Periodic Limb Movement Disorder and Restless Legs Syndrome - Biotech, Pharma and Life Science Channel
PubMed Articles
We examined the relationships between bone mineral density (BMD) and metabolic syndrome in 6,659 men and 7,826 women from South Korean. After adjusting for age, body mass index (BMI), tobacco and alco...
Tumor lysis syndrome and malignant melanoma.
Tumor lysis syndrome (TLS) is an oncological emergency that results from massive cytolysis of malignant cells with a sudden release of their contents into the systemic circulation. TLS was rarely desc...
Epigenetics: a new mechanism of regulation of heart failure?
Heart failure is a syndrome resulting from a complex genetic predisposition and multiple environmental factors, and is a leading cause of morbidity and mortality. It is frequently accompanied by chang...
INTRODUCTION. MCT8 is a specific transporter for the T4 and T3 thyroid hormones that allows their entry in the brain and other organs. Mutations in MCT8 (Allan-Herndon-Dudley syndrome) lead to a sever...
Ocular manifestations of Churg-Strauss syndrome : Review article and case report.
This paper summarizes the possible ocular manifestations of Churg-Straus syndrome (CCS) from the literature and presents an unusual case report from routine clinical practice with conjunctival granulo...
"Thinking outside the box" on takotsubo syndrome.
Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the...
Inflammatory and anti-inflammatory cytokines play an important role in the generation of effector and memory CD8(+) T cells. We used two different models, transgenic expression of truncated (dominant...
Dipeptidyl Peptidase IV Is a Human and Murine Neutrophil Chemorepellent.
In Dictyostelium discoideum, AprA is a secreted protein that inhibits proliferation and causes chemorepulsion of Dictyostelium cells, yet AprA has little sequence similarity to any human proteins. We...
Prolyl oligopeptidase (PREP) has been considered as a drug target for the treatment of neurodegenerative diseases. In plasma, PREP has been found altered in several disorders of the central nervous sy...
News Articles
Adamas reports positive PII/III data for ADS-5102
Adamas presented data from the Phase II/III EASED clinical trial during the Movement Disorders Society's 17th International Congress of Parkinson's Disease and Movement Disorders from 16 to 20 June in...
Passages Malibu Recognizes National PTSD Awareness Day
Post-traumatic Stress Disorder often leads to addiction and its significance in treatment needs to be better understood. Malibu, CA (PRWEB) June 19, 2013 For the last three years, a national day of r...
Hope For Treatment Of Non-24 Hour Sleep-Wake Disorder In The Blind
An investigational new drug significantly improved a common and debilitating circadian rhythm sleep disorder that frequently affects people who are completely blind, a multicenter study finds. The res...
Fat Tissues In Sheep Affected By Prenatal Exposure To BPA
New research suggests that fetal exposure to the common environmental chemical bisphenol A, or BPA, causes increased inflammation in fat tissues after birth, which can lead to obesity and metabolic sy...
Weight Loss Promoted By Drug Combination In Polycystic Ovary Syndrome
Women with polycystic ovary syndrome, or PCOS, lost significantly more weight when they took two drugs that are traditionally used to treat diabetes, rather than either drug alone, a study from Sloven...
SOPHIA ANTIPOLIS CEDEX, FRANCE -- (Marketwired) -- 06/19/13 -- Nicox Strengthens Ophthalmic Portfolio with Immco Diagnostics' Proprietary Test in the Dry Eye Market Exclusive North American Agreemen...
Discovery Of A Mutant Gene In Rett Syndrome
Discovery of a mutant gene responsible for a disease is a milestone, but for most conditions, it may be only a first step towards a treatment or cure. Understanding Rett Syndrome, an autism spectrum d...
Discovery Of Rare Genomic Mutations In 10 Families With Early-Onset, Familial Alzheimer's Disease
Although a family history of Alzheimer's disease is a primary risk factor for the devastating neurological disorder, mutations in only three genes - the amyloid precursor protein and presenilins 1 and...
Zyprexa Relprevv REMS May Need Revision Following Two Patient Deaths
FDA investigating reports of two patients who died three to four days after receiving Lilly’s long-acting intramuscular antipsychotic; it is uncertain whether they died from post-injection delirium...
