Pseudomonas aeruginosa Vaccines - Biotech, Pharma and Life Science Channel
Pseudomonas aeruginosa is an opportunistic gram-negative bacteria that lives in soil, water, and even in environments like hot tubs. For most healthy people, this bacteria seldom poses a problem. Pseudomonas aeruginosa is much more dangerous to populations who have weak immune systems, the elderly, and those who have been hospitalized for long periods of time. People with cystic fibrosis and with full-blown AIDS frequently die from infections created by the bacteria. Hospital-acquired pneumonia, particularly ventilator-associated pneumonia , causes considerable morbidity and mortality despite antimicrobial therapy and advances in supportive care. It is the second most frequent nosocomial infection and is the major cause of death among hospital-acquired infections.
At present there is no approved vaccine available for prevention of P. aeruginosa infection. Treatment of P. aeruginosa infection is limited to number of antibiotics. With the advent of biotechnology, a number of experimental vaccines and therapeutic antibodies are being evaluated in preclinical and clinical R&D. Peptide and small molecule therapeutics are being developed to fight bacterial infections including those caused by P. aeruginosa.
News Articles
Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results
BEIJING, May 17, 2013 /PRNewswire/ -- Sinovac Biotech Ltd. (Nasdaq: SVA), a leading provider of vaccines in China, today announced that it will release its unaudited financial results for the...
Pennsylvania Physicians Urge State Legislators to Support Immunization Expansion Bill
HARRISBURG, Pa., May 16, 2013 /PRNewswire/ -- The Pennsylvania Pharmacists Association announced today that numerous physicians throughout the Commonwealth are urging state legislators to support Hous...
The World Small Animal Veterinary Association Recommends Canine VacciCheck
KIBBUTZ GALED, Israel, May 16, 2013 /PRNewswire/ -- The World Small Animal Veterinary Association (WSAVA) Vaccination Guidelines Group has recently published the "Vaccination Guidelines for New Puppy...
Immunovaccine Announces Financial Results for the Quarter Ended March 31, 2013
HALIFAX, NOVA SCOTIA -- (Marketwired) -- 05/16/13 -- Immunovaccine Inc. ("Immunovaccine" or "IMV") (TSX VENTURE: IMV), a clinical stage vaccine company, today released its financial and operational...
Research Team Publishes New Methods for Synthetic Generation of Influenza Vaccines
LA JOLLA, Calif. and ROCKVILLE, Md., May 15, 2013 /PRNewswire/ -- A team of international researchers from the J. Craig Venter Institute (JCVI), Synthetic Genomics Inc. (SGI), Novartis Vaccines a...
Sinovac Appoints Ernst & Young Hua Ming Llp China as External Auditor
BEIJING, May 15, 2013 /PRNewswire/ -- Sinovac Biotech Ltd. (NASDAQ: SVA), a leading provider of biopharmaceutical products in China, has appointed China-based Ernst & Young Hua Ming LLP as...
KaloBios Reports First Quarter 2013 Financial Results
SOUTH SAN FRANCISCO, Calif., May 14, 2013 /PRNewswire/ -- KaloBios Pharmaceuticals, Inc. (Nasdaq:KBIO) a biopharmaceutical company with a portfolio of patient-targeted, first-in-class, antibodies...
BLUE BELL, Pa., May 14, 2013 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) announced today that in a preclinical study of Inovio's SynCon® DNA vaccine against Ebola and Marbur...
Sinovac Presents at the UBS Global Healthcare Conference in May 2013
BEIJING, May 14, 2013 /PRNewswire/ -- Sinovac Biotech Ltd. (NASDAQ: SVA), a leading provider of biopharmaceutical products in China, announced today that management is scheduled to present at...
Prevalence of Flu and Use of Flu Shots Last Winter Fairly Typical of Last Decade
NEW YORK, May 14, 2013 /PRNewswire/ -- Last winter's flu season was fairly typical of other winters over the last decade, with the prevalence of the flu and the number of people who had flu shots...
Events
Cancer Vaccines will provide attendees with a complete view of the cancer immunotherapy field. Focusing on the discovery of new vaccines, developments in target identification
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Companies
Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, a...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
VGTI Florida is the Florida-funded expansion of Oregon Health & Science University's highly successful Vaccine and Gene Therapy Institute. Research at the facility will focus on v...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell response helps confer protect...
Advaxis is a biotechnology company developing proprietary, live but attenuated Listeria monocytogenes (Listeria) vaccines that deliver engineered tumor antigens, which stimulate...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...
Achaogen is a clinical-stage biopharmaceutical company focused on the discovery and development of antibiotics for the treatment of serious infections caused by multi-drug resista...
Clinical Trials
RATIONALE: Vaccines made from a person's white blood cells may help the body build an effective immune response. PURPOSE: This phase I trial is studying the side effects of vaccine therap...
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy
Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...
