Myelin dysfunction - Biotech, Pharma and Life Science Channel
PubMed Articles
Novel aspects of excitation-contraction coupling in heart failure.
Excitation-contraction coupling is the process by which electrical activation is translated into contraction of a cardiac myocyte and thus the heart. In heart failure, expression, phosphorylation, and...
Myocardial energetics in heart failure.
It has become common sense that the failing heart is an "engine out of fuel". However, undisputable evidence that, indeed, the failing heart is limited by insufficient ATP supply is currently lacking....
Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the...
Case Description-An 8-week-old female domestic shorthair cat was treated for patent ductus arteriosus (PDA) with surgical ligation. Seven weeks postoperatively, the cat was evaluated because of increa...
Objective-To investigate cardiovascular changes and survival times following complete interventional device occlusion of uncomplicated left-to-right shunting patent ductus arteriosus in dogs. Design-R...
Insulin resistance (IR) and pancreatic β-cell dysfunction lead to type 2 diabetes mellitus (DM). We tested whether risk factors would differ for DM that was preceded predominantly by IR, β-cell dysf...
MicroRNA-155 Confers Encephalogenic Potential to Th17 Cells by Promoting Effector Gene Expression.
Th17 cells are central to the pathogenesis of autoimmune disease, and recently specific noncoding microRNAs have been shown to regulate their development. However, it remains unclear whether microRNAs...
Dendritic cells (DCs) have been shown to play a major role in oral tolerance, and this function has been associated with their ability to produce anti-inflammatory cytokines and to induce suppressive...
Reactive oxygen species, such as hypochlorite induce oxidative stress, which impairs nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signalling and leads to vascular dysfunction. It has been p...
NO-hybridization of the HIV protease inhibitor Saquinavir generates a new chemical entity named Saq-NO, that retains the anti-viral activity and exerts lower toxicity. We show that Saq-NO inhibited th...
News Articles
[Review] Neural tube defects: recent advances, unsolved questions, and controversies
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida...
Markers of beta-cell dysfunction associated with high rate of progression to type 1 diabetes
The majority of children at risk of type 1 diabetes who developed 2 or more diabetes-related autoantibodies developed type 1 diabetes within 15 years, findings that highlight the need for research int...
Baldness drug finasteride 'cuts men's drinking'
“Anti-baldness drug can cause men to lose interest in alcohol,” reports the Mail Online. This report is based on a small survey of young men who had been taking the drug, finasteride, for hair lo...
Lung Function Dramatically Decreased By Chronic Drinking Plus Exposure To Particulate Matter
Alveolar macrophage (AM) function plays a critical role in protecting the lungs from particulate matter inhalation by removing particulates from the airway and secreting elements that facilitate airwa...
One Side Effect Of Finasteride, For Male Pattern Hair Loss, May Be Decreased Drinking
Finasteride is a synthetic drug for the treatment of male pattern hair loss (MPHL) and an enlarged prostate. The side effects of finasteride for treatment of these two conditions can include increased...
On guard: coronin proteins in innate and adaptive immunity
Coronins were first characterized on the basis of their interactions with the actin cytoskeleton and were later linked to immune dysfunction. In this short, focused Review, the authors discuss the eme...
A Beta-Secretase Inhibitor Hits the Skids in Alzheimer's
The brutal drumbeat of Alzheimer's clinical failure continues at Eli Lilly. After the Phase III failure of their gamma-secretase inhibitor semagacestat, and a delusional attempt to pretend that the an...
Newly Discovered Channel In The Heart Could Illuminate Unsolved Cases Of Arrhythmia
The heart's regular rhythm is crucial to the delivery of oxygenated blood and nutrients to all the organs of the body. It is regulated by a bundle of cells called "the pacemaker," which use electrical...
Chronic drinking and exposure to particulate matter dramatically decreases lung function
Alveolar macrophage (AM) function plays a critical role in protecting the lungs from particulate matter inhalation by removing particulates from the airway and secreting elements that facilitate airwa...
Finasteride, medication for male pattern hair loss, may also decrease drinking
Finasteride is a synthetic drug for the treatment of male pattern hair loss (MPHL) and an enlarged prostate. The side effects of finasteride for treatment of these two conditions can include increased...
Events
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Companies
From its establishment in 1977, simply as a Distributor of diagnostic products, IDS has become a globally-recognised innovator and marketeer in the IVD industry.The Company is particularly well-known...
The Myelin Repair Foundation (MRF)
The Myelin Repair Foundation (MRF) - http://www.myelinrepair.org - is a Northern California-based, non-profit research organization focused on accelerating discovery and developme...
Headquartered in Morrisville, North Carolina, TearScience® has pioneered devices that provide significant clinical improvement in the treatment of evaporative dry eye. Of the m...
