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Nuclear Medicine - Biotech, Pharma and Life Science Channel

12:43 EST 20th February 2017 | BioPortfolio

Nuclear medicine is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease.

In nuclear medicine procedures, radionuclides are combined with other elements to form chemical compounds, or else combined with existing pharmaceutical compounds, to form radiopharmaceuticals. These radiopharmaceuticals, once administered to the patient, can localize to specific organs or cellular receptors.

This property of radiopharmaceuticals allows nuclear medicine the ability to image the extent of a disease process in the body, based on the cellular function and physiology, rather than relying on physical changes in the tissue anatomy. In some diseases, nuclear medicine studies can identify medical problems at an earlier stage than other diagnostic tests. 

Treatment of diseased tissue, based on metabolism or uptake or binding of a particular ligand, may also be accomplished, similar to other areas of pharmacology. However, the treatment effects of radiopharmaceuticals rely on the tissue-destructive power of short-range ionizing radiation.

In the future, nuclear medicine may provide added impetus to the field known as molecular medicine. As understanding of biological processes in the cells of living organisms expands, specific probes can be developed to allow visualization, characterization, and quantification of biologic processes at the cellular and subcellular levels.[

Source: Wikipedia

 

News Articles [42 Associated News Articles listed on BioPortfolio]

Global Radiopharmaceuticals Market Will Reach US$ 8.5 Billion Value by end of 2016-2026

VALLEY COTTAGE, New York, February 14, 2017 /PRNewswire/ -- - Presence of Radiopharmaceuticals in Cancer Medications has Increased as Research Institutes Have Derived Ways in Which Radioisotopes c...

Cerveau Technologies Signs Manufacturing Agreement with Siemens’ PETNET Solutions for Investigational Tau Imaging Agent

MK-6240 clinical trial doses to be manufactured and supplied by PETNET Solutions’ locations in the United States Cerveau Technologies, Inc. today announced it has signed an ...

Lantheus Holdings to Host Fourth Quarter and Full Year 2016 Earnings Conference Call and Provide 2017 Guidance on February 21, 2017 at 4:30 p.m. Eastern Time

Lantheus Holdings, Inc. (the “Company”) (NASDAQ: LNTH) today announced that it will host a conference call at 4:30 p.m. ET on Tuesday, February 21, 2017, to discuss its...

Aura Biosciences Receives FDA Clearance of Investigational New Drug Application for Light-activated AU-011 for the Treatment of Ocular Melanoma

Landmark clinical trial has launched for rare disease with no approved targeted therapy Aura Biosciences, a biotechnology company developing a new class of th...

Cambridge Isotope Laboratories, Inc. is Pleased to Offer Mouse Express® NeuCode™ Mouse Feed

Cambridge Isotope Laboratories, Inc. (CIL), the world’s leading supplier of stable isotopes and stable isotope-enriched compounds, is pleased to offer Mouse Express® NeuCode™...

IBA Molecular Acquires Mallinckrodt Nuclear Imaging to Create World-Class Radiopharmaceuticals Group

PARIS and ST. LOUIS, January 27, 2017 /PRNewswire/ --  Transaction follows receipt of regulatory approvals   Combined business produces diagnostic solutions for over 14 million patie...

Faxitron Announces Partnership with Health Beacons

AMSTERDAM, Jan. 26, 2017 /PRNewswire/ -- Faxitron® Bioptics, LLC and Health Beacons, Inc. today announced that Faxitron has been awarded exclusive worldwide distribution rights for Health B...

Radon is the Unknown Health Threat in Schools

LANSING, Mich., Jan. 25, 2017 /PRNewswire/ -- Parents will do anything to keep their kids safe and out of trouble. One of the ways parents can accomplish this is having their children go to school. In...

Advanced Accelerator Applications SA AAAP Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryAdvanced Accelerator Applications SA AAA is a radiopharmaceutical company that develops, produces and markets molecular nuclear medicine diagnostic and therapeutic products. The company's lead ...

