Monoclonal antibodies - Biotech, Pharma and Life Science Channel
PubMed Articles
Agonist anti-CD137 (4-1BB) mAbs enhance CD8-mediated antitumor immunity. Agonist anti-human CD137 mAbs binding to four distinct epitopes on the CD137 glycoprotein costimulated T cell activation irresp...
Bioanalytical LC-MS/MS of protein-based biopharmaceuticals.
Biotechnology increasingly delivers highly promising protein-based biopharmaceutical candidates to the drug development funnel. For successful biopharmaceutical drug development, reliable bioanalytica...
This study determined the prevalence of classical onconeural Ab in a series of 2063 consecutive patients that were investigated because of suspicion of PNS as well as evaluated individual onconeural A...
Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with...
GABA-B-receptor antibodies in paraneoplastic brainstem encephalitis.
Gamma-aminobutyric-acid B (GABA-B)-receptor encephalitis represents a novel entity among autoimmune CNS disorders. Most cases are characterised by limbic encephalitis.
The question of whether cannabinoid CB2 receptors are expressed on neurons in the brain and under what circumstances they are expressed is controversial in cannabinoid neuropharmacology. While some st...
Composite agarose (1.2 %) polyacrylamide (0.6 %) gel electrophoresis was used to separate discrete populations of native aggrecan and perlecan in newborn to 10 year old ovine intervertebral discs (...
The mechanism by which antibodies elicited against protein-derived peptides achieve cross-reactivity with their cognate proteins remains unknown. To address this question, we have carried out the comp...
Hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma. Glycan shielding has been proposed to be a mechanism by which HCV masks broadly neutralizing epitopes...
CD4 detected from Lactobacillus helps understand the interaction between Lactobacillus and HIV.
Human immunodeficiency virus (HIV) preferentially infects and destroys CD4+ cells and leads to a gradual decline in the number of CD4 cells. Despite evidence that probiotics increase CD4+ T lymphocyte...
News Articles
Athera and Boehringer Ingelheim enter option agreement on a novel therapy for atherosclerosis
Sweden-based Athera Biotechnologies, which is 65% owned by Karolinska Development, has entered into an option agreement with Boehringer Ingelheim on a novel preclinical antibody program, whereby Ather...
Japan first to approve Avastin in first-line glioblastoma
The regulatory clearance marks the first time worldwide for the VEGF-targeting monoclonal antibody to be approved specifically for first-line use in glioblastoma, the most aggressive form of malignant...
Celldex Turning Into A Compelling Immunotherapy Biotech
By Stephen Simpson:"Shoulda, coulda, woulda" will probably be my investing epitaph. While there is no shortage of investment advice telling you that long-term investment success is predicated on devel...
VGTI Florida Scientists to Receive $3.6 Million in NIH Research Grants
Scientists at the Vaccine & Gene Therapy Institute of Florida (VGTI Florida®) have been awarded three new federal research grants that will further support the Institute’s...
Index Ventures provides $11mm Series A financing to [XO1]
[XO1 Ltd.] (blood clotting antibodies) has raised $11mm in Series A financing from sole investor Index Ventures, via its $200mm Life Sciences Fund. The start-up will initially operate as a virtual ent...
Inexpensive Blood Test Reveals HPV Presence, Potential Cancer Risk
Brett Smith for redOrbit.com – Your Universe Online Earlier this month, actor Michael Douglas raised the prospect of oral sex leading to throat cancer through the transmission of the human papillo...
Thomas A. Shea Joins EPIRUS Biopharmaceuticals as Chief Financial Officer
EPIRUS Biopharmaceuticals, Inc. (EPIRUS), a privately held biotechnology company focused on the development and production of biosimilar products in and for major emerging markets...
Use of Daratumumab, a CD38 monoclonal antibody, in advanced multiple myeloma
Dr Henk Lokhorst presented the results from a phase I/II study in advanced Multiple Myeloma at the 18th EHA meeting. Multiple myeloma is the second most common haematological cancer. It is a cancer o...
Early HPV testing could detect sexually transmitted oral cancer
Antibodies to a high-risk type of human papillomavirus (HPV16) could help detect oropharyngeal cancer several years before the clinical onset of the disease, reveals a new study from the International...
