Pharmacodynamics - Biotech, Pharma and Life Science Channel

PubMed Articles [ 442 Associated PubMed Articles listed on BioPortfolio]

Pharmacokinetic and Pharmacodynamic Interaction of Nadolol With Itraconazole, Rifampicin and Grapefruit Juice in Healthy Volunteers.

To evaluate effects of itraconazole, rifampicin and grapefruit juice on pharmacokinetics and pharmacodynamics of a hydrophilic non-selective β-adrenoceptor blocker nadolol, we conducted an open-label...

Apixaban: A Review of its Use for Reducing the Risk of Stroke and Systemic Embolism in Patients with Nonvalvular Atrial Fibrillation.

The direct factor Xa inhibitor apixaban (Eliquis(®)) has predictable pharmacodynamics and pharmacokinetics and does not require routine anticoagulation monitoring. This article reviews the efficacy a...

Optimizing the Use of Aspirin for Cardiovascular Prevention.

This article describes the mechanism of action, pharmacokinetics, and pharmacodynamics of aspirin at doses used for cardiovascular prevention and provides specific management recommendations for optim...

Vandetanib: A novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer.

The pharmacology, pharmacokinetics, efficacy, safety and tolerability, drug and food interactions, cost, and place in therapy of vandetanib are reviewed.

Pharmacokinetics and Pharmacodynamics of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Subjects With Type 2 Diabetes Mellitus.

This study characterized single- and multiple-dose pharmacokinetics of canagliflozin and its O-glucuronide metabolites (M5 and M7) and pharmacodynamics (renal threshold for glucose [RTG ], urinary glu...

Modeling of PET data in CNS drug discovery and development.

Positron emission tomography (PET) is increasingly used in drug discovery and development for evaluation of CNS drug disposition and for studies of disease biomarkers to monitor drug effects on brain...

A Predictive Pharmacokinetic/Pharmacodynamic Model of Fentanyl for Analgesia/Sedation in Neonates Based on a Semi-Physiologic Approach.

BACKGROUND AND OBJECTIVES: Fentanyl is a synthetic opioid commonly used as an anesthetic and also increasingly popular as a sedative agent in neonates. Initial dosage regimens in this population are o...

Structural, Kinetic, and Pharmacodynamic Mechanisms of d-Amino Acid Oxidase Inhibition by Small Molecules.

We characterized the mechanism and pharmacodynamics of five structurally distinct inhibitors of d-amino acid oxidase. All inhibitors bound the oxidized form of human enzyme with affinity slightly high...

Phase I pharmacokinetic and biodistribution study with escalating doses of (223)Ra-dichloride in men with castration-resistant metastatic prostate cancer.

PURPOSE: (223)Ra-Dichloride ((223)Ra) is a novel bone-seeking alpha-emitter that prolongs survival in patients with castration-resistant metastatic prostate cancer. We conducted a study to better prof...

New Oral Anticoagulants in Non-Valvular Atrial Fibrillation.

Atrial fibrillation (AF) is associated with an increased risk of embolic stroke. Dose-adjusted vitamin K antagonists (VKAs) to a target international normalized ratio (INR) range of 2.0-3.0 reduce the...

News Articles [ 48 Associated News Articles listed on BioPortfolio]

Computational Biology Market - New Market Research Report Published by Transparency Market Research

According to a new market report published by Transparency Market Research, "Computational Biology (Pharmacodynamics, Cellular Modeling, Computational Genomics, Proteomics, Pharmacogenomics, Phar...

Merck Millipore Publishes White Paper: Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal Antibodies

Merck Millipore, the Life Science division of Merck, today announced the publication of a white paper, "Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal...

Epistem Presents Biomarker Data

Epistem Plc., the UK biotechnology and personalised medicine company, will be presenting advances in two independent research platforms at  the American Association  for Cancer Research Annu...

Epistem Presents Biomarker Data, and Its New Preclinical Model of Acute Myeloid Leukaemia, at the AACR 2013 Annual Meeting

MANCHESTER, UNITED KINGDOM -- (Marketwired) -- 04/08/13 -- Epistem Plc. (LSE: EHP), the UK biotechnology and personalised medicine company, today announced it will be presenting advances in two inde...

