Luteinizing hormone LH and folliclestimulating hormone FSH - Biotech, Pharma and Life Science Channel
PubMed Articles
INTRODUCTION: Nonunion of femoral neck fractures frequently occurs in elderly patients. In patients with rheumatoid arthritis, reoperation rates after internal fixation of a displaced femoral neck fra...
Of marsupials and men: "Backdoor" dihydrotestosterone synthesis in male sexual differentiation.
Following development of the fetal bipotential gonad into a testis, male genital differentiation requires testicular androgens. Fetal Leydig cells produce testosterone that is converted to dihydrotest...
The mitochondria are critical for steroidogenesis since the ability of cholesterol to move into mitochondria to be available for cytochrome P450, CYP11A1, determines the efficacy of steroid production...
Mass spectrometry theory and application to adrenal diseases.
The diagnosis and management of adrenal diseases hinge upon accurate determination of hormone concentrations in blood and other body fluids. The advent of immunoassays for various steroid hormones has...
Pheochromocytoma is a rare but potentially lethal chromaffin cell tumor with currently no effective treatment. Peptide hormone receptors are frequently overexpressed on endocrine tumor cells and can b...
The glucocorticoid receptor (GR) and corticotropin-releasing hormone (CRH) are important molecular regulators of an individual's ability to respond to stressful stimuli in an adaptive manner. Impaired...
Luteinizing hormone (LH) activates ERK1/2, MAP kinases (MAPKs) necessary for its action on steroidogenesis and cell proliferation, and also induces MAPK phosphatase-1 (MKP-1), which rapidly dephosphor...
Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis.
Steroid biosynthesis is a multi-step process controlled by pituitary hormones, which, via cAMP-dependent signaling pathways, drive tissue-specific steroid formation. Steroidogenesis begins with the tr...
N-POMC1-28 increases cyclin D expression and inhibits P27(kip1) in the adrenal cortex.
The Adrenocorticotropic hormone (ACTH) and Pro-opimelanocortin (POMC) 1-28N-terminal peptide (N-POMC1-28) have been shown to act as an adrenal mitogen in vivo. A possible role for cyclin E in the zona...
The production of glucocorticoids and aldosterone in the adrenal cortex is regulated at multiple levels. Biosynthesis of these hormones is initiated when cholesterol, the substrate, enters the inner m...
News Articles
Diet Doc’s hCG diets offer patients an end to the vicious cycle of weight gain through prescription strength medical weight loss aids and new education on how to lose weight with healthy eating habi...
Diet Doc offers new and improved medically supervised hCG diet plans, now capable of providing relief from symptoms or future development of asthma with fast and effective weight loss. Houston, TX (PR...
New Acid Reflux Cure Website Launches, Offering New eBook: Top 5 Secret Acid Reflux Home Remedies
Site created by long-term sufferer of Acid Reflux helps others with the latest info and natural cures that work. Los Angeles, CA (PRWEB) May 22, 2013 Jeremy Kemp, a former 10 year sufferer of acid re...
WomanCare Global launches Simplant, Long-acting Reversible Contraception, in Chile
SAN DIEGO, May 22, 2013 /PRNewswire-USNewswire/ -- WomanCare Global recently launched Simplant in Chile with an extensive training initiative attended by 90 health care providers. (Photo...
Albany, NY, May 22, 2013 --(PR.com)-- Musculoskeletal diseases/disorders (MSDs) are diseases of muscles and related ligaments, and other connective tissues and bones. Some of the most common musculos...
[Comment] Iodine and pregnancy: a call to action
Iodine, a crucial micronutrient, is essential for thyroid hormone production and for normal in-utero neuro-development. During pregnancy, iodine intake must be increased by 50% because of physiologica...
To the Editor: The article by Dr Spack concerning the management of persons with gender identity disorders misstated the prerequisites for cross-sex hormone therapy and omitted any explanation of tran...
Trigemina to Present at the 13th Annual Pain Therapeutics Conference in London
LONDON, May 20, 2013 /PRNewswire/ -- Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today annou...
