Prostate specific membrane antigen PSMA - Biotech, Pharma and Life Science Channel
Prostate-specific membrane antigen (PSMA) is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer and a well-known imaging biomarker for staging and monitoring therapy. PSMA represents an attractive antigen for antibody-based diagnostic and therapeutic intervention in prostate cancer, since it is highly restricted to the prostate and overexpressed in all tumor stages. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. In addition to the treatment modality antibodies, vaccines including dendritic cell (DC)-based vaccines hold promise as a safe therapy for prostate cancer, and PSMA fulfils the requirements for a tumor-associated antigen to be clinically effective. These findings have spurred development of PSMA-targeted therapies for cancer, and first-generation products have entered clinical testing.
Biologic and clinical effects were seen in a small fraction of patients and at doses near the maximum tolerated dose. The initial studies provided proof of concept for PSMA-based therapies. New or improved technologies such as antibody-based drug conjugates or dendritic cell based immunotherapies enabled second-generation antibody and vaccine products which have the promise to exploit PSMA for molecularly targeted therapy of prostate and other cancers.
Prostate-specific antigen (PSA) was discovered more than 20 years ago and has become the premier tumor marker for diagnosis, monitoring and prognosis of prostatic carcinoma despite its very controversially discussed relevance. Similar to PSAM, PSA serves as a molecular target for novel active and passive immunotherapies currently under investigation
News Articles
Following the conclusion of the Pharmacovigilance Risk Assessment Committee (PRAC) that the benefits of Diane 35 and its generics outweigh the risks in a specific patient group, the French National Ag...
European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) has concluded that the benefits of Diane 35 (cyproterone acetate 2 mg, ethinylestradiol 35 micrograms) and its generics...
News and press releases: Benefits of Diane 35 and generics outweigh risks in specific patient group
The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee (PRAC) has concluded that the benefits of Diane 35 (cyproterone acetate 2 mg, ethinylestradiol 35 micrograms) and its gene...
ImmunoCellular Therapeutics Announces Issuance of Key Patent Covering ICT-107 Cancer Vaccine Target
ImmunoCellular Therapeutics, Ltd. (“ImmunoCellular”) (NYSE MKT: IMUC) announced that the US Patent and Trademark Office (USPTO) has issued a patent covering methods of use of...
CHICAGO, May 16, 2013 /PRNewswire/ -- Zacks.com announces the list of stocks featured in the Analyst Blog. Every day the Zacks Equity Research analysts discuss the latest news and events...
Lund, Sweden, May 16, 2013, Active Biotech (NASDAQ OMX NORDIC: ACTI) will present data from two of its oncology projects, the drug candidates tasquinimod for the treatment of prostate cancer and ANYA...
Not Intended for US Media Oslo, Norway, 16 May 2013 - Algeta ASA (OSE: ALGETA) announces that further analyses of data subsets from the phase III ALSYMPCA study of the recently FDA-approved Xofig...
MONTREAL, QUEBEC -- (Marketwired) -- 05/16/13 -- Alethia Biotherapeutics Inc., a privately held biotechnology company focusing on the development of therapeutic monoclonal antibodies, announced toda...
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Industry-Specific Strategies for Complex and Evolving Accounting Issues in a Global Environment
Webinar - Oncology Clinical Trials in Eastern Europe
Main focus on Breast cancer, Prostate cancer, Ovarian cancer, Lung cancer, Colorectal cancer
Companies
Cerapedics is a privately-held medical device company focused on developing and commercializing novel osteobiologic products based on its proprietary anorganic bone mineral (ABM)...
Cancer Genetics, Inc. (CGI) is an emerging leader in the field of personalized medicine, offering products and services that enable cancer diagnostics as well as treatments that are tailored to the...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
Cell Medica is a clinical stage cellular therapeutics company engaged in the development and delivery of cellular immunotherapy treatment strategies for infectious disease and can...
Utilizing evidence-based best practices, Care Team Connect provides a technology platform which enables collaboration among hospitals, community providers, family members and pati...
Clovis Oncology, Inc. is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. Clovis...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
New England Journal of Medicine
The New England Journal of Medicine is published weekly, and the term of a regular subscription is for one year (52 weeks). Subscribers can elect to receive either a Print and Online Subscription or a...
Answerthink (www.answerthink.com) is an SAP gold channel partner that develops and offers qualified SAP Business All-in-One partner solutions â industry-specific softw...
Established in 2008, Neuronix has developed a non-invasive technology-based treatment of brain conditions and their related symptoms, with a focus on Alzheimer's Disease (âAD...
Clinical Trials
RATIONALE: Dutasteride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dutasteride works in tr...
