Respiratory syncytial virus RSV Vaccines - Biotech, Pharma and Life Science Channel

05:02 EDT 31st October 2014 | BioPortfolio

Respiratory syncytial virus (RSV) infection, which manifests primarily as bronchiolitis and/or viral pneumonia, is the leading cause of lower respiratory tract infection in infants and young children. In the US, RSV LRT infection develops annually in 4-5 million children, and more than 125,000 children are admitted per year for RSV-related illness. RSV disease is the no.1 cause of hospitalization in babies under a year of age in the US. While a monoclonal antibody is commercially available to help prevent RSV disease in infants and children at high risk for severe lung disease from RSV, a RSV vaccine still is not on the market. A number of RSV vaccine candidates have entered clinical development and further are to follow. Also, next generation antibodies against RSV with improved features are in the development pipeline as well as new therapies based on silencing RSV RNA or inhibiting key targets of the virus.

News Articles [1038 Associated News Articles listed on BioPortfolio]

Discovery Labs Announces Organizational Change and Enhanced Expertise in Neonatology

WARRINGTON, Pa., Oct. 30, 2014 /PRNewswire/ -- Discovery Laboratories, Inc. (NASDAQ: DSCO), a specialty biotechnology company dedicated to advancing a new standard in respiratory critical care, today ...

Meningococcal Vaccines Market (Polysaccharide, Conjugate, and Combination Vaccines, along with Pipeline Analysis) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019

LONDON, Oct. 30, 2014 /PRNewswire/ -- The global meningococcal vaccines market is studied on the basis of vaccine types such as polysaccharide, conjugate and combination vaccines. The vaccine typ...

ABIVAX Strengthens Executive Management Team With Senior Appointments

PARIS, October 30, 2014 /PRNewswire/ -- Karl Birthistle, M.D., appointed VP of Global Regulatory Affairs  Daniel Kenny appointed Chief Commercial Officer & VP of Business Development  ...

The COPD Foundation Launches COPD Hospital Readmissions Reduction Initiative Sponsored by Sunovion Pharmaceuticals Inc.

The COPD Foundation, today announced the launch of the COPD Praxis program – A Readmissions Collaboratory which will Prevent and Reduce COPD Admissions through eXpertise ...

Genocea to Announce Third Quarter 2014 Financial Results on November 6, 2014

Genocea Biosciences, Inc. (NASDAQ:GNCA), a clinical-stage biopharmaceutical company developing T cell-directed vaccines and immunotherapies, announced today that it will hold a c...

Should Nurse Hickox or Public Health Authorities Decide on Her Movements, Asks the Association of American Physicians and Surgeons (AAPS)

TUCSON, Ariz., Oct. 30, 2014 /PRNewswire-USNewswire/ -- Kaci Hickox, R.N., recently returned from caring for Ebola patients in West Africa, has announced her intention to defy Maine's quarantine ...

Affinivax Appoints Frances K. Heller to Board of Directors

Affinivax Inc., a biotechnology company dedicated to developing novel vaccines, today announced that it has appointed Frances K. Heller to the company’s Board of Directors. With...

Affinivax Launches Novel Conjugate Vaccine for Global Impact on Infectious Diseases

Investment from the Bill & Melinda Gates Foundation to Support Company Launch and Advance Lead Program targeting Pneumococcal Disease Exclusive License to Intellectua...

News and press releases: Revised framework for development of influenza vaccines

EMA releases third and final module for public consultation

Asklepios Klinikum Hamburg: Picaportes de cobre sólido Harburg 600 para la prevención de infecciones

HAMBURGO, Alemania, October 30, 2014 /PRNewswire/ -- - Cobre contra los gérmenes: Asklepios Klinikum Hamburg: Picaportes de cobre sólido Harburg 600 para la prevención de infeccio...

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Companies [218 Associated Companies listed on BioPortfolio]

Affinivax Inc.

Affinivax is advancing a next generation conjugate vaccine technology platform to enable the development of vaccines that provide the highest level of protection against challengi...

Mucosis B.V.

Mucosis B.V. (Mucosis) is a clinical-stage biotechnology company using a proprietary technology platform to develop next-generation needle-free human vaccines for infectious disea...

Vaxart, Inc.

Vaxart is a privately owned company developing oral recombinant vaccines based on its proprietary delivery platform. The Vaxart platform is suitable to deliver any protein vaccine...

Global Virus Network (GVN)

The Global Virus Network (GVN) is an independent, not for profit organization, comprised of leading medical virologists from Argentina, Australia, Belgium, Canada, China, France, ...

PharmaJet Inc.

PharmaJet Inc., affiliated with Genesis Medical Technologies, is a needle-free drug delivery technology company. Through the use of its needle-free jet injection technology, the Company’s goal is to...

Mucosis

Mucosis B.V. is a clinical-stage biotechnology company developing novel vaccines on its proprietary Mimopath® platform technology. The Mimopath® platform is being studied fo...

Cell Medica Limited

Cell Medica is a cellular therapeutics company engaged in the development, manufacturing and marketing of T cell immunotherapy approaches for the treatment of infections and cance...

Nanobiotix

NanoBio® Corp. is a privately held biopharmaceutical company focused on developing and commercializing dermatological products, anti-infective treatments and intranasal vaccine...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

Teva Neuroscience Inc.

Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) is a leading global pharmaceutical company, committed to increasing access to high-quality healthcare by developing, producing and...

Clinical Trials [2418 Associated Clinical Trials listed on BioPortfolio]

Safety, Tolerability, and Immunogenicity of the Ebola Chimpanzee Adenovirus Vector Vaccine (cAd3-EBO), VRC-EBOADC069-00-VP, in Healthy Adults

Background: - Ebola virus causes an infection known as Ebola virus disease (EVD). This it is generally a severe disease which can also lead to death. The 2014 outbreak of EVD in West Afri...

