Inherited Copper Toxicity - Biotech, Pharma and Life Science Channel
PubMed Articles
Accelerated hypofractionation (HF) using larger dose per fraction, delivered in fewer fractions over a shorter overall treatment time, is presently a consistent possibility for adjuvant whole breast r...
The aim of the study is to evaluate the efficacy and safety of a three-drug chemotherapy regimen including gemcitabine, carboplatin, and paclitaxel as induction therapy in clinical stage III non-small...
Recent phase-III trials show that platinum-based chemotherapy (PBCT) for patients with advanced non-small cell lung cancer and poor performance status (PS) improves survival without increasing toxicit...
To investigate the effects of a low bisphenol A (BPA) concentration on male reproduction, adult rats were administered a concentration of BPA that was less than the no observable adverse effect level...
Home sleep study characteristics in patients with mucopolysaccharidosis.
BACKGROUND: Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders caused by the deficiency of hydrolases involved in the degradative pathway of glycosaminoglycans. In MPS, u...
Gold amides as anticancer drugs: synthesis and activity studies.
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis a...
Copper nanoparticles have been the focus of intensive study due to their potential applications in diverse fields including biomedicine, electronics, and optics. Copper-based nanostructured materials...
An unusual copper(ii) coordination polymer {[Cu(tmtz)(H2O)4][Cu2(tmtz)2(sip)2]·4H2O}n () (tmtz = 1,4-bis(1,2,4-triazol-1-ylmethyl)-2,3,4,5-tetramethylbenzene, sip = 5-sulfoisophthalate) is synthesize...
QTL mapping of powdery mildew resistance in WI 2757 cucumber (Cucumis sativus L.).
Powdery mildew (PM) is a very important disease of cucumber (Cucumis sativus L.). Resistant cultivars have been deployed in production for a long time, but the genetic mechanisms of PM resistance in...
Development of structure-activity relationship for metal oxide nanoparticles.
Nanomaterial structure-activity relationships (nano-SARs) for metal oxide nanoparticles (NPs) toxicity were investigated using metrics based on dose-response analysis and consensus self-organizing map...
News Articles
Fighting Ovarian Cancer With Gold Nanoparticles
Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why and determined how to make the n...
Lean On Life Supports New Research Encouraging a Healthy Mix of Dried Fruit
Lean On Life, a leading healthy lifestyle website with the latest on weight loss, nutrition, and fitness is supporting the incorporation of dried fruit as part of a healthy diet. Toronto, ON (PRWEB) M...
Par Pharmaceutical Begins Shipment of Generic Atacand®
WOODCLIFF LAKE, N.J., May 22, 2013 /PRNewswire/ -- Par Pharmaceutical Companies, Inc. today announced that it has entered into an exclusive U.S. supply and distribution agreement with AstraZeneca to d...
Making gold nanoparticles more effective against ovarian cancer cells
Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Mayo Clinic researchers found out why and determined how to make the n...
Should we sequence everyone's genome? No
This is an exciting time to work in medicine. The enormous advances in our understanding of inherited diseases that have flowed from sequencing the human genome mean that many patients benefit from......
In situ magnetic separation of antibody fragments from Escherichia coli in complex media
Background: In situ magnetic separation (ISMS) has emerged as a powerful tool to overcome process constraints such as product degradation or inhibition of target production. In the present work, an in...
CA BOTANA International Introduces New Peptide Formulations
SAN DIEGO, May 21, 2013 /PRNewswire/ -- CA BOTANA International has created several novel peptide formulations that improve the skin's ability to defy aging, and that provide a more youthful, vibrant...
AAG Health is the First Age Management Center in Florida to Offer the OligoScan
The OligoScan is the latest addition to AAG Health’s line-up of state-of-the-art diagnostic testing devices which already include the research grade InBody 720 (body composition analyzer), the Korr...
How gold nanoparticles can help fight ovarian cancer
Positively charged gold nanoparticles are usually toxic to cells, but cancer cells somehow manage to avoid nanoparticle toxicity. Researchers found out why and determined how to make the nanoparticles...
Common Foot Deformities Like Bunions Are Inherited
A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings fro...
Companies
TRANSGENE is a leading integrated gene therapy company, dedicated to the discovery and development of gene delivery technologies and gene therapy products for the treatment of acquired and inherited d...
