Neoadjuvant therapy - Biotech, Pharma and Life Science Channel
Neoadjuvant therapy is the administration of therapeutic agents before the main treatment. One example is neoadjuvant hormone therapy prior to radical radiotherapy for adenocarcinoma of the prostate. The aim of neoadjuvant therapy is to reduce the size or extent of the cancer before using radical treatment intervention, thus making procedures easier and more likely to succeed, and reducing the consequences of a more extensive treatment technique that would be required if the tumor wasn't reduced in size or extent.
This systemic therapy (chemotherapy, immunotherapy or hormone therapy) or radiation therapy is commonly used in cancers that are locally advanced - where an operation is technically planned at a later stage. The use of such therapy can effectively reduce the difficulty and morbidity of more extensive procedures.
The use of therapy is to turn the tumour from untreatable to treatable by shrinking the volume down. Often it can be unclear which surrounding structures are directly involved in the disease and which are just showing signs of inflammation. By administering therapy a distinction can often be made. Some doctors give the therapy in the hope that a response will be seen so that they can then decide what is the best course of action. Unfortunately, not everyone is suitable for therapy in this way because it can be extremely toxic. In some cases, reactions are so severe that further treatments, especially surgery, are precluded because the patient is rendered unfit for anesthetic.
Common tumors that use this concept:
* Breast Cancer
* Colorectal cancer
* Lung cancer
* Esophageal cancer
Source: Wikapedia
PubMed Articles
Major aims of the 5th Central and Eastern Europe (CEE) Summit on Osteoporosis held in Bratislava, Slovakia, on 2 and 3 December 2011, were to provide participants with state-of-the-art knowledge in th...
The aim of this study was to interrogate whether blood-borne inflammatory and nutritional markers predict long-term survival and response to neoadjuvant chemotherapy in radically treated oesophagogast...
Differentiated thyroid carcinoma is rare in patients younger than 21Â years, especially in children, but it is associated with a greater risk of metastases and recurrence. The aim of our study was to...
This retrospective data analysis examined the outcome of 99 acute lymphoblastic leukemia (ALL) patients treated at Tawam Hospital between January 2000 and December 2009. Sixteen patients were treated...
Clinical implications of CIP2A protein expression in breast cancer.
The aim of this work is to study the expression and regulatory effects of CIP2A protein in breast cancer and the correlation between CIP2A protein expression and the prognosis of breast cancer. The CI...
Recently, novel molecular targeted agents markedly changed the treatment of renal cell carcinoma (RCC), with promising results. However, there is little understanding of how these agents affect immune...
Microdosimetry is a recommended method for characterizing radiation quality in situations when the biological effectiveness under test is not well known. In such situations, the radiation beams are de...
This study sought to evaluate whether prasugrel may serve as an alternative to clopidogrel in patients with triple therapy.
Triple antithrombotic therapy with prasugrel in the stented patient: concern for more bleeding.
Optimal control oriented to therapy for a free-boundary tumor growth model.
This paper is devoted to present and solve some optimal control problems, oriented to therapy, for a particular model of tumor growth. In the considered systems, the state is given by one or several f...
News Articles
Cold Snare Best Polyp Remover if Blood Thinners Involved (CME/CE)
ORLANDO (MedPage Today) -- Cold snare polypectomy outperformed conventional polypectomy for the removal of small colon polyps in patients on anticoagulation therapy, researchers reported here.
CoreValve Found Cost-Effective for TAVI (CME/CE)
PARIS (MedPage Today) -- Transcatheter aortic valve implantation using Medtronic's CoreValve is cost-effective compared with medical therapy for patients with severe aortic stenosis, researchers found...
New results from the National Health and Wellness Survey show patients with type 1 diabetes have significantly lower HbA1C levels. New York, NY (PRWEB) May 22, 2013 Patients with type 1 diabetes (T1D...
