Respiratory syncytial virus RSV Vaccines - Biotech, Pharma and Life Science Channel

12:35 EST 6th March 2015 | BioPortfolio

Respiratory syncytial virus (RSV) infection, which manifests primarily as bronchiolitis and/or viral pneumonia, is the leading cause of lower respiratory tract infection in infants and young children. In the US, RSV LRT infection develops annually in 4-5 million children, and more than 125,000 children are admitted per year for RSV-related illness. RSV disease is the no.1 cause of hospitalization in babies under a year of age in the US. While a monoclonal antibody is commercially available to help prevent RSV disease in infants and children at high risk for severe lung disease from RSV, a RSV vaccine still is not on the market. A number of RSV vaccine candidates have entered clinical development and further are to follow. Also, next generation antibodies against RSV with improved features are in the development pipeline as well as new therapies based on silencing RSV RNA or inhibiting key targets of the virus.

News Articles [925 Associated News Articles listed on BioPortfolio]

New Technologies, New Vaccines Conference Provides Opportunity to Share New Advancements in Combating Emerging Infectious Diseases, Including Ebola

More than 100 scientists, business leaders and regulatory agency representatives from around the world will convene at the Hotel DuPont in Wilmington, DE from March 22–25, 2015 ...

U.S. Census Bureau Daily Feature for March 6

WASHINGTON, March 6, 2015 /PRNewswire-USNewswire/ -- Following is the daily "Profile America" feature from the U.S. Census Bureau: MANDATORY VACCINATIONS Profile America — Friday, March 6th....

The Bill & Melinda Gates Foundation and CureVac Collaborate to Accelerate the Development of Transformative Vaccine Technology

SEATTLE and TÜBINGEN, Germany, March 5, 2015 /PRNewswire-USNewswire/ -- The Bill & Melinda Gates Foundation and CureVac today announced that the foundation has made a commitment to invest $52...

ndd Medical Technologies' Mobile Pulmonary Function Testing Helps Combat Pulmonary Fibrosis

ANDOVER, Mass., March 5, 2015 /PRNewswire/ -- ndd Medical Technologies, a leader in innovative mobile pulmonary function testing (PFT) that employs precise ultrasound technology, announced that i...

European Patent to Strengthen Medigene's Dendritic Cell (DC) Vaccines Program

Medigene AG / European Patent to Strengthen Medigene's Dendritic Cell (DC) Vaccines Program . Processed and transmitted by NASDAQ OMX Corporate Solutions. The issuer is solely responsible for th...

Soligenix to Present at the 27th Annual ROTH Conference

PRINCETON, N.J., March 5, 2015 /PRNewswire/ -- Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), a late stage biopharmaceutical company committed to developing products that address unmet medi...

Patterson Companies to Present at 2015 Barclays Global Healthcare Conference

Patterson Companies (Nasdaq:PDCO) today announced that Ann B. Gugino, vice president and chief financial officer of Patterson Companies, will be presenting at the Barclays ...

Adults may only get 'real flu' every five years

"Average adult catches virus just once every five years," the Daily Mail reports. A study has estimated that influenza infections become less frequent with age and occur every five years f...

Veterinary medicine European public assessment report (EPAR): Equip WNV (previously Duvaxyn WNV), adjuvanted vaccine against West Nile virus in horses, Revision: 9, Authorised

Hill-Rom Declares Second Quarter 2015 Dividend

CHICAGO, March 4, 2015 /PRNewswire/ -- Hill-Rom Holdings, Inc. (NYSE: HRC) announced today that its Board of Directors declared a fiscal year 2015 second quarter dividend of $0.16 per share. The divid...

Events [1 Associated Events listed on BioPortfolio]

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Companies [225 Associated Companies listed on BioPortfolio]

Zambon S.p.A.

Zambon is a leading Italian pharmaceutical and fine-chemical multinational company that has earned a strong reputation over the years for high quality products and services. Zambo...

RxC International

RxC International is a life sciences management consulting firm specializing in corporate strategy, new product development, and commercialization. RxC International brings strate...

Synexus

Synexus® is the world’s largest multi-national company dedicated to the recruitment and running of clinical trials at its own research centres across the globe on behalf o...

Global Virus Network

The Global Virus Network (GVN) is an independent organization comprised of leading medical virologists from Argentina, Australia, Canada, China, Germany, India, Ireland, Israel, I...

Seattle Biomedical Research Institute

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Sunovion Pharmaceuticals, Inc.

Sunovion is a leading pharmaceutical company dedicated to discovering, developing and commercializing therapeutic products that advance the science of medicine in the Psychiatry &...

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Dimension Therapeutics, Inc.

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Genocea Biosciences

Genocea Biosciences was founded in 2006 to commercialize key breakthroughs in vaccine discovery and development. The Company’s proprietary T cell-directed antigen disc...

Affinivax Inc.

Affinivax is advancing a next generation conjugate vaccine technology platform to enable the development of vaccines that provide the highest level of protection against challengi...

Clinical Trials [2543 Associated Clinical Trials listed on BioPortfolio]

REP 2139-Ca / Pegasys™ Combination Therapy in Hepatitis B / Hepatitis D Co-infection

REP 2139-Ca is nucleic acid polymer. Nucleic acid polymers have been previously shown to clear serum hepatitis B virus surface antigen (HBsAg) both preclinically (in duck HBV infected duc...

