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Renal responses - Biotech, Pharma and Life Science Channel

04:39 EDT 25th April 2014 | BioPortfolio

PubMed Articles [6290 Associated PubMed Articles listed on BioPortfolio]

Optimisation of low temperature extraction of banana juice using commercial pectinase.

The objective of this work was to develop a process with optimum conditions for banana juice. The procedure involves hydrolyzing the banana pulp by commercial pectinase followed by cloth filtration. R...

In situ damage assessment using synchrotron X-rays in materials loaded by a Hopkinson bar.

Split Hopkinson or Kolsky bars are common high-rate characterization tools for dynamic mechanical behaviour of materials. Stress-strain responses averaged over specimen volume are obtained as a functi...

Engaging adaptive immunity with biomaterials.

Adaptive immune responses, characterized by T cells and B cells engaging and responding to specific antigens, can be raised by biomaterials containing proteins, peptides, and other biomolecules. How d...

Endocan elicits severe vascular inflammatory responses in vitro and in vivo.

Endocan is a proteoglycan secreted by endothelial cells under the control of inflammatory cytokines. The aim of this study was to evaluate the effects of endocan on proinflammatory responses and on se...

Adaptive Responses of Mitochondria to Mild Copper Deprivation Involve Changes in Morphology, OXPHOS Remodeling and Bioenergetics.

Copper is an essential cofactor of complex IV of the electron transfer chain, and it is directly involved in the generation of mitochondrial membrane potential. Its deficiency induces the formation of...

Lessons learned from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC).

Renal cell carcinoma (RCC) extension into the renal vein or the inferior vena cava occurs in 4 %-10 % of all kidney cancer cases. This entity shows a wide range of different clinical and surgical sc...

Modeling the Time-Varying Subjective Quality of HTTP Video Streams With Rate Adaptations.

Newly developed hypertext transfer protocol (HTTP)-based video streaming technologies enable flexible rate-adaptation under varying channel conditions. Accurately predicting the users' quality of expe...

Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management.

Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100,000 adults, and accounts for ∼15% of newly diagnosed cases of leukemia in adu...

Family with sequence similarity 107: A family of stress responsive small proteins with diverse functions in cancer and the nervous system (Review).

Under conditions of acute stress, rapid adaptation is crucial for maximizing biological survival. The responses to environmental stress are often complex, involving numerous genes and integrating even...

Response to Comment on "Killer Ig-like Receptor 2DL4 Does Not Mediate NK Cell IFN-γ Responses to Soluble HLA-G Preparations".

News Articles [1322 Associated News Articles listed on BioPortfolio]

[Clinical Picture] Grey Turner's sign suggesting retroperitoneal haemorrhage

A 57-year-old man presented with dyspnoea and haemoptysis. He had a history of amyloid light-chain systemic amyloidosis with renal involvement and a remote history of pulmonary emboli. He was also cur...

Bold DECISION makes Nexavar a new standard in thyroid cancer

Nexavar was first approved in the US in 2005 as a treatment for patients with advanced renal cell carcinoma and later for use in unresectable hepatocellular carcinoma.

Fresenius Medical Care Social Worker Receives Robert W. Whitlock Lifetime Achievement Award

National Kidney Foundation’s Council of Nephrology Social Workers Recognizes Stephanie Johnstone’s Outstanding Achievements in Dialysis Patient Care Fresenius...

New Research Shows Survival Benefit With Daily Dialysis in a Nursing Home Setting

LAS VEGAS, April 24, 2014 /PRNewswire/ -- On Wednesday, April 23, 2014, Affiliated Dialysis Centers, LLC ("ADC") shared the release of clinical data in a Late Breaking Poster Session at the 2014...

Phase 3 study may be game-changer for acute myeloid leukemia

Moffitt Cancer Center researchers say clinical trials for a new experimental drug to treat acute myeloid leukemia (AML) are very promising. Patients treated with CPX-351, a combination of the chemothe...

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated and...

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbours specialized immune cells, including der...

Validating single-cell genomics for the study of renal development

Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia

(H. Lee Moffitt Cancer Center & Research Institute) Moffitt Cancer Center researchers say clinical trials for a new experimental drug to treat acute myeloid leukemia are very promising. Patients treat...

Kidney Stones Complications after PCNL are at 15%, while Dr. Allen’s Device Dissolves any Type of Renal Calculi without Side Effects

Dr. Allen’s Device for Kidney Care dissolves any type and size of kidney stones without surgical procedures, and causes no side effects. In contrast, new data on the outcomes of percutaneous nephrol...

