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Hypothalamic Controls - Biotech, Pharma and Life Science Channel

01:28 EDT 25th June 2017 | BioPortfolio

PubMed Articles [4375 Associated PubMed Articles listed on BioPortfolio]

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors.

Cannabinoid (CB) and opioid systems are both involved in analgesia, food intake, mood and behavior. Due to the co-localization of µ-opioid (MOR) and CB1 receptors in various regions of the central ne...

The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies.

Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence's and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (with...

(123)IFP-CIT ENC-DAT normal database: the impact of the reconstruction and quantification methods.

[(123)I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided ag...

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro.

B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of relapsing remitting MS (RRM...

Absence of autoreactive CD4(+) T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot.

Narcolepsy type 1, a neurological sleep disorder strongly associated with Human Leukocyte Antigen (HLA-)DQB1*06:02, is caused by the loss of hypothalamic neurons producing the wake-promoting neuropept...

Autoantibodies as diagnostic biomarkers for the detection and subtyping of multiple sclerosis.

The goal of this preliminary proof-of-concept study was to use human protein microarrays to identify blood-based autoantibody biomarkers capable of diagnosing multiple sclerosis (MS). Using sera from ...

Association of CD58 gene polymorphisms with NMO spectrum disorders in a Han Chinese population.

This study aimed to perform a comprehensive assessment of the association between CD58 polymorphisms and the risk of neuromyelitis optica spectrum disorders (NMOSD) in a Han Chinese population. Nine s...

Kinetics of the Human Papillomavirus Type 16 E6 Antibody Response Prior to Oropharyngeal Cancer.

In a European cohort, it was previously reported that 35% of oropharyngeal cancer (OPC) patients were human papillomavirus type-16 (HPV16) seropositive up to 10 years before diagnosis vs 0.6% of cance...

On-line immunoaffinity solid-phase extraction capillary electrophoresis mass spectrometry using Fab´antibody fragments for the analysis of serum transthyretin.

This paper describes an on-line immunoaffinity solid-phase extraction capillary electrophoresis mass spectrometry (IA-SPE-CE-MS) method using an immunoaffinity sorbent with Fab' antibody fragments (Fa...

Reduced fitness and physical functioning are long-term sequelae after curative treatment for esophageal cancer: a matched control study.

Reduced physical functioning is common following resections for esophageal cancer; however, objective data on physical performance outcomes in this cohort are rare. The aim of this study was to assess...

News Articles [625 Associated News Articles listed on BioPortfolio]

STOP Foodborne Illness Commends White House Administration On Release Of First Proposed Rules From Food Safety Modernization Act

CHICAGO, Jan. 4, 2013 /PRNewswire/ -- STOP Foodborne Illness (http://www.stopfoodborneillness.org) applauds the White House Administration's action today of releasing for public comment two proposed r...

BIRD - Israel-U.S. Binational Industrial R&D Foundation to Invest $9 Million in Ten New Projects

TEL AVIV, Israel, January 3, 2013 /PRNewswire/ -- During its meeting on December 19, 2012, held in Tel Aviv, Israel, the Board of Governors of the Israel-U.S. Binational Industrial Research and Devel...

[News] Atezolizumab in advanced non-small-cell lung cancer

In patients with PD-L1-positive non-small-cell lung cancer (NSCLC), the PD-L1 inhibitor atezolizumab can improve the proportion of patients achieving an objective response (ORR) compared with historic...

Cut US commercial building energy use 29 percent with widespread controls

(DOE/Pacific Northwest National Laboratory) The US could slash its energy use by the equivalent of what is currently used by 12 to 15 million Americans if commercial buildings fully used energy-effici...

Could Trump’s NAFTA Renegotiation Hit Canadian Drug Price Controls?

Thanks to forthcoming NAFTA renegotiations, the US could put Canada under pressure to rethink its plans to curb excessive pricing.   

MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines

CareCloud Announces SSAE 16 SOC 1 Cloud Security Compliance

Independent Audit Verifies CareCloud’s Internal Controls and Processes for Quality and Security of its Information Technology Services CareCloud, the platform for high-perfo...

Industrial Automation Market for Oil Gas by Solution Distributed Control System, Programable Logic Controller, SCADA, Instruments Field Instruments, Control Valve, Leakage Detection System, Flow Computer, and Geography Global Forecast to 2023 [Updated:

The industrial automation market for oil gas is expected to exhibit significant growth potential between 2017 and 2023The industrial automation market for oil gas is expected to reach USD 15.52 bill...

New Study Warns of Increasing Mesothelioma Risk Over Time, According to Surviving Mesothelioma

Instead of declining over time, the risk of contracting deadly pleural mesothelioma continues to rise, even decades after asbestos exposure. Raleigh, NC (PRWEB) June 22, 2017 Scientists in Poland say...

Kia, Genesis, Porsche dominate J.D. Power's 2017 Initial Quality Study. (Fiat, not so much.)

Kia has done it again: for a second year in a row, the South Korean brand has come out on top of J.D. Power's Initial Quality Study. The Initial Quality Study is a great one for new-car buyers t...