Transgender Adolescents Can Safely Receive Hormone Treatment To Halt Puberty
Hormone treatment to halt puberty in adolescents with gender identity disorder does not cause lasting harm to their bones, a new study finds. The results were presented at The Endocrine Society's 95th...
Events
Clinical Analytics for Decision Support Conference
Actionable patient data for enhanced clinical outcomes
3rd annual conference on Pharmacovigilance
SMi are proud to present their 3rd annual conference on Pharmacovigilance due to take place in Central London over the 1st & 2nd July 2013.
Companies
Since its founding in 1987, the Sturge-Weber Foundation (SWF) has provided information, education and friendly support to adults and families of children with Sturge-Weber syndrom...
Avaxia is a leader in the growing field of gut-targeted therapeutics â orally administered, minimally absorbed drugs that are designed to act locally in the gastrointestinal...
NeuroMetrix is a science-based health care company transforming patient care through neurotechnology. To date, our focus has been primarily on the assessment of neuropathies. We a...
Akebia Therapeutics is a discovery and development company focused on anemia and vascular disorders. Akebiaâs lead program, AKB-6548, an orally bioavailable HIF-prolyl hydrox...
Humanetics is a privately-held specialty pharmaceutical company headquartered in Minneapolis, Minnesota. The company focuses on the rapid discovery, development and commercializat...
Founded in 1989 and with headquarters in Ann Arbor, Michigan, Aastrom Biosciences is dedicated to the development of stem cell treatments for critical cardiovascular diseases. Aastrom is currently e...
Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in aesthetics, dermatology and neurology in the U.S. and Canad...
Eli Lilly and Company is a leading, innovation-driven corporation committed to developing a growing portfolio of best-in-class and first-in-class pharmaceutical products that help people live longer...
Forest Laboratories, Inc. & Ironwood Pharmaceuticals, Inc.
Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...
Ironwood Pharmaceuticals, Inc.
Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agonist, is...
Clinical Trials
Secondary Prevention of coRonary Events After Discharge From Hospital (SPREAD)
This is a randomized, open trial comparing post discharge interventions by community health workers (CHW) to standard care in acute coronary syndrome (ACS) patients. This trial will be co...
Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
Autism Spectrum Disorders (ASD) include Autistic disorder, Asperger's syndrome and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). These are developmental disorders be...
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of the upper limb are effective in treating spasticity in patients after stroke.
Safety and Pharmacokinetics of Ifetroban in Hepatorenal Syndrome Patients
Cumberland Pharmaceuticals Inc. (CPI) is developing ifetroban for treatment of hepatorenal syndrome (HRS) and proposes to conduct a study in hospitalized adult patients with HRS to assess...
This study is an extension of the European Multicentre Tics In Children Studies (EMTICS) COURSE study for which a separate study protocol exists; Aim of this clinical trial is to study the...
Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
The purpose of this study is to see if taking a substance called omega-3 fatty acids is effective, safe, and well-tolerated for treating adolescents with major depressive disorder (also ca...
MAESTRO-OL: Macitentan in Eisenmenger Syndrome To Restore Exercise Capacity (Open-Label)
Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.
Physical Activity and Cognitive Behavioural Therapy in Panic Disorder
Physical activity (treadmill) supports the effect of cognitive behavioural therapy in patients with panic disorder with/without agoraphobia
The purpose of this study is to evaluate the efficacy, safety, and tolerability of two doses (12.5 and 50 mg) of NBI-98854 administered once daily (q.d.) for the treatment of tardive dyski...
This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion. Cushing's synd...
Videos
Periodic Limb Movement (PLM) also known as Restless Leg Syndrome (RLS)
http://www.restlessleghope.com My wife suffers from restless periodic limb movement (PLM), often referred to as leg syndrome (RLS). RLS is a neurological dis...
Medical and Biotech [MESH] Definitions
Incidental Findings
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
Decapoda (crustacea)
The largest order of CRUSTACEA, comprising over 10,000 species. They are characterized by three pairs of thoracic appendages modified as maxillipeds, and five pairs of thoracic legs. The order includes the familiar shrimps, crayfish (ASTACOIDEA), true crabs (BRACHYURA), and lobsters (NEPHROPIDAE and PALINURIDAE), among others.
Anomura
An infraorder of CRUSTACEA, in the order DECAPODA comprising the hermit crabs and characterized by a small fifth pair of legs.
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Insomnia, Fatal Familial
An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).
