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PubMed Articles
The heart contains various types of cells, including cardiomyocytes, cardiac fibroblasts, many kinds of immune cells and vascular cells. Initial studies mainly focused on cardiomyocytes, which directl...
The Proto-Oncogene c-myc Regulates Antibody Secretion and Ig Class Switch Recombination.
The immune response involves the generation of Ab-secreting cells and memory B cells through a process called terminal B lymphocyte differentiation. This program requires the transcriptional repressor...
The microenvironment of human follicular lymphoma (FL), an incurable B cell non-Hodgkin's lymphoma, is thought to play a major role in its pathogenesis and course. Microenvironmental cells of likely i...
B7-H4, a member of the B7 family of T cell immunomodulatory proteins, has been shown to inhibit T cell responses and neutrophil expansion during bacterial infections. However, the role of B7-H4 in the...
Profound impairment of adaptive immune responses by alkylating chemotherapy.
Overall, cancer vaccines have had a record of failure as an adjuvant therapy for malignancies that are treated with alkylating chemotherapy, and the contribution of standard treatment to that failure...
Soluble CD27-Pool in Humans May Contribute to T Cell Activation and Tumor Immunity.
The interaction between CD27 and its ligand, CD70, has been implicated in regulating cellular immune responses to cancer. In this article, we report on the role of soluble CD27 (sCD27) in T cell activ...
Canonical and noncanonical wnt proteins program dendritic cell responses for tolerance.
Ag-presenting dendritic cells (DCs) interpret environmental signals to orchestrate local and systemic immune responses. They govern the balance between tolerance and inflammation at epithelial surface...
TLR4 signaling must be tightly regulated to provide both effective immune protection and avoid inflammation-induced pathology. Thus, the mechanisms that negatively regulate the TLR4-triggered inflamma...
Regulatory T cells can restrict the uncontrolled immune response and inflammation, avoiding pathologic immune injury to the host and thus playing important roles in the maintenance of immune homeostas...
Intracellular reactive oxygen species (ROS) are essential secondary messengers in many signaling cascades governing innate immunity and cellular functions. TLR3 signaling is crucially involved in anti...
News Articles
Doctoral research shows role of immune system in development of resistance to antibiotics
Leon Cantas' doctoral research shows that the immune response of the host to a bacterial infection may have a significant effect on the development of bacteria's resistance to antibiotics.
HPV Laser Surgery for Genital Warts: What are the Side Effects?; polyDNA Answers Survey Questions
In its June, 2013 survey, polyDNA found that three out of four respondents considering laser surgery to remove HPV genital warts were unaware of side effects. polyDNA highlights these side effects and...
Dynavax Chief Scientific Officer Awarded Prestigious Immunology Prize
BERKELEY, CA -- (Marketwired) -- 06/19/13 -- Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that the 2013 Novartis Prize for Basic Immunology has been awarded to Dr. Robert L. Coffma...
The Evolution of Type 1 Diabetes The Evolution of Type 1 Diabetes
Type 1 diabetes (T1D) occurs in individuals with a genetic predisposition to the disease, predominantly from a human leukocyte antigen (HLA)-related immunogenotype that accounts for approximately 60%...
The influence of ageing on the development and management of rheumatoid arthritis
The population of elderly patients with rheumatoid arthritis (RA) is growing, primarily as a consequence of increasing life expectancies. In addition, processes linked to ageing of the immune system m...
Restoring appropriate movement to immune cells may save seriously burned patients
(Massachusetts General Hospital) Patients who survive the immediate aftermath of major burns are at greatest risk from infections -- particularly the overwhelming, life-threatening immune reaction kno...
Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks
The transcription factors BATF (basic leucine zipper transcription factor ATF-like), BATF2 and BATF3 have unique positive transcriptional activities in the development and the function of dendritic ce...
Mucosal immunology: Autophagy helps man the barriers
Autophagy is an epithelial cell-intrinsic innate immune mechanism that protects against the dissemination of invasive intestinal bacteria.
MMR Booster Shots Safe, Effective in Juvenile Arthritis
Children who have juvenile idiopathic arthritis were not harmed by live attenuated measles-mumps-rubella booster vaccinations but did gain additional protective immune responses. Medscape Medical N...
Immune System Regulator Allows Inflammatory Response While Preventing Autoimmune Attack
The BACH2 gene was shown to encode for a protein that acts as a master immune system regulator by...
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Companies
Institute of Human Virology (IHV) at the University of Maryland School of Medicine
Formed in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University System of Maryland and the University of Maryland Medical System, IHV is an in...
Avaxia is a leader in the growing field of gut-targeted therapeutics â orally administered, minimally absorbed drugs that are designed to act locally in the gastrointestinal...
The Angeles Clinic and Research Institute
âThe Angeles Clinic and Research Instituteâs mission is to advance cancer care through groundbreaking research and delivering innovative therapeutic options to al...
Based in Brisbane, California, XDx is a molecular diagnostics company focused on the discovery, development and commercialization of noninvasive gene expression-based tests for th...
Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...
Defymed is a spin -off of the “Centre Europeen d’etude du Diabete” (CeeD) which has been working on the conception of a bio-artificial pancreas since 1996. This work was ca...
Cell Medica is a clinical stage cellular therapeutics company engaged in the development and delivery of cellular immunotherapy treatment strategies for infectious disease and can...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
Kite Pharma, Inc. is a privately held development stage biotechnology company engaged in the design and development of cutting-edge immunotherapeutic products to treat different c...
Clinical Trials
The purpose of this research study is to determine the effects of ProHema modulated umbilical cord blood units used in transplantation. ProHema modulated cord blood units are being tested...
This study will test the investigational antibody, anti-OX40, in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received...
Immune Response to Hepatitis C Virus
This study will identify and characterize immune factors involved in hepatitis C infection and elimination of the virus. Individual responses to hepatitis C infection vary; some people ar...
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy
Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...
This randomized phase II trial is studying how well giving tacrolimus and mycophenolate mofetil (MMF) together with or without sirolimus works in preventing acute graft-versus-host disease...
This study will evaluate the safety and effectiveness of treating patients with severe aplastic anemia (SAA) or myelopdysplastic syndrome (MDS) with both peripheral blood stem cells from a...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...
This pilot study is to assess whether using CytoGam® in combination with ganciclovir is more effective in reducing the CMV viral load over time, as compared to standard treatment with IV...
IRX-2 is designed to activate your own body's immune system so that it can better fight the invasion of head and neck cancer. Researchers hope that IRX-2 will help your immune system to m...
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Medical and Biotech [MESH] Definitions
Immunity, Herd
The non-susceptibility to infection of a large group of individuals in a population. A variety of factors can be responsible for herd immunity and this gives rise to the different definitions used in the literature. Most commonly, herd immunity refers to the case when, if most of the population is immune, infection of a single individual will not cause an epidemic. Also, in such immunized populations, susceptible individuals are not likely to become infected. Herd immunity can also refer to the case when unprotected individuals fail to contract a disease because the infecting organism has been banished from the population.
Virus Inactivation
Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.
Integrin Alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Oligoclonal Bands
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
Receptor, Cannabinoid, Cb2
A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.