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Companies [65 Associated Companies listed on BioPortfolio]

Extension Healthcare

Extension Healthcare is leading the industry into the next generation of clinical alarm safety systems. Extension has merged advanced alarm management software with an inno...

True North Therapeutics, Inc.

True North Therapeutics is a biotechnology company developing novel therapies that selectively target the Complement pathway of the immune system to address fundamental mechanisms...

CBSET

CBSET — Concord Biomedical Sciences & Emerging Technologies — is the preclinical research leader in critically important therapeutic fields such as interventional cardio...

Fibrotech Therapeutics

Fibrotech is an Australian biopharmaceutical company developing a new class of drugs to prevent a massive health burden associated with fibrosis (tissue scarring). The Company dev...

Advanced BioScience Laboratories, Inc. (ABL)

Profectus is a clinical-stage biotechnology company developing novel vaccines to prevent and treat major chronic viral infectious diseases and associated cancers for which standar...

Health Consumer Powerhouse (HCP)

The Health Consumer Powerhouse (HCP) monitors and compares healthcare systems among 35 countries, including all EU member states as well as Canada. Open benchmarking improves performance. Presenting...

Concert Pharmaceuticals, Inc.

Concert Pharmaceuticals is a clinical stage biotechnology company focused on applying the company’s DCE Platform™ (deuterated chemical entity platform) to create novel a...

Genocea Biosciences, Inc.

Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...

immatics biotechnologies GmbH

"immatics is a biopharmaceutical company from Tuebingen/Germany. With presently 40 employees immatics develops peptide-based therapeutic vaccines for oncology. The most advanced product candidate, IMA...

Atara Biotherapeutics, Inc.

Atara Biotherapeutics, Inc. is a privately-held drug development company with a focus on innovative therapies for patients with debilitating diseases. The research of Atara and it...

Clinical Trials [2100 Associated Clinical Trials listed on BioPortfolio]

A Model for Genetic Susceptibility: Melanoma

The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others are. To do this we will compare people who have had more than one m...

A Study for Monthly Methoxy Polyethylene Glycol-Epoetin Beta Treatment in Patients With Chronic Renal Anaemia

This open-label single-arm study will evaluate the efficacy, safety and tolerability of methoxy polyethylene glycol epoetin beta on long-term maintenance of haemoglobin levels in patients...

Clofarabine and Low-dose Cytarabine Followed by Consolidation Therapy in AML Patients Age Greater Than or Equal to 60 Years

Primary outcome measure: Evaluate the efficacy in terms of complete responses of induction therapy and first-line consolidation of Clofarabine and low-dose Cytarabine with AML patients ag...

Treatment Modification to Reduce Symptom Burden in Hemodialysis

Many patients on hemodialysis experience high rates of symptom burden, such as pain, depression, anxiety and difficulty breathing. This study seeks to reduce these symptoms by modifying t...

Treatment of Atrial Fibrillation in Patients by Pulmonary Vein Isolation, Renal Artery Denervation or Both.

Prospective, randomized, controlled, multicenter, international clinical trial. The study population consist of patients with paroxysmal or persistent atrial fibrillation with out range hy...

Tocilizumab for Renal Graft Inflammation

Randomized open label clinical trial in which 48 renal transplant recipients with inflammation in the 6 month allograft biopsy will either continue usual immunosuppression or receive month...

Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy

Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...

Microparticles in Stored RBC as Potential Mediators of Transfusion Complications

INTRODUCTION. Cell-derived microparticles (MP) are released in cell activation, apoptosis and other processes. MP derived from red cells (RMP) are known to be released from stored packed r...

RENABLATE Feasibility - EC12-02

The RENABLATE study is a prospective, multi-center, non-randomized feasibility study to evaluate the safety and effectiveness of the investigational Celsius® ThermoCool® RD Multi-electro...

Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery

An observational cohort study on safety and efficacy to generate additional data on the benefit/risk profile of the 150 mg dose of Pradaxa in patients with renal impairment

Medical and Biotech [MESH] Definitions

The amount of PLASMA that perfuses the KIDNEYS per unit time, approximately 10% greater than effective renal plasma flow (RENAL PLASMA FLOW, EFFECTIVE). It should be differentiated from the RENAL BLOOD FLOW; (RBF), which refers to the total volume of BLOOD flowing through the renal vasculature, while the renal plasma flow refers to the rate of plasma flow (RPF).

Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.

Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE. The most severe form is KIDNEY FAILURE. Renal function may deteriorate slowly (RENAL INSUFFICIENCY, CHRONIC) or precipitously (RENAL INSUFFICIENCY, ACUTE).

Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.

The amount of the RENAL BLOOD FLOW that is going to the functional renal tissue, i.e., parts of the KIDNEY that are involved in production of URINE.

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