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Nonproliferative retinopathy - Biotech, Pharma and Life Science Channel

19:05 EDT 22nd July 2014 | BioPortfolio

PubMed Articles [298 Associated PubMed Articles listed on BioPortfolio]

Genetics of Diabetic Retinopathy.

Diabetic retinopathy (DR) is a polygenic disorder. Twin studies and familial aggregation studies have documented clear familial clustering. Heritability has been estimated to be as high as 27 % for a...

Development of an Experimental Model of Proliferative Retinopathy by Intravitreal Injection of VEGF165.

Abstract Purpose: To develop an experimental model of proliferative retinopathy by intravitreal injection of vascular endothelial growth factor 165 (VEGF165) in pigmented rabbits. Methods: A prospecti...

Pharmacokinetics and local safety profile of propranolol eye drops in rabbits.

Background.Oral propranolol, a non-selective ß-blocker, is able to reduce the progression of retinopathy of prematurity in newborns, but it appeared unsafe. This study aimed to find, in rabbits, a pr...

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases.

Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma, diabetic retinopathy and retinitis pigmentosa each have a different etiology and pathogenesis. However, at the cellu...

Preliminary Anatomical and Neurodevelopmental Outcomes of Intravitreal Bevacizumab As Adjunctive Treatment for Retinopathy of Prematurity.

Abstract Purpose: To evaluate the two-year follow-up of patients with type 1 retinopathy of prematurity (ROP) who received intravitreal bevacizumab (IVB) as adjunctive treatment. Materials and methods...

Notch signaling functions in retinal pericyte survival.

Purpose: Pericytes, the vascular cells that constitute the outer layer of capillaries, have been shown to play a crucial role in vascular development and stability. Loss of pericytes precedes endothel...

Elevated Soluble VEGF Receptor sFlt-1 Correlates with Endothelial Injury in IgA Nephropathy.

Endothelial injury, which may present clinically as hypertension, proteinuria and increased von Willebrand Factor (vWF) level, is a common manifestation in IgA nephropathy (IgAN). However, causal fact...

Clock genes and behavioral responses to light are altered in a mouse model of diabetic retinopathy.

There is increasing evidence that melanopsin-expressing ganglion cells (ipRGCs) are altered in retinal pathologies. Using a streptozotocin-induced (STZ) model of diabetes, we investigated the impact o...

SURGICAL OUTCOMES OF FLORID DIABETIC RETINOPATHY TREATED WITH ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR.

To evaluate the effectiveness of vitreoretinal surgery combined with antivascular endothelial growth factor therapy to treat florid diabetic retinopathy, a rare and severe form of diabetic retinopathy...

Epigenetic modifications of Nrf2-mediated glutamate cysteine ligase: Implications in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression.

Diabetes increases oxidative stress in the retina and decreases the levels of intracellular antioxidant, GSH. Transcriptional factor Nrf2 regulates the expression of Gclc, the enzyme important in the...

News Articles [118 Associated News Articles listed on BioPortfolio]

Doxycycline: Double Duty in Eye Disease?

It already helps to treat meibomian gland dysfunction -- could doxycycline be useful in diabetic retinopathy as well? Medscape Optometry

South Nassau Communities Hospital Appoints Site Director of Ophthalmology Residency Program

Oceanside, NY, July 17, 2014 --(PR.com)-- South Nassau Communities Hospital’s chief of ophthalmology, Richard Nauheim, MD, has been appointed site director at South Nassau for ophthalmology res...

Retina Group of New York Now Offers Long-lasting Ozurdex® Treatment for Diabetic Retinopathy

The Retina Group of New York (RGONY), with offices in Hicksville and Hauppauge, NY, has announced the availability of Ozurdex® (dexamethasone intravitreal implant) as a long-lasting treatment for...

Veteran Retina Specialist, Ernest D. Kovarik, MD, FACS, Recruited to Join The Leading Physicians of the World

The International Association of HealthCare Professionals has carefully selected Ernest D. Kovarik, MD, FACS, to represent ophthalmology in their publication, The Leading Physicians of the World.  Dr...

EU IMI 2 program calls for diabetes, AMD proposals

The EU's Innovative Medicines Initiative (IMI) 2 launched its first call for proposals with EUR 49 million ($66.9 million) allocated for diabetic retinopathy and dry age-related macular degeneration (...

