Respiratory syncytial virus RSV Vaccines - Biotech, Pharma and Life Science Channel

19:53 EDT 24th October 2014 | BioPortfolio

Respiratory syncytial virus (RSV) infection, which manifests primarily as bronchiolitis and/or viral pneumonia, is the leading cause of lower respiratory tract infection in infants and young children. In the US, RSV LRT infection develops annually in 4-5 million children, and more than 125,000 children are admitted per year for RSV-related illness. RSV disease is the no.1 cause of hospitalization in babies under a year of age in the US. While a monoclonal antibody is commercially available to help prevent RSV disease in infants and children at high risk for severe lung disease from RSV, a RSV vaccine still is not on the market. A number of RSV vaccine candidates have entered clinical development and further are to follow. Also, next generation antibodies against RSV with improved features are in the development pipeline as well as new therapies based on silencing RSV RNA or inhibiting key targets of the virus.

News Articles [1018 Associated News Articles listed on BioPortfolio]

AARP-PA Alerts Pennsylvanians to Ebola-Related Frauds and Scams

PHILADELPHIA, Oct. 24, 2014 /PRNewswire-USNewswire/ -- As the nation becomes increasingly concerned about the Ebola virus, experts report more incidents of online scams preying on people's fear and a ...

Passionate Respiratory Therapist, Wernher R. Olivier, PhD, RRT, Showcased for Excellence in Respiratory Care in Worldwide Leaders in Healthcare

The International Association of HealthCare Professionals has carefully selected Wernher R. Olivier, PhD, RRT, to represent respiratory therapy in their publication, Worldwide Leaders in Healthcare. W...

TODAY-- National Nurses Co-President to Testify at Congressional Hearing on Ebola Preparedness In Wake of Latest Ebola Case in New York

OAKLAND, Calif., Oct. 24, 2014 /PRNewswire/ -- In the wake of news a doctor in New York City, recently returned from treating Ebola patients in Guinea in West Africa, has now tested positive for Ebola...

Pfizer Declares 26-Cent Fourth-Quarter 2014 Dividend

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UH Law Center releases updated health emergency law manual, plans Nov. 7 event on Ebola response

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Ebola Virus Highlights Importance of Infection Prevention; Xenex Integrates Germ-Zapping Robot with CDC Hospital Protocols for Outbreak Response

The arrival of the Ebola virus in the U.S. has served as a wake-up call for infection prevention in U.S. hospitals. Patients suspected of or diagnosed with an Ebola virus infectio...

Truven Health Analytics-NPR Health Poll Finds Over 56 Percent of Americans Worry of Ebola Outbreak, Opinions on U.S. Response Split

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NEW YORK, Oct. 23, 2014 /PRNewswire/ -- For weeks, Ebola has been in the news as the deadly disease has spread around parts of Africa. In the US, the one fatality associated with the virus has sparked...

Vaxart Accelerates Development of Ebola Tablet Vaccine

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Companies [217 Associated Companies listed on BioPortfolio]

Mucosis B.V.

Mucosis B.V. (Mucosis) is a clinical-stage biotechnology company using a proprietary technology platform to develop next-generation needle-free human vaccines for infectious disea...

Vaxart, Inc.

Vaxart is a privately owned company developing oral recombinant vaccines based on its proprietary delivery platform. The Vaxart platform is suitable to deliver any protein vaccine...

Global Virus Network (GVN)

The Global Virus Network (GVN) is an independent, not for profit organization, comprised of leading medical virologists from Argentina, Australia, Belgium, Canada, China, France, ...

PharmaJet Inc.

PharmaJet Inc., affiliated with Genesis Medical Technologies, is a needle-free drug delivery technology company. Through the use of its needle-free jet injection technology, the Company’s goal is to...

Mucosis

Mucosis B.V. is a clinical-stage biotechnology company developing novel vaccines on its proprietary Mimopath® platform technology. The Mimopath® platform is being studied fo...

Cell Medica Limited

Cell Medica is a cellular therapeutics company engaged in the development, manufacturing and marketing of T cell immunotherapy approaches for the treatment of infections and cance...

Nanobiotix

NanoBio® Corp. is a privately held biopharmaceutical company focused on developing and commercializing dermatological products, anti-infective treatments and intranasal vaccine...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

Teva Neuroscience Inc.

Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) is a leading global pharmaceutical company, committed to increasing access to high-quality healthcare by developing, producing and...

Meridian Bioscience Inc.

Meridian is a fully integrated life science company that develops, manufactures, markets and distributes a broad range of innovative diagnostic test kits, purified reagents and re...

Clinical Trials [2411 Associated Clinical Trials listed on BioPortfolio]

Long Term Follow-up Study at Years 2, 3, 4 and 5 Where 2 Dosing Schedules of the Combined Hepatitis A and B Vaccine Were Compared

To evaluate the persistence of anti-hepatitis A virus (HAV) and anti-hepatitis B surface antigen (HBs) antibodies up to 2, 3, 4 and 5 years after administration of the first dose of the st...

