Insulin - Biotech, Pharma and Life Science Channel
PubMed Articles
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds.
Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to man...
Fingerprint signatures of circularly polarized luminescence (CPL) are observed from Staphylococcus aureus nuclease (SNase), bovine serum albumin (BSA), and insulin (Ins) labeled with europium(iii) com...
Panax ginseng is a well-known traditional Chinese medicine and has been used for treatment of various diseases for more than four thousand years in Asia. Ginseng saponins or ginsenosides, the active c...
OBJECTIVE: Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its involvement in insulin resistance (HOMA-R). The purpose of this investigation was to assess the eff...
Case report of a patient with schizophrenia and a mutation in the insulin receptor substrate-4 gene.
This report deals with a female patient with schizophrenia who was found to have a mutation in the insulin receptor substrate-4 gene that is located on chromosome Xq22.3. Since this mutation is expect...
Black soybean seed coat has abundant levels of polyphenols such as anthocyanins (cyanidin 3-glucoside; C3G) and procyanidins (PCs). In this study, we found that dietary black soybean seed coat extract...
AIMS/HYPOTHESIS: The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is an important gene regulator in glucose and lipid metabolism. Unfortunately, PPARγ-activating drugs o...
BACKGROUND: The purpose of the present study was to determine the prevalence of diabetes and its effect on surgical outcomes in patients undergoing emergent, in-patient cholecystectomy for acute chole...
Copeptin concentrations are not elevated in gestational diabetes mellitus.
PURPOSE: To investigate copeptin levels in women with GDM and women with uncomplicated pregnancies. METHODS: This case-control study was conducted on 45 women with GDM and 40 women with uncomplicated...
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
News Articles
Newly discovered immune protein has potential to stop or reverse type 1 diabetes
Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destr...
Novo holding company buys Norwegian Xellia
COPENHAGEN, May 21 (Reuters) - Novo A/S, the holding company of Danish insulin producer Novo Nordisk, on Tuesday said it had acquired Norwegian-based Xellia Pharmaceuticals for about $700 million.
Melissa Productions Psychic CEO Raises Awareness for Type 1 Diabetes on Kiss 95.1
Melissa Productions psychic CEO raises awareness for type 1 diabetes on Kiss 95.1 by agreeing to provide the morning show host’s, Maney of ‘Drex and Maney’, wife a psychic consultation with proc...
Researchers Able To Prevent And Cure Type 1 Diabetes In Animal Models
Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destr...
Insight into the dazzling impact of insulin in cells
(Garvan Institute of Medical Research) Australian scientists have charted the path of insulin action in cells in precise detail like never before. This provides a comprehensive blueprint for understan...
Positive Ph III results for Novo Nordisk's FIX derivative for hemophilia B
Danish insulin giant Novo Nordisk (NOV: N) says it has completed paradigm 2, the first Phase III trial with a long-acting FIX derivative, N9-GP (glycopegylated recombinant factor IX), for hemophilia B...
HOLLYWOOD, Fla., May 20, 2013 /PRNewswire-USNewswire/ -- After successfully leading the Diabetes Research Institute Foundation (DRIF) for two decades, Robert A. Pearlman, 67, of Boca Raton, FL, a...
Immune protein could stop diabetes in its tracks, discovery suggests
Researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed. The...
Immune protein could stop diabetes in its tracks
Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destr...
Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S.
JERUSALEM, May 17, 2013 /PRNewswire/ -- Oramed Pharmaceuticals Inc. (NASDAQCM: ORMP) (http://www.oramed.com), a developer of oral drug delivery systems, announced today that the United States Food an...
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Companies
Defymed is a spin -off of the “Centre Europeen d’etude du Diabete” (CeeD) which has been working on the conception of a bio-artificial pancreas since 1996. This work was ca...
Founded in 2005 by cardiologists and researchers from the Stanford University School of Medicine , Aviir is focused on the discovery, development and commercialization of innovati...
Ember Therapeutics is a product-focused company harnessing breakthroughs in brown fat biology and insulin sensitization to revolutionize the treatment of metabolic disease. Today...
