Parathyroid - Biotech, Pharma and Life Science Channel
PubMed Articles
INTRODUCTION: Nonunion of femoral neck fractures frequently occurs in elderly patients. In patients with rheumatoid arthritis, reoperation rates after internal fixation of a displaced femoral neck fra...
Dosage Effect of a Phex Mutation in a Murine Model of X-Linked Hypophosphatemia.
X-linked hypophosphatemia (XLH) is caused by mutations in the PHEX gene, which increase circulating levels of the phosphaturic hormone, fibroblast growth factor 23 (FGF23). Because XLH is a dominant d...
There is increasing evidence of an association between a low maternal vitamin D status and a high risk of adverse pregnancy outcomes. In a cross-sectional study, we investigated the vitamin D status o...
Bone health and aldosterone excess.
A picture of hyperparathyroidism secondary to increased urinary calcium excretion was found in 116 patients with primary aldosteronism (PA), compared with 110 essential hypertensives. After medical or...
Markers of inflammation after zoledronic acid redosing.
The symptoms of acute phase response (APR) following the first infusion of zoledronic acid (ZA) are attenuated after re-administration. We investigated the reasons for this attenuation, focusing on th...
Radionuclide parathyroid imaging: a concise, updated review.
The hypercalcemia of hyperparathyroidism (HPT) can cause devastating effects to the patient and only surgical removal of the hyperfunctioning parathyroid tissue can definitely cure the disease. Radion...
Intraoperative monitoring: Normative range associated with normal postoperative glottic function.
OBJECTIVE: Despite increasing use of neural monitoring (IONM) there is limited information on normative elecrophysiologic EMG parameters. The objective of this study is to define normative parameters...
Both parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) are phosphaturic hormones. These hormones should increase in response to phosphate excess. However, they also regulate serum calc...
BACKGROUND: The most frequent location of ectopic or supernumerary inferior parathyroid is the thymus. Bilateral cervical thymectomy has therefore been recommended as an essential part of the initial...
Assessments of serum 25-hydroxyvitamin D levels in 1,683 Japanese from a population-based cohort revealed prevalences of vitamin D insufficiency and deficiency were 81.3 and 1.2 %, respectively. Vita...
News Articles
OPKO Surpasses 50% Enrollment in First Phase 3 Trial of RayaldyTM (CTAP101 Capsules)
OPKO Health, Inc. (NYSE: OPK), has surpassed 50% enrollment in the first phase 3 trial of RayaldyTM to treat patients with secondary hyperparathyroidism (SHPT), stage 3 or 4 chron...
PTH Not Affected by Patient Variations (CME/CE)
(MedPage Today) -- Individual patient characteristics likely don't affect the half-life of intraoperative parathyroid hormone (IOPTH) during parathyroidectomy, researchers found.
Study: Cinacalcet for ESRD Shouldn't be Routinely Prescribed
SAN FRANCISCO—Cinacalcet, a drug commonly given to patients with end-stage kidney disease to help keep phosphorus and parathyroid blood levels within a target range, has few patient level clinical b...
Florida Physician Becomes President Elect of Major Physician Organization
R. Mack Harrell, M.D., F.A.C.P., F.A.C.E., E.C.N.U., was elected President Elect of the American Association of Clinical Endocrinologists (AACE) at its 22nd Annual Scientif...
Prospect for Parathyroid Hormone Replacement Inches Closer
If licensed, rhPTH[1-84] would be the first hormone replacement treatment for hypoparathyroidism. Data are encouraging, but there are some tolerability concerns. Medscape Medical News
Parathyroid: Novel Tx Promising in Rare Disease (CME/CE)
(MedPage Today) -- PHOENIX - Treatment with a recombinant human parathyroid hormone may reduce the need for calcium and vitamin D requirements in patients diagnosed with hypoparathyroidism, researcher...
Routine Prescribing Of Cinacalcet For End Stage Kidney Disease No Longer Warranted
Cinacalcet, a drug commonly given to patients with end stage kidney disease to help keep phosphorus and parathyroid blood levels within a target range and has few patient level clinical benefits and s...
Routine Use Of Cinacalcet Therapy In People With Chronic Kidney Disease No Longer Recommended
Cinacalcet, a drug commonly given to patients with end stage kidney disease to help keep phosphorus and parathyroid blood levels within a target range has few patient level clinical benefits and sever...