Intermittent and Daily Dosing for Episodic (Periodic) Asthma (0476-302)(COMPLETED)

This is a year-long study evaluating the efficacy of both daily and intermittent treatment of asthma in children who experience symptoms episodically (i.e., seasonally, usually in the cont...

Safety and Tolerability Study for the Pneumococcal Conjugate Vaccine V114 Versus Prevnar™ (V114-001 EXT1)(COMPLETED)

This study is being conducted to evaluate the safety, tolerability, and immunogenicity of 15-valent Pneumococcal conjugate vaccine (V114) compared to Prevnar™ in healthy adults and toddl...

Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin)

The investigators are doing this research study to find out if giving a drug called prasugrel, which is used to prevent blood clots, can reduce reactions to aspirin in people with aspirin ...

Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position

Postoperative pulmonary complications are main cause of overall perioperative morbidity and mortality in the patients following general anesthesia. A protective ventilation strategy refers...

Assessment of a Dengue-1-Virus-Live Virus Human Challenge - (DENV-1-LVHC) Virus Strain

To evaluate the effectiveness of candidate dengue vaccine formulations, it is prudent to develop an appropriate challenge model. To this end, this first-in-human study will examine the saf...

Collection of Samples for the Clinical Evaluation of the Aptima HBV (Hepatitis B Virus) Quant (Quantification) Assay

This non-interventional clinical study will be conducted to prospectively collect serial plasma samples from subjects with chronic HBV infection who are initiating antiviral therapy. These...

Training Study to Characterize Biomarkers to Chickenpox and Yellow Fever Vaccines

It is thought that vaccines trigger innate inflammatory responses to induce antigenspecific adaptive immunity (the desired effect), but excessive inflammation may lead to serious inflammat...

PANVAC-V and PANVAC-F Vaccines Plus Sargramostim to Treat Advanced Cancer

Background: - Many cancers produce two proteins, carcinoembryonic antigen (CEA) and mucin-1 (MUC-1). - The PANVAC-V priming vaccine and PANVAC-F boosting vaccine contain human gene...

Civamide Nasal Solution for Postherpetic Neuralgia of the Trigeminal Nerve

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PubMed Articles [7569 Associated PubMed Articles listed on BioPortfolio]

The stability analysis of an SVEIR model with continuous age-structure in the exposed and infectious classes.

In this paper, an Susceptible-Vaccines-Exposed-Infectious-Recovered model with continuous age-structure in the exposed and infectious classes is investigated. These two ages are assumed to have arbitr...

Long-term impacts of unconventional drilling operations on human and animal health.

Public health concerns related to the expansion of unconventional oil and gas drilling have sparked intense debate. In 2012, we published case reports of animals and humans affected by nearby drilling...

In-vitro Characterization and Evaluation of Apoptotic Potential of Bicistronic Plasmid Encoding HN Gene of Newcastle Disease Virus and Human TNF-α

The viral gene oncotherapy in combination with cytokines emerges as an exciting strategy for cancer therapy due to its minimal side effects and tumor specificity. HN is the surface protein of NDV whic...

Mechanisms of sudden unexplained death in epilepsy.

Human and experimental research has identified cardioautonomic and respiratory dysfunction as a frequent accompaniment in human and animal model events of sudden unexpected death in epilepsy (SUDEP). ...

Faldaprevir and pegylated interferon α-2a/ribavirin in individuals co-infected with hepatitis C virus genotype-1 and HIV.

Faldaprevir is a potent, once-daily hepatitis C virus (HCV) NS3/4A protease inhibitor. STARTVerso4 assessed the efficacy and safety of faldaprevir and response-guided pegylated interferon α-2a/ribavi...

Up-regulation of Tim-3 on T cells during acute simian immunodeficiency virus infection and on antigen specific responders.

Understanding the role of T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) on T cells and dendritic cells during the course of simian immunodeficiency virus (SIV) infection.

Notes from the Field: Increase in Reported Crimean-Congo Hemorrhagic Fever Cases - Country of Georgia, 2014.

During January-September 2014, Georgia's National Centers for Disease Control and Public Health (NCDC) detected 22 cases of Crimean-Congo hemorrhagic fever (CCHF) in the country. CCHF is caused by inf...

Systems for Rapidly Detecting and Treating Persons with Ebola Virus Disease - United States.

The U.S. Department of Health and Human Services (HHS), CDC, other U.S. government agencies, the World Health Organization (WHO), and international partners are taking multiple steps to respond to the...

Update: Influenza Activity - United States, September 28, 2014-February 21, 2015.

Influenza activity in the United States began to increase in mid-November, remained elevated through February 21, 2015, and is expected to continue for several more weeks. To date, influenza A (H3N2) ...

Effect of HIV Infection and Highly Active Antiretroviral Therapy on Hearing Function: A Prospective Case-Control Study From Cameroon.

Human immunodeficiency virus (HIV) infection remains a major cause of morbidity and mortality worldwide. Many studies have found a higher prevalence of hearing impairment among HIV-positive individual...

Medical and Biotech [MESH] Definitions

Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

A species of PNEUMOVIRUS causing an important respiratory infection in cattle. Symptoms include fever, conjunctivitis, and respiratory distress.

An acute inflammatory disease of the upper RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.

The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

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Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can be spread, directly or indirectly, from one person to another. Zoonotic diseases are infectious diseases of animals that can caus...

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