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Moderate-to-Severe Plaque Psoriasis - Biotech, Pharma and Life Science Channel

12:21 EDT 23rd March 2017 | BioPortfolio

Psoriasis is a chronic, immune disease that affects the skin. It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis affects up to 1.8 million people in the UK,ix approximately 20 percent of whom have moderate-to-severe plaque psoriasis.Psoriasis can occur on any part of the body and is associated with other serious health conditions, such as diabetes and heart disease. The most common form of psoriasis, plaque psoriasis, appears as raised, red patches covered with a silvery white buildup of dead skin cells.

News Articles [130 Associated News Articles listed on BioPortfolio]

Dermatology Devices Market Worth $25 Billion by 2025 | CAGR: 12.7%: Grand View Research, Inc.

SAN FRANCISCO, March 23, 2017 /PRNewswire/ -- The global dermatology devices market is expected to reach a value of USD 25.7 billion by 2025, according to a new report by Grand View Research,...

Dermatology Devices Market Analysis By Type (Imaging, Dermatoscopes, Light Therapy, Lasers, Liposuction), By Application (Skin Cancer, Hair Removal, Acne, Wrinkle Removal, Fat Removal, Pigmented Lesion Removal), And Segment Forecasts, 2014 - 2025

LONDON, March 22, 2017 /PRNewswire/ -- The global dermatology devices market is expected to reach a value of USD 25.7 billion by 2025, according to a new report by Grand View Research, Inc. Derma...

Skyrocketing Demand for High Quality Cannabis Concentrates and Edibles Boosting Cannabis CBD Oil Extraction Market

PALM BEACH, Florida, March 22, 2017 /PRNewswire/ -- MarketNewsUpdates.com News Commentary  As the number of uses and applications for cannabis CBD oil continues to rise in popularity with...

Coherus BioSciences Inc CHRS Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 23022017] Prices from USD $250

SummaryCoherus BioSciences Inc Coherus BioSciences focuses on the development and commercialization of biosimilar drugs. Its pipeline portfolio includes candidates such as CHS1701, is a pegfilgrastim ...

Cannaisseur Brands Launches Aryn's Essentials, Cannabis Topicals: THERAPY Designed by Nature!

LOS ANGELES, March 21, 2017 /PRNewswire/ -- Cannaisseur Brands, based in Los Angeles, CA is launching Aryn's Essentials, a line of revolutionary premium CBD topicals that are non-psychoactive and...

OWC Pharmaceutical Research Corp Releases Promising Preliminary Results From Efficacy Tests of its Topical Cream

PETACH TIKVA, Israel, March 21, 2017 /PRNewswire/ -- OWC Pharmaceutical Research Corp. (OTCQB:OWCP), ("OWC" or the "Company"), an Israeli-based developer of cannabinoid-based therapies targeting a...

Actress Katie Lowes Reveals Her Journey With Psoriasis For The First Time Through "Psoriasis: The Inside Story" Awareness Campaign

HORSHAM, Pa., March 17, 2017 /PRNewswire/ -- Janssen Biotech, Inc. and the National Psoriasis Foundation (NPF) announced today the launch of Psoriasis: The Inside Story, a campaign that aims to s...

MetrioPharm Announces Positive Top-Line Results from a Phase IIa Study in Moderate-to-Severe Psoriasis with its Oral Lead Compound MP1032

Based on these positive results, MetrioPharm plans to move its MP1032 program forward into a phase IIb study in moderate-to-severe psoriasis. MetrioPharm AG, a biotech company...

Protalex Significantly Strengthens Global Intellectual Property Portfolio for Proprietary Immunomodulatory Therapeutic

Granted Six Key International Patents Protecting and Expanding Use for PRTX-100 Protalex, Inc. (OTCQB:PRTX), a clinical-stage biopharmaceutical company, announces that ...

