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Nuclear Scans - Biotech, Pharma and Life Science Channel

21:39 EDT 24th May 2013 | BioPortfolio

PubMed Articles [ 4993 Associated PubMed Articles listed on BioPortfolio]

Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion.

Hepatoma-derived growth factor (HDGF), a heparin-binding growth factor, has a wide range of biological functions, including mitogenic activity and vascular development. Recent studies demonstrated tha...

Identification of a non-canonical nuclear localization signal (NLS) in BRCA1 that could mediate nuclear localization of splice variants lacking the classical NLS.

The breast cancer type 1 susceptibility gene (BRCA1) is a tumor suppressor gene, mutations or loss of which lead to genomic instability and breast cancer. BRCA1 protein is part of a large multi-protei...

Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression.

Hypoxia inducible factor (HIF) and 5'-AMP-activated protein kinase are often activated under similar physiological conditions. Constitutive androstane receptor (CAR) translocates into the nucleus in a...

Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study.

Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating and fatal lung disorder with high mortality rate. Unfortunately, to date the treatment for IPF remains unsatisfying and in severe cas...

Investigation of the retrorenal colon frequency using computed tomography in patients with advanced scoliosis.

PURPOSE: The aim of this study is to investigate the frequency of retrorenal colon in patients with advanced scoliosis. MATERIALS AND METHODS: The existence of retrorenal colon was retrospectively inv...

A new method for apparent diffusion coefficient measurement using sequential (18)F-FDG PET and MRI: correlation with histological grade of invasive ductal carcinoma of the breast.

OBJECTIVE: The aim of this study was to measure the apparent diffusion coefficient (ADC) value at the region with the highest FDG uptake using sequential (18)F-FDG PET and MRI, and to correlate it wit...

Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions.

In addition to its important role in the regulation of somatic growth by acting as the major circulating transport protein for the insulin-like growth factors (IGFs), IGF binding protein-3 (IGFBP-3) h...

The activity and proliferation of pituitary prolactin-positive cells and pituitary VIP-positive cells are regulated by interleukin 6.

Interleukins are proteins involved in the immune system and have been related to the endocrine regulation of the hypothalamic-pituitary-adrenal axis as well as to the secretion of ACTH, prolactin (PRL...

Bortezomib inhibits proteasomal degradation of IκBα and induces Mitochondrial dependent Apoptosis in Activated B-Cell Diffuse Large B-Cell Lymphoma.

Activated B-cell lymphoma (ABC), a subgroup of Diffuse Large B-cell lymphoma (DLBCL) has a worse survival after upfront chemotherapy and is characterized by constitutive activation of the anti-apoptot...

The role of heavy-light-hole mixing on the optical initialization of hole spin in InAs quantum dots.

The initialization of a resident hole spin by the absorption of a circularly polarized light at resonance involves the formation of an excited state called a trion state. For a pure heavy hole, this o...

News Articles [ 1577 Associated News Articles listed on BioPortfolio]

AAA enters supply deal with Eli Lilly for Amyvid in France, Italy and Spain

France-based molecular nuclear medicine firm Advanced Accelerator Applications (AAA) says it has signed a non-exclusive manufacturing and service agreement to supply US pharma major Eli Lilly's (NYSE:...

Digirad Adopts Tax Benefit Preservation Plan to Protect Its Net Operating Loss Carryforwards

POWAY, CA -- (Marketwired) -- 05/24/13 -- Digirad Corporation (NASDAQ: DRAD) announced today that its Board of Directors has adopted a Tax Benefit Preservation Plan (the Plan) designed to preserve th...

Macrocyclics, Roche in Nuclear Medicine Pact

Aims to speed up the clinical development process

CT Scans May Increase Cancer Risk in Children, Adolescents

An Australian study has found higher cancer incidence but relatively low absolute risk in children and adolescents who undergo CT scans. Medscape Medical News

Series B round brings $48.2mm to [Karyopharm]

[Karyopharm Therapeutics Inc.] (nuclear transport modulators for cancer) plans to use the $48.2mm raised through a Series B round to fund clinical trials of its KPT330, a Phase I compound for advanced...

Macrocyclics to Collaborate with Roche on Molecular Innovation for Nuclear Medicine

DALLAS, May 23, 2013 /PRNewswire/ -- After the successful completion of their first 2012 collaboration, Macrocyclics (an AREVA Med company) announced today a new collaborative research...

Cancer risk to increase following CT scans in younger patients, study reveals

Study leader, Professor John Mathews from the University of Melbourne said this small increase in cancer risk must be weighed against the undoubted benefits from CT scans in diagnosing and monitoring...

Manchester nuclear hormone research approach is a UK first

Researchers and doctors from Manchester institutes have joined forces with pharmaceutical company GlaxoSmithKline (GSK) to launch an innovative joined-up approach to tackling chronic inflammatory dise...

Structural basis of histone H2A–H2B recognition by the essential chaperone FACT

Facilitates chromatin transcription (FACT) is a conserved histone chaperone that reorganizes nucleosomes and ensures chromatin integrity during DNA transcription, replication and repair. Key to the br...

Table 1: Stem cell types and methods for stem cell generation

Tools: Finding a home for nuclear transfer Table 1. Stem cell types and methods for stem cell generation. There are three major classes of stem cells: embryonic stem cells (ESCs), induced pluripotent...

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Companies [ 27 Associated Companies listed on BioPortfolio]

Algeta ASA

Algeta was founded in 1997 (as Anticancer Therapeutic Inventions) based upon a unique combination of radiation chemistry, nuclear medicine and clinical oncology expertise brought together by its two...

