Hypothalamic Controls - Biotech, Pharma and Life Science Channel

19:32 EDT 18th April 2015 | BioPortfolio

PubMed Articles [4366 Associated PubMed Articles listed on BioPortfolio]

Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome.

Ovarian cancer is one of the leading female cancers in the United States. Challenges remain in early diagnosis of this deadly disease. Matrix metalloproteinases (MMPs) family genes are paradoxically i...

Overlapping Dopaminergic Pathway Genetic Susceptibility to Heroin and Cocaine Addictions in African Americans.

Drugs of abuse activate the mesolimbic dopaminergic pathway. Genetic variations in the dopaminergic system may contribute to drug addiction. Several processes are shared between cocaine and heroin add...

Kullback-Leibler Distance Methods for Detecting Disease Association with Rare Variants from Sequencing Data.

Because next generation sequencing technology that can rapidly genotype most genetic variations genome, there is considerable interest in investigating the effects of rare variants on complex diseases...

Rare Variants in MYD88, IRAK4 and IKBKG and Susceptibility to Invasive Pneumococcal Disease: A Population-Based Case-Control Study.

Although rare variants within the Toll-like receptor signalling pathway genes have been found to underlie human primary immunodeficiencies associated with selective predisposition to invasive pneumoco...

Complexity Measures in Magnetoencephalography: Measuring "Disorder" in Schizophrenia.

This paper details a methodology which, when applied to magnetoencephalography (MEG) data, is capable of measuring the spatio-temporal dynamics of 'disorder' in the human brain. Our method, which is b...

Frequency-Dependent Changes in the Regional Amplitude and Synchronization of Resting-State Functional MRI in Stroke.

Resting-state functional magnetic resonance imaging (R-fMRI) has been intensively used to assess alterations of inter-regional functional connectivity in patients with stroke, but the regional propert...

Recognition of oral spelling is diagnostic of the central reading processes.

The task of recognition of oral spelling (stimulus: "C-A-T", response: "cat") is often administered to individuals with acquired written language disorders, yet there is no consensus about the underly...

Expression levels of urotensin II are associated with endoplasmic reticulum stress in patients with severe preeclampsia.

Hypertensive disorders in pregnancy remain a leading cause of maternal and perinatal mortality and morbidity. We aim to study urotensin II (UII) and its association with the markers of endoplasmic ret...

Key Glycolytic Enzyme Activities of Skeletal Muscle Are Decreased under Fed and Fasted States in Mice with Knocked Down Levels of Shc Proteins.

Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were m...

A study of cognitive functions in female elderly patients with osteoporosis: a multi-center cross-sectional study.

To investigate changes of cognitive performances in female elderly patients with osteoporosis and to determine whether any impairments can be attributed to dysregulation of the hypothalamic-pituitary-...

News Articles [477 Associated News Articles listed on BioPortfolio]

Rise of generics will curb France’s pharma growth

Generics are set to take a serious bite out of the market as a cash-strapped government pushes for cost controls

Circadian Clock Controls Sugar Metabolism

The body’s circadian rhythm has more of an effect on glucose tolerance than one’s eating and sleeping patterns, a study shows.  

Researchers discover gene that controls melting point of cocoa butter

The discovery of a gene involved in determining the melting point of cocoa butter—a critical attribute of the substance widely used in foods and pharmaceuticals—will likely lead to new and improve...

How come the plant hormone auxin functions one way in one location, and a different way elsewhere?

Auxin is a simple yet powerful hormone which, depending on where it accumulates, controls a large number of growth mechanisms in plants. Dolf Weijers, Professor in Biochemistry of Plant Development at...

Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo

Persistent experience-driven adaptation of brain function is associated with alterations in gene expression patterns, resulting in structural and functional neuronal remodeling. How synaptic activity&...

The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1{beta}

Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy was used in post-neonatal mice to delete...

Landauer, Inc. Announces Financial Leadership Transition

GLENWOOD, Ill., April 15, 2015 /PRNewswire/ -- Landauer, Inc. (NYSE: LDR), a recognized leader in personal and environmental radiation measurement and monitoring, outsourced medical physics servi...

Cancer Sequencing Controls

Comparing a patient’s tumor DNA sequence with that of her normal tissue can improve researchers’ identification of disease-associated mutations.

Comedy for a Cure Event to Benefit the National Organization of Rare Disorders (NORD)

Over 112 local runners team up to raise funds and awareness for Rare Disease Communities while participating in the Boston and Providence Marathons Norton, MA: For the eighth consecutive year, employe...

