Peroxisome Proliferator Activated Receptor PPAR Agonists - Biotech, Pharma and Life Science Channel
Despite the tremendous attrition rate of PPAR agonist R&D over the last 20 years, the ones in the market are commercially quite successful and spur development of improved successors. The current reassessment of benefit/risk ratio of the classical PPAR gamma agonist rosiglitazone by the FDA and the EMA highlights the need for safer PPAR agonists. One promising approach to achieve effective, but still well tolerated PPAR gamma agonists are selective PPAR gamma modulating agents. Other approaches try to combine PPAR alpha, gamma and delta agonism in one molecule and to find the right balance.
News Articles
Results in Science Translational Medicine Highlight the Benefits of the Zalicus Combination High-throughput Screening (cHTS) Technology to Identify Novel Treatments for Ebolavirus...
Lophius Biosciences GmbH Joins NEU² and Receives Substantial Grant Funding for the Diagnosis ...
Hamburg/Regensburg, Germany, June 19, 2013 / B3C newswire / - Bionamics GmbH, the coordinator of the NEU² consortium,and Lophius Biosciences GmbH announced today that Lophius Biosciences has joi...
RALEIGH, NC--(Marketwired - June 18, 2013) - DARA BioSciences, Inc. (NASDAQ: DARA), a specialty pharmaceutical company focused on oncology supportive care products, announced today that it has grant...
Aragon Pharmaceuticals Announces Acquisition by Johnson & Johnson
SAN DIEGO, CA -- (Marketwired) -- 06/17/13 -- Aragon Pharmaceuticals Inc., a leader in developing drugs for hormone driven cancers, today announced a definitive agreement with Johnson & Johnson w...
SOUTH SAN FRANCISCO, Calif., June 14, 2013 /PRNewswire-iReach/ -- CoMentis, Inc. and Anvyl announced today that the companies have agreed to form Alpharmagen, a joint venture committed to discovering...
Jeffrey Epstein, Science Financier, Changes the Course of Evolution at Harvard
NEW YORK, June 12, 2013 /PRNewswire/ -- Ten years ago the Program for Evolutionary Dynamics was founded at Harvard with a $30 million dollar grant from a financier called Jeffrey Epstein. Si...
David Julius Wins 2013 Dr. Paul Janssen Award for Biomedical Research
SAN FRANCISCO, June 12, 2013 /PRNewswire/ -- Johnson & Johnson today named David Julius, PhD, chair of the Department of Physiology at the University of California, San Francisco (UCSF), the winne...
GHENT, BELGIUM -- (Marketwired) -- 06/12/13 -- Ablynx (EURONEXT BRUSSELS: ABLX) today announced that it will have an oral and poster presentation on its novel anti-IL-6R Nanobody, ALX-0061, at the A...
Critical Diagnostics announced today that the American College of Cardiology Foundation/American Heart Association Task Force jointly released its expanded clinical practice guide...
- Lymphoseek demonstrated reliable identification of lymph nodes over 15 minutes to 30 hours, typical timeframes for lymphatic mapping in clinical setting - Navidea Bio...
Events
Diabetes: Secondary Complications, Regulation and Innovation Conference
SMi is very proud to present our 11th conference focusing on Diabetes and metabolic disorders taking place on 1st and 2nd Oct 2013, London.
Companies
Sequenta, Inc. is a privately held company developing and commercializing molecular diagnostic assays based on a proprietary sequencing approach to the profiling of T and B cell r...
TOMI Environmental Solutions, Inc.
TOMI Environmental Solutions, Inc. (OTCBB:TOMZ) is a leading provider of environmental indoor air and surface purification equipment and services that use either Ozone produced by...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
Izun Pharmaceuticals Corporation
Izun Pharmaceuticals is a US based pharmaceutical company with a wholly owned R&D center in Israel. Izunâs technology platform allows it to develop botanical drugs by optimiz...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
CytomX Therapeutics is an early stage biotechnology company developing Probodiesâ¢, or proteolytically-activated antibodies. Probodies combine the well-established power and s...
Seventh Sense Biosystems, Inc.
Seventh Sense Biosystems is an early stage, private company developing a new generation of blood access and diagnostic products that promise unprecedented convenience and simplici...
Kopin Corporationâs voice-activated, wireless, hands-free Golden-i® mobile computing headsets, ruggedized military imaging systems, ultra-small liquid crystal displays and...
