Invasive cancers - Biotech, Pharma and Life Science Channel
PubMed Articles
Over-expression of integrin αvβ6 and increased numbers of cancer-associated fibroblasts (CAFs) play an important role in the development and progression of cancers. The aim of this study is to inves...
PR (PRDI-BF1 and RIZ) domain containing proteins (PRDM) have been indicated to play important roles in several human cancers. The objectives of this study were to determine the frequency and prognosti...
Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer.
GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in tumorigenesis. High levels of GATA2 expression are correlated with poor survival outcomes in many types o...
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies in men and the second leading cause of male cancer mortality. MAZ (Myc-associated zinc-finger protein) is a transcription facto...
CIZ1, a p21(Cip1/Waf1)-interacting protein, functions as a tumor suppressor in vivo.
CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-def...
This study sought to evaluate the interrelation of atherosclerotic burden, as assessed by coronary artery calcium (CAC) score and coronary vascular function, as assessed by quantitative estimates of c...
Stromal expression of SPARC in pancreatic adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC) stands as the poorest prognostic tumor of the digestive tract, with a 5-year survival rate of less than 5 %. Therapeutic options for unresectable PDAC are extr...
The Adolescent and Young Adult with Cancer: State of the Art - Bone Tumors.
Primary malignant bone tumors in the pediatric to young adult populations are relatively uncommon and account for about 6 % of all cancers in those less than 20 years old [1] and 3 % of all cancers in...
OBJECTIVES: The value of conventional non-invasive Doppler parameters to predict ventricular end-diastolic pressure (EDP) and diastolic function in congenital heart diseases is limited. The aim of our...
Extranodal, nasal-type natural killer (NK)/T-cell lymphoma (NKCL) is an aggressive malignancy with poor prognosis in which, usually, signal transducer and activator of transcription 3 (STAT3) is const...
News Articles
Ecology: Invasive insect's inner weapon
Ladybirds from central Asia act as a Trojan horse for a microscopic killer.Farmers brought harlequin ladybird beetles (Harmonia axyridis, pictured) to North America and Europe to eat troublesome aphid...
CT Lung Screens Catch Most Cancers (CME/CE)
(MedPage Today) -- The National Lung Screening Trial found that CT scans were highly sensitive in detecting lung cancer in smokers but weren't very specific in ruling out the malignancy.
CT detects twice as many lung cancers as X-ray at initial screening exam
National Lung Screening Trial (NLST) investigators also conclude that the 20 percent reduction in lung cancer mortality with low-dose computed tomography (LDCT) versus chest X-ray (CXR) screening prev...
Data Indicate Improved Pulmonary Function, Need for Augmentation in Myeloma VCFs and Two-Year Durability of Pain Reduction and Functional Improvement DFINE, Inc....
Cancer Research Institute Hosting Free Cancer Immunotherapy Webinars in June
NEW YORK, May 22, 2013 /PRNewswire/ -- The Cancer Research Institute (CRI), a New York-based nonprofit organization committed to developing immune system-based cancer treatments, is holding a series o...
Researchers develop radioactive nanoparticles that target cancer cells
Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the n...
NIH-sponsored Trial Linked Reducing Left-sided Heart Volume to Improved Survival for Later-Stage Heart Failure Patients BioVentrix, pioneer of the Less Invasive Ventricular...
Is There Finally A Way To Stop Severe Excessive Sweating?
NEW YORK, May 22, 2013 /PRNewswire/ -- For the 3% of the population that suffer from hyperhidrosis, their severely excessive sweating is often embarrassing, uncomfortable, anxiety-inducing a...
Immunotherapeutic Cancer Drugs Tipped For Success
The next generation of cancer treatments could become the biggest class of drugs the world has ever seen, financial analysts have forecast. Citigroup believes that, ultimately, drugs that harness the...
Children Who Have CT Scans May Face Higher Cancer Risk
WEDNESDAY, May 22 (HealthDay News) -- Children and teens exposed to radiation during CT scans are 24 percent more likely to develop cancer, according to a large, long-term study. The risks, however,...
Events
3rd Annual Oncology Biomarkers Congress 2013
Over 150 oncology focused industry delegates Over 50 presentations/roundtables/panel discussions
3rd World Congress on Cancer Science & Therapy
3rd world congress on Cancer Science & Therapy serves as a reunion land for scientists in the area of cancer research.
Companies
TheraCoat is a specialty pharmaceutical company founded in 2004 by uro-oncologists and biomaterial specialists. TheraCoatâs Board of Directors and Scientific Advisory Board f...
The Multiple Myeloma Research Foundation
Multiple myeloma is an incurable blood cancer. The five-year relative survival rate for multiple myeloma is approximately 34 percent, one of the lowest of all cancers. In 2009, ap...
