Ocular - Biotech, Pharma and Life Science Channel
PubMed Articles
OBJECTIVES: Radioiodine therapy (RIT) is frequently used as the definitive treatment in patients with Graves' hyperthyroidism when remission is not achieved with anti-thyroid drugs (ATDs). In this obs...
Ocular histiocytic sarcoma in a cat.
A 13-year-old male neutered British blue cat presented with uveitis, hyphema, and dyscoria in the right eye. Light microscopic examination revealed that the ciliary body, iris root, drainage angle, an...
Limbal stem cells (LSCs) derived from human embryonic stem cells (hESCs) hold great potential for cell-based therapies for ocular surface diseases. The cell-based therapies mainly depend on an appropr...
Recent surveys have identified SLC22A4, SLC22A5, RUNX1, JAK1 as susceptibility genes for various immune-related diseases. An association study was performed in 738 Behcet's patients with ocular involv...
To clarify the changes of cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials induced by air-conducted sound (ACS) and bone-conducted vibration (BCV) in patients with vestibular...
This study aimed to determine the optimal bandpass filter (BPF) setting for acoustic stimuli in recording the ocular vestibular-evoked myogenic potential (oVEMP). Twelve healthy volunteers underwent o...
An eye on the future of inflammasomes and drug development in AMD.
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. While activation of the immune system has been implicated in disease progression, the pathways involved re...
Studies concerning the functional status of the corneal epithelium are of special interest due to its key role in preventing ocular surface disease and corneal infections. In particular, quantitative...
PURPOSE: Biotinylated lipid prodrugs of acyclovir (ACV) were designed to target the sodium dependent multivitamin transporter (SMVT) on the cornea to facilitate enhanced cellular absorption of ACV. ME...
BACKGROUND: To evaluate the vitreous fluid levels of soluble LR11 (sLR11), a novel circulating marker for proliferative diabetic retinopathy (PDR), in patients with PDR and non-PDR (NPDR) in compariso...
News Articles
Ocular prostheses in the last century: a retrospective analysis of 8018 patients
Ocular prostheses in the last century: a retrospective analysis of 8018 patients Eye advance online publication, May 17 2013. doi:10.1038/eye.2013.97 Authors: A Modugno, F Mantelli, S Sposa...
Antibiotic Resistance and Treating Ophthalmic Infections
Is antibiotic resistance a common problem for clinicians when treating ocular infections and, if so, how can they work around this problem to treat the infections effectively? Expert Review of Ophth...
GAITHERSBURG, Md., May 15, 2013 /PRNewswire/ -- Sigma-Tau Pharmaceuticals, Inc. announced today that the Company was recognized last evening as a rare disease pioneer at the 30th anniversary cele...
Dr. Eric D. Donnenfeld assumes new role as president of American Society of Cataract and Refractive Surgery (ASCRS) after serving as the association's vice president. Westbury, NY (PRWEB) May 15,...
PETACH TIKVA, Israel, May 10, 2013 /PRNewswire/ -- OphthaliX, Inc. (OTC BB: OPLI), announced today that it has come to its knowledge that Professor M. Francesca Cordeiro, a Professor of Glaucoma...
Healthcare Industry Challenged to Embrace Hospitality's Enhanced Guest Experience
PHILADELPHIA, May 10, 2013 /PRNewswire/ -- Could Health Care 2.0 be already in the making? A recent study by the Health Research Institute at PricewaterhouseCoopers (PwC) states 72% of...
Oxford BioMedica Announces Update from ARVO 2013
OXFORD, England, May 9, 2013 /PRNewswire/ -- -- UshStat® video selected to showcase theme of "Life-changing Research" -- Oxford BioMedica plc ("Oxford BioMedica" or "the Company") (LSE: OX...
Phase 1b clinical study data of EBI-005 for treatment of dry eye disease presented at ARVO meeting
Eleven Biotherapeutics, a biopharmaceutical company designing and engineering novel and differentiated protein-based biotherapeutics for ocular diseases, announced today the presentation of data for E...
Type: Original PaperPurposeBiotinylated lipid prodrugs of acyclovir (ACV) were designed to target the sodium dependent multivitamin transporter (SMVT) on the cornea to facilitate enhanced cellular abs...
EBI-005 is Clinical Candidate for Treating Dry Eye Disease with Potential in Other Ocular Surface Inflammatory Diseases Data Presented at ARVO 2013 Annual Meeting Demonst...
Events
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Companies
InSite Vision is an ophthalmic products company currently focused on ocular infection, glaucoma, and retinal disease. The Company specializes in three platform technologies: topical drug delivery (Dur...
