Immunotherapy - Biotech, Pharma and Life Science Channel
PubMed Articles
Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) represents an effective treatment for patients with metastatic melanoma. However, most of the Ag targets recognized by effective melano...
A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody.
Podoplanin (Aggrus), which is a type I transmembrane sialomucin-like glycoprotein, is highly expressed in malignant pleural mesothelioma (MPM). We previously reported the generation of a rat anti-huma...
Tumor-infiltrating lymphocytes (TILs) are important prognostic factors in cancer progression and key players in cancer immunotherapy. Although γδ T lymphocytes can target a diversity of tumor cell t...
B7-H4, a member of the B7 family of T cell immunomodulatory proteins, has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. However, the role of B7-H4 in the...
Profound impairment of adaptive immune responses by alkylating chemotherapy.
Overall, cancer vaccines have had a record of failure as an adjuvant therapy for malignancies that are treated with alkylating chemotherapy, and the contribution of standard treatment to that failure...
Soluble CD27-Pool in Humans May Contribute to T Cell Activation and Tumor Immunity.
The interaction between CD27 and its ligand, CD70, has been implicated in regulating cellular immune responses to cancer. In this article, we report on the role of soluble CD27 (sCD27) in T cell activ...
Foxp3 is a key marker of CD4CD25 regulatory T cells and appears highly specific for regulatory T cells. Human dendritic cells transfected with foxp3 gene also exhibit immunosuppressive functions. We w...
Canine NK cells still are not well-characterized due to the lack of information concerning specific NK cell markers and the fact that NK cells are not an abundant cell population. In this study, we se...
A series of oligovalent carbohydrate assemblies (ranging from mono- to pentavalent), derived from three structurally different β-linked or β-(1→2)-linked mannosides, has been chemically synthesize...
O-Acetyl-GD2 ganglioside is suitable antigen for tumor immunotherapy with specific therapeutic antibody. Here, we investigate the anti-tumor activity of O-acetyl-GD2-specific monoclonal antibody 8B6 o...
News Articles
ALK on track to file dust mite allergy immunotherapy
ALK on track to file dust mite allergy immunotherapy
Copenhagen, 2013-06-19 14:03 CEST (GLOBE NEWSWIRE) -- ALK announces positive outcome of the first of two pivotal Phase III trials with its new allergy immunotherapy tablet for the treatment of hous...
Celldex Turning Into A Compelling Immunotherapy Biotech
By Stephen Simpson:"Shoulda, coulda, woulda" will probably be my investing epitaph. While there is no shortage of investment advice telling you that long-term investment success is predicated on devel...
OncoSec Medical Announces Completion of Enrollment of Phase II Metastatic Melanoma Trial
Final Trial Data Expected in 6-12 Months OncoSec Medical Inc. (OTCQB: ONCS), a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy...
OncoSec Medical completes enrollment in ImmunoPulse trial for metastatic melanoma patients
OncoSec Medical Inc., a company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumor cancers, announced the completion of patient enrollment in a...
Immune Design joins forces with academia for novel immunotherapy research
Privately-held US biotech firm Immune Design, the Cancer Research Institute (CRI) and the Ludwig Institute for Cancer Research have a signed a collaboration agreement to advance cancer immunotherapy r...
Published in the Journal for ImmunoTherapy of Cancer, review offers recommendations for manufacturing, pre-clinical studies, and clinical trial designs of cancer immunotherapies Milwaukee, WI (PRWEB)...
Vemurafenib and ipilimumab for metastatic melanoma
Dr Caroline Robert talks to ecancer at 14th Education Workshop on Molecular Targeted Therapy of Cancer (MTTC) in Sorrento, Italy about two new targeted agents for metastatic melanoma BRAF inhibitor, v...
Importance of immune system in cancer
Prof Leif Håkansson talks to ecancer at 14th Education Workshop on Molecular Targeted Therapy of Cancer (MTTC) in Sorrento, Italy about immunotherapy in cancer treatment. The immune system plays a m...
Importance of the immune system in cancer
Prof Leif Håkansson talks to ecancer at 14th Education Workshop on Molecular Targeted Therapy of Cancer (MTTC) in Sorrento, Italy about immunotherapy in cancer treatment. The immune system plays a m...
Events
Cancer Vaccines will provide attendees with a complete view of the cancer immunotherapy field. Focusing on the discovery of new vaccines, developments in target identification
Stem Cells & Cell Therapy Summit
Select Biosciences' Stem Cells & Cell Therapy Summit is focused on providing an up-to-date expansive view of the current marketplace
Companies
Neovacs is a French biotechnology company focused on active immunotherapy for autoimmune and inflammatory diseases and cancer. Neovacs is a spin-off from Université Pierre et Marie Curie in P...
Cell Medica is a clinical stage cellular therapeutics company engaged in the development and delivery of cellular immunotherapy treatment strategies for infectious disease and can...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
Aduro BioTech is a clinical-stage immunotherapy company with a platform technology for therapeutic and prophylactic vaccines for cancer and infectious diseases. The platform of at...
OncoSec Medical Inc. is a biopharmaceutical company developing its advanced-stage ImmunoPulse DNA-based immunotherapy and NeoPulse therapy to treat solid tumor cancers. I...
Endocyte is a privately held biotechnology company with headquarters in the Purdue Research Park of West Lafayette, IN. Based on the applications of Endocyteâs advanced propr...
Cyto Pulse Sciences, Inc. is a biomedical device and treatment development company creating innovative technology to produce and deliver new therapeutics for cancer (immunotherapy...
Juvaris BioTherapeutics is a clinical stage company developing adjuvanted vaccines to treat infectious diseases. The Companyâs lead adjuvant, JVRS-100, is a cationic l...
Celldex is a biotechnology company focused on the discovery, development and commercialization of novel immunotherapeutics including human monoclonal antibodies for the treatment of cancer, infectious...
United Allergy Services⢠(UAS) brings effective and convenient allergy testing and immunotherapy to primary care physicians; pulmonologists; ENT physicians; pediatrici...
Clinical Trials
None
Videos
Immunotherapy: Boosting the immune system to fight cancer
The concept of 'teaching' the immune system to recognize and destroy cancer cells is over a century old, but the development of immunotherapeutic strategies ...
Medical and Biotech [MESH] Definitions
Monitoring, Immunologic
Testing of immune status in the diagnosis and therapy of cancer, immunoproliferative and immunodeficiency disorders, and autoimmune abnormalities. Changes in immune parameters are of special significance before, during and following organ transplantation. Strategies include measurement of tumor antigen and other markers (often by RADIOIMMUNOASSAY), studies of cellular or humoral immunity in cancer etiology, IMMUNOTHERAPY trials, etc.
Skin Test End-point Titration
A quantitative form of intradermal testing for the relative allergenicity of a substance. It is used to determine the amount of an allergen that will be tolerated in ALLERGEN IMMUNOTHERAPY.
Killer Cells, Lymphokine-activated
Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are INTERLEUKIN-2-activated NK cells that have no MAJOR HISTOCOMPATIBILITY COMPLEX restriction or need for antigen stimulation. LAK cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients.
Immunotherapy, Adoptive
Form of adoptive transfer where cells with antitumor activity are transferred to the tumor-bearing host in order to mediate tumor regression. The lymphoid cells commonly used are lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL). This is usually considered a form of passive immunotherapy. (From DeVita, et al., Cancer, 1993, pp.305-7, 314)
Immunotherapy, Active
Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system.