Routine cinacalcet for end stage kidney disease not warranted
Cinacalcet, a drug commonly given to patients with end stage kidney disease to help keep phosphorus and parathyroid blood levels within a target range and has few patient level clinical benefits and s...
Radius raises $43 million in series B
Radius Health Inc. (Cambridge, Mass.) raised $43 million in a series B round led by new investor F2 Biosciences. Existing investors Biotech Growth; MPM Capital; Brookside Capital; MPM Bio IV NVS Strat...
Events
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Companies
NPS Pharmaceuticals is engaged in the discovery, development and commercialization of therapeutic small molecules and recombinant proteins to treat bone and mineral, gastrointestinal and central nervo...
NPS Pharmaceuticals is developing new treatment options for patients with rare gastrointestinal and endocrine disorders. The company is currently advancing two Phase 3 registratio...
Clinical Trials
"PTHrP(1-36) IV Dose Escalation Study"
This is a single-blinded, one-treatment, combination dose escalation and pharmacokinetic study done in healthy volunteers. The investigators want to determine whether PTHrP(1-36) shares a...
A double-blind, placebo-controlled, parallel-group study to assess the safety and efficacy of 3 doses of ALX1-11 (recombinant human parathyroid hormone [rhPTH(1-84)])(50, 75 and 100 µg) i...
CRICKET Study, Coronary Calcium Scores in Patients With Chronic Kidney Disease
Patients with Chronic Kidney Disease (CKD) have been shown to have high coronary calcium scores (CAC), but the temporal association between Glomerular Filtration Rate, CVD risk factors and...
ACHIEVE: Optimizing the Treatment of Secondary Hyperparathyroidism
The purpose of this study is to compare the proportion of chronic kidney disease (CKD) subjects on dialysis receiving Sensipar® and low dose vitamin D or escalating doses of vitamin D alo...
Study of Teriparatide (FORTEO) to Treat Adults With Osteogenesis Imperfecta
The purpose of this study is to determine the effectiveness of teriparatide (FORTEO), which is human parathyroid hormone 1-34, for increasing bone mass and improving bone structure in adul...
Research Study Evaluating Cinacalcet for Patients With End Stage Renal Disease (ESRD)
The purpose of this study is to observe the effects of a treatment strategy that incorporates cinacalcet HCl into the management of secondary hyperparathyroidism (HPT) in subjects with ESR...
Citrate Effects and Bone Density in Long-Term Apheresis Donors
This study will examine the effects of repeated apheresis procedures on bone density and calcium balance. Apheresis is a procedure for collecting large numbers of a specific blood compone...
Parathyroid Hormone Levels in Relation to the Phosphorus Content of Meals
Patients on hemodialysis tend to have chronic elevations in the level of phosphorus in the blood and a secondary increase in the iPTH level. This chronic elevation in iPTH can have advers...
Parathyroid Hormone (PTH) With Alendronate for Osteoporosis
This study investigates the effectiveness of parathyroid hormone (PTH) in combination with alendronate, a standard treatment for osteoporosis that blocks or reduces bone loss. We are using...
Study of the Regulation of Parathyroid Hormone Secretion in Pseudohypoparathyroidism
OBJECTIVES: Determine the relationship between serum calcium concentrations and parathyroid hormone secretion in patients with pseudohypoparathyroidism.
Videos
What Are Parathyroid Glands? How Calcium is Controlled.
Parathyroid glands control calcium levels in your blood and bones. Adults should have calcium levels in the 9s. Parathyroid glands create parathyroid hormone...
Medical and Biotech [MESH] Definitions
Parathyroid Hormone-related Protein
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Receptor, Parathyroid Hormone, Type 1
A parathyroid hormone receptor subtype that recognizes both PARATHYROID HORMONE and PARATHYROID HORMONE-RELATED PROTEIN. It is a G-protein-coupled receptor that is expressed at high levels in BONE and in KIDNEY.
Receptors, Calcium-sensing
A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.
Receptor, Parathyroid Hormone, Type 2
A parathyroid hormone receptor subtype found in the BRAIN and the PANCREAS. It is a G-protein-coupled receptor with a ligand specificity that varies between homologs from different species.
Hyperparathyroidism, Primary
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
