Medullary Sponge Kidney - Biotech, Pharma and Life Science Channel
PubMed Articles
Traditional Chinese Medicine (TCM) operates on the general principle that compatible components of different herbal decoction may work together to synergistically enhance therapeutic efficacy or reduc...
Abelmoschus manihot (L.) medic (AM) is a natural medicinal plant used for the treatment of inflammatory diseases in China. Huangkui capsule (HKC), an extract from AM, has been proved clinically effect...
Patients with both chronic kidney disease (CKD) and diabetes mellitus (DM) are at increased risk for thrombotic events compared to those with one abnormality alone. Whether this can be attributed to c...
Secondary polycythemia with increased production of erythropoietin (EPO) is known to occur in kidney diseases such as hydronephrosis and cystic disease, but the mechanism remains unclear. We report an...
Current and future therapies for hepatitis C virus infection.
BACKGROUND: SBR759, an iron (III)-based oral phosphate binder, was developed for the treatment of hyperphosphataemia in chronic kidney disease stage V patients receiving maintenance renal replacement...
Urinary and glomerular podocytes in patients with chronic kidney diseases.
BACKGROUNDS: Podocytes are highly differentiated epithelial cells involved in glomerular filtration. This study determines the clinical and histological significance of podocyte detachment and excreti...
BACKGROUND: With the recent increase in renal transplantations in Japan, accurate assessment of renal function is required. METHODS: This study included 73 patients who had undergone renal transplanta...
PURPOSE: Pharmacists' contributions to improved inpatient medication practices and educational services for kidney transplant recipients at a community hospital were evaluated. SUMMARY: A retrospectiv...
News Articles
Kidneys discarded for transplant can be used for manufacturing replacement organs, say researchers
Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units...
AbbVie starts Phase 3 clinical study of atrasentan in patients with diabetic nephropathy
AbbVie announced today the initiation of a Phase 3 clinical study called SONAR (Study Of Diabetic Nephropathy with Atrasentan) to assess the effects of the investigational compound atrasentan - when a...
Thomas J. Henry Injury Attorneys is currently investigating new injuries, including kidney failure, alleged in BMS-986094 clinical trial patients. San Antonio, Texas (PRWEB) May 20, 2013 Thomas J. He...
Study suggests new source of kidneys for transplant
WINSTON-SALEM, N.C. – May 20, 2013 – Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood...
Bristol Myers Squibb And The New Wave Of Cancer Drugs
By Peter Geschek:Even with the best cancer drugs, doctors are forced to switch from one therapy to the next as the tumors rapidly develop resistance.A new wave of immunotherapy drugs, in the spotlight...
“Rather than teaching young doctors, ‘don't just stand there … do something’, we need to teach them, ‘don't just do something, stand there and listen’," says Michael Wilkes, M...
Baxter to Present at the Deutsche Bank 38th Annual dbAccess Health Care Conference
Baxter International Inc. (NYSE: BAX) announced today that it will present at the Deutsche Bank 38th Annual dbAccess Health Care Conference on Wednesday, May 29, 2013 at 7:00 a.m....
NORTH CHICAGO, Ill., May 20, 2013 /PRNewswire/ -- AbbVie (NYSE: ABBV) announced today the initiation of a Phase 3 clinical study called SONAR (Study Of Diabetic Nephropathy with Atrasentan) to as...
Fastcare Advises on How to Prevent a UTI
Miami, FL (PRWEB) May 20, 2013 Fastcare Miami Beach clinic advises patients to treat a possible urinary tract infection (UTI) within its first symptoms, as if not treated, it may involve the uret...
New Drug Combinations Block Kidney Cancer in Culture and Mouse Models
Drugs that block the activity of the enzyme Stearoyl-CoA desaturase-1 repress the growth of kidney cancer cells in culture and...
Events
Diabetes: Secondary Complications, Regulation and Innovation Conference
SMi is very proud to present our 11th conference focusing on Diabetes and metabolic disorders taking place on 1st and 2nd Oct 2013, London.
Companies
Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...
Tissue Regeneration Technologies, LLC
TRT is an international medical device company established to develop, manufacture and sell SoftWaveTM acoustical pressure pulse devices to treat various conditions poorly served...
Global Mission Statement: Committed to education, prevention, awareness, and access, the Shad Ireland Foundation is an international non-profit organization that is actively explo...
