Purpura Simplex - Biotech, Pharma and Life Science Channel
PubMed Articles
HSV type 1 (HSV-1)-specific CD8(+) T cells provide immunosurveillance of trigeminal ganglion (TG) neurons that harbor latent HSV-1. In C57BL/6 mice, the TG-resident CD8(+) T cells are HSV specific and...
Viral fusogens mediate the merger of the viral envelope and cellular membrane during viral entry. These proteins share little sequence similarity but all are thought to act by refolding through a seri...
Dye-sensitized solar cells with an energy storage function are demonstrated by modifying its counter electrode with a poly (vinylidene fluoride)/ZnO nanowire array composite. This simplex device could...
Comparative infectivity of three larval nematode species in three different salmonids.
Host specificity of parasites may depend both on ecological and physiological factors. Basic descriptions of the susceptibility/resistance of fish to specific nematodes are needed in order to reveal m...
A wide variety of qPCR methods currently exist for Salmonella spp., Escherichia coli O157 and Listeria monocytogenes detection. These methods target several genes and use different detection chemistri...
INTRODUCTION: Bleeding risk because of thrombocytopenia in patients with thrombotic thrombocytopenic purpura (TTP) often causes concern during placement of the central venous catheter for plasma excha...
Pregnancy in Upshaw-Schulman syndrome.
The Upshaw Schulman syndrome (MIM #274150) is a hereditary deficiency of the von Willebrand factor cleaving protease (ADAMTS13) due to homozygous or compound heterozygous mutations in the ADAMTS13 gen...
Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry.
Hereditary thrombotic thrombocytopenic purpura, Upshaw-Schulman syndrome, ADAMTS13 Hereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome, is a rare recessively i...
ADAMTS13 activity and genetic mutations in Japan.
Thrombotic thrombocytopenic purpura (TTP), a life threatening disease, can be induced by congenital or acquired deficiency of plasma metalloprotease ADAMTS13. Since the publication of the first geneti...
Pearls & Oy-sters: Acute ischemic stroke caused by atypical thrombotic thrombocytopenic purpura.
News Articles
Wohl Associates Inc. Now Selling Used Conveyors for Processing and Packaging Industries
Wohl Associates is now selling used conveyors that can be used by processing and production facilities. These conveyors are suitable for use by companies in the food & beverage, chemical, and phar...
GSK’s Revolade receives NICE approval for blood disorder treatment
GlaxoSmithKline has received approval from the UK’s National Institute for Health and Clinical Excellence (NICE), for its platelet-boosting drug Revolade in the treatment of adult bleeding disorder,...
UK's NICE gives thumbs up for GSK's Revolade as NHS blood disorder treatment
UK drugs watch dog the National Institute for Health and Care Excellence (NICE) has published final draft guidance recommending pharma major GlaxoSmithKline's (LSE: GSK) Revolade (eltrombopag) as an o...
Jennifer Moffatt, RN, of Chandler Regional Medical Center today received the DAISY Award for Extraordinary Nurses, presented by The DAISY Foundation and UnitedHealthcare....
Immune Response Exploited By Herpes Virus To Bolster Infection
Researchers at the University of California, San Diego School of Medicine and colleagues report that the herpes simplex virus type-1 (HSV-1), which affects an estimated 50 to 80 percent of all America...
Herpes Treatment | How “Stop Herpes Now” Helps People Get Rid Of Their Herpes Naturally – V-kool
Stop Herpes Now created by David Hogg is a new herpes treatment book that reveals to people natural remedies for herpes, and an internal and external herpes treatment program. A full Stop Herpes Now r...
HSV-1 exploits immune system receptor to boost infectivity and cause disease
Researchers at the University of California, San Diego School of Medicine and colleagues report that the herpes simplex virus type-1 (HSV-1), which affects an estimated 50 to 80 percent of all America...
Herpes virus exploits immune response to bolster infection
(University of California - San Diego) Researchers at the University of California, San Diego School of Medicine and colleagues report that the herpes simplex virus type-1, which affects an estimated...