Certara Launches Drug Development Consulting Services for Asia

Certara™ (headquartered in St. Louis, MO; Location of Japan office: Minato-ku, Tokyo), leading provider of software and scientific consulting services to improve productivity a...

Galapagos to start Phase 2a study with GLPG0974 in IBD patients

Positive Phase 1 study showed clean safety data and strong response of biomarker Phase 2a Proof of Concept study in ulcerative colitis will start next month Mechelen, Belgium; 27 March 2013 -...

BioCryst starts BCX4161 Phase 1 clinical trial for treatment of hereditary angioedema

BioCryst Pharmaceuticals, Inc. today announced the initiation of a Phase 1 clinical trial to evaluate the safety, pharmacokinetics and pharmacodynamics of orally-administered BCX4161 in healthy volunt...

[Seminar] Acute lymphoblastic leukaemia

Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous exposures, genetic suscep...

Upsher-Smith Presents Favorable Phase I Data For USL261, A Novel Formulation Of Intranasal Midazolam, At 65th Annual Meeting Of The American Academy Of Neurology

MAPLE GROVE, Minn., March 19, 2013 /PRNewswire/ -- Upsher-Smith Laboratories, Inc., (Upsher-Smith) today announced that Phase I data for USL261 (intranasal midazolam) in healthy volunteers were p...

CDER's OTS to house new Office of Computational Science

Janet Woodcock, director of FDA's Center for Drug Evaluation and Research, announced several changes to the center's Office of Translational Science (OTS), including the formation of the Office of Com...

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Clinical Trials [ 423 Associated Clinical Trials listed on BioPortfolio]

89Zr-trastuzumab PET for Imaging the Effect of HSP90 Inhibition

HSP90 inhibition is a potentially new targeted drug modality in the treatment of HER2 positive, trastuzumab refractory breast cancer. Little is known about the pharmacodynamics of HSP90 in...

Intravitreal LFG316 in Patients With Age-related Macular Degeneration (AMD)

This study is designed to test the efficacy of twelve successive monthly doses of intravitreal (IVT) LFG316 on the growth of geographic atrophy (GA) lesions. The study will also provide in...

First Human Dose Trial of NNC0195-0092 in Healthy Subjects

This trial is conducted in Europe. The aim of this trial is to assess safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect o...

Nicotinic Acid - Pharmacokinetics, Pharmacodynamics, Receptor Expression

The study will be a double-blind, randomized, placebo-controlled, single-center, 2 treatment, 3-­way crossover. Subjects will be randomly allocated to a treatment sequence – AAB, ABA or...

Ketoconazole Administration: How it is Affected by the Body and Broken Down and How it Acts on the Body When Used With Velcade

The purpose of this study is to investigate how ketoconazole (Nizoral) affects the pharmacokinetics (how the study drug is affected by the body and broken down) and pharmacodynamics (how t...

RAD001 Plus Octreotide Depot in Metastatic or Unresectable Low Grade Neuroendocrine Carcinoma

Objectives: Primary endpoint: -Assess the clinical activity of RAD 001 plus depot octreotide as defined by progression free survival duration defined by RECIST criteria in treated...

Study of the Tolerability, Pharmacokinetics, and Pharmacodynamics of INS50589 Intravenous Infusion in Healthy Volunteers

The objectives of this study are to look at the safety and tolerability of the experimental drug, how people process the drug, how the drug affects people, and to identify a dose or doses...

Escalating Multiple-Dose Safety and Tolerance of WR 6026 Hydrochloride in HIV-Infected Subjects

To determine the maximum tolerated dose (MTD) of WR 6026 in HIV-infected patients. To determine whether any unexpected toxicities are caused by WR 6026 in HIV-infected patients. To determi...

Effect of ACP-501 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Subjects With Coronary Artery Disease

This study is a phase 1, intravenous, open-label, single-dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of ACP-501 (recombinant human Lec...

A Multiple Ascending Dose Study of R1511 in Patients With Type 2 Diabetes Mellitus.

This 4 arm study will evaluate the pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of R1511 compared to placebo in patients with type 2 diabetes mel...

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