American Renal Associates LLC (âARAâ) is the operating subsidiary of American Renal Holdings, Inc. and is a leading owner and provider of outpatient kidney dialysis cent...
Baxter International Inc. and Takeda Pharmaceutical Company Limited
Baxter International Inc. (NYSE:Â BAX), through its subsidiaries, develops, manufactures and markets products that save and sustain the lives of people with hemophilia, immune d...
Falcon EHRTM helps physicians manage kidney patientsâ health records from CKD through ESRD and can be accessed wherever there is Internet access. Developed, tested and endors...
Thrasos is a private, clinical stage, bio-therapeutics Company focused on the discovery and development of targeted therapies for the prevention and treatment of severe organ fail...
Thrasos is a private, clinical stage, bio-therapeutics company focused on the discovery and development of targeted therapies for the prevention and treatment of kidney disease. T...
Established in 1982, Spectra Laboratories, Inc. is the leading provider of renal-specific laboratory testing services in the United States. The companyâs state-of-the-art ana...
DaVita Inc., a Fortune 500® company, is a leading provider of kidney care in the United States, delivering dialysis services to patients with chronic kidney failure and end sta...
Clinical Trials
Erlotinib and Sirolimus for the Treatment of Metastatic Renal Cell Carcinoma
The purpose of this study is to test the safety and efficacy of the combination of erlotinib hydrochloride (Tarceva™) and sirolimus (Rapamune™) in the treatment of patients with metast...
The investigators hypothesize that a calcineurin inhibitor-free, steroid-free, co-stimulatory blockade-based immunosuppressive regimen, in combination with a GLP-1 agonist, will reduce the...
Intervention to Motivate Teens to be a Designated Organ Donor on Driver's License
This study will test the effectiveness of a multimedia campaign to educate ethnic minority teens about the choice to become a designated organ donor on their first driver's license.
A Study in Patients With Diabetic Kidney Disease
The purpose of this study is to determine if LY2382770 is safe and effective at protecting kidney function in patients with kidney disease due to diabetes.
RATIONALE: Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Interfe...
Islet Transplantation in Type 1 Diabetic Patients
Our hypothesis is that a successful clinical islet transplant program can be established at the University of Wisconsin using a steroid -free, sirolimus- and low dose tacrolimus - based im...
This pilot study is to assess whether using CytoGam® in combination with ganciclovir is more effective in reducing the CMV viral load over time, as compared to standard treatment with IV...
Treatment with growth hormone (GH; a hormone made by the body that stimulates growth) has been shown to be helpful in treating children with chronic kidney disease who fail to grow. The a...
Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography
It is well known that X-ray contrast media can affect kidney function in some patients, especially when administered intra-arterially, and patients who already suffer from reduced kidney f...
Prediction of Acute Rejection in Renal Transplant
Acute rejection is still a major risk factor affecting the prognosis of kidney transplant patients. Alloreactive cells of the recipient infiltrate the kidney graft and cause inflammatory r...
Videos
Medullary Sponge Kidney (MSK)/Sponge Life
I'm Kayla, a 24 year old girl from MN with Medullary Sponge Kidney (MSK). This video is about my daily battles with this disease, from kidney stones to kidne...
Medical and Biotech [MESH] Definitions
Receptor, Epha1
The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
Receptor, Ephb3
An eph family receptor found in a number of tissues including BRAIN; LUNG; KIDNEY; PANCREAS; INTESTINE; and HEART. During embryogenesis EphB3 receptor is expressed at high levels in the brain.
Ephrin-a1
An ephrin that was originally identified as the product of an early response gene induced by TUMOR NECROSIS FACTORS. It is linked to the CELL MEMBRANE via a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR and binds EPHA2 RECEPTOR with high affinity. During embryogenesis high levels of ephrin-A1 are expressed in LUNG; KIDNEY; SALIVARY GLANDS; and INTESTINE.
Ephrin-a4
A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in variety of adult tissue such as KIDNEY; LUNG; COLON and OVARY. During embryonic development, ephrin-A4 is expressed in the HIPPOCAMPUS and CEREBRAL CORTEX. It binds preferentially to ephA receptors (EPH FAMILY RECEPTORS) with the exception of the EPHA1 RECEPTOR.
Ephrin-a5
A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It has been shown to mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It is found in a variety of adult tissues of BRAIN; HEART; and KIDNEY.
