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Joint Disorders - Biotech, Pharma and Life Science Channel

19:30 EDT 19th June 2013 | BioPortfolio

PubMed Articles [ 7156 Associated PubMed Articles listed on BioPortfolio]

From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders.

Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the...

Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice.

The complement system is involved in mediation of joint damage in rheumatoid arthritis, with evidence suggesting activation of both the classical and alternative pathway (AP). The AP is both necessary...

GABA-B-receptor antibodies in paraneoplastic brainstem encephalitis.

Gamma-aminobutyric-acid B (GABA-B)-receptor encephalitis represents a novel entity among autoimmune CNS disorders. Most cases are characterised by limbic encephalitis.

Brain metal accumulation in Wilson's disease.

Brain metal accumulation is suggested in the pathogenesis of numerous neurodegenerative disorders. In Wilson's disease (WD), only copper has been examined. The aim of the present study was to evaluate...

Dichotomy in the anxiolytic versus antidepressant effect of C-terminal truncation of the GluN2A subunit of NMDA receptors.

The glutamate system is thought to play an important role in modulating mood and anxiety. Ionotropic NMDA receptors critically influence neuronal circuits regulating emotional behaviour. Their pharmac...

Percutaneous cement-augmented screw fixation of bilateral osteoporotic sacral fracture.

We describe the case of a 71-year-old woman who presented with persisting painful symptoms of the back and pelvis which had begun 4 weeks previously. A preceding trauma was plausibly excluded. Diagno...

Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research.

Psychiatric disorders represent a large economic burden in modern societies. However, pharmacological treatments are still far from optimal. Drugs used in the treatment of major depressive disorder (M...

Joint commission warns of alarm fatigue: multitude of alarms from monitoring devices problematic.

Lumbar facet joint injection: feasibility as an alternative method in high-risk patients.

OBJECTIVE: To evaluate the effectiveness of therapeutic facet joint steroid injections for symptoms caused by lumbar spinal stenosis in patients who are at risk of bleeding. METHODS: We analysed 134 p...

Minimally invasive treatment for pubic ramus fractures combined with a sacroiliac joint complex injury.

PURPOSE: Fractures of the pubic rami due to low energy trauma are common in the elderly, with an incidence of 26 per 100,000 people per year in those aged more than 60 years. The purpose of this stud...

News Articles [ 5751 Associated News Articles listed on BioPortfolio]

Safinamide improves responder rates in fluctuating Parkinson's patients in Phase III study

Newron Pharmaceuticals S.p.A. ("Newron"), a research and development company focused on novel CNS and pain therapies, and its partner Zambon S.p.A., a pharmaceutical company strongly committed to the...

Journal of Bone and Joint Surgery reveals important trends and changes in orthopaedic practice

Data from the recent release from The Journal of Bone and Joint Surgery, The Third Annual Role of the Orthopaedic Surgeon Study 2013, reveals important trends in the ways that orthopaedic practice is...

Three Lessons Learned to Reduce Alarm Fatigue and Improve Alarm Management and Patient Safety in Hospitals

CHICAGO, June 19, 2013 /PRNewswire/ -- The Physician-Patient Alliance for Health & Safety recently released three lessons to reduce alarm fatigue. The need to urgently address this issue has been...

New technologies for retinal therapies

The future of the investigation and treatment of retinal disorders is already here at the MedUni Vienna: in the new Christian Doppler "OPTIMA" (Ophthalmic Image Analysis) laboratory headed by Ursula S...

Woman Experiences Astonishing Recovery from Fibromyalgia

SHELBY TOWNSHIP, Mich., June 19, 2013 /PRNewswire/ -- Heather Shinsky experienced the full range of trauma that is typical to the two to four percent of the population suffering from fibromyalgia...

Adamas reports positive PII/III data for ADS-5102

Adamas presented data from the Phase II/III EASED clinical trial during the Movement Disorders Society's 17th International Congress of Parkinson's Disease and Movement Disorders from 16 to 20 June in...

Dr. Garber's Natural Solutions Are Now Available in Oakland, California

Dr. Garber's Natural Solutions (http://www.drgarbers.com) condition-specific remedies that include anxiety, depression and sleep. The latest store to stock the entire line is located at 230 Bay Pl...

How is orthopaedic practice changing in today's healthcare environment?

NEEDHAM, Mass., June 19, 2013 /PRNewswire-USNewswire/ -- Data from the recent release from The Journal of Bone and Joint Surgery, The Third Annual Role of the Orthopaedic Surgeon Study 2013, reveals i...

Rational Biological Source Of Pain Found In The Skin Of Patients With Fibromyalgia

Fibromyalgia, a painful condition affecting approximately 10 million people in the U.S., is not imaginary after all, as some doctors have believed. A discovery, published this month in PAIN MEDICINE (...

