Malaria Vaccines - Biotech, Pharma and Life Science Channel
Malaria represents one of the international community’s most pressing public health problems. The disease exacts an economic toll of roughly $12 billion a year in Africa.
A vaccine is an essential tool in stopping malaria because:
* The current fight against the disease is being waged on a variety of fronts, including the distribution of bednets, the promotion of indoor spraying, and the development of new medicines and insecticides. A vaccine would close the gap left by these interventions.
* Malaria routinely develops resistance to drugs. Mosquitoes routinely develop resistance to insecticides.
* From small pox to polio to whooping cough, vaccines have offered a cost-effective and efficacious means of preventing disease and death.
* Even a modestly efficacious malaria vaccine would protect hundreds of thousands of people from disease and death each year.
Today, vaccine developers are trying to develop three types of vaccines:
1. Pre-erythrocytic vaccine candidates aim to protect against the early stage of malaria infection—the stage at which the parasite enters or matures in an infected person's liver cells. These vaccines would elicit an immune response that would either prevent infection or attack the infected liver cell if infection does occur. These candidates include recombinant or genetically engineered proteins or antigens from the surface of the parasite or the infected liver cell, DNA vaccines that contain the genetic information for producing the vaccine antigen and live, attenuated vaccines.
2. Blood-stage vaccine candidates target the malaria parasite at its most destructive stage—the rapid replication of the organism in human red blood cells. Blood-stage vaccines do not aim to block all infection. They are expected to decrease the number of parasites in the blood, and in so doing, reduce the severity of disease. Evidence suggests that people who have survived regular exposure to malaria develop natural immunity over time. The goal of a vaccine that contains antigens or proteins from the surface of the blood-stage parasite (the merozoite) would be to allow the body to develop that natural immunity with much less risk of getting ill.
3. Transmission-blocking vaccine candidates seek to interrupt the life cycle of the parasite by inducing antibodies that prevent the parasite from maturing in the mosquito after it takes a blood meal from a vaccinated person. These vaccines would not prevent a person from getting malaria, nor would they lessen the symptoms of disease. They would, however, limit the spread of infection by preventing mosquitoes that fed on an infected person from spreading malaria to new hosts. A successful transmission-blocking vaccine would be expected to reduce deaths and illness related to malaria in at-risk communities.
Source; http://www.malariavaccine.org/
Add the Malaira News Channel to your RSS reader;
News Articles
Company’s Virtual Conjugate Vaccine Program Shows Promise Liquidia Technologies today announced that its collaborative agreement with PATH, a global health nonprofit organiz...
Aduro BioTech, Inc. announces two poster presentations at the upcoming American Society of Clinical Oncology (ASCO) annual meeting in Chicago. Dr. Raffit Hassan, Head of the Solid...
Equatorial Guinea To Renovate All Its Hospitals Within Four Years
MALABO, Equatorial Guinea, May 17, 2013 /PRNewswire-USNewswire/ -- The government of Equatorial Guinea is working to renovate all the hospitals in the country within the next four years, according to...
OAKLAND, Calif., May 20, 2013 /PRNewswire/ -- Whole-cell pertussis vaccines were more effective at protecting against pertussis than acellular pertussis vaccines during a large recent outb...
A New 5-year Guarantee Has the Potential to Unlock Immense Private Sector Financing, Accelerating Efforts to Achieve MDGs Today, leading global health and development experts...
Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results
BEIJING, May 17, 2013 /PRNewswire/ -- Sinovac Biotech Ltd. (Nasdaq: SVA), a leading provider of vaccines in China, today announced that it will release its unaudited financial results for the...
Pennsylvania Physicians Urge State Legislators to Support Immunization Expansion Bill
HARRISBURG, Pa., May 16, 2013 /PRNewswire/ -- The Pennsylvania Pharmacists Association announced today that numerous physicians throughout the Commonwealth are urging state legislators to support Hous...
The World Small Animal Veterinary Association Recommends Canine VacciCheck
KIBBUTZ GALED, Israel, May 16, 2013 /PRNewswire/ -- The World Small Animal Veterinary Association (WSAVA) Vaccination Guidelines Group has recently published the "Vaccination Guidelines for New Puppy...
Immunovaccine Announces Financial Results for the Quarter Ended March 31, 2013
HALIFAX, NOVA SCOTIA -- (Marketwired) -- 05/16/13 -- Immunovaccine Inc. ("Immunovaccine" or "IMV") (TSX VENTURE: IMV), a clinical stage vaccine company, today released its financial and operational...
Research Team Publishes New Methods for Synthetic Generation of Influenza Vaccines
LA JOLLA, Calif. and ROCKVILLE, Md., May 15, 2013 /PRNewswire/ -- A team of international researchers from the J. Craig Venter Institute (JCVI), Synthetic Genomics Inc. (SGI), Novartis Vaccines a...
