Oxytocin - Biotech, Pharma and Life Science Channel
PubMed Articles
The neuropeptides oxytocin (OT) and vasopressin (AVP) are recognized for their modulation of social processes in humans when delivered peripherally. However, there is surprisingly little evidence for...
Stability and dynamics of forebrain V1aR and OTR during pregnancy in prairie voles.
During pregnancy, females undergo several physiologically driven changes that facilitate adaptive behaviours and prepare the mother to care for her developing offspring. The nonapeptide hormone oxytoc...
Adult male Brattleboro rats were used to investigate the impact of the congenital absence of vasopressin on the release pattern of oxytocin within the hypothalamic supraoptic nucleus (SON) in response...
Intranasal administration has been widely used to investigate effects of the neuropeptides vasopressin and oxytocin on human behaviors and neurological disorders, but exactly what happens when these n...
Volume transmission and its different forms in the central nervous system.
Volume transmission (VT) is a widespread mode of intercellular communication that occurs in the extracellular fluid (ECF) and in the cerebrospinal fluid (CSF) of the brain with VT signals moving from...
The present study investigated the long-lasting effects of prenatal repeated restraint stress on social behavior and anxiety, as well as its repercussions on oxytocin (OT) and vasopressin (VP)-positiv...
Oxytocin and vasopressin: Social neuropeptides with complex neuromodulatory functions.
Oxytocin (OXT) and arginine vasopressin (AVP) are 2 closely related neuropeptides, widely known for their peripheral hormonal effects. However, OXT, AVP, and their receptors are also expressed in seve...
Prenatal and postnatal hormone effects on the human brain and cognition.
This review examines the role of hormones in the development of social and nonsocial cognition and the brain. Research findings from human studies designed to elucidate the effects of both prenatal an...
The effect of labour on the coagulation system in the term neonate.
The coagulation system of the foetus is markedly different from that of adults. To assess the influence of maternal age, mode of delivery and intrapartum events, and foetal gender and weight on the fo...
Effects of group housing on stress induced emotional and neuroendocrine alterations.
Chronic restraint stress can induce depressive and anxiety-like behavior and neurophysiological disturbances. The social living shows the health-promoting and stress-protective effects on both human a...
News Articles
Trigemina to Present at the 13th Annual Pain Therapeutics Conference in London
LONDON, May 20, 2013 /PRNewswire/ -- Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today annou...
Intranasal Oxytocin Normalizes Core ASD Deficit
Intranasal oxytocin appears to normalize fixated or restricted interest, a core deficit in autistic spectrum disorder. Medscape Medical News
Is there a link between postpartum depression and the 'love hormone'?
UNC researchers are launching a 5-year study aimed at understanding the role of oxytocin in postpartum depression and bonding between mothers and babies.
Trigemina Presents at American Pain Society 32nd Annual Scientific Meeting
MORAGA, Calif., May 9, 2013 /PRNewswire/ -- Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, ...
Dame Sally Davies opens Centre for Better Births
Chief Medical Officer, Professor Dame Sally Davies has opened a new research centre, led by the University of Liverpool and Liverpool Women’s NHS Foundation Trust, aimed at improving experienc...
Oxytocin Makes Schizophrenia Patients More Socially Savvy
Intranasal oxytocin helps patients with schizophrenia discern when people are being sarcastic or telling white lies, and also improves their sense of smell. Medscape Medical News
Human brains are relatively huge – and we live in highly organised societies. Traditionally in the neurosciences, the brain has been studied in isolation but now the young disci...
Trigemina to Present at the 2013 BIO International Convention
MORAGA, Calif., April 22, 2013 /PRNewswire/ -- Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today...
Trigemina Hosts Clinical Investigator Meeting for Chronic Migraine Study
SANTIAGO, Chile, April 18, 2013 /PRNewswire/ -- Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products,...
ISP of Chile approves Trigemina's protocol for Phase 2 clinical study of TI-001
Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today announced that the Instituto de Salud Publica o...
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Clinical Trials
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness. This process is usually conducted medically...
Foot and Ankle Edema Post-Cesarean Delivery
Some women develop swollen feet and ankles after a cesarean delivery. These women will often complain that their shoes are too tight and their feet may become numb or they may have some ti...
Ergot and Oxytocin During Cesarean Delivery Following Failure to Progress in Labour
Despite of marked improvements in clinical management, early postpartum hemorrhage(PPH)remains a significant contributor to maternal morbidity and mortality both in developing countries an...
PreTerm Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone pro...
The objective of the study was to test the hypothesis that acupuncture treatment hastens recovery time from inflammatory symptoms of the breast during breastfeeding. 205 mothers with 210 c...
Post Term Pregnancy - Induction of Labor or Monitoring of Pregnancy
Post term pregnancy is a risk pregnancy. Aim of the study was to investigate whether induction of labor at gestational age 289(41 weeks+2 days) reduces neonatal morbidity compared to expec...
Oxytocin Administration in the Third Stage of Labour - A Study of Appropriate Route and Dose
Mothers are given the medication oxytocin after birth to help the uterus (womb) contract and therefore reduce blood loss. In Canada, oxytocin is given either into the muscle of the thigh o...
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood l...
Misoprostol for the Treatment of Postpartum Hemorrhage
The purpose of this study is to test whether misoprostol is as effective as oxytocin for treating primary postpartum hemorrhage (PPH) with uterine atony as the suspected cause in two circu...
The goal of our research is to check the levels of D-Serine, Glycine, and other Glutamatergic amino acids, in patients with First Psychotic Episode (FPE). These patients are in the early...
Videos
Paul Zak: Trust, morality - and oxytocin
http://www.ted.com Where does morality come from -- physically, in the brain? In this talk neuroeconomist Paul Zak shows why he believes oxytocin (he calls i...
Medical and Biotech [MESH] Definitions
Vasotocin
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
Tocolytic Agents
Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.
Receptors, Oxytocin
Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.
Cyclic Gmp
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
Hypothalamic Hormones
Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.
