Narcolepsy - Biotech, Pharma and Life Science Channel
PubMed Articles
The cat ventral oral pontine reticular nucleus (vRPO) is responsible for the generation and maintenance of rapid eye movement (REM) sleep. Hypothalamic neurons containing the peptide hypocretin-1 (als...
Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies.
In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated question...
Pharmacotherapy options for cataplexy.
Introduction: Narcolepsy with cataplexy is a rare disabling sleep disorder characterized by two major symptoms: excessive daytime sleepiness and cataplexy characterized by a sudden bilateral loss of v...
Hypersomnia and depressive symptoms: methodological and clinical aspects.
The associations between depressive symptoms and hypersomnia are complex and often bidirectional. Of the many disorders associated with excessive sleepiness in the general population, the most frequen...
The aim of this study was to describe the clinical and PSG characteristics of narcolepsy with cataplexy and their genetic predisposition by using the retrospective patient database of the European Nar...
BACKGROUND: Modafinil (Provigil) was marketed in the UK in 1998 to promote wakefulness in the treatment of narcolepsy. In April 2004, the licence was extended to include chronic pathological condition...
BACKGROUND: Gamma-hydroxybutyric acid (GHB), well known as a party drug, especially in Europe, is also legally used (sodium oxybate, Xyrem®) to treat a rare sleep disorder, narcolepsy with cataplexy....
In August 2010 reports of a possible association between exposure to AS03 adjuvanted pandemic A(H1N1)pdm09 vaccine and occurrence of narcolepsy in children and adolescents emerged in Sweden and Finlan...
High Prevalence of Precocious Puberty and Obesity in Childhood Narcolepsy with Cataplexy.
STUDY OBJECTIVES: We analyzed the potential predictive factors for precocious puberty, observed in some cases of childhood narcolepsy with cataplexy (NC) and for obesity, a much more common feature of...
Childhood Onset Narcolepsy Cataplexy-More Than Just a Sleep Disorder.
News Articles
FDA reviewers question safety of Merck's suvorexant
FDA reviewers said insomnia candidate suvorexant from Merck & Co. Inc. (NYSE:MRK) is effective at promoting sleep, but questioned the product's safety profile as well as the pharma's proposed dosing l...
FDA staff say Merck's sleep drug effective, question dose levels
May 20 (Reuters) - *FDA STAFF REVIEWERS SAY CLINICAL TRIALS OF MERCK'S SLEEP DRUG SUVOREXANT "OVERALL, ESTABLISH EFFECTIVENESS." *FDA STAFF REVIEWERS SAY SUVOREXANT SEEMS TO BE ASSOCIATED WITH EVENTS...
Jazz Pharmaceuticals Announces Participation In Upcoming Investor Events
DUBLIN, May 13, 2013 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the company will participate in three upcoming investor events. A live audio webcast of each presentat...
Is the risk of narcolepsy also increased with non-adjuvanted flu vaccines?
In line with previous studies, Miller and colleagues find an increased risk of narcolepsy after vaccination with AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine (Pandemrix; odds ratio 16.2,......
Jazz reports 1Q13 results, slides on Xyrem generic competition concerns
Jazz Pharmaceuticals plc (NASDAQ:JAZZ) disclosed in a 10-Q late Tuesday that a modified REMS for narcolepsy drug Xyrem sodium oxybate could include new requirements that could "make it easier for futu...
Jazz Pharmaceuticals To Report First Quarter 2013 Financial Results On May 7, 2013
DUBLIN, April 23, 2013 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that it will report its first quarter 2013 financial results on Tuesday, May 7, 2013, after the clos...
Is the adjuvant solely to blame?
We read with interest Miller and colleagues findings on the association between narcolepsy and the AS03 adjuvanted pandemic A/H1N1 2009 vaccine in England and, in particular, their call for...
The adjuvant may not be solely to blame
We read with interest Miller and colleagues findings on the association between narcolepsy and the AS03 adjuvanted pandemic A/H1N1 2009 vaccine in England and, in particular, their call for...