American College of Endocrinology Offering Free Thyroid Awareness Promotional Items
As part of its ongoing thyroid awareness efforts, the American College of Endocrinology (ACE) – the charitable, educational and scientific arm of the American Association...
Events
None
Companies
TheAmerican Association of Clinical Endocrinologists (AACE)
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
Hotze Pharmacy, a part of Hotze Enterprises, is leading a wellness revolution in bioidentical hormone replacement therapy by compounding the finest quality of biologically identic...
The American Association of Clinical Endocrinologists
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Antares Pharma, Inc. and Population Council
Antares Pharma focuses on self-injection delivery technologies and topical gel-based pharmaceutical products. The Companyâs subcutaneous injection technology platforms includ...
Neurogen Corporation & Ligand Pharmaceuticals
Ligand discovers and develops new drugs that address critical unmet medical needs of patients with muscle wasting, frailty, hormone-related diseases, osteoporosis, inflammatory di...
Neurotez Inc., founded in 2005, is a privately held Delaware corporation operating from New Jersey, formed to develop a Leptin product as a hormone replacement therapy for Alzheim...
GTx, Inc., headquartered in Memphis, Tenn., is a biopharmaceutical company dedicated to the discovery, development, and commercialization of small molecules that selectively targe...
Founded in 2003, BodyLogicMD physician-owned practices make up the nationâs largest and fastest growing network of the most highly trained physicians specializing in natural...
Neurotez Inc., founded in 2005, is a privately held Delaware corporation operating from New Jersey, formed to launch the clinical development of Leptin as a hormone replacement th...
Clinical Trials
Pelvic Pain in Women With Endometriosis
This study will examine pelvic pain associated with endometriosis and explore better approaches to treatment. In women with endometriosis, uterine tissue grows outside the uterus. Standa...
Screening Evaluation for Women With Postpartum Depression
This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not rece...
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein...
RATIONALE: Aromatase inhibitors, such as letrozole, prevent the formation of estradiol, a female hormone. Giving letrozole together with goserelin, leuprolide, or surgery may be an effecti...
This study will evaluate the safety and effectiveness of insulin-like growth factor-1 (IGF-1) to treat patients with X-linked severe combined immunodeficiency (XSCID). Those who have XSCID...
This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion. Cushing's synd...
First Human Dose Trial of NNC0195-0092 in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to assess safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect o...
Mediators of Abnormal Reproductive Function in Obesity (MARO)
The study is seeking to understand how being overweight and obese makes women less fertile. The studies the investigators have done so far indicate that there is a hormone or other substan...
A Study of Epirubicin With Estramustine Phosphate and Celecoxib for the Treatment of Prostate Cancer
The purpose of this clinical trial is to find out the effect of epirubicin with estramustine phosphate and celecoxib on PSA and objective response in patients with hormone resistant prosta...
Goserelin and Anastrozole in Treating Men With Recurrent or Metastatic Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin and anastrozole may fight breast cancer by blocking the use of estrogen by the tumor cells....
Videos
LH and FSH effects in the female
This tutorial for A&P students discusses the effects of LH and FSH, estrogen and progresterone in the human female over the course of a 28 day cycle. In the ...
Medical and Biotech [MESH] Definitions
Luteinization
Formation of CORPUS LUTEUM. This process includes capillary invasion of the ruptured OVARIAN FOLLICLE, hypertrophy of the GRANULOSA CELLS and the THECA CELLS, and the production of PROGESTERONE. Luteinization is regulated by LUTEINIZING HORMONE.
Thyroid Hormone Receptors Alpha
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRA gene (also known as NR1A1, THRA1, ERBA or ERBA1 gene) as several isoforms produced by alternative splicing.
Thyroid Hormone Receptors Beta
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.
Luteinizing Hormone, Beta Subunit
The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.
Follicle Stimulating Hormone, Beta Subunit
The beta subunit of follicle stimulating hormone. It is a 15-kDa glycopolypeptide. Full biological activity of FSH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the FSHB gene causes delayed puberty, or infertility.