Sagene Pharmaceuticals is a biopharmaceutical company developing novel applications for combinations of FDA-approved drugs to treat diseases associated with aging. Sagene h...
Accelerated Cure Project for Multiple Sclerosis
MS is a chronic demyelinating disorder of the central nervous system that often results in severe disability including the inability to walk, blindness, cognitive dysfunction, ext...
BioSante Pharmaceuticals, Inc. and ANI Pharmaceuticals, Inc.
BioSanteâs corporate strategy is to develop high value medically-needed pharmaceutical products and to implement strategic alternatives with respect to its products and its c...
BioSante Pharmaceuticals, Inc.
BioSante is a specialty pharmaceutical company focused on developing products for female sexual health and oncology. BioSanteâs lead products include LibiGel® (transdermal...
Rexahn Pharmaceuticals is a clinical stage pharmaceutical company dedicated to developing and commercializing first in class and market leading therapeutics for cancer, CNS disord...
CorMedix Inc. is a pharmaceutical company that seeks to in-license, develop and commercialize therapeutic products for the prevention and treatment of cardiac and renal dysfunctio...
Avid Radiopharmaceuticals, Inc.
Avid Radiopharmaceuticals is a leader in the development of molecular imaging products with the potential for earlier and more effective detection, diagnosis and monitoring of maj...
Clinical Trials
The overall aim is to conduct a human physiologic study to assess the renal and neurohumoral effects of CD-NP vs placebo in older subjects with stable chronic systolic heart failure and mo...
Fat Biology, Sleep Disorders, and Cardiovascular Disease
Endothelial dysfunction, or abnormal functioning of the lining of blood vessels, appears to be a key process in the development of cardiovascular disease. Endothelial dysfunction appears t...
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has...
Can Tadalafil Maintain Erectile Function In Patients Treated With Radiotherapy For Prostate Cancer?
Because of the high incidence of post-radiation erectile dysfunction (ED), up to 72% after external-beam radiotherapy, this patient category represents a most difficult therapeutic challen...
Clonidine and Left Ventricular Dysfunction
The objectives of this study are: 1. To evaluate the effect of clonidine, a sympathetic modulator, to reverse cardiac remodeling and to improve hemodynamics in diastolic heart fail...
Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-Year Manometric Follow-Up
Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. In...
The purpose of this study is to evaluate the effect of DHEA on endothelial dysfunction in patients with systemic lupus by measuring: 1. changes in brachial artery flow-mediated dilatati...
The purpose of this study is to determine if treatment using a medication (Arimidex), which lowers estrogen levels in the blood is better than placebo, a tablet that does not contain any a...
Impact of Exercise Training on Endothelial Function in CAD
Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promot...
Statin therapy has been shown to efficiently reduce mortality in patients with coronary artery disease and myocardial infarction, partially as a result of the lipid-lowering properties of...
Videos
Group 51 AM - Multiple Sclerosis
References: http://www.nationalmssociety.org/about-multiple-sclerosis/index.aspx http://www.webmd.com/multiple-sclerosis/default.htm http://www.ncbi.nlm.nih....
Medical and Biotech [MESH] Definitions
Nerve Fibers, Unmyelinated
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the unmyelinated nerve fibers are small. The axons to SCHWANN CELLS ratio is greater in the unmyelinated nerve fibers than that in the myelinated fiber (NERVE FIBERS, MYELINATED) which is 1:1. Usually several axons are surrounded by a single Schwann cell in the unmyelinated nerve fibers. Therefore, each unmyelinated fiber is not completely covered by the MYELIN SHEATH formed by the Schwann cell. Unmyelinated nerve fibers conduct impulses at low velocities. They represent the majority of peripheral sensory and autonomic fibers. They are also found in the spinal cord and brain.
Posterior Tibial Tendon Dysfunction
A condition characterized by a broad range of progressive disorders ranging from TENOSYNOVITIS to tendon rupture with or without hindfoot collapse to a fixed, rigid, FLATFOOT deformity. Pathologic changes can involve associated tendons, ligaments, joint structures of the ANKLE, hindfoot, and midfoot. Posterior tibial tendon dysfunction is the most common cause of acquired flatfoot deformity in adults.
Alexander Disease
A rare inherited disorder of myelin formation. Alexander disease is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of cytoplasmic inclusions called Rosenthal fibers. The fibers contain GLIAL FIBRILLARY ACIDIC PROTEIN in association with ALPHA-CRYSTALLIN B CHAIN. Rosenthal fibers are found predominantly in ASTROCYTES located in the subependymal, subpial, and periventricular areas of the BRAIN.
Diverticulosis, Colonic
A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.
Sphincter Of Oddi Dysfunction
Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.
