Riboflavin - Biotech, Pharma and Life Science Channel
Riboflavin, also known as vitamin B2, is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Vitamin B2 is a water-soluble vitamin, one that cannot be stored by the body except in insignificant amounts. It must be replenished daily.
Riboflavin or vitamin B2 is an essential nutrient in human nutrition and plays a key role in the production of energy. Vitamin B2 is needed to process amino acids and fats, activate vitamin B6 and folic acid, and help convert carbohydrates into the fuel the body runs on. Under some conditions, vitamin B2 can act as an antioxidant. Vitamin B2 is an intermediary the transfer of electrons in the cellular oxidation-reduction reactions which generate energy from protein, carbohydrate and fat. The riboflavin coenzymes are also important for the transformation of vitamin B6 and folic acid into their respective active forms, and for the conversion of tryptophan into niacin. Riboflavin is involved in energy production as part of the electron transport chain that produces cellular energy.
Sources of riboflavin include organ meats (liver, kidney, and heart) and certain plants such as almonds, mushrooms, whole grain, soybeans, and green leafy vegetables. The richest sources of riboflavin include organ meats such as liver, kidney and heart. Milk, yeast, cheese, oily fish, eggs and dark green leafy vegetables are also rich sources. Flour and cereals are enriched with riboflavin. Riboflavin is stable when heated but will leach into cooking water. It is easily destroyed by light, and foods stored in clear containers will lose their riboflavin content in a short period of time. Because riboflavin is destroyed by exposure to light, foods with riboflavin should not be stored in glass containers that are exposed to light. Breads and cereals are often fortified with riboflavin.
Riboflavin deficiency has profound effects on the metabolism of carbohydrates, fats, and protein. There is no known toxicity to riboflavin.
PubMed Articles
Triple therapy with deferiprone, idebenone and riboflavin in Friedreich's ataxia - open-label trial.
OBJECTIVES: The objective of the study was to test the efficacy, safety and tolerability of triple therapy with deferiprone, idebenone and riboflavin in Friedreich's ataxia (FRDA) patients in a clinic...
Recurrent myoglobinuria and deranged acylcarnitines due to a mutation in the mtDNA MT-CO2 gene.
Mitochondrial myopathies commonly present with exercise intolerance typified by breathlessness and fatigue on exercise. In contrast, exercise-induced rhabdomyolysis and myoglobinuria occur rarely. We...
Methyl nutrients, DNA methylation, and cardiovascular disease.
Diet plays an important role in the development and prevention of cardiovascular disease (CVD), but the molecular mechanisms are not fully understood. DNA methylation has been implicated as an underly...
Do Dutch nutrition and dietetics students meet nutritional requirements during education?
OBJECTIVES: To compare the dietary intakes of Dutch nutrition and dietetics students with the Dutch RDA and the Dutch National Food Consumption Survey (DNFCS), and to assess whether dietary intake cha...
Riboflavin requirements of white Pekin ducks from hatch to 21 d of age.
1. A 2 × 8 factorial experiment containing different sexes (female and male) and 8 dietary riboflavin concentrations (1.2, 3.2, 5.2, 7.2, 9.2, 11.2, 13.2 and 15.2 mg/kg) was conducted to evaluate...
Metabolomic profiles were used to characterise the effects of consuming a high-phytochemical diet compared with a diet devoid of fruits and vegetables (F&V) in a randomised trial and cross-sectional s...
BACKGROUND: Pathogen reduction technologies (PRTs) can induce platelet (PLT) lesions that reduce PLT survival and recovery from circulation and may be associated with acute lung injury (ALI). STUDY DE...
Inactivation of Plasmodium falciparum in whole blood by riboflavin plus irradiation.
BACKGROUND: Malaria parasites are frequently transmitted by unscreened blood transfusions in Africa. Pathogen reduction methods in whole blood would thus greatly improve blood safety. We aimed to dete...
Riboflavin (vitamin B2) belongs to a group of respiratory enzymes that occur widely in animals and plants participating in vital oxidation- reduction processes in the body. A computational study was c...
