protein amyloidosis - Biotech, Pharma and Life Science Channel
PubMed Articles
ALKBH1 (AlkB homologue 1) is a mammalian AlkB (2-oxoglutarate-dependent dioxygenase) homologue that possesses AP (abasic or apurinic/apyrimidinic) lyase activity. The AP lyase reaction is catalysed by...
Structure-based histidine substitution for optimizing pH-sensitive Staphylococcus protein A.
Optimizing antibody purification is crucial to overcoming a bottleneck in the costly manufacturing process for antibody therapy. To address this issue, we designed a pH-sensitive Staphylococcus aureus...
Viruses enter into complex interactions within human hosts, leading to facilitation or suppression of each other's replication. Upon coinfection, GB virus C (GBV-C) suppresses HIV-1 replication in viv...
Bioanalytical LC-MS/MS of protein-based biopharmaceuticals.
Biotechnology increasingly delivers highly promising protein-based biopharmaceutical candidates to the drug development funnel. For successful biopharmaceutical drug development, reliable bioanalytica...
Employing directed evolution for the functional analysis of multi-specific proteins.
Multi-specific proteins located at the heart of complex protein-protein interaction (PPI) networks play essential roles in the survival and fitness of the cell. In addition, multi-specific or promiscu...
The dengue capsid protein C is a highly basic alpha-helical protein of ∼100 amino acid residues that forms an emphipathic homodimer to encapsidate the viral genome and to interact with viral membran...
Improving bioorthogonal protein ubiquitylation by click reaction.
Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also n...
Total chemical synthesis of fully functional Photoactive Yellow Protein.
The Photoactive Yellow Protein (PYP) is a structural prototype for the PAS superfamily of proteins, which includes hundreds of receptor and regulatory proteins from all three kingdoms of life. PYP its...
INstruct: a database of high-quality 3D structurally resolved protein interactome networks.
INstruct is a database of high-quality, 3D, structurally resolved protein interactome networks in human and six model organisms. INstruct combines the scale of available high-quality binary protein in...
Silica nanorattle with enhanced protein loading: a potential vaccine adjuvant.
Nanoparticles are excellent carriers for drug and protein, and have the potential to be used in vaccine delivery system. Here, we prepared different structures silica nanoparticles such as silica nano...
News Articles
Download Presentation: New Solutions accelerating Protein Research
Developing therapeutic monoclonal antibodies and ADC’s is a key focus of the pharmaceutical industry’s R&D. The European Antibody Congress 2012 bought together senior level executives [...]
Eating Peanut Butter/Peanuts at Breakfast Helps Control Hunger and Blood Sugar All Day
ALBANY, Ga., June 18, 2013 /PRNewswire/ -- A new study, released in the current British Journal of Nutrition, showed that consuming peanut butter or peanuts for breakfast can control blood sugar...
Researcher studies protein's link to heart disease
(Medical Xpress)—The largest protein known to exist in the human body functions as a molecular spring, and University of Arizona researchers are gaining new insights into its role in heart disease.
(Medical Xpress)—Calories in, calories out. Any dieter is familiar with the two sides of the equation for weight loss, usually reduced to eating less and exercising more. But what controls the body'...
Missing brain enzyme increases concentrations of protein related to pain-killer addiction
A missing brain enzyme increases concentrations of a protein related to pain-killer addiction, according to an animal study. The results will be presented Monday at The Endocrine Society's 95th Annual...
MCL-1 protein is vital for normal heart function, shows study
A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which...
Targeting SALL4 protein with druglike molecules could halt tumor growth, say researchers
Harvard Stem Cell Institute researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that ca...
Link Between Missing Enzyme And Drug Addiction
A missing brain enzyme increases concentrations of a protein related to pain-killer addiction, according to an animal study. The results were presented at The Endocrine Society's 95th Annual Meeting i...
MGH researchers discover CNVs in members of 10 families with early-onset Alzheimer's
Although a family history of Alzheimer's disease is a primary risk factor for the devastating neurological disorder, mutations in only three genes - the amyloid precursor protein and presenilins 1 and...
New study identifies possible treatment to block deposition of calcium in arterial wall
HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin...
Events
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Companies
Research Corporation Technologies & BioGrammatics, Inc.
RCT is a Tucson, Ariz.-based technology investment and management company that provides early-stage funding and development for promising biomedical companies and technologies. RC...
PhaseBio Pharmaceuticals, Inc.
PhaseBio Pharmaceuticals, Inc. (PhaseBio), located in Research Triangle Park, NC, is a development stage, privately held protein engineering company focused on developing the next...
Health Discovery Corporation is a molecular diagnostics company that uses advanced mathematical techniques to analyze large amounts of data to uncover patterns that might otherwis...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
Itero Biopharmaceuticals, Inc.
Itero Biopharmaceuticals, Inc. is a specialty biopharmaceutical company focused on the development and commercialization of protein therapeutics that offer significant clinical an...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
Founded in 1992, Balance Bar, one of Americaâs original nutrition/energy bars, inspires consumers to lead active, well-rounded and balanced lives by providing great-tasting,...
Dr. Yie-Hwa Chang founded the Company in August 2001. The Company is commercializing core technologies for which it has secured an exclusive license from Saint Louis University, i...
Ansaris is a division of Locus Pharmaceuticals, a privately held biopharmaceutical company focused on solving todayâs small molecule drug discovery challenges, has been the l...
Tivorsan Pharmaceuticals http://www.tivorsan.com is a protein therapeutics company pioneering a unique approach to treating serious neuromuscular disorders, including DMD and Beck...
Clinical Trials
Feeding Trial in the Obese Critical Care Population
This study will assess enteral feeding in an obese critically ill population with a higher protein whey based peptide formula.
Malnutrition, including muscle wasting commonly occurs in children with cystic fibrosis (CF), negatively influencing their quality of life and survival. At the time of a diagnosis of CF, s...
Ventricular Arrhythmias in Uremic Cardiomyopathy
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue. When active this gene builds...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
Background: The interactive effects of resistance training and dietary protein on hormonal responses in overweight or obese adults are not clear and remain controversial. Investigators tes...
Glutamine and Intestinal Protein Metabolism
Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative...
Proteomic Study of Urinary Stone Disease
Urinary protein levels are not routinely measured in stone patients while there is strong evidence that proteins play a role in the etiology of stones. The purpose of this study is to exa...
ACTH Stimulation and G Protein
Males and females may exhibit different responses to testing of adrenal function. The hormones responsible for controlling adrenal function are ACTH (adrenocorticotropic hormone or cortic...
Intravenous Immune Globulin to Treat Hereditary Inclusion Body Myopathy
This study will evaluate patients with Hereditary Inclusion Body Myopathy (HIBM) and examine the effects of immune globulin (IG) treatment on muscle and muscle function. HIBM is a progress...
In an attempt to simplify the diagnosis of ectopic pregnancy, the researchers will investigate the presence of specific molecular markers of ectopic pregnancy. The quantification of these...
Videos
Amyloid Precursor Protein [Alzheimer's Disease]
Genetics project Nicole Fasano.
Medical and Biotech [MESH] Definitions
Transferrin-binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Transferrin-binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Adaptor Protein Complex 1
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
Adaptor Protein Complex 2
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
Adaptor Protein Complex 3
An adaptor protein complex found primarily on perinuclear compartments.