Ember Therapeutics is a product-focused company harnessing breakthroughs in brown fat biology and insulin sensitization to revolutionize the treatment of metabolic disease. Today...
CPEX Pharmaceuticals, Inc. is an emerging specialty pharmaceutical company focused on the development, licensing and commercialization of pharmaceutical products utilizing CPEXâ...
CPEX Pharmaceuticals, Inc. is an emerging specialty pharmaceutical company focused on the development, licensing and commercialization of pharmaceutical products utilizing CPEXâ...
The Barton Center for Diabetes Education, Inc.
The Barton Center for Diabetes Education, Inc. (www.BartonCenter.org), a nonprofit 501 (c)(3) organization, offers a powerful support system to children and families with insulin-...
Kadimastem (www.kadimastem.com) is a biotechnology company focused on the industrial development and commercialization of human pluripotent stem cell-based products. At Kad...
Hygieia, Inc. is an emerging diabetes health care company developing new ways to improve the effectiveness of therapy while reducing the cost of diabetes care. Hygieiaâs firs...
Oramed Pharmaceuticals is a technology pioneer in the field of oral delivery solutions for drugs and vaccines presently delivered via injection. Oramed is seeking to revolutionize the treatment of...
Clinical Trials
Effects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes
This Phase 3, open-label, multicenter study is designed to compare the effects of exenatide and insulin glargine (Lantus® injection) on beta-cell function in patients with type 2 diabetes...
The investigators hypothesize that a calcineurin inhibitor-free, steroid-free, co-stimulatory blockade-based immunosuppressive regimen, in combination with a GLP-1 agonist, will reduce the...
Exercise and Metformin in Colorectal and Breast Cancer Survivors
Metformin is a medication that is commonly used in the treatment of diabetes. Recently small studies in cancer patients without diabetes suggest that metformin may benefit in lowering ins...
The Role of Endocannabinoids in Insulin Production and Action
Background: - The endocannabinoid system is involved in different body functions and processes. It helps regulate appetite and mood, and sends signals to the nervous system. It may also b...
This project examines the effects of a 4 month structured exercise intervention program in patients with non-alcoholic fatty liver disease (NAFLD). We will examine changes in total and dep...
Genotype 1 hepatitis C virus (HCV) patients who did not respond (did not lose virus during treatment) or relapsed (virus went away on treatment but came back after treatment was stopped) a...
Evaluation of an ICU Hyperglycemia Protocol Using Insulin Aspart
In response to the evidence supporting “tight” glucose control (70 – 110) in the critical care setting, the MMH ICU developed a protocol utilizing regular intravenous insulin. This p...
Janssen - Glucose Regulation/Risp/Olanz
Abnormalities in peripheral glucose regulation and type 2 diabetes can occur more commonly in individuals with schizophrenia than in healthy subjects or in other psychiatric conditions. A...
Glitazones and Endothelial Function (GATE)
The purpose of the study is to determine if the addition of rosiglitazone to subjects with fair glucose control on other oral agents improves endothelial function, a surrogate marker of va...
This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) ant...
Videos
Insulin, Glucose and you
3 minutes to understand how important insulin is for your body.
Medical and Biotech [MESH] Definitions
Persistent Hyperinsulinemia Hypoglycemia Of Infancy
A form of nontransient HYPOGLYCEMIA, unique to infancy, due to autosomal recessive mutations of the sulfonylurea receptor gene on CHROMOSOME 11. Defects in the sulfonylurea receptors (ATP-BINDING CASSETTE TRANSPORTERS) on the PANCREATIC BETA CELLS prevent negative feedback of GLUCOSE-regulated INSULIN release thus resulting in HYPERINSULINEMIA. Clinical phenotype includes SEIZURES; COMA; and often large BIRTH WEIGHT for GESTATIONAL AGE.
Thiazolidinediones
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
Laron Syndrome
An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.
Insulin, Long-acting
Insulin formulation containing substance which delays or retards time period of the absorption of insulin.
Insulin-secreting Cells
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