Events
Cancer Vaccines will provide attendees with a complete view of the cancer immunotherapy field. Focusing on the discovery of new vaccines, developments in target identification
Antimicrobial Resistance Conference
Incentivizing Change towards a Global Solution
Companies
Zoetis (zÅ-EH-tis) is the leading animal health company, dedicated to supporting its customers and their businesses. Building on a 60-year history as the animal health business...
We have a challenging and inspiring mission: to improve the quality of human life by enabling people to do more, feel better and live longer. This mission gives us the purpose to develop innovative me...
Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, a...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
VGTI Florida is the Florida-funded expansion of Oregon Health & Science University's highly successful Vaccine and Gene Therapy Institute. Research at the facility will focus on v...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell response helps confer protect...
Advaxis is a biotechnology company developing proprietary, live but attenuated Listeria monocytogenes (Listeria) vaccines that deliver engineered tumor antigens, which stimulate...
Clinical Trials
RATIONALE: Vaccines made from a person's white blood cells may help the body build an effective immune response. PURPOSE: This phase I trial is studying the side effects of vaccine therap...
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy
Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...
Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children
There is a necessity for the development of new malaria drugs. Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effect...
GSK Biologicals is developing in partnership with the Malaria Vaccine Initiative at PATH a candidate malaria vaccine RTS,S/AS02 for the routine immunization of infants and children living...
Malaria is an important cause of death and serious illness among Mozambican children. Although the risk of malaria can be reduced by drugs and by impregnated bed nets, it would be helpful...
GSK Biologicals is developing in partnership with the Program for Appropriate Technology in Health (PATH) Malaria Vaccine Initiative a candidate malaria vaccine for the routine immunizatio...
A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers
Croup is an illness of young children that is caused by a virus. With this illness, the child has fever, cough, and hoarseness. Although the illness usually gets better in 2 to 4 days, so...
Vitamin A Supplementation With Routine Childhood Vaccines and Mortality and Morbidity
Vitamin A supplementation (VAS) is important for the immune system and may interact with different childhood vaccinations. We have hypothesized that the improved survival after VAS may dep...
Treatment of Malaria With Quinine Plus Sulfadoxine-Pyrimethamine
Quinine remains the treatment of choice of hospitalised malaria cases. The long treatment duration of 7 days, and adverse reactions often hamper its adequate use. Reducing the treatment du...
Efficacy and Effectiveness of Combined Therapy for Uncomplicated Malaria Treatment in Peru
This is a study of the efficacy and effectiveness of combination therapy for malaria due to P. falciparum in the Loreto Department, Iquitos, Peru. The investigators will enroll subjects ...
PubMed Articles
Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica.
The seeds of Brucea javanica (L.) Merr. (Yadanzi in Chinese) have been used for the treatment of inflammation, dysentery, malaria, and cancer in Chinese traditional medicine. However, the anti-inflamm...
Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.
Tithonia diversifolia (Hemsl.) A. Gray has been commonly used in folk medicine to treat abscesses, microbiological infections, snake bites, malaria and diabetes. Both anti-inflammatory and anti-malari...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreting cellular tumor vaccines contribute to the induction of potent antitumor immune responses in murine models and patients suffering fro...
In many organisms the Y chromosome initiates sex determination and regulates male fertility and mating behaviour. However, molecular characterization of Y genes is rare outside of a few model species...
Metabolic plasticity for isoprenoid biosynthesis in bacteria.
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate)...
Using a capillary isoelectric focusing-whole column imaging detection (CIEF-WCID) method the isoelectric points (pI) of complete intact polioviruses were determined. The polio viruses that were analyz...
In 2007 Timor-Leste, a malaria endemic country, changed its Malaria Treatment Protocol for uncomplicated falciparum malaria from sulphadoxine-pyrimethamine to artemether-lumefantrine. The change in tr...
Plasmodium spp. parasites, the causative agents of malaria, survive and replicate in human hosts by modulating host protective immune responses. In a rodent model, malaria manifests as a severe spleno...
Cancer immunotherapies, their safety and toxicity.
Introduction: Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system. Some immunotherapies broadly activate the immune system wh...
Videos
Why Malaria Vaccines Remain Elusive
An investigation into the mysterious inner workings of the malaria parasite has revealed that it survives and proliferates in the human bloodstream thanks in...
Medical and Biotech [MESH] Definitions
Tuberculosis Vaccines
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
Plasmodium Ovale
A species of protozoan parasite causing MALARIA. It is the rarest of the four species of PLASMODIUM infecting humans, but is common in West African countries and neighboring areas.
Ebola Vaccines
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Anopheles Gambiae
A species of mosquito in the genus Anopheles and the principle vector of MALARIA in Africa.
Schizonts
Multinucleate cells or a stage in the development of sporozoan protozoa. It is exemplified by the life cycle of PLASMODIUM FALCIPARUM in the MALARIA infection cycle.