Transgene (NYSE-Euronext: TNG), a member of the Institut Mérieux Group, is a biopharmaceutical company. It creates, develops and manufactures targeted immunotherapeutics for th...
Itamar Medical Ltd. is a publicly-traded medical technology company utilizing PAT⢠(Peripheral Arterial Tone) signal technology and applications. The PAT signal is a non-inva...
RS Medical is the premier provider of non-invasive medical products designed to relieve pain and improve function. The company sells its products including the RS-4i Sequential St...
Blue Belt Technologies, Inc. has developed the next generation of âsmartâ surgical instruments with precision robotics for use initially in orthopedic procedures and the...
Cancer Genetics, Inc. (CGI) is an emerging leader in the field of personalized medicine, offering products and services that enable cancer diagnostics as well as treatments that are tailored to the...
Eutropics Pharmaceuticals Inc.
Eutropics is addressing the need for improving the treatment of aggressive forms of leukemia, myeloma, lymphoma, and other cancers. The company is developing a novel diagnostic te...
OncoMed Pharmaceuticals is a clinical-stage company that discovers and develops novel therapeutics targeting cancer stem cells, the cells believed to be capable of driving tumor growth, recurrence and...
Verastem, Inc. is a private biopharmaceutical company focused on discovering and developing novel drugs that selectively target cancer stem cells. Cancer stem cells are an underly...
Clinical Trials
89Zr-trastuzumab PET for Imaging the Effect of HSP90 Inhibition
HSP90 inhibition is a potentially new targeted drug modality in the treatment of HER2 positive, trastuzumab refractory breast cancer. Little is known about the pharmacodynamics of HSP90 in...
Background: - BRCA1 and BRCA2 gene mutations have been linked to a higher risk of developing breast cancer and other cancers, and may be associated with types of breast cancer that are mo...
patients who had failed previous H. pylori eradication on standard triple therapy were randomized into two regimens: 1, esomeprazole (20 mg b.i.d), tripotassium dicitrate bismuthate (300 m...
Vemurafenib, Cetuximab, and Irinotecan in Advanced Solid Cancers
The goal of this clinical research study is to find the highest tolerable dose of vemurafenib that can be given in combination with cetuximab and irinotecan to patients with advanced cance...
PTK787 + Trastuzumab for HER2 Overexpressing Metastatic Breast Cancer
HER2 gene amplification increases VEGF production in breast cancers; combined inhibition of HER2 and VEGF enhances response in xenograft models. The upregulation of VEGF in HER2-overexpres...
Follow-up Modalities of Low Grade Precancerous Bronchial Lesions
The goal of this multicentric French randomized trial is to determine the best auto fluorescence bronchial endoscopic follow-up strategy in high risk patients bearing low grade bronchial...
PS-341 With Oral Temozolomide in Patients With Advanced Refractory Solid Tumors or Melanoma
Patients are asked to participate in this research because they have been diagnosed as having cancer that is not curable by any standard means including surgery or radiation therapy or oth...
Exhale (R) Stent for Emphysema
Current treatment for emphysema is limited to measures that include inhaled oxygen, bronchodilators, anti-inflammatory drugs and pulmonary rehabilitation. Highly invasive procedures such...
Prediction of Acute Rejection in Renal Transplant
Acute rejection is still a major risk factor affecting the prognosis of kidney transplant patients. Alloreactive cells of the recipient infiltrate the kidney graft and cause inflammatory r...
Post-Surgical Non-Small Cell Lung Cancer (NSCLC) Follow-up
The follow-up of patients operated on for lung cancer is heterogeneous. An intensive follow-up including routine clinic visits, chest X-rays, chest computed tomography (CT) scans and fiber...
Videos
Invasive Ductal and Lobular Breast Cancer, Is a Combination Possible?
In this video, Dr. Harness discusses the possibility of having both ductal and lobular invasive cancers. He goes on to explain how that diagnosis would affec...
Medical and Biotech [MESH] Definitions
Viridans Streptococci
A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS SANGUIS; STREPTOCOCCUS SOBRINUS; and the STREPTOCOCCUS MILLERI GROUP. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses.
Peripheral Blood Stem Cell Transplantation
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Receptor, Ephb4
An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.
Caulerpa
A genus of toxic marine GREEN ALGAE found throughout tropical and subtropical seas. One species, Caulerpa taxifolia, is highly invasive and produces the poison caulerpenyne, deadly to marine organisms though not humans.
Cholangiopancreatography, Magnetic Resonance
Non-invasive diagnostic technique for visualizing the PANCREATIC DUCTS and BILE DUCTS without the use of injected CONTRAST MEDIA or x-ray. MRI scans provide excellent sensitivity for duct dilatation, biliary stricture, and intraductal abnormalities.