The Global Blood Industry

LONDON, April 14, 2015 /PRNewswire/ -- REPORT HIGHLIGHTSGlobal sales of blood products grew to nearly $30.2 billion in 2014 from $28.7 billion in 2013. The market is expected to grow at a five-year co...

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Companies [36 Associated Companies listed on BioPortfolio]

Xamin, Inc.

Founded in 1999, Xamin, Inc. is a Chicago based company offering industry leading IT services to financial institutions as well as other highly regulated industries. The company p...

NanoSpeed Diagnostics, Inc.

DiaSys Diagnostic Systems is a leading specialist in the development and manufacturing of diagnostic system solutions of highest quality, trusted by customers in more than 100 cou...

Phytecs

Phytecs develops healthcare and nutrition products targeting the endocannabinoid system responsible for the regulation of nearly every physiologic process within the human ...

Digital Lumens

Digital Lumens is a global supplier of enterprise-scale intelligent LED lighting to commercial and industrial customers, delivering 90% energy savings and granular building intell...

SageGlass

SageGlass®, a product of Saint-Gobain, is advanced dynamic glass that can be electronically tinted or cleared to optimize daylight and improve the human experience in buildings...

Linnea SA

Located in the Swiss canton of Ticino, Linnea is a high-quality manufacturer of active ingredients for use in the health food and cosmetic industries and pharmaceutical industries...

AsiaInspection

Founded in Hong Kong, AsiaInspection (www.asiainspection.com) is the leading online platform for performing product inspections, testing and factory audits in Asia for impor...

22nd Century Group, Inc.

Founded in 1998, 22nd Century Limited, LLC (22nd Century) is a plant biotechnology company whose proprietary technology allows for the level of nicotine (and other nicotinic alkal...

Daylight Solutions, Inc.

Daylight Solutions develops molecular detection, imaging and high-power illumination systems for use in industrial process controls, scientific research, medical diagnostics, envi...

China Kangtai Cactus Bio-tech Inc.

China Kangtai Cactus Bio-tech, Inc. is a leading grower, developer, producer, and marketer of cactus-derived products, including nutraceuticals, nutritious food, health and energy...

Clinical Trials [607 Associated Clinical Trials listed on BioPortfolio]

Comparison of the Hoya Surgical Optics (HSO) iSert 251 Posterior Chamber Aspheric Aphakic Intraocular Lens to Historical / Literature Controls.

The purpose of this multi-center clinical trail is to determine the safety and efficacy of the iSert 251 for the correction of aphakia.

Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias

Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhance...

Intrapartum Hydration

The purpose of this study is to determine that maternal hydration during labor with fluids containing glucose at a rate of 125 ml per hour does not affect the duration of labor compared to...

Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism

This is a clinical study comparing targeted levothyroxine dosing based on thyroid anatomy as visualized on ultrasound (normal vs. ectopic/sublingual vs. athyreosis) to empiric levothyroxin...

The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia

Iatrogenic hypoglycemia is the most frequent acute complication of insulin therapy in people with type 1 diabetes (T1DM). Recurrent hypoglycemic events initiate a process of habituation, c...

Protein Synthesis in the Brain of Patients With Fragile X Syndrome

Biosynthesis of proteins is essential for growth and continued maintenance of the entire neuron including axons, dendrites, and synaptic terminals, and it is clearly one of the important b...

Intestinal and Nasal Microbiota of Patients With Idiopathic Parkinson's Disease

The cause of Parkinson's disease (PD) is unknown and a reliable biomarker to identify PD patients as early as possible is urgently needed. Nerve cells near the nose and in the gut become f...

An Investigation of Pituitary Tumors and Related Hypothalmic Disorders

There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in ch...

Vilazodone for Corticosteroid-Induced Memory Impairment

The purpose of this study is to examine whether vilazodone attenuates the memory and mood effects of corticosteroids on the human hippocampus in 18 healthy controls.

Oligomeric Alpha-synuclein in Multiple System Atrophy

The main objectives are to determine on one hand whether oligomeric alpha-synuclein levels are increased in MSA patients compared to controls and on other hand whether there is a good agre...

Medical and Biotech [MESH] Definitions

The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial mamillary nucleus, lateral mamillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.

A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.

This area is bounded medially by the mammillothalamic tract and the anterior column of fornix. The medial edge of the internal capsule and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p710)

The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular gray matter of the rostral portion of the third ventricle and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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