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Companies [44 Associated Companies listed on BioPortfolio]

BioProcess Technology Consultants Inc.

Founded in 1994, BPTC is the recognized worldwide leader in biologics Chemistry, Manufacturing, and Controls consulting, providing a full range of technical, regulatory, and strat...

Kyriba Corp.

Kyriba is the global leader in cloud treasury solutions, delivering Software-as-a-Service (SaaS) treasury technology to corporate CFOs and Treasurers. More than 1,300 global organ...

Alfresco Software

Alfresco provides modern enterprise content management (ECM) software built on open standards that enables organizations to unlock the power of their business-critical content. Wi...

Excel Dryer, Inc.

For over 50 years, Excel Dryer has been manufacturing the finest American made hand dryers featuring the XLERATOR® Hand Dryer. Excel Dryer is a family owned and operated compan...

Voxello, Inc.

Voxello provides solutions for disabled hospitalized patients who cannot communicate by traditional means. The company’s first product, the noddle™, allows disabled pati...

Degree Controls, Inc.

Indigo-Clean

Indigo-Clean is an affiliate of Kenall Manufacturing, which has earned a reputation for superior quality, innovation, sustainability and exceptional value in the lighting industry...

Intermatic Incorporated

Intermatic has delivered quality products and service to its customers for over 100 years. As a leading manufacturer of controls and energy-management solutions for electrical, HV...

Xamin, Inc.

Founded in 1999, Xamin, Inc. is a Chicago based company offering industry leading IT services to financial institutions as well as other highly regulated industries. The company p...

NanoSpeed Diagnostics, Inc.

DiaSys Diagnostic Systems is a leading specialist in the development and manufacturing of diagnostic system solutions of highest quality, trusted by customers in more than 100 cou...

Clinical Trials [1068 Associated Clinical Trials listed on BioPortfolio]

Tooth Wear and Associated Risk Factors

This study compares the associated risk factors between adults with tooth wear and age- and sex-matched controls without tooth wear.

NK Cell Mediated Influenza Immunity During Pregnancy

Pregnant women have increased morbidity and mortality due to infection with influenza. Changes in T cell function have been proposed as possible mechanisms for this finding. We believe tha...

CardioTOxicity Induced by andRogeNICS and Their Antagonists (TORNICS)

Anti-androgenic therapies relying on peripheral and/or central blockade for the treatment of prostate cancer seems to have an impact on the cardio-vascular system. This study investigates ...

Tau PET Imaging in the NACC Study Cohort

The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). 18F-AV-1451 is a speciali...

Visual Information Processing in Schizophrenia Patients With Visual Hallucinations

Occurrence of visual hallucinations (VHs) in schizophrenia depend in part on disorders in the processing of late visual information (Top-Down). The broader question of how these top-down m...

Ciliation and Mucus Rheology Parameters Determined Via Air-liquid-interface Cell Cultures in Non-smoking, Smoking, COPD and Asthmatic Patients

This is a prospective study comparing 4 groups: (1) non-smoking controls, (2) smokers without chronic obstructive pulmonary disease (COPD), (3) smokers with COPD, (4) severe asthma. ...

Coparenting, Infant Sleep, and Infant Development

This 3-arm RCT tests the effects of a sleep-enhanced adaptation (FF+) of a well-known, evidence-based transition-to-parenting coparenting intervention program (Family Foundations; FF). In ...

Autologous Bronchial Basal Cell Transplantation for Treatment of COPD

Chronic Obstructive Pulmonary Disease (COPD) is usually characterized by long-term poor airflow, resulting in chronic pulmonary heart disease, chronic respiratory failure or even death. Fo...

Ultrasound Evaluation of Gastric Emptying in Diabetic Patients

This is a prospective cohort study. The main objective is to compare the frequency of a "full stomach" in the diabetic population compared to healthy controls 2 h after clear liquid and 6h...

Improving Quality of Care With a Digital Behavioral Program in IBD Patient Centered Medical Home

Anxiety disorders and depression are more prevalent in patients living with inflammatory bowel disease (IBD) than in healthy controls. Approximately 40% of IBD patients have elevated anxie...

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Medical and Biotech [MESH] Definitions

The part of the hypothalamus posterior to the middle region consisting of several nuclei including the medial mamillary nucleus, lateral mamillary nucleus, and posterior hypothalamic nucleus (posterior hypothalamic area). The posterior hypothalamic area is concerned with control of sympathetic responses and is sensitive to conditions of decreasing temperature and controls the mechanisms for the conservation and increased production of heat.

A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.

This area is bounded medially by the mammillothalamic tract and the anterior column of fornix. The medial edge of the internal capsule and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p710)

The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular gray matter of the rostral portion of the third ventricle and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.

Cell surface receptors that bind the hypothalamic hormones regulating pituitary cell differentiation, proliferation, and hormone synthesis and release, including the pituitary-releasing and release-inhibiting hormones. The pituitary hormone-regulating hormones are also released by cells other than hypothalamic neurons, and their receptors also occur on non-pituitary cells, especially brain neurons, where their role is less well understood. Receptors for dopamine, which is a prolactin release-inhibiting hormone as well as a common neurotransmitter, are not included here.

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