Interleukin 1 IL 1 Receptor IL 1R - Biotech, Pharma and Life Science Channel
Interleukin-1 (IL-1) beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. Current therapy targeting IL-1 in rheumatoid arthritis (RA) is based on a recombinant form of the IL-1 receptor antagonist (IL-1Ra; anakinra), which binds to the IL-1 receptor without eliciting a signal and therefore competes with the binding of the two natural ligands, namely IL-1α and IL-1β. As compared with TNF-α inhibitors, it appears that treatment with the recombinant IL-1Ra is less efficacious in RA. However, it is unclear whether this is due to biological superiority of TNF-α over IL-1 in RA pathogenesis or whether the approach to block the IL-1 receptor with anakinra is only partly effective in neutralizing IL-1 activity in vivo because of short half-life or inability to achieve sufficient exposure at the target site with the current dosing regimen.
News Articles
Aragon Pharmaceuticals Announces Acquisition by Johnson & Johnson
SAN DIEGO, CA -- (Marketwired) -- 06/17/13 -- Aragon Pharmaceuticals Inc., a leader in developing drugs for hormone driven cancers, today announced a definitive agreement with Johnson & Johnson w...
SOUTH SAN FRANCISCO, Calif., June 14, 2013 /PRNewswire-iReach/ -- CoMentis, Inc. and Anvyl announced today that the companies have agreed to form Alpharmagen, a joint venture committed to discovering...
GHENT, Belgium, 12 June 2013 - Ablynx [Euronext Brussels: ABLX] today announced that it will have an oral and poster presentation on its novel anti-IL-6R Nanobody, ALX-0061, at the Annual European...
GHENT, BELGIUM -- (Marketwired) -- 06/12/13 -- Ablynx (EURONEXT BRUSSELS: ABLX) today announced that it will have an oral and poster presentation on its novel anti-IL-6R Nanobody, ALX-0061, at the A...
Critical Diagnostics announced today that the American College of Cardiology Foundation/American Heart Association Task Force jointly released its expanded clinical practice guide...
- Lymphoseek demonstrated reliable identification of lymph nodes over 15 minutes to 30 hours, typical timeframes for lymphatic mapping in clinical setting - Navidea Bio...
Sobi gets FDA approval to manufacture substance for Kineret® with partner Boehringer Ingelheim
Swedish Orphan Biovitrum AB (publ) (Sobi) today announced receipt of approval from the Food and Drug Administration (FDA) for the manufacture of drug substance for Kineret® (anakinra) at Boehringer...
Sobi gets FDA approval to manufacture substance for Kineret(R) with partner Boehringer Ingelheim
STOCKHOLM, SWEDEN -- (Marketwired) -- 06/11/13 -- Swedish Orphan Biovitrum AB (publ) (Sobi) today announced receipt of approval from the Food and Drug Administration (FDA) for the manufacture of drug...
Tocilizumab approved in Europe to treat rare childhood arthritis
Children in Europe with a rare form of arthritis called polyarticular juvenile idiopathic arthritis (PJIA) may now be offered a drug called tocilizumab after the European Medicines Agency (EMA) gave i...
Early research may pave way for lower-risk painkillers
US scientists have identified a novel approach that could one day result in the development of new painkillers with fewer side-effects and a lower risk of addiction.Published in the Proceedings of the...
Events
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Companies
Sequenta, Inc. is a privately held company developing and commercializing molecular diagnostic assays based on a proprietary sequencing approach to the profiling of T and B cell r...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
Izun Pharmaceuticals Corporation
Izun Pharmaceuticals is a US based pharmaceutical company with a wholly owned R&D center in Israel. Izunâs technology platform allows it to develop botanical drugs by optimiz...
Interleukin Genetics, Inc. (OTCQB: ILIU) develops and markets a line of genetic tests under the Inherent Health® brand. The products empower individuals to prevent ce...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, galeterone (TOK-001), i...
EnVivo Pharmaceuticals, Inc. and its subsidiaries (âEnVivo Pharmaceuticalsâ or âEnVivoâ) are dedicated to discovering and developing small molecule therapeutic...
bioTheranostics discovers, develops, and commercializes a growing array of molecular diagnostic tests for cancer patients. Leveraging its unique expertise in expression profiling...
