Multiple Myeloma - Biotech, Pharma and Life Science Channel
PubMed Articles
8p21.3 deletion was recently characterized in B cell lymphoma suggesting that TRAIL-R1 and TRAIL-R2 may be the target of the deletion and act as dosage-dependent tumor suppressor genes. As multiple my...
Despite extensive early prevention efforts, recent surveys suggest that sexual risk taking may again be on the rise in Thailand. The present cross-sectional study surveyed 3,299 recruits in the Thai N...
Activity-Based Imaging Probes of the Proteasome.
Over the years, the proteasome has been extensively investigated due to its crucial roles in many important signaling pathways and its implications in diseases. Two proteasome inhibitors-bortezomib an...
A 12-year-old girl with a history of celiac disease, anxiety, and depression was seen in the outpatient psychiatry clinic of this hospital because of irritability, hypersomnia, and multiple somatic sy...
Multiple sclerosis (MS) and epilepsy are common disorders, the co-occurrence of which has been of considerable interest. This study aimed to evaluate the prevalence and clinical features of epileptic...
Adenosine A2A receptors in secondary progressive multiple sclerosis: a (11)CTMSX brain PET study.
In this study, positron emission tomography (PET) imaging with a radioligand to adenosine A2A receptors (A2AR)-a potent regulator of inflammation-was used to gain insight into the molecular alteration...
OBJECTIVE: To evaluate the relationship between multiple MR perfusion parameters and symptoms of patients with osteoid osteomas after percutaneous laser therapy. METHODS: MR perfusion studies of 20 pa...
Perspectives in the treatment of multiple myeloma.
Introduction: The development of proteasome inhibitor (PI) and immunomodulatory drugs (IMiDs) and advances in supportive care have considerably changed the treatment paradigm of multiple myeloma (MM)...
Immunologic microenvironment and personalized treatment in multiple myeloma.
Introduction: Multiple myeloma (MM) is characterized by generalized immune suppression and increased susceptibility to infections and secondary malignancies. Malignant plasma cells (PCs) modulate the...
News Articles
Going live: Immune cell activation in multiple sclerosis
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would ne...
Going live – immune cell activation in multiple sclerosis
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would n...
Novel multiplex immunoassay approach to capture HIV antibodies
Detection of HIV antibodies is used to diagnose HIV infection and monitor trials of experimental HIV/AIDS vaccines. New, more sensitive detection systems being developed use microspheres to capture HI...
Takeda begins MLN9708 phase 3 clinical trial in newly diagnosed myeloma patients
Takeda Pharmaceutical Company Limited today announced the initiation of an international phase 3 clinical trial evaluating once a week MLN9708 in combination with lenalidomide and dexamethasone in pat...
Early screening for prostate cancer could become as easy for men as personal pregnancy testing is for women, thanks to UC Irvine research published in the /iJournal of the American Chemical Society. A...
Going live -- immune cell activation in multiple sclerosis
(Max-Planck-Gesellschaft) Scientists from the Max Planck Institute of Neurobiology in Martinsried have now presented not one, but two studies introducing new indicator molecules which can visualize th...
Strong control over multiple endpoints: are we adding value to the assessment of medicines?
A fate worse than death for scores of African women
It’s a condition practically unheard of in the United States and most Western countries. But in a culture where a woman’s status and dignity is decided by her ability to provide a husband...
Multiple research teams unable to confirm high-profile Alzheimer's study
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal...
Events
2nd Annual Forum on Global Publication Planning and Clinical Trial Registries
Attend this highly anticipated forum to learn more about how professionals working in publication planning and clinical trial disclosure can coordinate data sharing to ensure transparency.
Companies
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat deb...
The Multiple Myeloma Research Foundation
Multiple myeloma is an incurable blood cancer. The five-year relative survival rate for multiple myeloma is approximately 34 percent, one of the lowest of all cancers. In 2009, ap...
Acorda Therapeutics, Inc. was established in March 1995 to develop therapeutic products for spinal cord injury ("SCI") and other central nervous system disorders. Acorda is focusing its initial develo...