Zalicus focuses its internal drug development efforts on pain and immuno-inflammatory diseases. Our pipeline for pain includes Exalgo⢠(hydromorphone HCl) extended-release ta...
With a history of over 150 years, Reichert Inc., of Buffalo, NY, continues to be a global leader in the design and manufacture of high-quality diagnostic instruments and equipment...
Headquartered in Morrisville, North Carolina, TearScience® has pioneered devices that provide significant clinical improvement in the treatment of evaporative dry eye. Of the m...
Clearside Biomedical is an ophthalmic company specializing in the research, development and commercialization of therapeutic products through a proprietary ocular microinjection p...
PolyActiva is a pioneering biotechnology company developing drug-polymer conjugates that allow for site specific drug delivery from medical device components such as ocular implan...
SOOFT italia S.p.A. a Company of OOgroup , is an Italian pharmaceutical firm specialized in the research of new solutions , in carrying out and marketing of products for general a...
Lux Biosciences, Inc. is a privately held biotechnology company focused on the treatment of ophthalmic diseases. Lux Biosciences has exclusive worldwide rights to voclosporin for...
Ocular Therapeutix, Inc. is a privately held company based in Bedford, MA, focused on the development and commercialization of ophthalmic therapeutic products using its proprietar...
InSite Vision is committed to advancing new and superior ophthalmologic products for unmet eye care needs. InSite Vision is recognized for the discovery and development of novel o...
Clinical Trials
The exact mechanism of the pathogenesis of Graves’ ophthalmopathy is still unknown. Histopathologically, extraocular muscle inflammation and orbital fat inflammation are two prominent ch...
Ocular Blood Flow in Early Glaucoma Patients Before and After Treatment With Dorzolamide
Impaired ocular blood flow is an important risk factor in the pathogenesis of primary open angle glaucoma (POAG). A few studies suggest that topical dorzolamide 2% may increase optic nerve...
Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Hypotheses: 1. The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than...
The use of intravitreal injections of corticosteroid (triamcinolone acetonide) appears to be a promising treatment for a variety of ocular diseases associated with inflammation. To date, t...
Interferon Beta in Treating Patients With Metastatic Cutaneous Melanoma or Ocular Melanoma
RATIONALE: Interferon beta may interfere with the growth of tumor cells. PURPOSE: This phase II trial is studying how well interferon beta works in treating patients with metastatic cutan...
RATIONALE: Drugs used in chemotherapy such as melphalan and temozolomide use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs in diff...
To evaluate the safety and efficacy of BETOPTIC S and Timolol Gel-forming solution in pediatric patients. Patients will dose with study drug at 8 am and 8 pm daily for twelve weeks. Patien...
To evaluate the safety and efficacy of both BETAXON and AZOPT in pediatric patients. Patients will dose with study drug at 8 am and 8 pm daily for twelve weeks. Patients will have vision t...
OBJECTIVES: I. Demonstrate the safety and efficacy of dihematoporphyrin derivative (DHP) in laser photodynamic therapy (PDT) in patients with corneal neovascularization. II. Docume...
Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens
This study will investigate congenital or developmental eye abnormalities that affect the iris, cornea and lens, and are usually accompanied by elevated pressure within the eye. These diso...
Videos
Actions of the ocular muscles
This short video demonstrates how the eye muscles work together to move the eye. Get my new (May 2013) interactive book on your iPad, http://itun.es/i6xT3Yf ...
Medical and Biotech [MESH] Definitions
Photobleaching
Light-induced change in a chromophore, resulting in the loss of its absorption of light of a particular wave length. The photon energy causes a conformational change in the photoreceptor proteins affecting PHOTOTRANSDUCTION. This occurs naturally in the retina (ADAPTATION, OCULAR) on long exposure to bright light. Photobleaching presents problems when occurring in PHOTODYNAMIC THERAPY, and in FLUORESCENCE MICROSCOPY. On the other hand, this phenomenon is exploited in the technique, FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING, allowing measurement of the movements of proteins and LIPIDS in the CELL MEMBRANE.
Ocular Physiological Processes
Biological action and events that support the functions of the EYE and VISION, OCULAR.
Leopard Syndrome
An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.
Sunct Syndrome
A primary headache disorder that is characterized by frequent short-lasting, unilateral, neuralgiform pain attacks in the ocular area, with CONJUNCTIVA fluid-filling and tearing. SUNCT syndrome is usually resistant to treatment.
Phakic Intraocular Lenses
Lenses, generally made of plastic or silicone, that are implanted into the eye in front of the natural EYE LENS, by the IRIS, to improve VISION, OCULAR. These intraocular lenses are used to supplement the natural lens instead of replacing it.