Extremities, Emerging Markets Continue To Top M&A Ortho Interest

With hip and knee joint markets still registering slow to modest growth, orthopedic companies looking to add bulk to their bottom line through mergers and acquisitions have pursued two distinct direct...

Events [ 2 Associated Events listed on BioPortfolio]

NGS & Bioinformatics Summit Europe

This summit includes two parallel conferences including joint sessions, featuring discussions on opportunities and challenges in NGS track dedicated to NGS-related topics, Bioinformatics, and data ma...

CNS Diseases World Summit 2013

Parallel conferences: 6th CNS Partnering & Deal-Making 7th Neurodegenerative Conditions Research & Development

Companies [ 288 Associated Companies listed on BioPortfolio]

LiveProcess Corporation

LiveProcess is the market leader in web-based emergency preparedness and incident management for healthcare. The LiveProcess platform provides hospitals, other healthcare provider...

Institute of Human Virology (IHV) at the University of Maryland School of Medicine

Formed in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University System of Maryland and the University of Maryland Medical System, IHV is an in...

AstraZeneca and Bristol-Myers Squibb

Dedicated to addressing the global burden of diabetes by advancing individualized patient care, AstraZeneca and Bristol-Myers Squibb are working in collaboration to research, deve...

Nautilus Neurosciences, Inc.

Nautilus Neurosciences, Inc. is a neurology-focused specialty pharmaceutical company committed to providing the healthcare community with medically relevant products and services...

Reverse Medical Corporation

Reverse Medical Corporation is a privately-held medical device company focused on expanding the endovascular management of acute stroke and neurovascular disease. The technology p...

NeuroMetrix

NeuroMetrix, Inc. was founded in June 1996 as a spin-off from the Harvard-M.I.T. Division of Health Sciences and Technology. The Company’s mission is to: Create value for our customers by developi...

Concert Pharmaceuticals Inc.

Concert Pharmaceuticals is a clinical stage biotechnology company with a broad development pipeline targeting renal disease, CNS disorders, inflammation and hematologic disorders....

The Joint Corp.

Akebia Therapeutics, Inc.

Akebia Therapeutics is a discovery and development company focused on anemia and vascular disorders. Akebia’s lead program, AKB-6548, an orally bioavailable HIF-prolyl hydrox...

Bioness Inc.

Bioness offers innovative Neuromodulation products designed to help certain individuals with central nervous system disorders and diseases such as Stroke, Multiple Sclerosis, Trau...

Clinical Trials [ 1582 Associated Clinical Trials listed on BioPortfolio]

Oral Collagen for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by swelling and inflammation of the joints. In RA, the immune system attacks a person's own cells inside joints, eventually...

Pyroxamide in Treating Patients With Advanced Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of pyroxamide in...

Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism

Autism Spectrum Disorders (ASD) include Autistic disorder, Asperger's syndrome and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). These are developmental disorders be...

Omega-3 Fatty Acids in Autism Spectrum Disorders

This is a 12-week open label trial to evaluate whether omega-3 fatty acids is effective in reducing the severity of autism and its comorbidities.

Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders

The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of,...

Pharmacokinetics, Efficacy, and Safety Study of RI-002 (IGIV) in Subjects With Primary Immunodeficiency Diseases (PIDD)

This is a Phase III, multicenter, open-label study of RI-002 administered as an intravenous infusion of RI-002 (IGIV) every 21 or 28 days in approximately 60 subjects with Primary Immunode...

An Interventional Study to Assess the Efficacy and Safety of Buprenorphine in Korean Patients With Spinal Disorders

The purpose of this study is to assess the pain reduction rate after 8 weeks treatment of NORSPAN® from baseline. And secondary purpose are: pain reduction rate after 4 weeks treatment f...

Paroxetine-CR to Treat Post-Traumatic Stress Disorder (PTSD) Symptomatic After Initial Exposure Therapy

Both pharmacotherapeutic and psychosocial interventions have domenstrated efficacy for PTSD. However, although these interventions can be helpful, many patients remain symptomatic despite...

Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-Year Manometric Follow-Up

Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. In...

A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement

The purpose of this study is to monitor the performance of the DePuy PROXIMA™ hip in the treatment of patients with hip joint disease requiring a total hip replacement. Patients who ente...

Medical and Biotech [MESH] Definitions

Tribulus

A plant genus of the family ZYGOPHYLLACEAE. Members contain steroidal saponins. Ingestion by grazing animals causes PHOTOSENSITIVITY DISORDERS called geeldikkop (yellow thick head) in South Africa.

Foot Joints

The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.

Genetic Services

Organized services to provide diagnosis, treatment, and prevention of genetic disorders.

Gordonia Bacterium

A genus of gram-positive BACTERIA in the family Gordoniaceae, isolated from soil and from sputa of patients with chest disorders. It is also used for biotransformation of natural products.

Mastocytosis, Systemic

A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.

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