Meningitis - Biotech, Pharma and Life Science Channel
PubMed Articles
Significant sequelae after bacterial meningitis in Niger: a cohort study.
BACKGROUND: Beside high mortality, acute bacterial meningitis may lead to a high frequency of neuropsychological sequelae. The Sahelian countries belonging to the meningitis belt experience approximat...
Cryptococcal meningitis is rarely complicated by immune-mediated leukoencephalopathy, but the precise pathomechanism is uncertain. A 72-year-old Japanese man treated with prednisolone for Sweet diseas...
As of May 6, 2013, Michigan had reported 167 (52%) of the 320 paraspinal or spinal infections without meningitis associated with the 2012-2013 fungal meningitis outbreak nationally. Although the index...
SUMMARY We used a database of 248 659 births, with follow-up to subsequent disease, in the Oxford record linkage archive (1979-1999) to study the influence of family, maternal, and perinatal factors...
Small molecule inhibitors of West Nile virus.
West Nile virus is a human pathogen which is rapidly expanding worldwide. It is a member of the Flavivirus genus and it is transmitted by mosquitos between its avian hosts and occasionally in vertebra...
Streptococcus suis causes meningitis, septicemia, arthritis, endocarditis and death in both pigs and humans. Sudden death is rarely documented in the forensic field and almost all cases were diagnosed...
Tubercular Ventriculitis: An Uncommon Entity.
Although tubercular meningitis is common in children, tubercular ventriculitis is uncommon. The authors report a 3-mo-old infant who had tubercular ventriculitis secondary to disseminated tuberculosis...
Implications of postneurosurgical meningitis caused by carbapenem-resistant Acinetobacter baumannii.
Acinetobacter baumannii is an important cause of postneurosurgical meningitis. The emergence of carbapenem-resistant strains in this setting has caused a therapeutic challenge. We investigated the cli...
To our knowledge, no previous study has examined functioning in adult life among persons who had bacterial meningitis in childhood.
Comment: Neoplastic meningitis--Improving accuracy of a sometimes elusive diagnosis.
Leptomeningeal metastasis (LM) represents an area of neuro-oncology that has been remarkably resistant to therapeutic breakthroughs. Several factors contribute to dismal prognosis, including (often) c...
News Articles
RPT-FEATURE-Pfizer takes its shot at a vaccine for evasive superbug
CHICAGO, May 23 (Reuters) - Kathrin Jansen is a microbiologist with at least two breakthrough vaccines to her name: she brought the cervical cancer vaccine Gardasil to market for Merck and helped deve...
Pfizer takes its shot at a vaccine for evasive superbug
CHICAGO (Reuters) - Kathrin Jansen is a microbiologist with at least two breakthrough vaccines to her name: she brought the cervical cancer vaccine Gardasil to market for Merck and helped develop the...
FEATURE-Pfizer takes its shot at a vaccine for evasive superbug
CHICAGO, May 23 (Reuters) - Kathrin Jansen is a microbiologist with at least two breakthrough vaccines to her name: she brought the cervical cancer vaccine Gardasil to market for Merck and helped deve...
Study examines outbreak of spinal infections in Michigan
(HealthDay)—Factors such as increased case finding may explain why Michigan had half of the total spinal infections associated with contaminated methylprednisolone acetate in the recent fungal menin...
Widespread But Neglected Disease Leptospirosis A Significant Health Threat In Africa
The newest public health threat in Africa, scientists have found, is coming from a previously unknown source: the banded mongoose. Leptospirosis, the disease is called. And the banded mongoose carries...
Human disease leptospirosis identified in new species, the banded mongoose, in Africa
(National Science Foundation) Leptospirosis is the world's most common illness transmitted to humans by animals. It's a two-phase disease that begins with flu-like symptoms. If untreated, it can cause...
Widespread but neglected disease a health threat in Africa, Virginia Tech researchers say
(Virginia Tech) Virginia Tech researchers have identified leptospirosis as a significant health threat in Botswana. The world's most common disease transmitted to humans by animals, according to the W...
Senate Bill On FDA Oversight Of Compounding Pharmacies Gets Broad Backing As Hearings Move Closer
A bill to give the FDA greater authority over compounding pharmacies like the one behind a deadly meningitis outbreak gets broad -- including bipartisan -- backing, and a key committee chairman readie...
Woodcock: More compounding deaths not matter of if, but when
If action is not taken, the "appalling tragedy" of a nationwide fungal meningitis outbreak, which has sickened 741 Americans, killing 55, linked to tainted medicines mixed by a rough Massachusetts com...
Senate Bill on Compounding Coming Closer
WASHINGTON (MedPage Today) -- The Senate appears ready to move on a bill that aims to provide greater oversight to large-scale compounders like the one at the center of last fall's fungal meningitis o...
Events
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Companies
BioFire Diagnostics, Inc., formerly Idaho Technology, Inc., is a privately held clinical diagnostics company based in Salt Lake City, Utah. The Company manufactures and distribute...
BioFire Diagnostics, Inc., formerly Idaho Technology, Inc., is a privately held clinical diagnostics company based in Salt Lake City, Utah. The company manufactures and distribute...
Meningitis Angels is a national nonprofit organization founded in memory of Ryan Wayne Milley, the only child of Bob and Frankie Milley. Ryan's life was taken at age 18, as a resu...
Clinical Trials
Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria
This study will evaluate the safety and effectiveness of the experimental drug eculizumab for treating paroxysmal nocturnal hemoglobinuria (PNH), a disorder that can cause premature destru...
RATIONALE: Drugs used in chemotherapy, such as topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. PURPOSE...
DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor
The purpose of this study is to find out how well an experimental drug called DepoCyt works for neoplastic meningitis (cancer that has spread to the tissues around the brain and spinal cor...
Pilot Study of Familial Nonsyndromal Mondini Dysplasia
OBJECTIVES: I. Determine the mode of inheritance of nonsyndromal Mondini inner ear dysplasia, an inner ear malformation causing deafness, vestibular dysfunction, and recurrent meningitis...
Melphalan in Patients With Neoplastic Meningitis
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of melphalan in p...
To evaluate and estimate the safety and efficacy of the combination of fluconazole and flucytosine as treatment for acute cryptococcal meningitis in patients with AIDS. Fluconazole and fl...
To evaluate the safety and effectiveness of fluconazole as an intravenous dose as initial treatment for acute cryptococcal meningitis followed by oral therapy in AIDS and non-AIDS patients...
To compare the safety and effectiveness of a new drug, fluconazole, with that of the usual therapy, amphotericin B, in the prevention of a relapse of cryptococcal meningitis (CM) in patien...
To evaluate the effectiveness and safety of amphotericin B plus flucytosine (5-fluorocytosine) compared to amphotericin B alone for a first episode of acute cryptococcal meningitis in AIDS...
RTA 744 Injection in Patients With Leptomeningeal Disease
1. The primary objectives of this study are: 1. To determine the tolerability of RTA 744 Injection in patients with leptomeningeal disease (LMD) secondary to any type of...
Videos
Meningitis Trust and Meningitis UK - Branding Update
Chief Executive Sue Davie updates supporters on the rebranding process.
Medical and Biotech [MESH] Definitions
Ralstonia
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
Tuberculosis, Meningeal
A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)
Uveomeningoencephalitic Syndrome
A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)
West Nile Fever
A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)
Fluconazole
Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
