Notch Pathway Inhibitors DLL4 - Biotech, Pharma and Life Science Channel
The Notch signaling pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes in an ever-increasing number of cancers. Notch signaling is also thought to be important for the maintenance of cancer stem cell populations in tumors. Cancer stem cells may cause tumor metastasis and relapse following anti-tumor treatments by regenerating the tumor tissue. Eradication of cancer stem cells may lead to increased survival in cancer patients.
First generation Notch inhibitors have entered clinical testing. Use of gamma secretase inhibitors may be associated with gastro-intestinal on-target side effects such as diarrhea. Targeting the vascular ligand of Notch (delta-like ligand 4, DLL4) by antibodies may offer tremendous promise as novel anti-tumor agents. At present, five different constructs targeting Notch - DLL4 are in early clinical development.
News Articles
Impact Analytical Opens New State-of-the-Art Laboratory Facility
Impact Analytical, a full-service, contract analytical testing laboratory that serves the pharmaceutical, plastics, consumer products, medical device, packaging, automotive...
Thousands Of Free Dental Procedures Provided To Needy Patients At Mission Of Mercy In Bemidji
MINNEAPOLIS, June 19, 2013 /PRNewswire-USNewswire/ -- The Minnesota Dental Association and the Minnesota Dental Foundation hosted its Minnesota Mission of Mercy on June 14 and 15 in Bemidji, prov...
eTECH RESOURCES Continues to Expand: Donna Goles Joins Firm as Senior Account Executive
Sacramento-based technology focused staffing firm expands its recruiting team as growth continues eTECH RESOURCES, a leading IT recruitment and staffing company based i...
Swimsuit Season Inspires Dogs to Hit the Treadmill at Pooch Hotel's Summer Get Fit Camp
SAN DIEGO, June 18, 2013 /PRNewswire/ -- As swimsuit season approaches, fitness routines are being taken up a notch and dogs are getting in on the action too with Pooch Hotel's Summer Get Fit Cam...
SEATTLE, June 17, 2013 /PRNewswire/ -- Cell Therapeutics, Inc. (CTI) (NASDAQ and MTA: CTIC) today announced results from a pooled analysis of data from completed Phase 1 and 2 studies of pacriti...
Pathway Innovations and Technologies, Inc. Officially Releases the HoverCam Air Station
SAN DIEGO, June 17, 2013 (GLOBE NEWSWIRE) -- Wirelessly accessing a HoverCam document camera is now possible with Air Station I from Pathway Innovations and Technology, Inc. The Air Station I makes t...
Pathway Genomics announces it will begin offering a BRCA test for breast cancer at a price substantially below the competition Pathway Genomics led the evenin...
Enanta Pharmaceuticals to Present at the Wells Fargo Securities 2013 Healthcare Conference
Enanta Pharmaceuticals, Inc., (NASDAQ: ENTA), a research and development-focused biotechnology company dedicated to creating small molecule drugs in the infectious disease field,...
The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) has concluded that the effects of the painkiller diclofenac on the heart and circulation when given systemically (b...
Pathway Genomics, a genetic testing laboratory on the forefront of bringing physicians a broad genetic testing portfolio covering a wide range of diseases, announces the pending l...
Events
Diabetes: Secondary Complications, Regulation and Innovation Conference
SMi is very proud to present our 11th conference focusing on Diabetes and metabolic disorders taking place on 1st and 2nd Oct 2013, London.
Companies
Verdezyne is an industrial biotechnology company using proven and proprietary metabolic pathway engineering tools to create unique yeast strains for cost-effective production of b...
Citibabes (www.citibabes.com) is the leading family lifestyle brand offering best-in-class education, amenities, information, and family membership clubs in SoHo and Scarsdale, NY. Their goal is to b...
Located in San Diego, California, Pathway Genomics owns and operates an onsite federally CLIA (Clinical Laboratory Improvement Amendments) certified and California state-licensed...
The Angeles Clinic and Research Institute
âThe Angeles Clinic and Research Instituteâs mission is to advance cancer care through groundbreaking research and delivering innovative therapeutic options to al...
DOV is a biopharmaceutical company historically focused on the development of novel product candidates for disorders of the central nervous system. DOV has previously funded drug development and disco...
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat deb...
Onconova, based in Newtown, PA and Lawrenceville, NJ, discovers and develops novel patent- protected small molecule therapeutic agents for cancer, radiation protection and hematol...
Enanta Phatmaceuticals ARE A RESEARCH AND DEVELOPMENT-FOCUSED BIOTECHNOLOGY COMPANY that uses its robust chemistry-driven approach and drug discovery capabilities to create small molecule drugs in t...
HemoShear LLC is a biotechnology research company that combines its scientific expertise with its unique technology in partnership with pharmaceutical companies to accelerate drug...
