Molecular Abnormalities - Biotech, Pharma and Life Science Channel
PubMed Articles
Adenosine-based molecular beacons as light-up probes for sensing heparin in plasma.
This study presents an adenosine-based molecular beacon (MB) for the selective and sensitive detection of heparin based on the competitive binding between heparin and the MB stem to coralyne.
CIZ1, a p21(Cip1/Waf1)-interacting protein, functions as a tumor suppressor in vivo.
CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-def...
Bifunctional star-burst amorphous molecular materials displaying both efficient solid-state luminescence and high hole-transport properties are developed in this study. A high external electroluminesc...
BACKGROUND: This study aimed to evaluate the clinical phenotype and investigate the molecular genetic defect in a Chinese family with autosomal dominant cone-rod dystrophy (ADCRD). METHODS: Family his...
The lateral habenula (LHb) is part of the habenular complex in the dorsal diencephalon. The LHb is an important regulator of several neurotransmitter systems in the midbrain; disturbances in this regu...
Molecular classification and molecular targeted therapy of cancer.
Synthesis of peptoid based small molecular gelators by a multiple component reaction.
We report the synthesis and self-assembling properties of a new class of tripeptoids synthesized by a one-pot Ugi reaction from simple starting materials. Among the focused library of tripeptoids synt...
The application of a novel bipolar molecular glass in field-effect transistors leads to devices with photoinduced magnetoresistance (MR) sign change. In darkness a low external magnetic field increase...
PLK2 Modulates α-Synuclein Aggregation in Yeast and Mammalian Cells.
Phosphorylation of α-synuclein (aSyn) on serine 129 is one of the major post-translation modifications found in Lewy bodies, the typical pathological hallmark of Parkinson's disease. Here, we found t...
Light-inducible molecular beacons for spatio-temporally highly defined activation.
We have developed a new molecular beacon design that requires an additional UV pulse for fluorescence activation. This improves the signal-to-noise ratio tremendously compared to previous approaches a...
News Articles
Kennedy Krieger Institute and Partek Incorporated Awarded $1.8M NIH Grant
Research partnership aimed at developing computational tools to analyze genomic data from patients with autism spectrum disorder and mental health disorders Partek...
Clearance also includes Clinical Investigation of PER977 to Reverse the Anticoagulation Activity of Unfractionated Heparin, Low Molecular Weight Heparins, and Fondaparinux...
Dietary exposure to certain plastics may cause metabolic and hormonal abnormalities in children
Plastic additives known as phthalates (pronounced THAL-ates) are odorless, colorless and just about everywhere: They turn up in flooring, plastic cups, beach balls, plastic wrap, intravenous tubing an...
BUFFALO, N.Y., May 22, 2013 /PRNewswire/ -- Empire Genomics announced today it has acquired an exclusive license for a patent pending novel genomic biomarker from Cornell University for use in de...
Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference
PHILADELPHIA and REHOVOT, Israel, May 22, 2013 /PRNewswire/ -- Rosetta Genomics Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces that Kenne...
New molecular probes that shed light on biological systems
Reactive sulfur species have attracted increasing attention in biomedical research because of their involvement in a variety of physiological functions. There has been a rising interest in sulfane sul...
Plastic additives known as phthalates (pronounced THAL-ates) are odorless, colorless and just about everywhere: They turn up in flooring, plastic cups, beach balls, plastic wrap, intravenous tubing an...
Preclinical SCA1 and SCA2 mutation carriers seem to have mild coordination deficits and abnormalities in the brain that are more common in carriers who are closer to the estimated onset of ataxia. Ind...
Identification Of Molecular Trigger For Alzheimer's Disease
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease - when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of...
(NYU Langone Medical Center / New York University School of Medicine) Plastic additives known as phthalates are odorless, colorless and just about everywhere: They turn up in flooring, plastic cups, b...
Companies
Ambry Genetics is a CAP-accredited, CLIA-certified commercial clinical laboratory headquartered in Aliso Viejo, California. Since the company's inception in 2000, it has become a leader in provi...
Foundation Medicine is dedicated to the development of comprehensive tests that will help physicians personalize cancer treatment for their patients. Foundation Medicineâs la...
Health Discovery Corporation is a molecular diagnostics company that uses advanced mathematical techniques to analyze large amounts of data to uncover patterns that might otherwis...
Certara is dedicated to improving human health through a broad spectrum of software products and services, from molecular discovery through clinical development, with special focu...
GenMark, a provider of automated, multiplex molecular diagnostic testing systems, detects and measures DNA and RNA targets to diagnose disease and to optimize the treatment of pat...
Founded in 2010 in Barcelona, STAT-Diagnostica is focused on the development of Near Patient Testing solutions where fast and accurate diagnostic results are needed. Its in vitro...
CSI Laboratories is a specialized cancer diagnostic laboratory focused specifically on meeting the unique needs and challenges of pathologists and community hospitals. The company...
The International Society for Interferon and Cytokine Research (ISICR), based in Bethesda, Md., is a non-profit organization devoted to interferon, cytokine and chemokine r...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
MolecularImaging.net hosts Molecular Imaging's eNewsletter, quarterly magazine, special sections and portals. The site engages molecular imaging physicians and executives w...
Clinical Trials
Biomarkers in Phototherapy of Barrett's Esophagus
This study is being done to find out if Photodynamic Therapy (treatment with a red light and a drug called photofrin) or Radiofrequency ablation works the same for patients who have biomar...
Hip Pathomorphology in Collegiate Athletes and Controls
In a previous study, the investigators have shown that 95% of the University of Utah football players had at least one radiographic abnormality consistent of FAI (IRB #40479). Siebenrock e...
The purpose of this study is to obtain an estimate of catheter survival in the setting of upper extremity deep vein thrombosis (UEDVT) in patients treated with dalteparin and warfarin....
This is a prospective study of surgically resected samples and lymph nodes of lung cancer patients. For histopathologically positive lymph nodes from a complete resection, the investigator...
The Survey About Resting Metabolic Rate and Its Related Factors in Terminal Patients
According to data from the Taiwanese government, cancer mortality has been the leading cause of death in Taiwan since 1982. The trend is increasing day by day. As the people are aging in T...
Janssen - Glucose Regulation/Risp/Olanz
Abnormalities in peripheral glucose regulation and type 2 diabetes can occur more commonly in individuals with schizophrenia than in healthy subjects or in other psychiatric conditions. A...
Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death
People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population...
Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
Summary Acute promyelocytic leukemia is defined by a characteristic morphology (AML FAB M3/M3v), by the specific translocation t(15;17) and its molecular correlates (PML/RARa and RARa/PML...
In an attempt to simplify the diagnosis of ectopic pregnancy, the researchers will investigate the presence of specific molecular markers of ectopic pregnancy. The quantification of these...
HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)
This is a prospective, non-randomised, 48 week study of the effect of protease inhibitor (PI) containing and non-PI containing antiretroviral regimens on the expression of adipocyte specif...
Videos
Understanding Molecular Abnormalities in Mood Disorders
Q&A with Xiaohua Li, PhD, Director for the Division of Behavioral Neurobiology at the University of Alabama at Birmingham.
Medical and Biotech [MESH] Definitions
Dynamins
A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.
Leukocyte Rolling
Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)
Flaveria
A plant genus of the family ASTERACEAE that is used for experiments in molecular genetic studies in plant physiology and development.
Calreticulin
A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Lower Extremity Deformities, Congenital
Congenital structural abnormalities of the LOWER EXTREMITY.