Norit is a global leader in the research, development, manufacturing and sale of high-grade activated carbons used in a growing range of environmental, health, safety and industri...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, galeterone (TOK-001), i...
Clinical Trials
Ventricular Arrhythmias in Uremic Cardiomyopathy
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue. When active this gene builds...
RATIONALE: Aromatase inhibitors, such as letrozole, prevent the formation of estradiol, a female hormone. Giving letrozole together with goserelin, leuprolide, or surgery may be an effecti...
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has...
Antithrombotic Triple Therapy in Humans
Background:The acute coronary syndrome (ACS) is a complication of coronary artery disease (CAD) and associated with increased mortality. Dual antiplatelet therapy of acetylsalicylic acid (...
D-Serine Monotherapy for Schizophrenia
N-methyl-D-aspartate receptor (NMDAR) agonist, added to classical or atypical antipsychotic medication, has reduced negative, depressive, and cognitive symptomatology. We will be investiga...
D-Serine Adjuvant Treatment for Parkinson's Disease
The proposed experiment will evaluate the effects of the NMDA receptor full agonist D-serine (~2g/day) on persistent symptoms of Parkinson's Disease and on antiparkinsonian drugs-induced d...
The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria
An open labelled trial of Kineret (anakinra) induction therapy (100mg./day) in over a four week period in the treatment of Familial Cold Urticaria. Familial Cold Urticaria (FCU) is a rare...
"Salvage Use" of Recombinant Factor VIIa After Inadequate Haemostasis in Complex Cardiac Surgery
Aims and Hypotheses: This randomised placebo controlled study will test the hypothesis that Recombinant Activated Factor VII (rVIIa) will improve haemostasis after an inadequate response...
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately. Th...
Pilot Studies of Novel Therapies to Treat Resistant Focal Segmental Glomerulosclerosis (FSGS)
The current management of primary FSGS is predicated on the assumption that the disease is caused by an immune-mediated disturbance in glomerular barrier function. Therefore, most treatmen...
PubMed Articles
TMEM16A and TMEM16B proteins are CaCCs (Ca2+-activated Cl- channels) with eight putative transmembrane segments. As shown previously, expression of TMEM16B generates CaCCs characterized by a 10-fold l...
A Detailed Study on Understanding Glycopolymer Library and Con A Interactions.
Synthetic glycopolymers are important natural oligosaccharides mimics for many biological applications. To develop glycopolymeric drugs and therapeutic agents, factors that control the receptor-ligand...
Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3.
Besides the necessary changes in the expression of cell cycle-related proteins, cancer cells undergo a profound series of metabolic adaptations focused to satisfy their excessive demand for biomass. A...
Agonist anti-CD137 (4-1BB) mAbs enhance CD8-mediated antitumor immunity. Agonist anti-human CD137 mAbs binding to four distinct epitopes on the CD137 glycoprotein costimulated T cell activation irresp...
Superantigen-induced steroid resistance depends on activation of phospholipase cβ2.
The glucocorticoid receptor is present in a TCR-associated complex, which includes the Src family tyrosine kinase Lck. Glucocorticoids rapidly dissociate this complex, resulting in the inhibition of c...
Endogenous mechanisms regulating the host response during inflammation resolution are critical in ensuring disposal of noxious stimuli and return to homeostasis. In this article, we engineered novel A...
Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of inflammation. In this study we have explored the impact of LXR activation on the macrophage response to the endogeno...
SOCS3 Regulates BAFF in Human Enterocytes under Ribosomal Stress.
Although the activation of B cells in the gastrointestinal tract is of great importance in the context of immunity to pathogens and mucosal inflammatory diseases, little is known about the mechanisms...
Although extensive homology exists between their extracellular domains, NK cell inhibitory receptors killer Ig-like receptor (KIR) 2DL2*001 and KIR2DL3*001 have previously been shown to differ substan...
Pseudogout is an autoinflammatory condition triggered by calcium pyrophosphate dehydrate (CPPD) crystal deposition in the joints. The innate immune system is irritated by and responds to the presence...
Videos
Let's Play Medal of Honor - Merker's Upper Mine 20
Thiazolidinediones like pioglitazone and rosiglitazone increase peripheral tissue insulin sensitivity by stimulating the peroxisome proliferator-activated re...
Medical and Biotech [MESH] Definitions
Transferrin-binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Transferrin-binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Bacterial Transferrin Receptor Complex
A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum.
Receptors, Eph Family
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
Receptor, Epha1
The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