NeurAxon, Inc. (www.neuraxon.com) discovers and develops next-generation pain therapeutics focused on its first-in-class selective inhibitors of neuronal nitric oxide synthase...
Clinical Trials
The purpose of this research study is to: 1) Determine the highest dose of the drug vorinostat that can be given safely in combination with carboplatin and gemcitabine and 2) determine how...
Pilot Trial to Assess Effect of CNI Conversion of Efalizumab on T Reg Cells
The purpose of this pilot trial is to determine whether a conversion from calcineurin inhibitors (CNI) and mycophenolate mofetil (MMF) to a regimen consisting of efalizumab and sirolimus i...
89Zr-trastuzumab PET for Imaging the Effect of HSP90 Inhibition
HSP90 inhibition is a potentially new targeted drug modality in the treatment of HER2 positive, trastuzumab refractory breast cancer. Little is known about the pharmacodynamics of HSP90 in...
RATIONALE: Aromatase inhibitors, such as letrozole, prevent the formation of estradiol, a female hormone. Giving letrozole together with goserelin, leuprolide, or surgery may be an effecti...
Impact of Hot Flashes on Sleep and Mood Disturbance
We plan to enroll 60 healthy, non-pregnant premenopausal women age 18-45 who do not have hot flashes (in order to have 30 women complete all study procedures) in a trial investigating the...
Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer
Imatinib mesylate is an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular...
A Study Of Nasopharyngeal Carcinoma (NPC) Treated With Celecoxib And ZD1839
EGFR and COX-2 are involved in tumorigenesis, angiogenesis and metastases and are frequently over expressed in NPC.COX-2 and EGFR inhibitors are active in NPC.There is synergistic action b...
The Effects of Anabolic Steroids and Protease Inhibitors on People Living With HIV/AIDS
The main aim of the study is to investigate the combined effects of using anabolic steroids and protease inhibitors on fat metabolism and body composition of People Living with HIV/AIDS....
Statins in Proteinuric Nephropathies
End stage renal disease (ESRD) is rapidly growing worldwide. Patients with ESRD have increased morbidity and mortality mostly because of a dramatic excess of cardiovascular disease. Thus,...
Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection
Proton pump inhibitors (PPIs) are mainly metabolized in the liver by CYP2C19, one of the cytochrome P450 isoenzymes, which shows a genetic polymorphism associated with enzyme activities. T...
PubMed Articles
Arteries and veins show marked differences in their anatomy, physiology and genetic expression pattern. In this study, we analyzed impact of overexpression or downregulation of arterial marker gene He...
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.
The majority of human cancers harbour mutations promoting activation of the Akt protein kinase, and Akt inhibitors are being evaluated in clinical trials. An important question concerns the understand...
Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3.
Besides the necessary changes in the expression of cell cycle-related proteins, cancer cells undergo a profound series of metabolic adaptations focused to satisfy their excessive demand for biomass. A...
CCL15, a member of the CC chemokine family, is a potent chemoattractant for leukocytes and endothelial cells (ECs). Given that chemokines play key roles in vascular inflammation, we investigated the e...
Superantigen-induced steroid resistance depends on activation of phospholipase cβ2.
The glucocorticoid receptor is present in a TCR-associated complex, which includes the Src family tyrosine kinase Lck. Glucocorticoids rapidly dissociate this complex, resulting in the inhibition of c...
Engagement of NKG2D and DNAX accessory molecule-1 (DNAM-1) receptors on lymphocytes plays an important role for anticancer response and represents an interesting therapeutic target for pharmacological...
Elevated numbers of activated platelets circulate in patients with chronic inflammatory diseases, including atherosclerosis and coronary disease. Activated platelets can activate the complement system...
Regulatory T cells can restrict the uncontrolled immune response and inflammation, avoiding pathologic immune injury to the host and thus playing important roles in the maintenance of immune homeostas...
Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem cells are unknown. In this study, we enumerate and characterize T/NK precursors among CD34(+)Lin(-) cell population...
Adam8 limits the development of allergic airway inflammation in mice.
To determine whether a disintegrin and metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyperresponsiveness (AHR), we compared AAI and AHR in wild-type (WT) versus A...
Videos
Cell Growth with Delta-Notch Signaling
This is a CompuCell3D (CC3D) simulation that incorporates cell growth and division along with cell-cell communication through delta-notch signaling. 'Interna...
Medical and Biotech [MESH] Definitions
Taxodium
A plant genus of the family TAXODIACEAE. Members contain taxodione and taxodone, which are diterpenoid quinone methide tumor inhibitors.
Huperzia
A plant genus of the family LYCOPODIACEAE. Members contain huperzine, one of the CHOLINESTERASE INHIBITORS.
Complement Pathway, Mannose-binding Lectin
Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Mannose-binding Lectin
A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.
Monoterpenes
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
