Lacunar infarcts - Biotech, Pharma and Life Science Channel
PubMed Articles
Enlarged perivascular spaces and cerebral small vessel disease.
BACKGROUND AND AIMS: Enlarged perivascular spaces (also known as Virchow-Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel a...
Experimental evidence suggests that interstitial fluid flow is a stimulus for mechanoadaptation in bone. Bone adaptation is sensitive to the frequency of loading and rest insertion between load cycles...
Syncope and orthostatic intolerance increase risk of brain lesions in migraineurs and controls.
OBJECTIVES: We and others showed that migraineurs are at increased risk of subclinical and clinical ischemic brain lesions. Migraineurs also have a higher prevalence of frequent syncope and orthostati...
Multiple splenic infarcts in acute Plasmodium vivax malaria: A rare case report.
In tropical countries like India, malaria has been one of the most common parasitic illnesses leading to frequent hospitalization and causing major economic burden among the masses. Although Plasmodiu...
Multi-Tiered Analysis of Brain Injury in Neonates With Congenital Heart Disease.
Early brain injury occurs in newborns with congenital heart disease (CHD) placing them at risk for impaired neurodevelopmental outcomes. Predictors for preoperative brain injury have not been well des...
Teaching NeuroImages: Treatment-resistant rapidly progressive amyloid β-related angiitis.
A 76-year-old woman presented with 1 month of progressive aphasia, headache, and subsequent right hemiparesis. Initial brain MRI showed a punctate infarct (figure 1, A and C). Susceptibility-weighted...
An 88-year-old woman with a medical history of diabetes, hypertension, and atrial fibrillation presented to the emergency room after being found unresponsive with a NIH Stroke Scale score of 23 and Gl...
Rostral basilar artery syndrome following transsphenoidal surgery-a report of four cases.
Vascular complications can arise from transsphenoidal surgery (TSS) and have a high incidence of mortality and serious morbidity. Though haemorrhage from the injury to internal carotid is well know, i...
News Articles
Lowering BP May Cut Risk of Recurrent Stroke (CME/CE)
HONOLULU (MedPage Today) -- Treating patients with lacunar strokes to a systolic blood pressure target of less then 130 mm Hg was feasible and may have prevented recurrent strokes, a randomized trial...
St. Jude Medical, Inc. (NYSE:STJ), a global medical device company, today announced the presentation of additional data from its landmark RESPECT trial at the American Stroke Asso...
Monocular Visual Loss -- Is It Brain Infarct?
A retrospective study determines the frequency of acute brain infarcts on diffusion-weighted imaging in patients with monocular visual loss of presumed ischemic origin. Medscape Neurology
W. L. Gore & Associates (Gore) today released the following statement from the Gore REDUCE Clinical Study Principal Investigators on behalf of the Gore REDUCE Clinical...
Silent Cerebral Infarcts After Cardiac Catheterization
How often does unperceived cerebral injury occur -- after cardiac catheterization? American Heart Journal
SCIPIO: Cardiac Stem Cells Reverse Heart Failure
A small trial of injecting cardiac stem cells to repair infarcts in patients with ischemic myopathy once again raises hopes that this technology will eventually provide a solution in this difficult pa...
Sickle Cell Kids Vulnerable to Brain Infarcts (CME/CE)
(MedPage Today) -- Small but potentially significant brain infarcts occur far more frequently in children with sickle cell disease than previously believed, researchers said.
Long-term Dual Antiplatelet Therapy for Lacunar Stroke
Some specific ischemic stroke subtypes, such as lacunar stroke, may not benefit from long-term combination aspirin and clopidogrel therapy. Journal Watch
Neuroprotectant success in aneurysm coiling
Treatment with the novel neuroprotective agent NA-1 reduces the number of ischemic infarcts sustained by patients undergoing coiling of cerebral aneurysms, show the ENACT results.
Secondary Stroke Prevention: An Adjunct to Avoid
Dr. Hans-Christoph Diener looks at a potential aspirin adjunct in patients who have had a recent lacunar stroke. Medscape Neurology
Events
None
Companies
None
Clinical Trials
Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts
The purpose of this study is to determine if patients with malignant middle cerebral artery infarction have a better clinical outcome after early decompressive surgery compared to standard...
Vasomotor Reactivity In Cerebral Small Vessel Disease And New Approach To Treat Lacunar Stroke
The main purpose of this study is to evaluate the efficacy of atorvastatin treatment during 3 months (80mg/day) on cerebral vasoreactivity (CVR) in lacunar patients.
Edaravone and Argatroban Stroke Therapy Study for Acute Ischemic Stroke
Edaravone, a free radical scavenger, is a novel neuroprotective agent, and argatroban is a selective thrombin inhibitor. Both the drugs were approved by the Japanese Government, and have...
Abciximab for Prevention of Stroke Recurrence Before Endarterectomy in Symptomatic Carotid Stenosis
The purpose of the present prospective, randomized, double-blind, double dummy controlled multicenter pilot study is to investigate whether abciximab, compared with aspirin, is able to red...
In elderly patients with atrial fibrillation (AF) the presence of silent brain infarcts and neurocognitive deficit is high despite adequate treatment with oral anticoagulation. Atheroscler...
Vitamin D and Inflammatory Cytokine Levels After Acute Myocardial Infraction (MI)
Vitamin D is known to have immune-modulator effects including suppression of proinflammatory cytokine expression and regulation of immune cell activity. Vitamin D supplementation has been...
The purpose of this study is to delineate early neurological features and their progression in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoenc...
Videos
BRAIN MRI Multiple lacunar infarcts
results: MRI examination has been carried out head pieces axial, sagittal and coronal with T 1 WI and T 2 WI, slice thickness 10 mm without contrast Gd.DTPA ...
Medical and Biotech [MESH] Definitions
Cadasil
A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)
Ticlopidine
Ticlopidine is an effective inhibitor of platelet aggregation. The drug has been found to significantly reduce infarction size in acute myocardial infarcts and is an effective antithrombotic agent in arteriovenous fistulas, aorto-coronary bypass grafts, ischemic heart disease, venous thrombosis, and arteriosclerosis.
Tooth Resorption
Resorption of calcified dental tissue, involving demineralization due to reversal of the cation exchange and lacunar resorption by osteoclasts. There are two types: external (as a result of tooth pathology) and internal (apparently initiated by a peculiar inflammatory hyperplasia of the pulp). (From Jablonski, Dictionary of Dentistry, 1992, p676)
Myocardial Stunning
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. It occurs frequently, both in the experimental laboratory and in clinical medicine. Since stunned myocardium occurs adjacent to necrotic tissue after prolonged coronary occlusion, many myocardial infarcts may be a mixture of necrotic and stunned tissue. (Braunwald, Heart Disease, 1992, p1176)
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
