Neuromuscular blockade - Biotech, Pharma and Life Science Channel
PubMed Articles
Long-term potentiation (LTP) is accompanied by increased spine density and dimensions triggered by signaling cascades involving activation of the neurotrophin brain-derived neurotrophic factor (BDNF)...
An ultrasound needle insertion guide in a porcine phantom model.
We compared nerve blockade with and without the Infiniti(TM) needle guide in an ultrasound in-plane porcine simulation. We recruited 30 anaesthetists with varying blockade experience. Using the guide,...
Since the initial description in 2010 of anoctamin 5 deficiency as a cause of muscular dystrophy, a handful of papers have described this disease in cases of mixed populations. We report the first lar...
Cancer immunotherapies, their safety and toxicity.
Introduction: Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system. Some immunotherapies broadly activate the immune system wh...
The energy and work of a ligand-gated ion channel.
Ligand-gated ion channels are allosteric membrane proteins that isomerize between C(losed) and O(pen) conformations. A difference in affinity for ligands in the two states influences the C↔O "gating...
PURPOSE We previously reported the eradication of human epidermal growth factor receptor 2 (HER2)- amplified human xenografts in mice by inhibition of the HER2 pathway with lapatinib and trastuzumab t...
The main aim was to analyse the impact of an official match on hormonal and redox status, muscle damage and inflammation and neuromuscular function. Seven high-level male soccer players from the same...
The peroneal reaction time (PRT) is used in the assessment of neuromuscular deficits in chronic functional ankle instability. Powered by the Editorial Manager® and Preprint Manager® from Aries Syste...
News Articles
MDA Hosts Annual Charlotte Muscle Team Event
Top athletes, local heroes and business leaders come together for fundraiser. CHARLOTTE, N.C., (PRWEB) May 17, 2013 Charlotte’s top professional athletes and local heroes are set to share the spotl...
The Detroit Institute for Children Needs Your Vote To Win $25,000
The Organization is Competing in Art Van Furniture’s Third Annual Million Dollar Charity Challenge Bonus Challenge The Detroit Institute for Children (DIC) needs your help...
Sofia University Hosts James Fadiman, Ph.D. “Psychedelic Experience: Healing, Growth and Discovery”
Brad Burge, Communications Director for the Multidisciplinary Association for Psychedelic Studies (MAPS), served as interviewer at the event. Palo Alto, CA (PRWEB) May 17, 2013 Sofia University (form...
Another New Immune Therapy Effective in Multiple Cancers
Immune checkpoint blockade is one of the hottest treatment concepts in cancer, and first-ever data on a new agent have been unveiled. Medscape Medical News
Neuropathy Diagnosis Obstacles Damaging to Patients' Health
For National Neuropathy Awareness Week (May 13-17), The Neuropathy Association and the Hereditary Neuropathy Foundation Call Attention to the Diagnostic Challenges Hurting Millions of Neuropathy Patie...
Cytokinetics to Hold Annual Meeting of Stockholders
South San Francisco, CA., May 15, 2013 - Cytokinetics, Incorporated (Nasdaq: CYTK) announced today that its Annual Meeting of Stockholders will be held on Tuesday, May 22, 2013 at 1:30 PM Pacific Ti...
ecancer reporter Peter Goodwin talks to Dr Yanina Dockx at the 2013 IMPAKT meeting in Brussels. Aberrant activation of the PI3K-Akt-mTOR pathway is an important driver of resistance to HER2 targeted...
FDA to discuss Merck's sugammadex
FDA's Anesthetic and Analgesic Drug Products Advisory Committee will meet on July 18 to discuss a resubmitted NDA from Merck & Co. Inc. (NYSE:MRK) for sugammadex for the reversal of neuromuscular bloc...
Questcor Pharmaceuticals to Present at Bank of America Merrill Lynch 2013 Healthcare Conference
ANAHEIM, Calif., May 8, 2013 /PRNewswire/ -- Questcor Pharmaceuticals, Inc. (NASDAQ: QCOR) announced today that executive management will present at the Bank of America Merrill Lynch 2013 Healthc...
Events
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Companies
Tivorsan Pharmaceuticals http://www.tivorsan.com is a protein therapeutics company pioneering a unique approach to treating serious neuromuscular disorders, including DMD and Beck...