MolecularImaging.net

MolecularImaging.net hosts Molecular Imaging's eNewsletter, quarterly magazine, special sections and portals. The site engages molecular imaging physicians and executives w...

iBASEt

iBASEt is a leading provider of software solutions to complex, highly regulated industries, like Aerospace, Defense, Nuclear, Industrial Equipment, Electronics, Medical Devices an...

SDS Medical

SDS Medical is the vision of two healthcare entrepreneurs with over 30 years of experience in their respective fields – Allan Thomas and Phillip Clifford. Allan Thomas, CEO a...

Sperling Laser Associates

Dan Sperling, MD, D.A.B.R., is the Medical Director at the New Jersey Institute of Radiology, in Carlstadt, N.J. Certified by the American Board of Radiology and licensed in New Y...

Radia Inc., PS

Radia’s board-certified physicians provide professional services in diagnostic imaging, interventional radiology, and vascular surgery. A broad range of services, including C...

AspenBio Pharma, Inc.

AspenBio Pharma, Inc. is an emerging in vitro diagnostic company focused on obtaining FDA clearance for its lead product, AppyScore, which is a unique blood-based test in developm...

Texas Radiology Associates L.L.P.

Texas Radiology Associates provides radiology services to the North Dallas, Texas, community, practicing high-quality, 24-hour, hospital-based radiology. As a large, dynamic group...

MPR Associates, Inc.

MPR Associates is an employee-owned specialty engineering and project management services firm founded in 1964 headquartered in Alexandria, VA. MPR provides solutions to clients i...

MPR Associates

MPR Associates is an employee-owned specialty engineering and project management services firm founded in 1964 headquartered in Alexandria, Va. MPR provides solutions to clients i...

Clinical Trials [ 476 Associated Clinical Trials listed on BioPortfolio]

Positron Emission Tomography (PET) to Study Brain Signaling

This study uses positron emission tomography (PET) to examine brain function and signaling involving phospholipids, and to see how signaling is related to blood flow. Much of the brain is...

Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression

Background: - Atherosclerosis (thickening of the artery walls caused by cholesterol and other deposits) commonly occurs in the heart vessels and carotid (neck) arteries of adults. This i...

Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion

This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion. Cushing's synd...

Exploration of Tumor Accumulation of BAY94-9392 in Patients With Cancer

The study will be conducted as an open label, single-dose, explorative study with patients with histologically proven cancer and, preferably, tumor positive lesions in previously performed...

A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement

The purpose of this study is to monitor the performance of the DePuy PROXIMA™ hip in the treatment of patients with hip joint disease requiring a total hip replacement. Patients who ente...

Post-Surgical Non-Small Cell Lung Cancer (NSCLC) Follow-up

The follow-up of patients operated on for lung cancer is heterogeneous. An intensive follow-up including routine clinic visits, chest X-rays, chest computed tomography (CT) scans and fiber...

Digital Mammography, Ultrasound, MRI, and PET Scans in Women With Newly Diagnosed Breast Cancer

RATIONALE: Diagnostic procedures, such as digital mammography, ultrasound, MRI, and PET scans, may help find breast cancer and find out how far the disease has spread. PURPOSE: This phase...

Positron Emission Tomography Scanning and Epstein-Barr Virus DNA Levels in the Staging and Follow-Up of Nasopharyngeal Carcinoma.

The standard treatment for nasopharyngeal cancer involves either radiation alone or radiation plus chemotherapy. Before the start of treatment,patients require an imaging scan to assess th...

CT Perfusion Scans for Assessment of Lung Cancer Before and After Chemo +/- Radiotherapy

Cancer of the lung is treated with surgery, radiation or chemotherapy, depending on the stage or extent of the disease. Some patients are treated with chemotherapy and/or radiation therapy...

Effects of Sleep Deprivation and Recovery on Cognitive Functions

This study will measure brain activity in individuals performing language tasks while in various states of alertness to learn more about how the central nervous system is affected by impai...

Medical and Biotech [MESH] Definitions

Heterogeneous-nuclear Ribonucleoproteins

A family of ribonucleoproteins that were originally found as proteins bound to nascent RNA transcripts in the form of ribonucleoprotein particles. Although considered ribonucleoproteins they are primarily classified by their protein component. They are involved in a variety of processes such as packaging of RNA and RNA TRANSPORT within the nucleus. A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM.

Heterogeneous-nuclear Ribonucleoprotein Group A-b

A class of closely related heterogeneous-nuclear ribonucleoproteins of approximately 34-40 kDa in size. Although they are generally found in the nucleoplasm, they also shuttle between the nucleus and the cytoplasm. Members of this class have been found to have a role in mRNA transport, telomere biogenesis and RNA SPLICING.

Heterogeneous-nuclear Ribonucleoprotein Group C

A group of closely related heterogeneous-nuclear ribonucleoproteins of approximately 41-43 kDa in size found in the cell nucleus. Members of this class have been implicated in a variety of processes including splicing, polyadenylation, and nuclear retention of RNA.

Heterogeneous-nuclear Ribonucleoprotein D

A heterogeneous-nuclear ribonucleoprotein that has specificity for AU-rich elements found in the 3'-region of mRNA and may play a role in RNA stability. Several isoforms of hnRNP D protein have been found to occur due to alternative mRNA splicing (RNA SPLICING).

Nuclear Matrix-associated Proteins

A broad category of nuclear proteins that are components of or participate in the formation of the NUCLEAR MATRIX.

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