DermTech Presents Four Molecular Dermatology Studies at AAD 2017

LA JOLLA, Calif., March 13, 2017 /PRNewswire/ -- DermTech, Inc., the global leader in non-invasive molecular dermatology, announced today the presentation of four studies at the 75th Annual Meeting of...

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Companies [19 Associated Companies listed on BioPortfolio]

Santalis Pharmaceuticals, Inc.

Santalis Pharmaceuticals, Inc. is a wholly-owned subsidiary of TFS Corporation, Ltd. (ASX: TFC). Santalis, and its sister company, ViroXis, were acquired by TFS in July 2015 and a...

Ziarco Pharma Ltd.

Ziarco is a clinical-stage biotechnology company developing innovative therapeutics targeting dermatological and inflammatory diseases. ZPL-389, the Company’s lead compound, ...

Akaal Pharma Pty Ltd.

Akaal Pharma Pty Ltd (Akaal Pharma) is a clinical-stage drug discovery and development company focused on the development of novel small molecule drugs for the treatment of inflam...

Provectus Biopharmaceuticals, Inc.

Provectus Biopharmaceuticals specializes in developing oncology and dermatology therapies. Its novel oncology drug PV-10 is designed to selectively target and destroy cancer cells...

Shape Pharmaceuticals, Inc.

Shape Pharmaceuticals, Inc. is developing SHP-141, a novel, topical, “soft-drug” HDAC inhibitor for the treatment of patients with cutaneous T cell lymphoma (CTCL) and p...

Helmedix Pty Ltd

Helmedix is developing new therapies for autoimmune diseases. The company has identified peptides derived from helminthic worms that have immune-modulating properties. These peptides are being explo...

HealOr

Founded in 2002, HealOr is a privately owned, clinical-stage specialty biopharmaceutical company developing a first-in-class pipeline of topical therapeutics to treat a variety of...

fOCUS Pharmaceuticals, LLC

fOCUS Pharmaceuticals is a privately held generic and branded pharmaceutical company specializing in the research and development of prescription dermatology products. Our primary focus are in the are...

Lycera Corp.

Lycera Corp. is focused on the discovery and development of small-molecule immunomodulators for the treatment of immunologic diseases, including psoriasis, rheumatoid arthritis, lupus erythematosis, i...

Galderma Laboratories, L.P.

Galderma, created in 1981 as a joint venture between Nestle and L'Oreal, is a fully-integrated specialty pharmaceutical company dedicated exclusively to the field of dermatology. The Company has a pre...

Clinical Trials [519 Associated Clinical Trials listed on BioPortfolio]

The Role of Food Sensitivity in Psoriasis

Psoriasis is a common chronic skin disorder that affects over 4 million people. There is no cure for psoriasis and treatment is directed at controlling patients' symptoms. The purpose of t...

Vascular Inflammation in Psoriasis - Apremilast

The purpose of the VIP-A study is to determine the effect of apremilast on aortic vascular inflammation, cardiometabolic biomarkers and body composition in patients with moderate-severe ps...

Enstilar in Combination With Biologic Agents

Patients receiving biologic therapy with 5% or less body surface area will receive Enstilar topical foam for 16 weeks.

Study to Evaluate the Efficacy and Safety of P-3073 Nail Solution in the Treatment of Mild to Moderate Psoriatic Fingernail/s

The objective of this phase III study is to evaluate the efficacy, systemic safety and local tolerability of P-3073 (calcipotriene 0.005%) nail solution in patients with mild to moderate p...

A Comparison of 188-0551 Solution Versus Vehicle Solution in Subjects With Plaque Psoriasis (Study 203)

This Phase 2 study (Study 203) has been designed to determine and compare the efficacy and safety of 188-0551 Solution and Vehicle Solution applied twice daily for up to four weeks in subj...