Vaccine and Antibody Treatment of Prostate Cancer

This study will evaluate the side effects of a fixed dose of vaccine and GM-CSF with increasing doses of anti-CTLA-4 antibody in patients with advanced prostate cancer. The vaccine consist...

A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line Treatment

The purpose of this study is to demonstrate noninferiority (a new treatment is equivalent to standard treatment) in terms of the percentage of patients who have plasma human immunodeficien...

Therapeutic Effects Of Epstein-Barr Virus Immune T-Lymphocytes Derived From A Normal HLA- Compatible Or Partially- Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and EBV-Associated Malignancies

This study is testing to see how well transfusions of T-cells work in treating Epstein-Barr Virus (EBV). These T-cells are made from the blood of normal donors who are immune to EBV. A tra...

Viral Infections in Healthy and Immunocompromised Hosts

Background: - Viral infections are an important cause of illness and death in hospitalized patients as well as outpatients. New strains of viruses may appear and infect both healthy peopl...

Evaluation of Respiratory Acoustic Monitor in Children After Surgery

The study will evaluate the performance of measuring respiration rate with the Respiratory Acoustic Monitoring (RAM).

Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy

Upper gastrointestinal endoscopy, like many other diagnostic and therapeutic procedures, may be associated with discomfort. Although upper endoscopy is usually of shorter duration and bett...

Environmental Risk Factors for Myositis in Military Personnel

Background: - Myositis is a rare disease in which the body s immune cells attack the muscle tissue. It can cause muscle weakness, swelling, and pain. It can develop in people wi...

Evaluation of Safety and Immunogenicity of a Human Papillomavirus (HPV) Vaccine in Human Immunodeficiency Virus (HIV) Infected Females

Infection with human papillomavirus (HPV) has been clearly established as the central cause of cervical cancer. This Phase IV, observer-blind study is designed to evaluate the safety and i...

PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer

Background: - Many cancers produce two proteins, carcinoembryonic antigen (CEA) and mucin-1 (MUC-1). - The PANVAC-V priming vaccine and PANVAC-F boosting vaccine contain human gene...

PubMed Articles [7515 Associated PubMed Articles listed on BioPortfolio]

Mouse models of rhinovirus infection and airways disease.

Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infecti...

Reverse genetic engineering of the human rhinovirus serotype 16 genome to introduce an antibody-detectable tag.

The ability to accurately detect viral proteins during infection is essential for virology research, and the lack of specific antibodies can make this detection difficult. Reverse genetic engineering ...

Reverse genetics system for studying human rhinovirus infections.

Human rhinovirus (HRV) contains a 7.2 kb messenger-sense RNA genome which is the template for reproducing progeny viruses after it enters the cytoplasm of a host cell. Reverse genetics refers to the r...

Proteases of human rhinovirus: role in infection.

Human rhinoviruses (HRV) are the major etiological agents of the common cold and asthma exacerbations, with significant worldwide health and economic impact. Although large-scale population vaccinatio...

Capillary electrophoresis, gas-phase electrophoretic mobility molecular analysis, and electron microscopy: effective tools for quality assessment and basic rhinovirus research.

We describe standard methods for propagation, purification, quality control, and physicochemical characterization of human rhinoviruses, using HRV-A2 as an example. Virus is propagated in HeLa-OHIO ce...

Application of FCS in Studies of Rhinovirus Receptor Binding and Uncoating.

Fluorescence correlation spectroscopy (FCS) allows determining diffusion and relaxation properties of fluorescent molecules. It requires only extremely small amounts of sample, down to picomolar conce...

Infectivity assays of human rhinovirus-a and -B serotypes.

Infectivity is a fundamental property of viral pathogens such as human rhinoviruses (HRVs). This chapter describes two methods for measuring the infectivity of HRV-A and -B serotypes: end point diluti...

Growth of Human Rhinovirus in H1-HeLa Cell Suspension Culture and Purification of Virions.

HeLa cell culture is the most widely used system for in vitro studies of the basic biology of human rhinovirus (HRV). It is also useful for making sufficient quantities of virus for experiments that r...

Molecular genotyping of human rhinovirus by using PCR and sanger sequencing.

Human rhinovirus (HRV) is the virus most often associated with acute upper respiratory tract infections. Advances in molecular detection have shown that HRV is also the major viral cause of asthma exa...

Molecular identification and quantification of human rhinoviruses in respiratory samples.

PCR-based molecular assays have become standard diagnostic procedures for the identification and quantification of human rhinoviruses (HRVs) and other respiratory pathogens in most, if not all, clinic...

Medical and Biotech [MESH] Definitions

Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

A species of PNEUMOVIRUS causing an important respiratory infection in cattle. Symptoms include fever, conjunctivitis, and respiratory distress.

An acute inflammatory disease of the upper RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.

The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

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Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can be spread, directly or indirectly, from one person to another. Zoonotic diseases are infectious diseases of animals that can caus...

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