Based in Woburn, Mass., Convergence Medical Devices, Inc. is an early-stage medical device company dedicated to supporting early, effective care for neuromuscular disease through...
Blockade Medical is a privately held medical device company focused on expanding the endovascular management of hemorrhagic stroke and related disease of the neurovascular system....
iWorx advanced research solutions include high performance recording hardware, software, and components that accelerate metabolic, cardiovascular, neuromuscular and respiratory ph...
Tibion is a privately held company located at NASA Research Park, Moffett Field, California. The companyâs mission is to develop smart medical devices and therapies that addr...
Based in Kingston, MA the Jett Foundation is a non-profit organization dedicated to increasing worldwide awareness of Duchenne Muscular Dystrophy with the purpose of raising and a...
Tivorsan Pharmaceuticals, Inc.
Tivorsan Pharmaceuticals, Inc. is a protein therapeutics company pioneering a unique approach to treating serious neuromuscular disorders, including DMD and Becker Muscular...
AVEO Oncology & Astellas Pharma Inc.
In February 2011, AVEO and Astellas entered into a worldwide agreement to develop and commercialize tivozanib outside of Asia for the treatment of a broad range of cancers. Tivoza...
Prosensa is an innovative Dutch biopharmaceutical company focused on the discovery, development and commercialization of RNA modulating therapeutics correcting gene expression in...
Tau Therapeutics is a clinical stage company developing oncology drugs for solid tumors that selectively inhibit the T-type calcium channel â a novel mechanism of action for...
Clinical Trials
The investigators hypothesize that a calcineurin inhibitor-free, steroid-free, co-stimulatory blockade-based immunosuppressive regimen, in combination with a GLP-1 agonist, will reduce the...
USG Nerve Blocks for ACL Reconstruction
Anterior cruciate ligament reconstruction is a routine surgical procedure. Traditional femoral/sciatic block combinations effectively reduce postoperative pain, but results in considerable...
Surgical trauma causes nerve sensitization leading to amplification and prolongation of postoperative pain. In experimental studies, pre-injury neural blockade using local anesthetics has...
Intravenous Immune Globulin to Treat Hereditary Inclusion Body Myopathy
This study will evaluate patients with Hereditary Inclusion Body Myopathy (HIBM) and examine the effects of immune globulin (IG) treatment on muscle and muscle function. HIBM is a progress...
Botox as a Treatment for Chronic Male Pelvic Pain Syndrome
Chronic pelvic pain syndrome (CPPS) is thought to affect approximately 8% of men aged 18 and older. Patients with this condition experience pain in the perineum, the genitalia, and the rec...
Botox as a Treatment for Interstitial Cystitis in Women
Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pel...
Kallikrein-Kinin (KKS) and Renin-Angiotensin-Aldosterone System (RAAS) in Primary Aldosteronism
The tissue kallikrein-kinin (KKS) and renin-angiotension-aldosterone system (RAAS) had been implicated in regulating blood pressure and electrolyte homeostasis. Both of the KKS and RAAS ma...
Sarpogrelate is an antiplatelet agent that decreases 5-hydroxytryptamine( 5-HT )levels in platelets via blockade of 5-HT2 receptors, has been used in atherosclerotic peripheral arterial di...
Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer
Radiotherapy (RT) with concurrent chemotherapy represents the state of the art in curative intent treatment for locally advanced squamous carcinoma of the head and neck. Tumor hypoxia and...
The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is in...
Videos
Neuromuscular block (1956), pt 1 of 2
An unconventional and delightful presentation by means of animated diagrams, actual experiments and stop-frame animated cartoon characters of the theory and ...
Medical and Biotech [MESH] Definitions
Channelopathies
A variety of neuromuscular conditions resulting from MUTATIONS in ION CHANNELS manifesting as episodes of EPILEPSY; HEADACHE DISORDERS; and DYSKINESIAS.
Polymyxins
Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter.
Pralidoxime Compounds
Various salts of a quaternary ammonium oxime that reconstitute inactivated acetylcholinesterase, especially at the neuromuscular junction, and may cause neuromuscular blockade. They are used as antidotes to organophosphorus poisoning as chlorides, iodides, methanesulfonates (mesylates), or other salts.
Propantheline
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Pyrantel
A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