Amgen's virus therapy shows survival trend in cancer, faces skeptics
Amgen’s experimental therapy that uses a modified herpes simplex virus to kill cancer showed a trend toward improved survival in a study of melanoma patients, although the data are not yet matu...
ASCO '13: Amgen's Cancer-Killing Virus Shows Skin-Cancer Survival Trend (Update)
Updated with new survival data. CHICAGO (TheStreet) -- A herpes simplex virus re-engineered to kill cancer cells shrank tumors and produced an early trend towards prolonging the lives of patients wit...
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Companies
Diabetes Care Club, a Simplex brand, has grown to become the third largest mail-order supplier of diabetic testing supplies for seniors. The company provides home delivery...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell response helps confer protect...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...
Simplex Healthcare is based in Franklin, Tennessee and provides home delivery of medical supplies to help patients with diabetes. Simplex secured $50 million in venture capital fr...
Clinical Trials
Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission
The University of Washington has received funding to conduct a proof-of-concept trial to assess the impact of suppression of genital herpes on HIV infectiousness. This study (the Partners...
Genital herpes (GH) is a commonly occurring sexually transmitted disease caused by herpes simplex virus (HSV). There are two types of HSV, type 1 (HSV-1) and type 2 (HSV-2); both can cause...
This study is a double-blind, randomized, placebo-controlled, parallel group, repeat-dose, study conducted in two parts (Part A and Part B) examining 30, 50, and 75 mg doses of SB-497115-G...
Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection
This study will evaluate the safety and blood levels of a new pediatric formulation of Famvir in children 1-12 years of age. In Part A, patients will receive a single dose of famciclovir...
Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates
The purpose of this study is to test whether long term treatment with acyclovir given orally (by mouth) improves the outcome for infants with herpes simplex virus infection of the brain or...
This clinical trial will study the safety and effectiveness of an engineered herpes virus, G207, administered directly into the brain of patients with recurrent brain cancer. G207 has bee...
Seroprevalence of Kaposi's Sarcoma Herpes Virus in the United States
This study will investigate patterns of Kaposi's sarcoma herpes virus (KSHV) in the United States and its potential impact on the U.S. population. KSHV is a newly discovered virus that i...
OBJECTIVES: I. Determine the efficacy of long term suppressive therapy with oral acyclovir in infants with herpes simplex virus infection limited to skin, eyes, and mouth. II. De...
OBJECTIVES: I. Determine the efficacy of long term suppressive therapy with oral acyclovir in infants with herpes simplex virus infection involving the central nervous system. II. Deter...
OBJECTIVES: I. Determine whether there is prompt engraftment after autologous peripheral blood stem cell transplantation using filgrastim (G-CSF) mobilization in patients with life threat...
Videos
Visión Púrpura, Ellas.
Videoclip de la agrupación Visión Púrpura. Dedicado a las chicas del programa televisivo Destino Mundo Maya. Producción y Dirección de video por: Enrique Pal...
Medical and Biotech [MESH] Definitions
Host Cell Factor C1
A cellular transcriptional coactivator that was originally identified by its requirement for the stable assembly IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. It is a nuclear protein that is a transcriptional coactivator for a number of transcription factors including VP16 PROTEIN; GA-BINDING PROTEIN; EARLY GROWTH RESPONSE PROTEIN 2; and E2F4 TRANSCRIPTION FACTOR. It also interacts with and stabilizes HERPES SIMPLEX VIRUS PROTEIN VMW65 and helps regulate GENETIC TRANSCRIPTION of IMMEDIATE-EARLY GENES in HERPES SIMPLEX VIRUS.
Receptors, Tumor Necrosis Factor, Member 14
A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Keratin-14
A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.
Keratin-5
A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.
Purpura Fulminans
A severe, rapidly fatal reaction occurring most commonly in children following an infectious illness. It is characterized by large, rapidly spreading skin hemorrhages, fever, or shock. Purpura fulminans often accompanies or is triggered by DISSEMINATED INTRAVASCULAR COAGULATION.