Study of Efficacy and Safety of Secukinumab in Subjects With Moderate to Severe Chronic Plaque-type Psoriasis

The purpose of this study is to determine if secukinumab is effective and safe in the treatment of plaque type psoriasis

A Study of PRCL-02 in Healthy Volunteers and Plaque Psoriasis

This study consists of three parts: single oral dose escalation in healthy volunteers (Part A), and multiple oral dose escalations in healthy volunteers (Part B) and in participants with c...

Study to Explore the Effect of Secukinumab, Compared to Placebo, on Fat Tissue and Skin in Plaque Psoriasis Patients

This study will provide a comparison of secukinumab to placebo with respect to skin inflammation as measured by skin exams in comparison to skin biopsies, adipose tissue and blood sample a...

A Study to Test the Efficacy and Safety of Certolizumab Pegol in Japanese Subjects With Moderate to Severe Chronic Psoriasis

The purpose of this study is to demonstrate the efficacy and safety of Certolizumab Pegol (CZP) in the treatment of moderate to severe chronic plaque Psoriasis (PSO) in Japanese subjects.

MED in UVB Devices in the Presence and Absence of UV Filter

Psoriasis affects 2-3% of the American population. While a wide variety of therapies currently exist, including topical corticosteroids and Vit D analogs, oral immunosuppressant and retino...

PubMed Articles [363 Associated PubMed Articles listed on BioPortfolio]

Clinical characteristics of Psoriasis in Inflammatory Bowel Diseases patients.

Crohn's Disease (CD) and Ulcerative Colitis (UC) account for most cases of Inflammatory Bowel Diseases (IBD). These diseases share common genetic abnormalities and pathogenic mechanisms with other imm...

Successful Secukinumab treatment of generalized pustular psoriasis and erythrodermic psoriasis.

Erythrodermic psoriasis (EP) and generalized pustular psoriasis (GPP) are the most severe forms of psoriasis, resulting in significant morbidity and even mortality (1) . There are few evidence-based d...

A cross-sectional survey of the nature and correlates of sleep disturbance in people with psoriasis.

Research suggests that sleep disturbance is common in psoriasis. Despite 32 studies conducted in sleep, many demonstrate methodological flaws, often using unvalidated measurement, with no study examin...

Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO).

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied by psoriasis or infla...

Reaching complete or near complete resolution of psoriasis: benefit and risk considerations.

The incremental benefits of obtaining higher levels of skin clearance for patients with psoriasis have been established across several patient reported outcomes (PROs). Patients who obtain clear or al...

A Topical Treatment Optimisation Programme (TTOP) improves clinical outcome to calcipotriol/betamethasone gel in psoriasis: Results of the 64-week, multinational, randomized, phase IV study in 1790 patients (PSO-TOP).

Around two-thirds of psoriasis patients do not adhere to topical treatment. The 'Topical Treatment Optimisation Programme' (TTOP), a five-element tool, includes guidance for the conversation between d...

Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population.

Previously, we determined that the CARD11 rs4722404 single nucleotide polymorphism (SNP) increases risk of early-onset psoriasis vulgaris (PsV). Moreover, the CARD14 gene polymorphism c.C2458T (p.Arg8...

Cutaneous mucinosis in a patient taking ustekinumab for palmoplantar psoriasis.

Discrete papular lichen myxedematosus (DPLM), asubset of localized lichen myxedematosus, is a rarecutaneous mucinosis of unknown etiology. We reporta case of a 57-year-old woman with palmoplantarpsori...

TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold.

TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. D...

Kynurenic acid downregulates IL-17/1L-23 axis in vitro.

Exploring the function of interleukin (IL) 17 and related cytokine interactions have been proven useful toward understanding the role of inflammation in autoimmune diseases. Production of the inflamma...

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Medical and Biotech [MESH] Definitions

A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

A topical anti-inflammatory glucocorticoid used in DERMATOSES, skin allergies, PSORIASIS, etc.

A glucocorticoid used topically in the treatment of DERMATITIS; ECZEMA; or PSORIASIS. It may cause skin irritation.

An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.

An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic.

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