Oncoinvent Patent Issues in the USA

Oncoinvent announced today that US Patent 9,539,346 entitled ”Radiotherapeutic particles and suspensions” has issued. The patent relates to a particle or pharmaceutical compos...

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Companies [9 Associated Companies listed on BioPortfolio]

Advanced Medical Isotope Corporation

Advanced Medical Isotope Corporation (ADMD) is a late stage development company engaged in the development of brachytherapy devices for therapeutic applications. AMIC's focus is o...

Lantheus Holdings, Inc.

Lantheus Holdings, Inc. is the parent company of Lantheus Medical Imaging, Inc. (“LMI”), which is a global leader in developing, manufacturing, selling and distributing ...

Cambridge Isotope Laboratories, Inc.

Cambridge Isotope Laboratories, Inc. (www.isotope.com) is the world's premier supplier of stable isotopes and stable isotope labeled compounds for research applications in structu...

Navidea Biopharmaceuticals Inc.

Navidea Biopharmaceuticals, Inc. (NYSE MKT: NAVB) is a biopharmaceutical company focused on the development and commercialization of precision diagnostics and radiopharmaceutical ...

Navidea Biopharmaceuticals, Inc.

Navidea Biopharmaceuticals, Inc. (NYSE Amex: NAVB) is a biopharmaceutical company focused on the development and commercialization of precision diagnostics and radiopharmaceutical...

Neoprobe Corporation and Navidea Biopharmaceuticals, Inc.

Navidea Biopharmaceuticals (NYSE Amex: NAVB) is a biopharmaceutical company focused on the development and commercialization of precision diagnostics and radiopharmaceutical agent...

Navidea Biopharmaceuticals

Navidea Biopharmaceuticals (NYSE Amex: NAVB) is a biopharmaceutical company focused on the development and commercialization of precision diagnostics and radiopharmaceutical agent...

KineMed, Inc.

KineMed, Inc. ("KineMed" or the "Company") is a drug discovery and development company employing its proprietary translational medicine technology (AquaTag™ and KineMarkerâ...

Symbiotic Research Services

SR is a contract research organization (CRO) which is licensed to conduct research with radio labeled C-14 materials. SR has been inspected by the US-EPA and the NJ-DEP Division o...

Clinical Trials [333 Associated Clinical Trials listed on BioPortfolio]

Gastric Cancer Sentinel Lymph Node Mapping

Gastric cancer has an incidence in North America of over 24,000 new cases annually, of which approximately 15% are diagnosed at an early stage. Standard of care for early gastric cancer (E...

Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta 3-Adrenergic Receptor Agonists

Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if BAT helps ...

Efficacy of Apatinib in Radioactive Iodine-refractory Differentiated Thyroid Cancer

Radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) is a great challenge in the treatment of thyroid cancer. Tyrosine kinase inhibitors (TKIs), like sorafenib and lenvat...

Study to Evaluate the Safety of Combining Two Radionuclide Therapies to Treat Mid-gut Neuroendocrine Tumors

This study is designed to identify the best tolerated doses of [131]Iodine-MIBG and [90]Yttrium-DOTATOC when co-administered to treat midgut neuroendocrine tumors. These drugs (131I-MIBG, ...

Mapping Sound Propagation Through the Human Lung for Better Diagnosis

This study addresses the question, how does sound propagate from a source in the chest to the chest wall? Using sound recorded at the chest as a diagnostic technique has the advantage of b...

Copper Cu-64 TP3805 PET/CT in Imaging Patients With Urothelial Cancer Undergoing Surgery or Biopsy

This pilot clinical trial studies how well copper Cu-64 TP3805 positron emission tomography (PET)/computed tomography (CT) works in imaging patients with urothelial cancer undergoing surge...

Sodium Pertechnetate (99Tc) Injection Generator: 99mTc From Neutron-activation 99Mo v 99mTc From Fission 99Mo

A non-fission sourced, solvent generator produced 99mTc intravenous injection, as 99mTc -MDP, is to be used as a bone scan diagnostic radiopharmaceutical for assessment of bone pathology u...