GSK Biologicals is developing in partnership with the Malaria Vaccine Initiative at PATH a candidate malaria vaccine RTS,S/AS02 for the routine immunization of infants and children living...
A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers
Croup is an illness of young children that is caused by a virus. With this illness, the child has fever, cough, and hoarseness. Although the illness usually gets better in 2 to 4 days, so...
Vitamin A Supplementation With Routine Childhood Vaccines and Mortality and Morbidity
Vitamin A supplementation (VAS) is important for the immune system and may interact with different childhood vaccinations. We have hypothesized that the improved survival after VAS may dep...
MMR and Varicella Vaccine in Premature Infants
This research is designed to address the question, "Does the relative deficit in vaccine immunogenicity in extremely premature infants persist beyond the first 6 months of life?" We propos...
Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF)
This was a randomized multi-center clinical trial to compare the microbiological efficacy, clinical efficacy, and safety of using standard versus biofilm susceptibility testing of P. aerug...
Study to Eliminate Hib Carriage in Rural Alaska Native Villages
Hib disease rates in rural Alaska before introduction of HIb conjugate vaccine were among the highest in the world. Since vaccine introduction, rates have fallen by 90% but the disease ha...
Rituximab in the Treatment of Graves' Disease
Aim: In a phase II pilot study encompassing 20 patients with Graves’ disease to evaluate the effect of rituximab: 1. Biochemically as assessed by markers of disease activity ( fr...
Antibody Responses to Pneumococcal Vaccines Among HIV-Infected Adults.
Streptococcus pneumoniae is the major cause of bacterial infection in HIV-infected patients. The current pneumococcal vaccine is poorly efficacious in patients with a CD4 cell count lower...
PubMed Articles
Filters physically remove contaminants, including microbes, from water in treated recreational water venues, such as pools. Because contaminants accumulate in filters, filter concentrates typically ha...
Less than 1 % of bacterial populations present in environmental samples are culturable, meaning that cultivation will lead to an underestimation of total cell counts and total diversity. However, it...
Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms.
Bacterial biofilms are surface-associated, multicellular, morphologically complex microbial communities. Biofilm-forming bacteria such as the opportunistic pathogen Pseudomonas aeruginosa are phenotyp...
Hyperspectral imaging was exploited for its potential in direct and fast determination of Pseudomonas loads in raw chicken breast fillets. A line-scan hyperspectral imaging system (900-1700nm) was emp...
Synthesis of a selective inhibitor of a fucose binding bacterial lectin from Burkholderia ambifaria.
Burkholderia ambifaria is a bacterium member of the Burkholderia cepacia complex (BCC), a closely related group of Gram-negative bacteria responsible for "cepacia syndrome" in immunocompromised patien...
Using a capillary isoelectric focusing-whole column imaging detection (CIEF-WCID) method the isoelectric points (pI) of complete intact polioviruses were determined. The polio viruses that were analyz...
The association of biofilms with wound chronicity has prompted a search for antimicrobial interventions that are effective against biofilms. A patented preparation of glucose oxidase, lactoperoxidase...
Cancer immunotherapies, their safety and toxicity.
Introduction: Cancer immunotherapy encompasses a wide range of treatment modalities that harness the anti-tumor effects of the immune system. Some immunotherapies broadly activate the immune system wh...
Novel Description of mcl-PHA Biosynthesis by Pseudomonas chlororaphis from Animal-Derived Waste.
A novel description of mcl-PHA biosynthesis by Ps. chlororaphis from tallow-based biodiesel as an inexpensive carbon feed stock is presented. Fermentation protocols, kinetic analysis, an efficient pro...
Designing CAF-adjuvanted dry powder vaccines: Spray drying preserves the adjuvant activity of CAF01.
Dry powder vaccine formulations are highly attractive due to improved storage stability and the possibility for particle engineering, as compared to liquid formulations. However, a prerequisite for fo...
Videos
Pseudomonas Aeruginosa: Method for obtaining water samples
Experts from Public Health England advise on the correct methodology for obtaining water samples when testing for Pseudomonas Aeruginosa. Read further guidan...
Medical and Biotech [MESH] Definitions
Tuberculosis Vaccines
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
Ralstonia Solanacearum
A species of Ralstonia previously classed in the genera PSEUDOMONAS and BURKHOLDERIA. It is an important plant pathogen.
Pseudomonas Alcaligenes
A species of gram-negative bacteria in the genus PSEUDOMONAS. It cannot utilize FRUCTOSE; GLUCOSE; or MALTOSE for energy.
Pseudomonas Mendocina
A species of gram-negative bacteria in the genus PSEUDOMONAS, which is found in SOIL and WATER.
Pseudomonas Oleovorans
A species of gram-negative bacteria in the genus PSEUDOMONAS. It is isolated from oil-water emulsions used as lubricants and cooling agents in the cutting and grinding of materials.
