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Renal responses - Biotech, Pharma and Life Science Channel

19:33 EDT 18th April 2014 | BioPortfolio

PubMed Articles [6133 Associated PubMed Articles listed on BioPortfolio]

Optimisation of low temperature extraction of banana juice using commercial pectinase.

The objective of this work was to develop a process with optimum conditions for banana juice. The procedure involves hydrolyzing the banana pulp by commercial pectinase followed by cloth filtration. R...

In situ damage assessment using synchrotron X-rays in materials loaded by a Hopkinson bar.

Split Hopkinson or Kolsky bars are common high-rate characterization tools for dynamic mechanical behaviour of materials. Stress-strain responses averaged over specimen volume are obtained as a functi...

Engaging adaptive immunity with biomaterials.

Adaptive immune responses, characterized by T cells and B cells engaging and responding to specific antigens, can be raised by biomaterials containing proteins, peptides, and other biomolecules. How d...

Endocan elicits severe vascular inflammatory responses in vitro and in vivo.

Endocan is a proteoglycan secreted by endothelial cells under the control of inflammatory cytokines. The aim of this study was to evaluate the effects of endocan on proinflammatory responses and on se...

Adaptive Responses of Mitochondria to Mild Copper Deprivation Involve Changes in Morphology, OXPHOS Remodeling and Bioenergetics.

Copper is an essential cofactor of complex IV of the electron transfer chain, and it is directly involved in the generation of mitochondrial membrane potential. Its deficiency induces the formation of...

Lessons learned from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC).

Renal cell carcinoma (RCC) extension into the renal vein or the inferior vena cava occurs in 4 %-10 % of all kidney cancer cases. This entity shows a wide range of different clinical and surgical sc...

Modeling the Time-Varying Subjective Quality of HTTP Video Streams With Rate Adaptations.

Newly developed hypertext transfer protocol (HTTP)-based video streaming technologies enable flexible rate-adaptation under varying channel conditions. Accurately predicting the users' quality of expe...

Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management.

Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of 1-2 cases per 100,000 adults, and accounts for ∼15% of newly diagnosed cases of leukemia in adu...

Teriflunomide and Its Mechanism of Action in Multiple Sclerosis.

Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments (DMTs) must both limit unwanted immune responses associated with disease initiation and propagation (as T and B lympho...

Expression of heat shock proteins (hsp) 27 and 70 in various organ systems in cases of death due to fire.

The expression of heat shock proteins (hsp) increases in case of variable types of endogenous and exogenous cellular stress, as for example thermal stress. Immunohistochemical staining with hsp antibo...

News Articles [1274 Associated News Articles listed on BioPortfolio]

CKD: Is Birth Weight a Risk Factor? (CME/CE)

(MedPage Today) -- Prenatal programming is suspected of playing a role in certain renal diseases in adults, and there is now evidence that it may also put children at risk for chronic kidney disease (...

Significance of white-coat and masked hypertension in chronic kidney disease and end-stage renal disease

More effective kidney stone treatment, from macroscopic to nanoscale

Researchers have hit on a novel method to help kidney stone sufferers ensure they receive the correct and most effective treatment possible. Kidney stones represent a major medical problem in the west...

Rad17, the clamp loader that loads more than clamps

Rad17 is best known as a checkpoint clamp loader in the activation of ATR kinase signaling. A new study in The EMBO Journal suggests that it also plays a role in initial recruitment of the MRN complex...

JCI online ahead of print table of contents for April 17, 2014

(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers published online, April 17, 2014 in the JCI: 'Double-sta...

Anika Therapeutics Announces Date of First-Quarter 2014 Financial Results Conference Call

Anika Therapeutics, Inc. (Nasdaq: ANIK) today announced that it plans to issue its first-quarter 2014 financial results after the close of the market on Tuesday, April 29,...

Phase 1 Results Positive for Tumor Vaccine

Celldex Therapeutics Inc. announced that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine. Th...

Research may help doctors predict who gets long-term complications from Lyme disease

A team of scientists led by Johns Hopkins and Stanford University researchers has laid the groundwork for understanding how variations in immune responses to Lyme disease can contribute to the many di...

Immune system research may help predict who gets long-term complications from Lyme Disease

The groundwork has been laid for understanding how variations in immune responses to Lyme disease can contribute to the many different outcomes of this bacterial infection seen in individual patients....

New cancer vaccine approach directly targets dendritic cells

Celldex Therapeutics announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine. T...

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Companies [65 Associated Companies listed on BioPortfolio]

True North Therapeutics, Inc.

True North Therapeutics is a biotechnology company developing novel therapies that selectively target the Complement pathway of the immune system to address fundamental mechanisms...