Mari's to Offer New Treatment from Europe
Mari's Skin Care is the first to offer Meta Therapy in the state of Texas. Dallas, TX (PRWEB) May 22, 2013 Mari’s Skin Care, a peaceful sanctuary for skin rejuvenation and nourishment in Dallas...
Prevalence of Phenotypic Silver Resistance in Clinical Isolates
Is silver's antimicrobial reputation as a wound therapy starting to tarnish -- due to resistant organisms? Wounds
Photodynamic Therapy vs Laser for Port-Wine Stains
Could vascular-targeted photodynamic therapy be an effective alternative to pulsed-dyed laser for the treatment of port-wine stain birthmarks? The British Journal of Dermatology
New Summer Group Programs for Kids Announced by Mental Health Practice - In Step
Three programs geared to help children improve their social skills while having fun are being offered by In Step this summer in Northern Virginia. Fairfax, VA (PRWEB) May 22, 2013 In Step, one of the...
Asymptomatic Carotid Stenosis: Medical Therapy Best Option
Most adults with asymptomatic carotid stenosis are likely to benefit from best medical therapy alone, a new review concludes, but more data are needed on interventional approaches. Medscape Medical...
Guest blog: Assessing the uptake and impact of the Cell Therapy Catapult Centre
CCRM and Cell Therapy Catapult Sponsored Drinks Reception VIEW SLIDE SHOW DOWNLOAD ALL Cell Therapy Catapult: a global leader in bridging the translational gap of [...]
MindStart Offers New Resource for Incorporating Horticulture Therapy into Dementia Care
Horticulture therapy can provide meaningful and stimulating activities for people receiving dementia care. MindStart announces the release of a new product, A Calendar Year of Horticulture Therapy boo...
Events
The 12th annual Evolution Summit is a premium forum bringing together leaders in biopharmaceutical clinical operations with the most renowned CROs and solution providers.
Stem Cells & Cell Therapy Summit
Select Biosciences' Stem Cells & Cell Therapy Summit is focused on providing an up-to-date expansive view of the current marketplace
3rd World Congress on Cancer Science & Therapy
3rd world congress on Cancer Science & Therapy serves as a reunion land for scientists in the area of cancer research.
Companies
THE Surgical Hospital of Phoenix
THE Surgical Hospital of Phoenix, the first licensed surgical specialty facility of its kind in Arizona, first opened its doors in May of 2005. Specializing in spine, orthopedics,...
TRANSGENE is a leading integrated gene therapy company, dedicated to the discovery and development of gene delivery technologies and gene therapy products for the treatment of acquired and inherited d...
Acorda Therapeutics, Inc. was established in March 1995 to develop therapeutic products for spinal cord injury ("SCI") and other central nervous system disorders. Acorda is focusing its initial develo...
KineMed, Inc. ("KineMed" or the "Company") is a drug discovery and development company employing its proprietary translational medicine technology (AquaTag™ and KineMarkerâÂ...
From its establishment in 1977, simply as a Distributor of diagnostic products, IDS has become a globally-recognised innovator and marketeer in the IVD industry.The Company is particularly well-known...
Defymed is a spin -off of the “Centre Europeen d’etude du Diabete” (CeeD) which has been working on the conception of a bio-artificial pancreas since 1996. This work was ca...
Devon Medical, Inc. (www.devonmedicalproducts.com) is an ISO 13485 certified medical device manufacturer, designer, and distributor. Since 2005, we have developed innovative and h...
LDM Group is comprised of seasoned leaders with proven track records in consumer based communication and measurement. Our physician based patient messaging system (ScriptGuide®...
Founded in 1990, U.S. Physical Therapy, Inc. (NASDAQ:USPH) operates 369 clinics in 43 states. The Company's clinics provide preventative and post-operative care for a variety of o...
Onconova, based in Newtown, PA and Lawrenceville, NJ, discovers and develops novel patent- protected small molecule therapeutic agents for cancer, radiation protection and hematol...
