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Hypothalamic Controls - Biotech, Pharma and Life Science Channel

23:34 EDT 5th May 2016 | BioPortfolio

PubMed Articles [4217 Associated PubMed Articles listed on BioPortfolio]

Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.

Background The impact of genetic variation in the thiopurine S-methyltransferase (TPMT) gene on thiopurine-induced leukopenia has been well demonstrated. Although xanthine dehydrogenase (XDH) is the s...

Reevaluating PSA Testing Rates in the PLCO Trial.

The PLCO trial generated data that argue against PSA screening. However, participants in the control group also reported being screened. An analysis of health questionnaires suggests that more than 80...

Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands.

Human fatty acid synthase (hFASN), a homo dimeric lipogenic enzyme with seven catalytic domains, is an important clinical target in cancer, metabolic syndrome and infections. Here, molecular modeling ...

Altered Functional Subnetwork During Emotional Face Processing: A Potential Intermediate Phenotype for Schizophrenia.

Although deficits in emotional processing are prominent in schizophrenia, it has been difficult to identify neural mechanisms related to the genetic risk for this highly heritable illness. Prior studi...

Neonatal prefrontal inactivation results in reversed dopaminergic responses in the shell subregion of the nucleus accumbens to NMDA antagonists.

Striatal dopaminergic dysregulation in schizophrenia could result from a prefronto-striatal dysconnectivity, of neurodevelopmental origin, involving N-Methyl-D-aspartate (NMDA) receptors. The dorsomed...

Metabolism regulates cellular functions of bone marrow-derived cells used for cardiac therapy.

Administration of bone marrow-derived mononuclear cells (BMC) may increase cardiac function after myocardial ischemia. However, the functional capacity of BMC derived from chronic heart failure (CHF) ...

Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of (1) H-MRS studies.

The inhibitory gamma-aminobutyric acid (GABA) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major depressive disorder (M...

GLUCOCORTICOID FAST FEEDBACK INHIBITION OF STRESS-INDUCED ACTH SECRETION IN THE MALE RAT: RATE-INDEPENDENCE AND STRESS-STATE RESISTANCE.

Normal glucocorticoid secretion is critical for physiological and mental health. Glucocorticoid secretion is dynamically regulated by glucocorticoid negative feedback, however, the mechanisms of that ...

Caloric restriction paradoxically increases adiposity in mice with genetically reduced insulin.

Anti-adiposity effects of caloric restriction (CR) are associated with reduced insulin/insulin-like growth factor 1 signalling, but it is unclear whether the effects of CR would be additive to genetic...

Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice.

Estrogen receptor 1 (ESR1) mediates major reproductive functions of 17β-estradiol (E2). Male Esr1 knockout (Esr1KO) mice are infertile due to efferent ductule and epididymal abnormalities. The majori...

News Articles [508 Associated News Articles listed on BioPortfolio]

Merck beats 1Q profit views with tight cost controls

Merck posted an 18 percent jump in first-quarter income, beating Wall Street expectations, as reduced spending on marketing, administration and research easily offset lower sales of its medicines outs...

Combined acupuncture, metformin therapy increases insulin sensitivity in diabetes

Adults with type 2 diabetes and overweight or obesity randomly assigned 3 weeks of combined acupuncture and metformin lost weight and improved insulin sensitivity vs. those assigned metformin and a sh...

BRIEF-Kindred Biosciences submits Kind-010 new animal drug application technical section to FDA

* Kindred Biosciences submits Kind-010 new animal drug application technical section for chemistry, manufacturing, and controls to FDA Source text for Eikon: Further company coverage: (Bengaluru ...

Kindred Biosciences Submits KIND-010 New Animal Drug Application Technical Section for Chemistry, Manufacturing, and Controls to FDA

SAN FRANCISCO, May 4, 2016 /PRNewswire/ -- Kindred Biosciences, Inc. (NASDAQ: KIN), a biopharmaceutical company focused on saving and improving the lives of pets, today announced the submission t...

RAI fails to increase atherosclerosis markers

Among patients treated with radioactive iodine for benign thyroid disease, no changes were found in carotid intima-media thickness in short-term follow-up or in plaque presence longer term, study data...

Endometrial Cancer Genetic Risk Factors Double

The strength of genome-wide association studies (GWAS) lies in their ability to identify new disease biomarkers through large-scale genomic comparisons of afflicted individuals and unaffected contro...

Fast and slow—learning how the brain controls movement

What if you couldn't move faster even when you wanted to? Researchers thought that the part of the brain that determines how fast we perform voluntary movements, such as walking across a room or playi...

Inheritable bacterium controls Aedes mosquitoes' ability to transmit Zika

(Cell Press) Aedes mosquitoes carrying the bacterium Wolbachia -- found inside the cells of 60 percent of all insect species -- are drastically less able to transmit Zika virus, say researchers at Bra...

