Refractory hypoxemia - Biotech, Pharma and Life Science Channel
PubMed Articles
Despite the well-defined role of autologous haematopoietic stem cell transplantation (autoHCT) in the treatment of patients with relapsed or refractory Hodgkin lymphoma (HL), relapse remains the main...
Objective-To evaluate risk factors for outcome for dogs with adrenal gland tumors with or without invasion of the caudal vena cava treated via adrenalectomy. Design-Retrospective study. Animals-86 dog...
Refractory epilepsy is reportedly associated with an overexpression of ATP-binding cassette transporters such as P-glycoprotein (Pgp) and breast cancer resistance protein (Bcrp). In this study, we exa...
Tetralogy of Fallot (TOF) results in chronic progressive right ventricular (RV) pressure overload and shunt hypoxemia. We investigated the global changes in the proteome of RV among infant patients wi...
Data for 125 patients with cytogenetically normal acute myeloid leukemia (CN-AML) regarding BAALC and combinatorial molecular markers at diagnosis were evaluated. Fewer patients with higher BAALC expr...
Cardiorenal syndrome : Limits of heart failure therapy.
The cardiorenal syndrome is an interdisciplinary challenge with increasing health economic relevance. Renal failure is a strong predictor for mortality in patients with severe congestive heart failure...
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end.
Chronic hepatitis caused by infection with hepatitis C virus C (HCV) (therefore known as chronic hepatitis C (CHC)) is a leading cause of liver disease worldwide. For the past 25 years, recombinant in...
Since obesity seems to play a causal role in both obstructive sleep apnea/hypopnea syndrome (OSAHS) and type 2 diabetes, the question arises whether diet-induced weight loss is equally efficacious in...
Alternative therapies in the management of chronic prostatitis/chronic pelvic pain syndrome.
PURPOSE: Standard medical therapy for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) including such agents as nonsteriodal anti-inflammatories, alpha-blockers, antimicrobial therapy, and 5...
Abstract Background: Ulcerating stasis dermatitis is a major cause of decreased quality of life and a challenging therapeutic problem. Objective: To assess the efficacy and safety of autologous PRP co...
News Articles
− Analysis showed more than 60 percent of patients achieved longer progression-free survival following treatment with ADCETRIS compared to prior therapy − Takeda Ph...
Study shows pomalidomide prolongs survival in refractory myeloma patients
Prof Jesus San Miguel presents data during press conference at the 18th EHA meeting in Stockholm. Treatment for patients with multiple myeloma (MM) has improved over the last decade due to the introd...
Tokyo, June 18, 2013 - Astellas Pharma Inc. (Tokyo: 4503; “Astellas”) and Kyoto University’s Center for iPS Cell Research and Application (Director: Dr. Shinya Yamanaka; &...
Daratumumab Responses High and Durable in Multiple Myeloma
The investigational agent has shown unprecedented responses in a phase 1 trial, leading to an FDA breakthrough therapy designation for refractory disease. Medscape Medical News
Lurasidone Effective for 'Real-World' Refractory BP Disorder
Adjunctive treatment with lurasidone is safe and effective for outpatients with treatment resistant bipolar disorder. Medscape Medical News
Gilead reports interim ORR data for idelalisib
Gilead Sciences Inc. (NASDAQ:GILD) reported interim data showing twice-daily oral idelalisib led to an overall response rate (ORR), the primary endpoint, of 53.6% in the Phase II Study 101-09 to treat...
-- Data Presented at the 18th Congress of the European Hematology Association -- Acetylon Pharmaceuticals Inc., the leader in development of selective histone deacetyla...
Array BioPharma Reports Interim Data From ARRY-520, Kyprolis Combination Trial
WASHINGTON (dpa-AFX) - Array BioPharma Inc. (ARRY) reported interim data from an ongoing combination trial of ARRY-520 with Kyprolis in patients with relapsed or refractory Multiple Myeloma who ar...
Positive Ph II results for Gilead's idelalisib in refractory indolent non-Hodgkin's lymphoma
US biotech firm Gilead Sciences (Nasdaq: GILD) today (June 17) announced encouraging interim results from a single-arm, open-label Phase II study (Study 101-09) evaluating idelalisib (formerly GS-1101...
Events
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Companies
Dendreon Corporation is a biotechnology company whose mission is to target cancer and transform lives through the discovery, development, commercialization and manufacturing of no...
Based in Yehud, Israel, CerebralRx was founded in 2010 as a spin-off of BioControl Medical to develop breakthrough implantable neuromodulation systems for the treatment of autonom...
Mountain View Pharmaceuticals, Inc.
MVP is a privately-held California corporation with expertise in the application of advanced polymer-coupling technology to make protein-based drugs safer and longer acting. To da...
Allos Therapeutics, Inc. (Nasdaq: ALTH) is a biopharmaceutical company committed to the development and commercialization of innovative anti-cancer therapeutics. Allos is currentl...
Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the U.S. and the only chronic disease growing in mortality. It affects approximately 24 millio...
NeuroPace was founded to design, develop, manufacture and market implantable devices for the treatment of neurological disorders by responsive brain stimulation. The company's initial focus is the tre...
Clinical Trials
To evaluate the efficacy and safety of Vanquix for the management of selected, refractory, patients with epilepsy who require intermittent medical intervention provided by caregivers who a...
Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts
The primary objective of this study is to compare overall survival (OS) in patients receiving ON 01910.Na + best supportive care (BSC) to OS of patients receiving BSC in a population of pa...
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
This phase I trial is studying the side effects and the best dose of selumetinib in treating young patients with recurrent or refractory low grade glioma. Selumetinib may stop the growth o...
Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)
This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant a...
RATIONALE: Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. PURPOSE: This randomized phase I...
RATIONALE: Drugs used in chemotherapy, such as vorinostat, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Vorinos...
Rituximab and Gemcitabine for Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Rituximab has been demonstrated to sensitize drug-resistant NHL cells to the cytotoxic actions of several chemotherapy agents by enhancing sensitivity of tumor cells to chemotherapy-induce...
Imatinib Mesylate in Combination With Docetaxel for Advanced, Platinum-Refractory Ovarian Cancer
Imatinib mesylate is an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular...
Research in Severe Asthma (RISA) Trial
The purpose of this study is to evaluate the safety and efficacy of the Alair System for the treatment of severe refractory asthma. This will be a multicenter, randomized controlled study...
Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death
People with epilepsy are at a higher risk for sudden unexpected death than the general population. Sudden unexpected death in epilepsy (SUDEP) is a major cause of death in this population...
Videos
Pearls and Pitfalls of Acid-Base Analysis (Understanding ABGs - Lecture 14)
Some pearls and pitfalls of ABG interpretation. Topics covered include whether a VBG can substitute for an ABG, whether one should use the measure bicarb or ...
Medical and Biotech [MESH] Definitions
Vagus Nerve Stimulation
An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.
Refractory Period, Electrophysiological
The period of time following the triggering of an ACTION POTENTIAL when the CELL MEMBRANE has changed to an unexcitable state and is gradually restored to the resting (excitable) state. During the absolute refractory period no other stimulus can trigger a response. This is followed by the relative refractory period during which the cell gradually becomes more excitable and the stronger impulse that is required to illicit a response gradually lessens to that required during the resting state.
Refractory Period, Psychological
A delayed response interval occurring when two stimuli are presented in close succession.
Spironolactone
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Trichomonas Vaginalis
A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.
