Parathyroid Hormone PTH Receptor - Biotech, Pharma and Life Science Channel
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.
* parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.
* parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.
Parathyroid Hormone (PTH) Receptor Agonists or PTH Analogs are used to stimulate the PTH receptor for the treatment of osteoporosis or other bone-related diseases. PTH analogs are recombinant and synthetic peptides delivered by injection, inhalation, nasal, oral and transdermal administration. In cases of systemic sclerosis, PTH may stimulate aberrant calcification.
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Parathyroid hormone, parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts...
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