Gastric Emptying: in Vivo Studies in Healthy Volunteers

The Investigators institution has used a meal consisting of mashed potato, peas and Beanfeast (soya mince) for gastric emptying studies for a number of decades. Validation of the study met...

Copper Cu 64 TP3805 PET in Detecting Prostate Cancer in Patients With Persistently Elevated PSA

This pilot phase I trial studies how well copper Cu 64 TP3805 positron emission tomography (PET) works in detecting prostate cancer in patients with persistently elevated prostate specific...

A Pilot Study of [Ga-68]PSMA PET/MRI for the Assessment of PSMA-positive Tumors

The purpose of this study is to see if positron emission tomography/ magnetic resonance imaging (PET/MRI) can be used to monitor the effectiveness of cancer treatment using an investigatio...

PubMed Articles [209 Associated PubMed Articles listed on BioPortfolio]

Accuracy of (177)Lu activity quantification in SPECT imaging: a phantom study.

The aim of the study is to assess accuracy of activity quantification of (177)Lu studies performed according to recommendations provided by the committee on Medical Internal Radiation Dose (MIRD) pamp...

Radon Release and Its Simulated Effect on Radiation Doses.

One of the main factors that affect the uncertainty in calculating the gamma-radiation absorbed dose rate inside a room is the variation in the degree of secular equilibrium of the considered radioact...

Isotope Tracers To Study the Environmental Fate and Bioaccumulation of Metal-Containing Engineered Nanoparticles: Techniques and Applications.

The rapidly growing applicability of metal-containing engineered nanoparticles (MENPs) has made their environmental fate, biouptake, and transformation important research topics. However, considering ...

Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA.

A new family of (99m)Tc(I)- tricarbonyl complexes and (125)I-heteroaromatic compounds bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy. Characterization of the DNA in...

Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter.

Iodine is a key ingredient in the synthesis of thyroid hormones and also a major factor in the regulation of thyroid function. A local reduction of iodine content in follicular lumen leads to overexpr...

Internal exposure to neutron-activated (56)Mn dioxide powder in Wistar rats: part 1: dosimetry.

There were two sources of ionizing irradiation after the atomic bombings of Hiroshima and Nagasaki: (1) initial gamma-neutron irradiation at the moment of detonation and (2) residual radioactivity. Re...

A low redox potential affects monoclonal antibody assembly and glycosylation in cell culture.

Glycosylation and intracellular assembly of monoclonal antibodies (MAbs) is important for glycan profile consistency. To better understand how these factors may be influenced by a lower redox potentia...

The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.

Active iodide (I(-)) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na(+)/I(-) symporter (NIS). In the thyroid, NIS-mediated I(-) uptake plays a pivotal role in thyro...

Internal dosimetry with the Monte Carlo code GATE: validation using the ICRP/ICRU female reference computational model.

The purpose of this work was to validate GATE-based clinical scale absorbed dose calculations in nuclear medicine dosimetry. GATE (version 6.2) and MCNPX (version 2.7.a) were used to derive dosimetric...

Desirable Properties of Radiopharmaceuticals for Sentinel Node Mapping in Patients With Breast Cancer Given the Paradigm Shift in Patient Management.

Over the past 2 decades, lymphoscintigraphy and sentinel node biopsy have become widely accepted and are used by surgeons to stage many solid cancers, especially breast cancer. However, despite growin...

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Medical and Biotech [MESH] Definitions

Radioactive substances which act as pollutants. They include chemicals whose radiation is released via radioactive waste, nuclear accidents, fallout from nuclear explosions, and the like.

Uncontrolled release of radioactive material from its containment. This either threatens to, or does, cause exposure to a radioactive hazard. Such an incident may occur accidentally or deliberately.

Liquid, solid, or gaseous waste resulting from mining of radioactive ore, production of reactor fuel materials, reactor operation, processing of irradiated reactor fuels, and related operations, and from use of radioactive materials in research, industry, and medicine. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.

A nontoxic radiopharmaceutical that is used in the clinical evaluation of hepatobiliary disorders in humans.

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