused on the discovery and early development of antibody based therapeutics. The key advantage of its proprietary immun...

Pronutria Biosciences Inc.

Pronutria Biosciences is pioneering new nutritional and therapeutic modalities: amino acid biologics. Amino acids (AA) are known as the “building blocks of life,” and ar...

Merial

Merial is a world-leading, innovation-driven animal health company that provides a comprehensive range of products to enhance the health, well-being and performance of a wide rang...

Mirus Bio Corporation

Mirus Bio Corporation is a biopharmaceutical company focused on discovering, developing and commercializing innovative nucleic acid based technologies and products. The company currently markets a ran...

Voyager Therapeutics, Inc.

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advanc...

Ontario, Canada

Ontario, Canada’s business environment is designed for global success. Ontario is an efficient North American hub for international investment and trade. It offers direct acc...

Clinical Trials [1709 Associated Clinical Trials listed on BioPortfolio]

Dietary Lipid Induced Insulin Resistance

The overall goal of the proposal is to use a saturated fatty acid (SFA)- enriched, high fat diet to rapidly induce insulin resistance (IR) to provide insight into underlying proximal mecha...

Effect of Betaine and Food on Gastric pH

Food will decrease stomach acidity due to its buffering effect.This has implications when providing drugs that are dosed with food but require higher levels of stomach acid, such as some m...

Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma

The standard therapy of glioblastoma (GBM) consists of gross total resection followed by focal irradiation to the tumor bed with concomitant and adjuvant temozolomide (TMZ). The associatio...

A Toll-like Receptor Agonist as an Adjuvant to Tumor Associated Antigens (TAA) Mixed With Montanide ISA-51 VG With Bevacizumab for Patients With Recurrent Glioblastoma

This is a phase II study to determine the immunogenicity and efficacy of a vaccine composed of tumor associated long synthetic peptides mixed with Montanide ISA-51 VG administered with pol...

Clinical Study on 5-aminolevulinic Acid Hydrochloride (5-ALA) for Fluorescence-guided Resection of Malignant Gliomas

This study is planned to detect a dose-efficacy relationship between the chosen dose levels of MC506/1 and the extent and quality of fluorescence in the tumour core in patients with newly ...

Development of Novel Strategy for Treatment of Anterior Cruciate Ligament (ACL) Injury Using Stem Cell

Purpose:Development of novel strategy for treatment of anterior cruciate ligament (ACL) injury using stem cell.

Daratumumab in Combination With ATRA

Multiple myeloma (MM) patients who develop bortezomib and lenalidomide-resistant disease have a very poor survival of only a median of 9 months, indicating that new agents are urgently nee...

Photodynamic Therapy for Prevention of Nonmelanoma Skin Cancer in Organ Transplant Recipients

The study will draw patients from the Transplant Dermatology specialty clinic, where the investigators see organ transplant recipients (OTR) for regular screening and serve as a regional r...

Platelet Inhibition of Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients After Elective Percutaneous Coronary Intervention

This will be a single-center, randomized, open-label, active-controlled, parallel-group study to investigate the platelet inhibition of Ticagrelor versus Clopidogrel with acetylsalicylic a...

C. Difficile and Ursodiol

In vitro findings have established that ursodeoxycholic acid is a surrogate for deoxycholic acid in preventing the growth of C. difficile, and interrupting recurrence. Investigators will a...

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Medical and Biotech [MESH] Definitions

A group of high molecular weight chondroitin sulfate proteoglycans that form aggregates with HYALURONIC ACID.

Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

A therapeutic treatment typically involving INTRA-ARTICULAR INJECTIONS of HYALURONIC ACID and related compounds. The procedure is commonly used in the treatment of OSTEOARTHRITIS with the therapeutic goal to restore the viscoelasticity of SYNOVIAL FLUID, decrease pain, improve mobility and restore the natural protective functions of hyaluronan in the joint.

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.

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