CBSET

CBSET — Concord Biomedical Sciences & Emerging Technologies — is the preclinical research leader in critically important therapeutic fields such as interventional cardio...

Fibrotech Therapeutics

Fibrotech is an Australian biopharmaceutical company developing a new class of drugs to prevent a massive health burden associated with fibrosis (tissue scarring). The Company dev...

Advanced BioScience Laboratories, Inc. (ABL)

Profectus is a clinical-stage biotechnology company developing novel vaccines to prevent and treat major chronic viral infectious diseases and associated cancers for which standar...

Health Consumer Powerhouse (HCP)

The Health Consumer Powerhouse (HCP) monitors and compares healthcare systems among 35 countries, including all EU member states as well as Canada. Open benchmarking improves performance. Presenting...

Concert Pharmaceuticals, Inc.

Concert Pharmaceuticals is a clinical stage biotechnology company focused on applying the company’s DCE Platform™ (deuterated chemical entity platform) to create novel a...

Genocea Biosciences, Inc.

Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...

immatics biotechnologies GmbH

"immatics is a biopharmaceutical company from Tuebingen/Germany. With presently 40 employees immatics develops peptide-based therapeutic vaccines for oncology. The most advanced product candidate, IMA...

Atara Biotherapeutics, Inc.

Atara Biotherapeutics, Inc. is a privately-held drug development company with a focus on innovative therapies for patients with debilitating diseases. The research of Atara and it...

DaVita HealthCare Partners

DaVita HealthCare Partners, a Fortune 500® company, is the parent company of DaVita and HealthCare Partners. DaVita is a leading provider of kidney care in the United States, d...

Clinical Trials [2100 Associated Clinical Trials listed on BioPortfolio]

A Model for Genetic Susceptibility: Melanoma

The goal of this study is to find out if some people are more likely to get melanoma, a form of skin cancer, than others are. To do this we will compare people who have had more than one m...

A Study for Monthly Methoxy Polyethylene Glycol-Epoetin Beta Treatment in Patients With Chronic Renal Anaemia

This open-label single-arm study will evaluate the efficacy, safety and tolerability of methoxy polyethylene glycol epoetin beta on long-term maintenance of haemoglobin levels in patients...

Clofarabine and Low-dose Cytarabine Followed by Consolidation Therapy in AML Patients Age Greater Than or Equal to 60 Years

Primary outcome measure: Evaluate the efficacy in terms of complete responses of induction therapy and first-line consolidation of Clofarabine and low-dose Cytarabine with AML patients ag...

Tocilizumab for Renal Graft Inflammation

Randomized open label clinical trial in which 48 renal transplant recipients with inflammation in the 6 month allograft biopsy will either continue usual immunosuppression or receive month...

Treatment of Atrial Fibrillation in Patients by Pulmonary Vein Isolation, Renal Artery Denervation or Both.

Prospective, randomized, controlled, multicenter, international clinical trial. The study population consist of patients with paroxysmal or persistent atrial fibrillation with out range hy...

Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy

Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...

Microparticles in Stored RBC as Potential Mediators of Transfusion Complications

INTRODUCTION. Cell-derived microparticles (MP) are released in cell activation, apoptosis and other processes. MP derived from red cells (RMP) are known to be released from stored packed r...

RENABLATE Feasibility - EC12-02

The RENABLATE study is a prospective, multi-center, non-randomized feasibility study to evaluate the safety and effectiveness of the investigational Celsius® ThermoCool® RD Multi-electro...

Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery

An observational cohort study on safety and efficacy to generate additional data on the benefit/risk profile of the 150 mg dose of Pradaxa in patients with renal impairment

Effects of Intentional Weight Loss Interventions in Chronic Kidney Disease

Obesity is an established risk factor for development and progression of kidney disease. Intentional weight loss in people without kidney disease results in an improvement in diabetes, blo...

Medical and Biotech [MESH] Definitions

The amount of PLASMA that perfuses the KIDNEYS per unit time, approximately 10% greater than effective renal plasma flow (RENAL PLASMA FLOW, EFFECTIVE). It should be differentiated from the RENAL BLOOD FLOW; (RBF), which refers to the total volume of BLOOD flowing through the renal vasculature, while the renal plasma flow refers to the rate of plasma flow (RPF).

Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.

Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE. The most severe form is KIDNEY FAILURE. Renal function may deteriorate slowly (RENAL INSUFFICIENCY, CHRONIC) or precipitously (RENAL INSUFFICIENCY, ACUTE).

Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.

The amount of the RENAL BLOOD FLOW that is going to the functional renal tissue, i.e., parts of the KIDNEY that are involved in production of URINE.

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