Research sheds light the neural structure that controls our sleep, eating habits, hormones and more

What's that old saying about Mussolini? Say what you will but he made the trains run on time. Well, the suprachiasmatic nucleus—SCN for short—makes everything in the body run on time. The SCN is t...

How Cell Corrects Errors Made in Gene Transcription

RNA polymerase II (Pol II), a key enzyme in our gene expression, is responsible for transcribing DNA into messenger RNA. Errors in transcription can cause deleterious effect upon repeated translation ...

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Companies [42 Associated Companies listed on BioPortfolio]

Alfresco Software

Alfresco provides modern enterprise content management (ECM) software built on open standards that enables organizations to unlock the power of their business-critical content. Wi...

Excel Dryer, Inc.

For over 50 years, Excel Dryer has been manufacturing the finest American made hand dryers featuring the XLERATOR® Hand Dryer. Excel Dryer is a family owned and operated compan...

Voxello, Inc.

Voxello provides solutions for disabled hospitalized patients who cannot communicate by traditional means. The company’s first product, the noddle™, allows disabled pati...

Degree Controls, Inc.

Indigo-Clean

Indigo-Clean is an affiliate of Kenall Manufacturing, which has earned a reputation for superior quality, innovation, sustainability and exceptional value in the lighting industry...

Intermatic Incorporated

Intermatic has delivered quality products and service to its customers for over 100 years. As a leading manufacturer of controls and energy-management solutions for electrical, HV...

Xamin, Inc.

Founded in 1999, Xamin, Inc. is a Chicago based company offering industry leading IT services to financial institutions as well as other highly regulated industries. The company p...

NanoSpeed Diagnostics, Inc.

DiaSys Diagnostic Systems is a leading specialist in the development and manufacturing of diagnostic system solutions of highest quality, trusted by customers in more than 100 cou...

Phytecs

Phytecs develops healthcare and nutrition products targeting the endocannabinoid system responsible for the regulation of nearly every physiologic process within the human ...

Digital Lumens

Digital Lumens is a global supplier of enterprise-scale intelligent LED lighting to commercial and industrial customers, delivering 90% energy savings and granular building intell...

Clinical Trials [814 Associated Clinical Trials listed on BioPortfolio]

Effectiveness of Musical Training in Children From Low Income Families

This study aims to examine the effectiveness of musical training in in improving the psychological well-being, in particular their self-esteem, depression, happiness and quality of life of...

The Effects of the RSVP Bone Builders Program on Strength, Balance, Fall Risk and Life Satisfaction

The hypothesis of this study is that participation in the Retired and Senior Volunteer Program (RSVP) Bone Builders program 1 hour, twice per week, for a minimum of 12 weeks will result in...

Gluten-free Oats and Gastrointestinal Health in Coeliac Disease, Part 2

The research aims to investigate how gluten-free oats affect the gastrointestinal health in celiac disease by analyzing the effects of gluten-free oats on the intestinal parameters and on ...

Unique Brainstem Biomarkers of Early Parkinson's Disease

This study seeks to establish the sensitivity and specificity of what appears to be a unique brainstem biomarker of Parkinson's Disease - an electrically induced olygosynaptic nasotrigemin...

Gait and Balance in Thoracolumbar Spinal Deformity

Surgical intervention may provide pain relief and improvement in function but one area of significant clinical interest is the restoration/improvement in gait and functional balance. Based...

Canine-Assisted Profiling of Lung Cancer From Human Breath

The study aims to optimize and define a reproducible and non-invasive method for canine assisted lung cancer detection, using human breath samples from patients and controls for training a...

Effectiveness of Musical Training in Children Surviving Brain Tumours

This study aims to examine the effects of musical training on improving the neurocognitive function and psychological well-being of children surviving brain tumours. Half of the participan...

Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease

In this explorative longitudinal study 50 patients with Alzheimer's disease (AD) and 50 age-matched control subjects will be recruited for their 2 years follow-ups and undergo extensive co...

Pain Processing in Adults With Migraines

Primary Objective of this study: To assess experimental heat pain responses (pain intensity, pain unpleasantness, pain catastrophizing, emotional reactivity) in migraineurs vs. healthy con...

Study of the Personal Identity in Adults With Autism Spectrum Disorder Without Intellectual Deficiency

The research aims at clarifying the impact of autism on personal identity in adulthood. Two studies will be made in order to compare adults with autistic spectrum disorders without intelle...

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Medical and Biotech [MESH] Definitions

The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial mamillary nucleus, lateral mamillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.

A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.

This area is bounded medially by the mammillothalamic tract and the anterior column of fornix. The medial edge of the internal capsule and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p710)

The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular gray matter of the rostral portion of the third ventricle and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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