Protein C Deficiency - Biotech, Pharma and Life Science Channel
PubMed Articles
Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer.
GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in tumorigenesis. High levels of GATA2 expression are correlated with poor survival outcomes in many types o...
Clinical implications of CIP2A protein expression in breast cancer.
The aim of this work is to study the expression and regulatory effects of CIP2A protein in breast cancer and the correlation between CIP2A protein expression and the prognosis of breast cancer. The CI...
The breast cancer type 1 susceptibility gene (BRCA1) is a tumor suppressor gene, mutations or loss of which lead to genomic instability and breast cancer. BRCA1 protein is part of a large multi-protei...
Complement component C6 deficiency is a genetic disease presenting as increased susceptibility to invasive Neisseria meningitidis infections. This disorder has rarely been diagnosed in the Spanish pop...
Enzymatic analysis of biomarkers for the monitoring of Gaucher patients in Colombia.
Gaucher disease is caused by a deficiency of the enzyme acid beta-glucosidase. There is treatment available, but given the wide variability in phenotypes, it is difficult to establish the adequate adm...
One of the oldest known gene clusters that are involved in biological oxidation processes is the sox operon. This operon is present in different microbial species. In the present study an attempt has...
Recent studies have revealed heterogeneity in the structure of eukaryotic cytoplasmic ribosomes, including a difference in protein composition. It has been proposed that this heterogeneity, or the spe...
Regulation of Pichia pastoris promoters and its consequences for protein production.
The methylotrophic yeast Pichia pastoris is a widely used host for heterologous protein production. Along with favorable properties such as growth to high cell density and high capacities for protein...
Low pulmonary vascular compliance predisposes post-Fontan patients to protein-losing enteropathy.
Protein-losing enteropathy (PLE) is a life-threatening and poorly understood complication after the Fontan operation. We sought to determine the pre-operative risk factors for PLE which developed afte...
Newly synthesized polypeptides fold and assemble with assistance from protein chaperones. Full maturation can take multiple attempts, exchanging chaperones at each round. Improperly folded molecules m...
News Articles
The levels of bacterial biofilm regulator c-di-GMP are controlled in E. coli by two diguanylate cyclase/phosphodiesterase pairs acting sequentially, YegE/YhjH and YdaM/YciR. Interestingly, YciR both d...
Background: Mitochondrial outer membrane permeabilization (MOMP) is a crucial step leading to apoptotic destruction of cancer cells. Bcl-2 family proteins delicately regulate mitochondrial outer membr...
FOPO nets $11.6mm for [Venaxis]
Diagnostics developer [Venaxis Inc.] (formerly AspenBio Pharma) netted $11.6mm through a follow-on public offering of 10mm common shares at $1.25. The company also issued five-year warrants to buy ano...
Promising Alzheimer’s Drug Bombs In Second Round Of Trials
Brett Smith for redOrbit.com - Your Universe Online While the recent failure of a potential Alzheimer’s disease treatment is bad news for patients, it serves as an important reminder of the importa...
Molecular snapshot of a multitasking protein
A research team at IFOM in Milan has perfected a sophisticated technique that allowed them to capture a molecular snapshot of the process coordinated by ubiquitin. This is a protein with a complex ro...
New animal model gives insights into mechanisms of Parkinson's disease pathogenesis
In Parkinson's disease, the protein "alpha-synuclein" aggregates and accumulates within neurons. Specific areas of the brain become progressively affected as the disease develops and advances. The mec...
Celgene sNDA of Abraxane obtains FDA priority review status
Celgene International has obtained FDA priority review status for Abraxane (paclitaxel protein-bound particles for injectable suspension) supplemental new drug application (sNDA).
Scientists have developed a novel experimental model that reproduces for the first time this pattern of alpha-synuclein brain spreading and provides important clues on the mechanisms underlying this p...
MedImmune and KineMed study protein dynamics related to neurodegenerative diseases
MedImmune and KineMed Inc have formed an agreement to study how a monoclonal antibody affects the dynamics of the cellular prion protein (PrPc), which is known to have altered conformation and functio...
Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology
Quincy Bioscience announces publication of safety assessment study of apoaequorin in the July issue of Food and Chemical Toxicology. Apoaequorin is used in dietary supplements and as a food ingredient...
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Companies
Health Discovery Corporation is a molecular diagnostics company that uses advanced mathematical techniques to analyze large amounts of data to uncover patterns that might otherwis...
Columbia Laboratories, Inc. is focused on developing products that utilize its novel bioadhesive drug delivery technologies to optimize drug delivery in a controlled, sustained ma...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
TheAmerican Association of Clinical Endocrinologists (AACE)
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Kamada is a public biopharmaceutical company (TASE: KMDA) developing, producing and marketing a line of specialty life-saving biopharmaceuticals. Licensed and marketed worldwide,...
Itero Biopharmaceuticals, Inc.
Itero Biopharmaceuticals, Inc. is a specialty biopharmaceutical company focused on the development and commercialization of protein therapeutics that offer significant clinical an...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
Founded in 1992, Balance Bar, one of Americaâs original nutrition/energy bars, inspires consumers to lead active, well-rounded and balanced lives by providing great-tasting,...
Dr. Yie-Hwa Chang founded the Company in August 2001. The Company is commercializing core technologies for which it has secured an exclusive license from Saint Louis University, i...
Ansaris is a division of Locus Pharmaceuticals, a privately held biopharmaceutical company focused on solving todayâs small molecule drug discovery challenges, has been the l...
Clinical Trials
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein...
Ventricular Arrhythmias in Uremic Cardiomyopathy
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue. When active this gene builds...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
Background: The interactive effects of resistance training and dietary protein on hormonal responses in overweight or obese adults are not clear and remain controversial. Investigators tes...
Glutamine and Intestinal Protein Metabolism
Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative...
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency). It is unc...
Trial of the Impact of Vitamin A on Maternal Mortality
Main objectives: To evaluate the impact of weekly vitamin A supplementation (VAS) to women of reproductive age (15-45 years) on maternal mortality in rural Ghana, and to compare this with...
Proteomic Study of Urinary Stone Disease
Urinary protein levels are not routinely measured in stone patients while there is strong evidence that proteins play a role in the etiology of stones. The purpose of this study is to exa...
ACTH Stimulation and G Protein
Males and females may exhibit different responses to testing of adrenal function. The hormones responsible for controlling adrenal function are ACTH (adrenocorticotropic hormone or cortic...
Intravenous Immune Globulin to Treat Hereditary Inclusion Body Myopathy
This study will evaluate patients with Hereditary Inclusion Body Myopathy (HIBM) and examine the effects of immune globulin (IG) treatment on muscle and muscle function. HIBM is a progress...
Videos
Part 5 - Everything You Ever Wanted to Know About Clotting
Venous Thromboembolism, Genetic Predisposition, Acquired Trigger(s), Thrombosis, family history of blood clotting, genetic thrombophilia, Factor V Leiden, Pr...
Medical and Biotech [MESH] Definitions
Transferrin-binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Transferrin-binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Adaptor Protein Complex 1
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
Adaptor Protein Complex 2
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
Adaptor Protein Complex 3
An adaptor protein complex found primarily on perinuclear compartments.