Dose-finding and Safety of 2 Intradermal MEN-ACYW135-conjugate Vaccines

Invasive meningococcal disease is a worldwide problem with serious repercussions for those affected. Vaccination is recognized as the best way to combat it. The cost of vaccination is proh...

Quality of Life of HIV-infected Participants Switched to Raltegravir Versus Other Antiretroviral Regimens (MK-0518-266)

This is a multi-center, longitudinal observational study of adult human immunodeficiency virus (HIV) participants at academic and community-based practices in the United States who are swi...

Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function

Following deployment to Operations Enduring and Iraqi Freedom and Operation New Dawn (OEF/OIF/OND), Veterans report breathing problems, difficulty exercising and other symptoms. These symp...

A Study to Evaluate the Safety of the Respiratory Syncytial Virus Vaccine MEDI7510 in Older Adults

The purpose of this study is to determine if the administration of single ascending intramuscular doses of the RSV sF antigen or MEDI7510 will be safe and well tolerated in adults 60 years...

Ketamine Effect After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study

Laparoscopic surgery for gastric reduction is frequently associated with high levels of postoperative pain. Postoperative pain is very often treated with opioids. However large doses of op...

Immunogenicity Study of an Anti-pneumococcal Vaccination Strategy in Patients With Sickle Cells Disease

Streptococcus pneumoniae is the major cause of bacterial infection in patients with sickle cells disease. The 23-valent pneumococcal polysaccharide vaccine (PSV) is supposed to be poorly ...

Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough

Respiratory infections, such as pneumonia and bronchitis, occur frequently in the spinal cord injured population, due to paralysis of the muscles responsible for coughing. Using spinal cor...

Prospective Observational Epidemiologic Study of Maraviroc's Safety

The study will assess if use of maraviroc along with an optimized background regimen of antiretroviral drugs in usual clinical practice is as safe as using only an optimized regimen of ant...

Vaccine and Antibody Treatment of Prostate Cancer

This study will evaluate the side effects of a fixed dose of vaccine and GM-CSF with increasing doses of anti-CTLA-4 antibody in patients with advanced prostate cancer. The vaccine consist...

PubMed Articles [7535 Associated PubMed Articles listed on BioPortfolio]

Mouse models of rhinovirus infection and airways disease.

Mouse models are invaluable tools for gaining insight into host immunity during virus infection. Until recently, no practical mouse model for rhinovirus infection was available. Development of infecti...

Reverse genetic engineering of the human rhinovirus serotype 16 genome to introduce an antibody-detectable tag.

The ability to accurately detect viral proteins during infection is essential for virology research, and the lack of specific antibodies can make this detection difficult. Reverse genetic engineering ...

Reverse genetics system for studying human rhinovirus infections.

Human rhinovirus (HRV) contains a 7.2 kb messenger-sense RNA genome which is the template for reproducing progeny viruses after it enters the cytoplasm of a host cell. Reverse genetics refers to the r...

Proteases of human rhinovirus: role in infection.

Human rhinoviruses (HRV) are the major etiological agents of the common cold and asthma exacerbations, with significant worldwide health and economic impact. Although large-scale population vaccinatio...

Capillary electrophoresis, gas-phase electrophoretic mobility molecular analysis, and electron microscopy: effective tools for quality assessment and basic rhinovirus research.

We describe standard methods for propagation, purification, quality control, and physicochemical characterization of human rhinoviruses, using HRV-A2 as an example. Virus is propagated in HeLa-OHIO ce...

Application of FCS in Studies of Rhinovirus Receptor Binding and Uncoating.

Fluorescence correlation spectroscopy (FCS) allows determining diffusion and relaxation properties of fluorescent molecules. It requires only extremely small amounts of sample, down to picomolar conce...

Infectivity assays of human rhinovirus-a and -B serotypes.

Infectivity is a fundamental property of viral pathogens such as human rhinoviruses (HRVs). This chapter describes two methods for measuring the infectivity of HRV-A and -B serotypes: end point diluti...

Growth of Human Rhinovirus in H1-HeLa Cell Suspension Culture and Purification of Virions.

HeLa cell culture is the most widely used system for in vitro studies of the basic biology of human rhinovirus (HRV). It is also useful for making sufficient quantities of virus for experiments that r...

Molecular genotyping of human rhinovirus by using PCR and sanger sequencing.

Human rhinovirus (HRV) is the virus most often associated with acute upper respiratory tract infections. Advances in molecular detection have shown that HRV is also the major viral cause of asthma exa...

Molecular identification and quantification of human rhinoviruses in respiratory samples.

PCR-based molecular assays have become standard diagnostic procedures for the identification and quantification of human rhinoviruses (HRVs) and other respiratory pathogens in most, if not all, clinic...

Medical and Biotech [MESH] Definitions

Vaccines or candidate vaccines used to prevent infection with RESPIRATORY SYNCYTIAL VIRUSES.

Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.

A species of PNEUMOVIRUS causing an important respiratory infection in cattle. Symptoms include fever, conjunctivitis, and respiratory distress.

An acute inflammatory disease of the upper RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.

The type species of PNEUMOVIRUS and an important cause of lower respiratory disease in infants and young children. It frequently presents with bronchitis and bronchopneumonia and is further characterized by fever, cough, dyspnea, wheezing, and pallor.

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Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can be spread, directly or indirectly, from one person to another. Zoonotic diseases are infectious diseases of animals that can caus...

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