Eutropics Pharmaceuticals Inc.
Eutropics is addressing the need for improving the treatment of aggressive forms of leukemia, myeloma, lymphoma, and other cancers. The company is developing a novel diagnostic te...
Scientific excellence that achieves new standards of care drives the company's work. 17 products are currently in clinical development addressing a variety of key medical needs.With patients in more t...
Theravance is a biopharmaceutical company with a pipeline of internally discovered product candidates and strategic collaborations with pharmaceutical companies. Theravance is focused on the discove...
Elan Corporation, plc is a neuroscience-based biotechnology company focused on discovering and developing advanced therapies in neurodegeneration and autoimmune diseases, and real...
Mazor Robotics (TASE:MZOR) is dedicated to the development and marketing of innovative surgical robots and complementing products that provide a safer surgical environment for pat...
The Myelin Repair Foundation (MRF)
The Myelin Repair Foundation (MRF) - http://www.myelinrepair.org - is a Northern California-based, non-profit research organization focused on accelerating discovery and developme...
The International Society for Interferon and Cytokine Research (ISICR), based in Bethesda, Md., is a non-profit organization devoted to interferon, cytokine and chemokine r...
Clinical Trials
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis
This study will use positron emission tomography (PET) to measure a brain protein called peripheral benzodiazepine receptor (PBR) in patients with multiple sclerosis. PBR is created during...
The primary objective is to demonstrate that early intervention with Teriflunomide in patients presenting with their first clinical episode consistent with MS prevents or delays conversio...
Study assessing cognitive function and physical activity in people with relapsing remitting multiple sclerosis.
Intravitreal LFG316 in Patients With Age-related Macular Degeneration (AMD)
This study is designed to test the efficacy of twelve successive monthly doses of intravitreal (IVT) LFG316 on the growth of geographic atrophy (GA) lesions. The study will also provide in...
A Multiple Dose Study of MK-5172 in Hepatitis C-Infected Participants (MK-5172-010 AM1)
This study will compare hepatic pharmacokinetics (PK) derived from liver tissue to plasma PK after administration of MK-5172 to participants with chronic hepatitis C virus (HCV) infection....
1. To determine the safety and tolerability of oral Cellcept when used in combination with weekly intramuscular Avonex in early MS. 2. To document changes in exacerbation frequency...
Fatigue is a symptom present in 76 to 92% of people with multiple sclerosis (MS). Fatigue is usually described as an overwhelming sense of tiredness, lack of energy, and feeling of exhaust...
Pharmacokinetic Drug Interaction Between Pregabalin and Thioctic Acid.
A randomized, open-label, six-sequence, three-period, three-treatment, multiple dosing clinical trial to investigate the pharmacokinetic drug interaction between Pregabalin and Thioctic ac...
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemopro...
Zoledronic Acid in the Management of Patients With Asymptomatic/Early Stage Multiple Myeloma
Evidence for the beneficial effects of bisphosphonates on bone resorption in multiple myeloma has been reported extensively, showing reductions in skeletal events and improvement of severa...
Videos
CancerTV: Understanding Multiple Myeloma
Multiple myeloma is a cancer of the bone and blood. This cancer education video explains the disease and its treatment.
Medical and Biotech [MESH] Definitions
Monascus
A genus in the family Monascaceae, order EUROTIALES. One species, Monascus purpureus, has multiple uses in traditional Chinese medicine (MEDICINE, CHINESE TRADITIONAL).
Crangonidae
A family of shrimp in the class CRUSTACEA, order DECAPODA, containing a single genus, Crangon, with multiple species.
Oocysts
Zygote-containing cysts of sporozoan protozoa. Further development in an oocyst produces small individual infective organisms called SPOROZOITES. Then, depending on the genus, the entire oocyst is called a sporocyst or the oocyst contains multiple sporocysts encapsulating the sporozoites.
Heterogeneous-nuclear Ribonucleoprotein K
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Electronic Mail
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