Clinical Trials
This is a randomized, double-blind, placebo-controlled, parallel-group, multi-national study alirocumab (REGN727/ SAR236553) in patients with Heterozygous Familial Hypercholesterolemia (he...
Music Therapy in Methodist Homes: a Study Investigating the Impact of a Music Therapy Programme
The study is a cluster randomised control trial, which aims to investigate the effectiveness of music therapy in minimising Behavioural and Psychological Symptoms of Dementia (BPSD) in old...
Physical Activity and Cognitive Behavioural Therapy in Panic Disorder
Physical activity (treadmill) supports the effect of cognitive behavioural therapy in patients with panic disorder with/without agoraphobia
Family-Based Drug Services for Young Disaster Victims
This protocol seizes this rare scientific opportunity to test an integrative family based model to address youths' coexisting substance abuse and trauma in the wake of Hurricane Katrina. T...
Neoadjuvant Axitinib in Prostate Cancer
The goal of this clinical research study is learn if adding axitinib to hormonal therapy can help to control prostate cancer when given before surgery. The safety of this drug will also be...
Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Psychological therapies for depression have demonstrated efficacy, but outcomes are still unsatisfactory, especially in cases with high comorbidity. Depression and anxiety co-occur in up t...
RATIONALE: Drugs used in chemotherapy, such as 5-fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing and a...
Neurosurgical Use of Interstitial Laser Therapy (ILT)
The researchers' specific aims are to test the following hypotheses: Hypothesis 1: A tumor can be completely ablated by ILT with MRI-guidance. Hypothesis 2: The MRI-based 3D temperature...
Randomized clinical study of two CAM therapies, 1) Reiki and 2) Relaxation Response Therapy with Cognitive Restructuring counseling (RRT with CR), compared to an education-only control arm...
Extension Neoadjuvant Taxotere: Study of the Effects of Taxotere in Patients With Breast Cancer
We, the investigators at Baylor Breast Care Cancer, are doing this study to learn how well Taxotere makes tumors become smaller. We are also doing this study to find out how well Taxotere...
Videos
What Is Neoadjuvant Therapy? - Dr. David Margileth, BreastCancerAnswers.com
Click Here & Get The 15 Breast Cancer Questions To Ask Your Doctor http://www.breastcanceranswers.com/what-breast-cancer-questions-to-ask/# The question abou...
Medical and Biotech [MESH] Definitions
Photobleaching
Light-induced change in a chromophore, resulting in the loss of its absorption of light of a particular wave length. The photon energy causes a conformational change in the photoreceptor proteins affecting PHOTOTRANSDUCTION. This occurs naturally in the retina (ADAPTATION, OCULAR) on long exposure to bright light. Photobleaching presents problems when occurring in PHOTODYNAMIC THERAPY, and in FLUORESCENCE MICROSCOPY. On the other hand, this phenomenon is exploited in the technique, FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING, allowing measurement of the movements of proteins and LIPIDS in the CELL MEMBRANE.
Hiv-associated Lipodystrophy Syndrome
Defective metabolism leading to fat maldistribution in patients infected with HIV. The etiology appears to be multifactorial and probably involves some combination of infection-induced alterations in metabolism, direct effects of antiretroviral therapy, and patient-related factors.
Nutrition Therapy
Improving health status of an individual by adjusting the quantities, qualities, and methods of nutrient intake.
Continuous Positive Airway Pressure
A technique of respiratory therapy, in either spontaneously breathing or mechanically ventilated patients, in which airway pressure is maintained above atmospheric pressure throughout the respiratory cycle by pressurization of the ventilatory circuit. (On-Line Medical Dictionary [Internet]. Newcastle upon Tyne(UK): The University Dept. of Medical Oncology: The CancerWEB Project; c1997-2003 [cited 2003 Apr 17]. Available from: http://cancerweb.ncl.ac.uk/omd/)
Microbubbles
Very small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content, etc. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.