This is a phase 3, randomized, double-blind, placebo-controlled study to evaluate new or worsening lens opacifications in subjects with non-metastatic prostate cancer receiving denosumab f...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
This project examines the effects of a 4 month structured exercise intervention program in patients with non-alcoholic fatty liver disease (NAFLD). We will examine changes in total and dep...
Neoadjuvant Axitinib in Prostate Cancer
The goal of this clinical research study is learn if adding axitinib to hormonal therapy can help to control prostate cancer when given before surgery. The safety of this drug will also be...
Testing the Helpfulness of 2 Decision Aids for Prostate Cancer
The purpose of this study is to test different methods for communicating information about prostate cancer treatment to men. The investigators are studying how best to present information...
Impact of Hot Flashes on Sleep and Mood Disturbance
We plan to enroll 60 healthy, non-pregnant premenopausal women age 18-45 who do not have hot flashes (in order to have 30 women complete all study procedures) in a trial investigating the...
A Study of Epirubicin With Estramustine Phosphate and Celecoxib for the Treatment of Prostate Cancer
The purpose of this clinical trial is to find out the effect of epirubicin with estramustine phosphate and celecoxib on PSA and objective response in patients with hormone resistant prosta...
RATIONALE: The use of nutritional supplements, such as selenium, may stop prostate cancer from growing. Internal radiation, such as brachytherapy, uses radioactive material placed directly...
Fulvestrant in Treating Patients With Recurrent Prostate Cancer
RATIONALE: Estrogen may cause the growth of prostate cancer cells. Hormone therapy using fulvestrant may fight prostate cancer by blocking the use of estrogen by the tumor cells. PURPOSE:...
PubMed Articles
Antisense oligonucleotides (oligos) have been employed against prostate cancer models in both in vivo and in vitro systems. While most target growth factors or their receptors, other oligos are direct...
The aim of this study was to investigate the clinical significances of the mRNA expression of survivin gene and its four splice variants in the pathogenesis of colorectal cancer (CRC). CRC samples, ma...
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies in men and the second leading cause of male cancer mortality. MAZ (Myc-associated zinc-finger protein) is a transcription facto...
Inflammatory phenotype of the nurse cell harboring Trichinella spp.
The nurse cell (NC), formed from muscle cells upon infection with the parasitic nematode Trichinella spp. constitutes a confined habitat for muscle larvae of encapsulating species. Signaling pathway-d...
Protection against Trichinella infections has been achieved using various parasite antigens and adjuvants. Recently, we reported that immunization of mice with an attenuated Salmonella strain displayi...
Ts87 is an immunodominant antigen that induces protective immunity against Trichinella spiralis larval challenge in mice. To determine if a combination of recombinant Ts87 protein and its coding DNA i...
Trichinella pseudospiralis infection can modulate the immunological response of autoimmune and allergic diseases leading to the amelioration of these diseases. The present study was undertaken to comp...
An electrocatalytic membrane reactor assembled using a nano-MnO2 loading microporous Ti membrane as an anode and a tubular stainless steel as a cathode was used to oxidize n-propanol to produce propio...
A conjugated polymer-peptide hybrid system for prostate-specific antigen (PSA) detection.
We developed fast and readily applicable microarray chips to detect PSA by designing a novel conjugated polymer (energy donor) and combining it with on-chip peptide synthesis. The selective cleavage o...
Nanoporous organosilica membrane for water desalination.
Nanoporous organosilica membranes are successfully coated on porous alumina tubes and tested for desalination via membrane distillation. The membranes produced pure water (up to 13 kg m(-2) h(-1)) acr...
Videos
Mitotic Spindle and Cell Cycle, Rate My Science
http://ratemyscience.com/ Publish and rate science Prostate-specific membrane antigen (PSMA, NAAG Peptidase, FOLH1) is localized in the vicinity of mitotic s...
Medical and Biotech [MESH] Definitions
Spectral Karyotyping
The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.
Ethics Consultation
Services provided by an individual ethicist (ETHICISTS) or an ethics team or committee (ETHICS COMMITTEES, CLINICAL) to address the ethical issues involved in a specific clinical case. The central purpose is to improve the process and outcomes of patients' care by helping to identify, analyze, and resolve ethical problems.
Mitochondrial Membrane Transport Proteins
Proteins involved in the transport of specific substances across the membranes of the MITOCHONDRIA.
Periplasmic Binding Proteins
Periplasmic proteins that scavenge or sense diverse nutrients. In the bacterial environment they usually couple to transporters or chemotaxis receptors on the inner bacterial membrane.
Vesicular Transport Proteins
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.