Doxycycline Fails to Slow Diabetic Retinopathy Progression

Doxycycline does not appear to improve retinal function or slow diabetic retinopathy progression in patients with mild to moderate nonproliferative diabetic retinopathy (NPDR), according to results fr...

Ischemic diabetic retinopathy as a possible prognostic factor for chronic kidney disease progression

Ischemic diabetic retinopathy as a possible prognostic factor for chronic kidney disease progression Eye advance online publication, July 4 2014. doi:10.1038/eye.2014.130 Authors: W J Lee,...

Retinopathy of Prematurity: Telemedicine Screening Promising

Telemedicine screening for retinopathy of prematurity is valid when done by trained nonphysicians, according to a new study. Medscape Medical News

No Change in Retinopathy in Diabetes 2 Years After Surgery

Two years after diabetic patients undergo bariatric surgery, diabetic retinopathy has neither worsened nor improved, data from STAMPEDE show. Regular eye exams are still important, investigators s...

Study validates telemedicine approach to ROP screening

Trained non-physician evaluators who studied retinal images transmitted to computer screens at a remote central reading center successfully identified newborn infants likely to require a specialized m...

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Companies [6 Associated Companies listed on BioPortfolio]

Acucela Inc.

Acucela Inc. is a clinical-stage biotechnology company focused on leveraging promising science in visual cycle modulation (VCM) to develop new methods for treating blinding eye di...

Promedior, Inc.

Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...

Acucela

Acucela Inc. (www.acucela.com) is a clinical-stage biotechnology company focused on leveraging promising science in visual cycle modulation (VCM) to develop new methods for...

NormOxys, Inc.

NormOxys is developing a novel class of small molecule drugs, oxyrens, which enhance the body’s ability to deliver oxygen more efficiently to diseased tissues with oxygen def...

Allegro Ophthalmics, LLC

With more than 100 years of combined experience in vision science and medicine, the leadership team at Allegro Ophthalmics, LLC is establishing Integrin Peptide Therapy as the...

Optos plc

Optos plc is a leading medical retinal imaging technology company. Both eye and non-eye diseases often first exhibit in the periphery of the retina. These are very difficult to de...

Clinical Trials [166 Associated Clinical Trials listed on BioPortfolio]

Near Infrared Photobiomodulation Treatment for Diabetic Macular Oedema

This pilot study aims to establish that treatment with near infrared light (NIR) reduces diabetic macular oedema in patients suffering diabetic retinopathy by exerting a positive beneficia...

Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema

The purpose of the study is to find out which is a better treatment for diabetic macular edema (DME): laser alone, laser combined with an intravitreal injection of triamcinolone, laser co...

The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT)

Noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneratio...

Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Diabetic Vitreous Hemorrhage

Postoperative vitreous hemorrhage is a common complication after vitrectomy for proliferative diabetic retinopathy. There have been efforts to lower the incidence of postoperative vitreous...

Prevalence of Diabetic Retinopathy in São José do Rio Preto-SP-Brazil

Prevalence of Diabetic Retinopathy in São José do Rio Preto-SP-Brazil Abstract Objective: To determine the prevalence and characteristics of diabetic retinopathy (DR) among patie...

Canthaxanthin Retinopathy: A Long-term Observation

Canthaxanthine is a naturally occurring carotenoid that has been a popular over-the-counter oral artificial tanning agent in Europe, Canada, and Australia since 1979. It is also used at lo...

Spectralis HRA+OCT Imaging of the Retina With Autofluorescence in Sickle Cell Disease

To determine the retinal and choroidal thickness in patients with sickle cell disease compared to age, race matched population without sickle cell disease to allow a better understanding o...

The Vascular Effects of Vildagliptin in Insulin Resistant Individuals

Animal models have demonstrated that incretins have a glucose-independent effect on vascular perfusion, and there is limited evidence that incretins may enhance endothelial function in hea...

Severe Proliferative Diabetic Retinopathy

The purpose of this study is to examine and compare, prospectively, best corrected visual acuity (BCVA) outcomes and complications of a cohort of patients with Proliferative Diabetic Retin...

Panretinal Photocoagulation (PRP) Plus Ranibizumab for Proliferative Diabetic Retinopathy

The purpose of this study is to evaluate the effects of panretinal photocoagulation plus intravitreal ranibizumab for the treatment of patients with high risk proliferative diabetic retino...

Medical and Biotech [MESH] Definitions

A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)

Degenerative changes to the RETINA due to HYPERTENSION.

A drug used to reduce hemorrhage in diabetic retinopathy.

Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.

Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.

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