HemoGenix® is a privately-held Contract Research Service and Assay Development Laboratory based in Colorado Springs, Colorado. Specializing in predictive in vitro stem cell tox...
Cellectis stem cells, is a business unit within the Cellectis group and is a global leader in stem cell technology. Cellectis stem cells, created in November 2011 from Cellartis A...
AGTC is focused on the research and development of novel therapeutics for patients with unmet medical needs utilizing AGTCâs proprietary, non-pathogenic adeno-associat...
PURE Bioscience develops and markets technology-based bioscience products that provide solutions to numerous global health challenges, including Staph (MRSA). PURE's proprietary h...
Absorption Systems, founded in 1996, assists pharmaceutical, biotechnology and medical device companies in identifying and overcoming ADMET (Absorption, Distribution, Metabolism,...
CSL Behring is a leader in the plasma protein therapeutics industry. Committed to saving lives and improving the quality of life for people with rare and serious diseases, the com...
Pro-Pharmaceuticals, OTCBB: PRWP, is the leader in the field of Galectin therapeutics and is engaged in the discovery, development and commercialization of therapeutics that targe...
Techulonâ¢, Inc. is an early stage life sciences company with a core capability in novel biodegradable and low toxicity DNA and RNA delivery reagents for cell-based research a...
BRO is an optical engineering firm of global reach and reputation. BRO's optical software products and training courses help engineers turn creative visions into working prototype...
Clinical Trials
This randomized, multicenter, open label study will evaluate the safety and efficacy of RO5083945 in combination with FOLFIRI as compared to FOLFIRI plus cetuximab or FOLFIRI alone as seco...
Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)
This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant a...
A Study of Epirubicin With Estramustine Phosphate and Celecoxib for the Treatment of Prostate Cancer
The purpose of this clinical trial is to find out the effect of epirubicin with estramustine phosphate and celecoxib on PSA and objective response in patients with hormone resistant prosta...
XELOX (Capecitabine and Oxaliplatin) is an effective and convenient regimen for patients with metastatic colorectal cancer. Chronomodulated therapy may reduce toxicity. Patients will be ra...
Development of an Evaluation Method of Elderly Condition in Patient Receiving Chemotherapy Treatment
Number of elderly people over 70 is increasing in France. In 2002, in the south-west, 273,741 of them were over 75 years, i.e. 9.2% of Aquitaine population. Incidence of cancer in this old...
Cetuximab, Capecitabine, Oxaliplatin and Bevacizumab in Advanced Colorectal Cancer
This is a study to assess the efficacy and safety of the addition of cetuximab to the combined regimen of capecitabine, oxaliplatin and bevacizumab in patients with previously untreated ad...
Lactate Metabolism Study in HIV Infected Persons
Lactic acidosis is a potentially life-threatening disease associated with the treatment of chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long ter...
Patients with acute lymphoblastic leukaemia or very aggressive lymphoma and documented isolated CNS relapse or CNS relapse combined with other relapse sites should receive therapy with int...
This is a Phase II study of gemcitabine- Vinorelbine combination in a 3-weekly schedule as first line chemotherapy in patients with metastatic breast cancer. Eighty patients with measurabl...
Gemcitabine and Pemetrexed in Primary Unknown Adenocarcinoma
There is no standard treatment for the patient population being asked to participate in this study. Although one current regimen, used by some investigators, has a high rate of response co...
Videos
Opportunity, Montana: Big Copper, Bad Water, and the Burial of an American Landscape
http://www.beacon.org/productdetails.cfm?PC=2306 In 2002, Texas journalist Brad Tyer strapped a canoe on his truck and moved to Montana, a state that has lon...
Medical and Biotech [MESH] Definitions
Iron-regulatory Proteins
Proteins that regulate cellular and organismal iron homeostasis. They play an important biological role by maintaining iron levels that are adequate for metabolic need, but below the toxicity threshold.
Genetic Research
Research into the cause, transmission, amelioration, elimination, or enhancement of inherited disorders and traits.
Toxicity Tests, Chronic
Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.
Pulmonary Surfactant-associated Protein B
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Alexander Disease
A rare inherited disorder of myelin formation. Alexander disease is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal, subpial, and periventricular areas of the BRAIN.