Gram Scale Transient Antibody Production in CHO Cells with MaxCyte Electroporation
Dr. Hua Tu, CEO of LakePharma, and Dr. Peer Heine, Applications Scientist at MaxCyte, to Present Data Demonstrating Superior Performance and Scalability of MaxCyte Flow Electropor...
Events
Diabetes: Secondary Complications, Regulation and Innovation Conference
SMi is very proud to present our 11th conference focusing on Diabetes and metabolic disorders taking place on 1st and 2nd Oct 2013, London.
6TH ANNUAL RECOMBINANT ANTIBODIES Conference
An insight into novel therapeutics and future technologies
Companies
ADC Therapeutics sarl (ADCT) is a Swiss-based oncology drug development company that specializes in the development of proprietary Antibody Drug Conjugates (ADCs) targeting major...
OncoMed is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class monoclonal antibody therapeutics targeting cancer stem cells, or CSCs. Our appr...
Symphogen A/S, the biotech company pioneering recombinant human polyclonal antibodies for the treatment and prevention of human disease, today announced the initial closing of a USD 25 million Series...
Acorda Therapeutics, Inc. was established in March 1995 to develop therapeutic products for spinal cord injury ("SCI") and other central nervous system disorders. Acorda is focusing its initial develo...
Source BioScience LifeSciences
Source BioScience LifeSciences are European leaders in DNA sequencing, genomic services, bioinformatic analyses and offers a comprehensive portfolio of genomic reagents and antibodies. Source Bio...
Onconova, based in Newtown, PA and Lawrenceville, NJ, discovers and develops novel patent- protected small molecule therapeutic agents for cancer, radiation protection and hematol...
Seattle Genetics is a clinical-stage biotechnology company focused on the development and commercialization of monoclonal antibody-based therapies for the treatment of cancer and...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
Itero Biopharmaceuticals, Inc.
Itero Biopharmaceuticals, Inc. is a specialty biopharmaceutical company focused on the development and commercialization of protein therapeutics that offer significant clinical an...
CytomX Therapeutics is an early stage biotechnology company developing Probodiesâ¢, or proteolytically-activated antibodies. Probodies combine the well-established power and s...
Clinical Trials
This randomized phase III trial is studying giving tamoxifen citrate or letrozole together with bevacizumab to see how well it works compared with tamoxifen citrate or letrozole alone in t...
This is an open-label, dose-escalation, non-randomized, phase I study in patients with histologically confirmed Stage III or IV melanoma and at least three metastatic cutaneous or subcutan...
This study will test the investigational antibody, anti-OX40, in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received...
Ustekinumab for the Treatment of Patients With Active Ankylosing Spondylitis
This study is aimed at investigation of efficacy and safety of ustekinumab (monoclonal antibody against interleukin 12 and 23) treatment in patients with active ankylosing spondylitis (AS)...
Background: - Studies conducted at the National Cancer Institute suggest that certain chemotherapy drugs may be more effective if given by continuous infusion into the vein rather...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stoppi...
RATIONALE: Herpesvirus is found in the cancer cells of patients with primary effusion lymphoma. Antiviral drugs, such as zidovudine and valganciclovir, may be able to act against the herpe...
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and he...
Hospitalized patients at least 18 years of age, with Staphylococcus aureus bacteremia (SAB) will be enrolled into the study and receive one dose of Aurexis® intravenously on Study Day 1,...
Videos
Monoclonal Antibodies
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a un...
Medical and Biotech [MESH] Definitions
Hepatitis A Antibodies
Antibodies to the HEPATITIS A ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Lectins
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Oligoclonal Bands
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
Antibodies, Phospho-specific
Antibodies directed against immunogen-coupled phosphorylated PEPTIDES corresponding to amino acids surrounding the PHOSPHORYLATION site. They are used to study proteins involved in SIGNAL TRANSDUCTION pathways. (From Methods Mol Biol 2000; 99:177-89)
Plantibodies
Recombinant antibodies produced in TRANSGENIC PLANTS. The plants serve as BIOREACTORS to produce the antibodies for medical use or industrial processes.
