POEMS Syndrome - Biotech, Pharma and Life Science Channel
PubMed Articles
Tumor lysis syndrome and malignant melanoma.
Tumor lysis syndrome (TLS) is an oncological emergency that results from massive cytolysis of malignant cells with a sudden release of their contents into the systemic circulation. TLS was rarely desc...
The increasing incidence of cancer is at the same time one of the leading causes of death all over the world. Many clinical studies show that the psychological disorders are more frequent in cancer pa...
Chorea due to TITF1/NKX2-1 mutation: phenotypical description and therapeutic response in a family.
INTRODUCTION. Chorea due to a mutation in the TITF1 gene, which is also known as benign hereditary chorea, is an autosomal dominant disorder that usually begins before the age of 5 years. In most case...
Boerhaave's syndrome is spontaneous rupture of the esophagus, a rare condition with high mortality that occurs most often after forceful vomiting. Polyethylene glycol (PEG) solution is the most common...
Preventing ovarian hyperstimulation syndrome: cabergoline versus coasting.
PURPOSE: The use of cabergoline and coasting are both effective in reducing the risk of ovarian hyperstimulation syndrome (OHSS). Our aim was to compare the effectiveness of cabergoline with coasting...
Primary Budd-Chiari syndrome in a 3-year-old boy with homozygous factor V Leiden G1691A mutation.
Budd-Chiari syndrome (BCS) is an uncommon disorder characterized by obstruction of hepatic venous outflow. The primary BCS is a rare disease with an incidence about 0.2 per million inhabitants per yea...
Severe autoimmune hemolytic anemia with renal neoplasm.
Autoimmune hemolytic anemia is a type of hemolytic anemia characterized by autoantibodies directed against red blood cells shortening their survival. When autoimmune hemolytic anemia is secondary to a...
ABSTRACT Background: The Charles Bonnet syndrome (CBS) is characterized by distinct visual hallucinations and ocularpathology causing visual impairment in patients with insight and the absence of psyc...
Prospective study of restless legs syndrome and risk of erectile dysfunction.
In our previous cross-sectional study, we found that restless legs syndrome (RLS) was associated with erectile dysfunction (ED). Thus, we conducted a prospective study to examine whether RLS was assoc...
Maternal cfDNA screening for Down syndrome - a cost sensitivity analysis.
OBJECTIVE: To determine the principal factors contributing to the cost of avoiding a birth with Down syndrome, using cell free (cf)DNA to replace conventional screening. METHODS: A range of unit costs...
News Articles
Clermont Chiropractor Offers Non-Surgical Carpal Tunnel Syndrome Treatments
CLERMONT, Fla., May 19, 2013 (GLOBE NEWSWIRE) -- According to Dr. Kurtis Michaux of Michaux Family Chiropractic, a diagnosis of carpal tunnel syndrome (CTS) does not have to mean a choice between sur...
Neupro reduces PLMS and total NSBP elevations in patients with RLS, study finds
UCB today announced data from a double-blind, placebo-controlled study that found that Neupro (Rotigotine Transdermal System) reduced total nocturnal systolic blood pressure elevations associated with...
The personal injury law firm of d’Oliveira & Associates has issued an infographic on Stevens Johnson Syndrome, which details potential causes and serious conditions that may result from the synd...
Statins May Reduce Exercise Benefits For Obese Adults
Statins, the most widely prescribed drugs worldwide, are often suggested to lower cholesterol and prevent heart disease in individuals with obesity, diabetes and metabolic syndrome, which is a combina...
FOPO nets $13.4mm for [Discovery Laboratories]
[Discovery Laboratories Inc.] (respiratory therapeutics) has netted $13.4mm through the follow-on public offering of 9.5mm common shares at $1.50. The company will use the funds to commercialize FDA-a...
New study shows UCB's Neupro reduces NSBP in RLS patient
Leading Belgian drugmaker UCB (Euronext Brussels: UCB) today (May 17) announced data from a double-blind, placebo-controlled study that found that Neupro (rotigotine transdermal system) reduced total...
UCB unveils effects of Neupro on cardiovascular measures in RLS patients
UCB has unveiled data from a double-blind, placebo-controlled study, which found that Neupro (Rotigotine Transdermal System) reduced total nocturnal systolic blood pressure (NSBP) elevations associate...