Vaccine fear-mongering has muffled legitimate research on vaccine safety
It’s been 15 years since the former British physician Andrew Wakefield launched his now thoroughly discredited fear-mongering campaign against the measles-mumps-rubella (MMR) vaccine. His 1998 paper...
Does JAZZ Have Any Pizzazz Left?
By The Tenacious Trader: Company: Jazz Pharmaceuticals (JAZZ) is a mid-cap biopharmaceutical company that has a small portfolio of drugs used to treat a range of disorders. JAZZ markets its products...
Events
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Companies
Jazz Pharmaceuticals plc and Concert Pharmaceuticals, Inc.
Jazz Pharmaceuticals plc is a specialty biopharmaceutical company focused on improving patients' lives by identifying, developing and commercializing innovative products that a...
Clinical Trials
Modafinil in Multiple Sclerosis
Deficits in new learning and memory in MS are a major complaint of patients, and have been noted to be a significant contributor to disability by numerous researchers. Modafinil is a psych...
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine abuse and dependence have for some time been significant issues in other parts of the world, including several southeast Asian countries, and have now become one of the mos...
The primary objective of the study is to evaluate the safety and tolerability of treatment with PROVIGIL in children and adolescents with excessive sleepiness (ES) associated with narcolep...
The primary objective of the study is to evaluate the safety and tolerability of treatment with PROVIGIL in children and adolescents with excessive sleepiness (ES) associated with narcolep...
The primary objective of this study is to evaluate the safety and tolerability of Armodafinil (CEP-10953) administered on a flexible-dosage regimen of 100 to 250 mg/day for up to 12 months...
This study will be conducted as a randomized, double blind, double-dummy, placebo-controlled, parallel-group trial in patients diagnosed with narcolepsy. Volunteers for this trial will be...
The initial portion of the protocol involves discontinuing any medications for cataplexy that the patient may be taking. Subsequently, the patient is prescribed a dose of oral solution of...
15 patients with narcolepsy and 15 healthy controls will be included in the study. According to a randomized, double-blind protocol they will receive intranasally at night first Orexine A...
A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsy
The purpose of this study is to evaluate the safety and effectiveness of JNJ-17216498 compared to modafinil and placebo in patients with narcolepsy, with and without cataplexy.
Methylphenidate and Parkinson's Disease
The purpose of this trial is to determine if methylphenidate (MPD), a drug marketed in the U.S. to treat hyperactivity and narcolepsy, added to levodopa, will increase the beneficial effec...
Videos
Channel 5TV: My Day Out with narcolepsy Part 1
Channel 5TV: Follow me on a day out while fighting narcolepsy and cataplexy.
Medical and Biotech [MESH] Definitions
Hla-b7 Antigen
Human histocompatibility (HLA) surface antigen encoded by the B locus on chromosome 6. There is a weak association between the presence of the HLA-B7 antigen and the diseases of narcolepsy and idiopathic hemochromatosis. HLA-B7 is in linkage disequilibrium with HLA-A3 and HLA-DR2.
Hla-dr2 Antigen
Human immune-response, D-related antigen encoded by the D locus on chromosome 6 and found on lymphoid cells. It is in linkage disequilibrium with HLA-A3 and HLA-B7 and is strongly associated with Goodpasture syndrome, multiple sclerosis, and narcolepsy.
Hypersomnolence, Idiopathic
A sleep disorder of central nervous system origin characterized by prolonged nocturnal sleep and periods of daytime drowsiness. Affected individuals experience difficulty with awakening in the morning and may have associated sleep drunkenness, automatic behaviors, and memory disturbances. This condition differs from narcolepsy in that daytime sleep periods are longer, there is no association with CATAPLEXY, and the multiple sleep latency onset test does not record sleep-onset rapid eye movement sleep. (From Chokroverty, Sleep Disorders Medicine, 1994, pp319-20; Psychiatry Clin Neurosci 1998 Apr:52(2):125-129)
Sleep Paralysis
A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)
Cataplexy
A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396)
