Immunomodulating drugs - Biotech, Pharma and Life Science Channel
PubMed Articles
TL-118-anti-angiogenic treatment in pancreatic cancer: a case report.
Pancreatic cancer is one of the most aggressive malignant tumors. In recent years, little progress has been made in understanding and treatment of the disease. The two most commonly used chemotherapy...
Clinically approved organic chemotherapeutic drugs such as cytarabine, dacarbazine and anastrozole were attached to B12via a {CN-trans-Pt(NH3)2}-bridge to yield [{Co}-CN-{trans-Pt(NH3)2}-{drug}](2+)....
Gold amides as anticancer drugs: synthesis and activity studies.
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis a...
Both KNI-10033 and KNI-10075 are high affinity preclinical HIV-1 protease (PR) inhibitors with affinities in the picomolar range. In this work, the molecular mechanics Poisson-Boltzmann surface area (...
β3-Receptor Agonists for Overactive Bladder-New Frontier or More of the Same?
The new information generated over the last decade on the physiology/pharmacology of the normal bladder and on the pathophysiology of the overactive bladder has resulted in the introduction of a new t...
Treatment strategies for gastric cancer patients with peritoneal metastasis.
Although the treatment of gastric cancer improves the clinical outcomes, the survival of gastric cancer patients with peritoneal metastasis is still very poor. Effective drugs against peritoneal metas...
The unrelenting fall of the pharmacological treatment of obesity.
Nowadays pharmacological therapy to limit obesity has reached a critical stage: not only have Authorities limited the use of antiobesity drugs due to their proven inefficacy and dangerous side effects...
Ru(ii)-catalyzed intermolecular C-H amidation of weakly coordinating ketones.
An efficient Ru(ii)-catalyzed intermolecular amidation of weakly coordinating ketones with sulfonyl azides via C-H bond activation is described. The reaction proceeds with high functional group tolera...
The serotonin transporter (SERT) is involved in various psychiatric disorders, including depression and autism. Recently, chemical chaperones have been focused as potential therapeutic drugs that can...
Introduction: Phosphodiesterase type 5 inhibitors (PDE5-i) are used for the oral treatment of erectile dysfunction (ED). Since the launch of sildenafil more than 15 years ago, new molecules have becom...
News Articles
Bed sharing raises risk of cot death
Researchers said more than half of cot deaths happen with babies sleep in same bed as parents.NICE guidance warns parents not to share bed with their baby if they smoke or have consumed alcohol or dr...
Pioneering cancer gene testing announced
Cancer patients to be tested for 100 risk genes in pioneering programme to start in London.The treatment will look for the type of genes that led to Angelina Jolie having a double mastectomy. The resu...
Abilify And Six New Drugs Push Otsuka’s 2012 Results Up 7.8%
Otsuka Holdings announced 2012 Japan sales results of ¥351.8 billion ($3.4 billion), a 7.8% increase from the previous year.
Pfizer halts study of lymphoma drug unlikely to help survival
(Reuters) - Pfizer Inc, which has been on a hot streak with three recent approvals of cancer drugs, stumbled on Monday, saying it was halting a late-stage trial of a drug for aggressive non-Hodgkin ly...
Karyopharm Grabs $48.2M Series B to Advance Cancer Drugs
Karyopharm Therapeutics believes it can build a platform of cancer drugs off of the idea of keeping the body’s tumor-suppressing proteins in the nucleus of cells, where they can do their jobs proper...
One in Ten Teens Using 'Study Drugs'
Just one in 100 parents believe their kids have used prescription stimulants to boost grades, according to new University of Michigan National Poll on Children's Health. Study drugs refer to stimul...
1 in 10 teens using ‘study drugs,’ but parents aren’t paying attention
As high schoolers prepare for final exams, teens nationwide may be tempted to use a “study drug” — a prescription stimulant or amphetamine — to gain an academic edge. But a......
Bristol Myers Squibb And The New Wave Of Cancer Drugs
By Peter Geschek:Even with the best cancer drugs, doctors are forced to switch from one therapy to the next as the tumors rapidly develop resistance.A new wave of immunotherapy drugs, in the spotlight...
Medical Research Impacted by Sequester Cuts
Chris Matthews talks with Francis Collins the director of the National Institute of Health about how sequester cuts are hurting medical research. In particular programs for a universal flu vaccine, ne...
Hikma is Latest Firm to Stop Drugs Being Sold for Lethal Injections
Hikma has become the latest injectable manufacturer to take measures to stop its drugs being used in lethal injections.
Events
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Companies
Aradigm Corporation and Grifols S.A.
Aradigm is an emerging specialty pharmaceutical company focused on the development and commercialization of drugs delivered by inhalation for the prevention and treatment of sever...
Monarch Medical Technologies is a privately held medical technology company founded by clinicians with a vision of dramatically improving hospital-based glucose management by repl...
R-Tech Ueno is a bio-venture company established in September 1989 for the purpose of marketing and R&D of drugs. Under leadership of the president, also a medical doctor, the company is developing ne...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
Verastem, Inc. is a private biopharmaceutical company focused on discovering and developing novel drugs that selectively target cancer stem cells. Cancer stem cells are an underly...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
TPP is a UK-based, drug development company operating in the preclinical area of the drug discovery process. TPP in-licenses novel intellectual property (IP) from universities, re...
Ipsen is a global biopharmaceutical group, with sales exceeding 1 billion euros in 2009. The Group has total worldwide staff of more than 4,400 employees, of which nearly 900 cont...
GlycoMimetics is a privately held biotechnology company that capitalizes on advances in the field of glycobiology. The company uses rational design of small molecule drugs that mi...
Clinical Research Advantage, Inc.
Tempe, Ariz.-based Clinical Research Advantage, Inc. (CRA) is a provider of a range of research services to pharmaceutical companies and clinical research organizations (CR...
Clinical Trials
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as goserelin, may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetax...
Pixantrone or Other Chemotherapy Drugs in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known whether...
RATIONALE: Drugs used in chemotherapy, such as eflornithine, work in different ways to stop tumor cells from dividing so they stop growing or die. Androgens can stimulate the growth of pro...
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as goserelin and leuprolide may fight prostate cancer by stopping the adrenal glands from producing andro...
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Drugs used in immunotherapy such as rituximab can locate cancer cel...
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as nilutamide, bicalutamide, flutamide, or cyproterone may stop the adrenal glands from producing androge...
Pyroxamide in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of pyroxamide in...
This is a 48-week study to collect additional information on the safety, tolerability, pharmacokinetics, and antiviral activity of an investigational regimen (course of therapy) including...
Ketoconazole and Docetaxel in Treating Patients With Metastatic Prostate Cancer
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as ketoconazole may stop the adrenal glands from producing androgens. Drugs used in chemotherapy use diff...
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Dru...
Videos
Inflammation, Cancer and Immunomodulatory Drugs Part 1 of 2
http://www.integrativeonc.org Dr. Daniel Weber on Interleukin 6; Inflammation, Cancer and Immunomodulatory Drugs [IMiDs] at Society of Integrative Oncology I...
Medical and Biotech [MESH] Definitions
Cinnamomum Aromaticum
A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).
Epimedium
A plant genus of the family BERBERIDACEAE which is used in DRUGS, CHINESE HERBAL. Members contain flavonol glycosides including epimedins, icariin and noricariin.
Cuscuta
A plant genus of the family Cuscutaceae. It is a threadlike climbing parasitic plant that is used in DRUGS, CHINESE HERBAL.
Histamine H1 Antagonists, Non-sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Herb-drug Interactions
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