Drug Reaction in a Patient on Phenytoin and Levetiracetam
This case report highlights a potentially life-threatening hypersensitivity reaction -- the DRESS syndrome -- associated with a variety of medications, especially anti-epileptics. Journal of Medical...
FDA approves Novartis juvenile arthritis drug
The FDA has approved Novartis’ drug Ilaris (canakinumab) for the treatment of active systemic juvenile idiopathic arthritis (SJIA) in patients aged two years and older. Ilaris is the first interleuk...
CDC Mental Health Report Finds Seven Percent Of Children Have ADHD
redOrbit Staff & Wire Reports - Your Universe Online Attention deficit-hyperactivity disorder (ADHD) is the most prevalent diagnosis amongst youngsters between the ages of three and 17, according...
Events
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Companies
Forest Laboratories, Inc. & Ironwood Pharmaceuticals, Inc.
Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...
Ironwood Pharmaceuticals, Inc.
Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agonist, is...
Almirall, S.A. and Ironwood Pharmaceuticals, Inc.
Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwood's GC-C agon...
Auspex Pharmaceuticals is a privately held biopharmaceutical company located in La Jolla, California. The company is a pioneer in the use of deuterium in medicinal chemistry, and...
Founded in 2005 by cardiologists and researchers from the Stanford University School of Medicine , Aviir is focused on the discovery, development and commercialization of innovati...
Akebia Therapeutics is a discovery and development company focused on anemia and vascular disorders. Akebiaâs lead program, AKB-6548, an orally bioavailable HIF-prolyl hydrox...
Headquartered in Osaka, Japan, Shionogi & Co., Ltd. is a major research-driven pharmaceutical company dedicated to placing the highest value on patients. Shionogiâs Research...
Ironwood Pharmaceuticals, Inc. and Bionomics Limited
Ironwood Pharmaceuticals (NASDAQ: IRWD) is an entrepreneurial pharmaceutical company dedicated to the art and science of great drugmaking. Linaclotide, Ironwoodâs GC-C agonis...
Global Down Syndrome Foundation (GDSF)
WHAT
Nathealth Solutions is the U.S.-based distributor of BergaMet MEGA, the most powerful, natural agent for the management of lipid disorders. Derived from the Citrus bergamia Risso...
Clinical Trials
This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion. Cushing's synd...
This study will evaluate the safety and effectiveness of treating patients with severe aplastic anemia (SAA) or myelopdysplastic syndrome (MDS) with both peripheral blood stem cells from a...
Nephrotic Syndrome Study Network
Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for appr...
Safety and Pharmacokinetics of Ifetroban in Hepatorenal Syndrome Patients
Cumberland Pharmaceuticals Inc. (CPI) is developing ifetroban for treatment of hepatorenal syndrome (HRS) and proposes to conduct a study in hospitalized adult patients with HRS to assess...
MAESTRO-OL: Macitentan in Eisenmenger Syndrome To Restore Exercise Capacity (Open-Label)
Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.
The Study of the Safety and Efficacy of Ampligen in Chronic Fatigue Syndrome
multi-center, double-blind, randomized, placebo-controlled study of the safety and efficacy.
Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts
The primary objective of this study is to compare overall survival (OS) in patients receiving ON 01910.Na + best supportive care (BSC) to OS of patients receiving BSC in a population of pa...
In this study, newborn babies with respiratory distress syndrome (RDS), receiving oxygen via nasal CPAP, and needing surfactant treatment will be randomized to standard delivery of surfact...
Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates
A research study that will evaluate if giving surfactant medication to premature babies weighing < 1250 gm at birth during the second and third weeks of life will help their lungs. We are...
The Survey About Resting Metabolic Rate and Its Related Factors in Terminal Patients
According to data from the Taiwanese government, cancer mortality has been the leading cause of death in Taiwan since 1982. The trend is increasing day by day. As the people are aging in T...
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POEMS Syndrome
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Medical and Biotech [MESH] Definitions
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Thyroid Hormone Receptors Beta
High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.
Pulmonary Surfactant-associated Protein B
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Hammer Toe Syndrome
A condition characterized by a series of interrelated digital symptoms and joint changes of the lesser digits and METATARSOPHALANGEAL JOINTS of the FOOT. The syndrome can include some or all of the following conditions: hammer toe, claw toe, mallet toe, overlapping fifth toe, curly toe, EXOSTOSIS; HYPEROSTOSIS; interdigital heloma, or contracted toe.
Alpha-crystallin B Chain
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