Neumedicines Inc. is developing protein therapeutics that address unmet clinical and societal needs in the fields of oncology, hematology and immunology. The companyâs lead p...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
Clinical Trials
Ustekinumab for the Treatment of Patients With Active Ankylosing Spondylitis
This study is aimed at investigation of efficacy and safety of ustekinumab (monoclonal antibody against interleukin 12 and 23) treatment in patients with active ankylosing spondylitis (AS)...
RATIONALE: Aromatase inhibitors, such as letrozole, prevent the formation of estradiol, a female hormone. Giving letrozole together with goserelin, leuprolide, or surgery may be an effecti...
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy
Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has...
D-Serine Monotherapy for Schizophrenia
N-methyl-D-aspartate receptor (NMDAR) agonist, added to classical or atypical antipsychotic medication, has reduced negative, depressive, and cognitive symptomatology. We will be investiga...
D-Serine Adjuvant Treatment for Parkinson's Disease
The proposed experiment will evaluate the effects of the NMDA receptor full agonist D-serine (~2g/day) on persistent symptoms of Parkinson's Disease and on antiparkinsonian drugs-induced d...
The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria
An open labelled trial of Kineret (anakinra) induction therapy (100mg./day) in over a four week period in the treatment of Familial Cold Urticaria. Familial Cold Urticaria (FCU) is a rare...
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately. Th...
This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) ant...
Cisplatin and ZD1839 + Re-Irradiation in Recurrent Squamous Cell Cancer of the Head and Neck
To determine safety profile of the epidermal growth factor receptor (EGFR) antagonist, ZD1839 in combination with cisplatin and radiation therapy in patients with local-regional recurrent...
PubMed Articles
Estrogens and IL-12 play a pivotal role in the development and progression of non-small-cell lung cancer (NSCLC); at the same time, estrogen receptor β2 and (interleukin-12 receptor β2)IL-12Rβ2 are...
A Detailed Study on Understanding Glycopolymer Library and Con A Interactions.
Synthetic glycopolymers are important natural oligosaccharides mimics for many biological applications. To develop glycopolymeric drugs and therapeutic agents, factors that control the receptor-ligand...
Superantigen-induced steroid resistance depends on activation of phospholipase cβ2.
The glucocorticoid receptor is present in a TCR-associated complex, which includes the Src family tyrosine kinase Lck. Glucocorticoids rapidly dissociate this complex, resulting in the inhibition of c...
Endogenous mechanisms regulating the host response during inflammation resolution are critical in ensuring disposal of noxious stimuli and return to homeostasis. In this article, we engineered novel A...
Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of inflammation. In this study we have explored the impact of LXR activation on the macrophage response to the endogeno...
Although extensive homology exists between their extracellular domains, NK cell inhibitory receptors killer Ig-like receptor (KIR) 2DL2*001 and KIR2DL3*001 have previously been shown to differ substan...
Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1.
Dendritic cells (DCs) consist of various subsets that play crucial roles in linking innate and adaptive immunity. In the murine spleen, CD8α(+) DCs exhibit a propensity to ingest dying/dead cells, pr...
Cell-autonomous regulation of neutrophil migration by the d6 chemokine decoy receptor.
Chemokines, acting on their cognate receptors on infiltrating leukocytes, drive the inflammatory response. We have been interested in determining roles and potential mechanisms for the atypical chemok...
New azole antagonists with high affinity for the P2Y1 receptor.
Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chai...
Role of macrophage receptor with collagenous structure in innate immune tolerance.
Macrophages play a key role in host defense against microbes, in part, through phagocytosis. Macrophage receptor with collagenous structure (MARCO) is a scavenger receptor on the cell surface of macro...
Videos
Molecular Structure Animation
Interleukin-1 binding to its receptor on a cell surface, created from structural data.
Medical and Biotech [MESH] Definitions
Transferrin-binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Transferrin-binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Bacterial Transferrin Receptor Complex
A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum.
Receptors, Eph Family
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
Receptor, Epha1
The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
