Lichen Simplex Chronicus - Biotech, Pharma and Life Science Channel
PubMed Articles
Microbicides for Prevention of HIV Infection: Clinical Efficacy Trials.
Microbicides are an important HIV prevention technology under development, but the clinical testing of candidate products for efficacy faces many design and ethical challenges. Nevertheless, several m...
In total hip arthroplasty, wear particles generated at articulating surfaces and interfaces between bone, cement and implants have a negative impact on osteoblasts, leading to osteolysis and implant l...
Natural Compounds May Open New Routes to Treatment of Amyloid Diseases.
Protein misfolding disorders, such as Alzheimer's disease and Parkinson's disease, have in common that a protein accumulates in an insoluble form in the affected tissue. The process of aggregation fol...
Herpes simplex virus (HSV) has evolved multiple strategies to modulate host immune responses. In a screen of HSV open reading frames to identify additional HSV-encoded proteins that affect NF-κB sign...
The aim of this study was to evaluate the antiviral potential of methanolic extract (ME) of Achyranthes aspera, an Indian folk medicine and one of its pure compound oleanolic acid (OA) against herpes...
A multi-centre audit on genital Lichen sclerosus in the North West of England.
BACKGROUND: Guidelines for the management of genital Lichen sclerosus (LS) have recently been updated. OBJECTIVE: To look at the audit points suggested by the updated guidelines: performance of biopsi...
Some viruses are sensitive to high pressure. The freeze-pressure generation method (FPGM) applies pressure as high as 250 MPa on a substance, simply by freezing a pressure-resistant reservoir in whic...
Diversity of Endosymbiotic Nostoc in Gunnera magellanica (L) from Tierra del Fuego, Chile.
Global warming is causing ice retreat in glaciers worldwide, most visibly over the last few decades in some areas of the planet. One of the most affected areas is the region of Tierra del Fuego (south...
Reduced immune responses to purified protein derivative and Candida albicans in oral lichen planus.
BACKGROUND: Impairment of cellular immunity is reported in lichen planus, an autoimmune disease affecting mucosae and skin. Our aim was to investigate immune responses directed against a set of microb...
Response of the lichen Cladonia rei Schaer. to strong heavy metal contamination of the substrate.
The phenomenon of mass occurrence of the lichen Cladonia rei in extremely contaminated post-smelting slag dumps was studied in relation to metal accumulation capacity of this lichen. The research was...
News Articles
A new study in The Journal of Sexual Medicine reported in April, 2013 that “Male patients with GW (genital warts) have higher rates of sexual dysfunction.” (1) polyDNA recommends killing the laten...
Leading provider of mail-order diabetic testing supplies becomes one of only 18 companies in nation authorized by CMS to serve Medicare patients...
Revealing hidden fungal species using DNA: The importance of recognizing cryptic diversity
(Pensoft Publishers) In contrast to traditional approaches using morphological characters to delimit species, five new lichen-forming fungal species were described from what was traditionally consider...
Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection
Most herpes simplex virus 2 (HSV-2) reactivations in humans are subclinical and associated with rapid expansion and containment of virus. Previous studies have shown that CD8+ T cells persist in gen...
There is no waiting for appointment. Threeo’clock in shady moss, the lichen ties the Celtic cross.My compass fails true north, O’Grady.Degree by degree, Polaris dies beside O’Grady:starry-lit cr...
DURHAM, N.C., April 29, 2013 /PRNewswire-iReach/ -- Scioderm announced its investigational product SD-101 has received Breakthrough Therapy designation by the U.S. Food and Drug Administration...
Herpes Solution Provider, Viradux Research Announces JV Partnership
Los Angeles, CA, April 26, 2013 --(PR.com)-- Viradux Research, LTD, a provider of anti-herpetic treatment solutions targeted at the rapid resolution of symptoms related to HSV1 and HSV2 infections, a...
Flexible partnership allows lichens to occur in different habitats
(Pensoft Publishers) A group of researchers led by the German lichenologist Christian Printzen, Senckenberg Research Institute (Frankfurt), discovered the survival secrets of a lichen that occurs in p...
Events
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Companies
Diabetes Care Club, a Simplex brand, has grown to become the third largest mail-order supplier of diabetic testing supplies for seniors. The company provides home delivery...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell response helps confer protect...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...
Simplex Healthcare is based in Franklin, Tennessee and provides home delivery of medical supplies to help patients with diabetes. Simplex secured $50 million in venture capital fr...
Clinical Trials
Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission
The University of Washington has received funding to conduct a proof-of-concept trial to assess the impact of suppression of genital herpes on HIV infectiousness. This study (the Partners...
Genital herpes (GH) is a commonly occurring sexually transmitted disease caused by herpes simplex virus (HSV). There are two types of HSV, type 1 (HSV-1) and type 2 (HSV-2); both can cause...
The purpose of this study is to find out how safe and effective an investigational drug called alefacept (amevive) is for the treatment of moderate to severe erosive mucosal lichen planus....
Safety and Effectiveness of Efalizumab to Treat Oral Lichen Planus
This study is to determine whether efalizumab 1.0mg/kg given by subcutaneous injection for 12 weeks is effective in treating oral lichen planus. This is a 20 week, single center, open-lab...
Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus
This study will compare two treatments for oral lichen planus - hydroxychloroquine (Plaquenil) tablets and clobetasol oral rinse. Oral lichen planus is a chronic disorder in which patients...
Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection
This study will evaluate the safety and blood levels of a new pediatric formulation of Famvir in children 1-12 years of age. In Part A, patients will receive a single dose of famciclovir...
Clinical Research Core Dental Screening Protocol
This study will screen patients for eligibility in studies sponsored by the Craniofacial Genetics Section (HCGS), the Clinical Research Core (CRC), and other branches located within the Na...
Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates
The purpose of this study is to test whether long term treatment with acyclovir given orally (by mouth) improves the outcome for infants with herpes simplex virus infection of the brain or...
This clinical trial will study the safety and effectiveness of an engineered herpes virus, G207, administered directly into the brain of patients with recurrent brain cancer. G207 has bee...
Seroprevalence of Kaposi's Sarcoma Herpes Virus in the United States
This study will investigate patterns of Kaposi's sarcoma herpes virus (KSHV) in the United States and its potential impact on the U.S. population. KSHV is a newly discovered virus that i...
Videos
Lichen Simplex Chronicus ¦ Treatment and Symptoms
XXXXXX ◅ Lichen Simplex Chronicus treatment — Finding the right information about Lichen Simplex Chronicus treatment & symptoms, is crucial to managing Liche...
Medical and Biotech [MESH] Definitions
Host Cell Factor C1
A cellular transcriptional coactivator that was originally identified by its requirement for the stable assembly IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. It is a nuclear protein that is a transcriptional coactivator for a number of transcription factors including VP16 PROTEIN; GA-BINDING PROTEIN; EARLY GROWTH RESPONSE PROTEIN 2; and E2F4 TRANSCRIPTION FACTOR. It also interacts with and stabilizes HERPES SIMPLEX VIRUS PROTEIN VMW65 and helps regulate GENETIC TRANSCRIPTION of IMMEDIATE-EARLY GENES in HERPES SIMPLEX VIRUS.
Receptors, Tumor Necrosis Factor, Member 14
A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Keratin-14
A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.
Keratin-5
A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.
Stomatitis, Herpetic
Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.