Early confocal microscopy findings after cross-linking treatment.
OBJECTIVE: To determine the effects of in vivo cross-linking treatment of the cornea. METHODS: Eighteen eyes of eighteen keratoconus patients underwent cross-linking treatment using a 0.1% riboflavin...
News Articles
Liquid Health, Inc. Launches New Website in Connection with New Liquid Prenatal Supplement
This month marks the release of Liquid Health’s newest product, Prenatal Multi. To help spread the word, they have launched a new website to promote this liquid prenatal supplement. Murrieta, CA (P...
Liquid Health, Inc. Announces the Winner of their Prenatal Vitamin Giveaway
To promote their new prenatal vitamin, Liquid Health, Inc. recently held a contest to give away a 9-month supply of the product. The winner, Carie A. of Port Orchard, WA, was randomly chosen on Frida...
CHICAGO, May 7, 2013 /PRNewswire-USNewswire/ -- Celiac disease is estimated to affect one out of 141 of Americans, or just under 1 percent of the population. The Academy of Nutrition and Dietetic...
Vitamin B2 May Be An Antidote To Cyanide Poisoning
With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FAS...
Zebrafish study suggests that vitamin B2 (riboflavin) is an antidote to cyanide poisoning
(Federation of American Societies for Experimental Biology) With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder how...
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis
ATP-binding cassette (ABC) transporters, composed of importers and exporters, form one of the biggest protein superfamilies that transport a variety of substrates across the membrane, powered by ATP h...
Pharmaceutical Research: Riboflavin-Targeted Polymer Conjugates for Breast Tumor Delivery
Type: Original PaperPurposeIn breast cancer, a significant decrease in riboflavin (RF) serum levels and increase in RF carrier protein occurs, indicating a potential role of RF in disease progression....
SOOFT italia S.p.A., a company of OOgroup, announce the worldwide launch of its “Device and method for Corneal delivery of Riboflavin by Iontophoresis procedure for the treatmen...
Avedro Announces Preparation for Anticipated Hyperopic Lasik Xtra® US Clinical Trial
Avedro today announced that in preparation for its US clinical trial, a select group of US refractive surgeons have just completed Lasik Xtra procedure training under Gustavo Tama...
Avedro raises $43 million in series D
Avedro Inc. (Waltham, Mass.) raised $43 million in a series D round led by new investor Abingworth. New investor Third Point joined existing investors Prism Venture Works; De Novo Ventures; Flagship V...
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Clinical Trials
Lactate Metabolism Study in HIV Infected Persons
Lactic acidosis is a potentially life-threatening disease associated with the treatment of chronic HIV infection. Although acidosis is rare, hyperlactatemia is common and may have long ter...
D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)
The purpose of this study is to determine the best way to treat people on d4T (stavudine) with high levels of lactic acid. Switching from d4T to abacavir will be assessed. Adding riboflavi...
The purpose of this study is to see if certain vitamins (C, E, B1, and B2) can keep lactate levels from becoming too high in patients who are taking nucleoside reverse transcriptase inhibi...
Vitamin B Therapy for Hyperlactatemia
The purpose of this study is to see if vitamin B can treat mild hyperlactatemia (a higher than normal level of lactate in the blood) in patients who take nucleoside reverse transcriptase i...
Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus
Background: Corneal cross linking is a procedure that induces collagen cross linking of the corneal stroma due to release of reactive oxygen radicals upon activation of topically applied r...
German Corneal Cross Linking Register
Corneal Cross Linking is new treatment modality for patients with keratoconus. A keratoconus is characterized by progressive bulging and thinning of the eye's cornea. Keratoconus is a pote...
Comparison of the Efficacy and Acceptability of Three Types of Micronutrient Supplements in Ghana
1. At 12 mo of age, all three intervention groups will have significantly better iron and vitamin A status than the NI group. 2. Infants who receive the Foodlet or Nutributter will...
Folate and Protection Against Cervical Cancer
This is a randomised double-blind placebo-controlled trial to see whether giving a low dose of the vitamins folic acid and riboflavin is beneficial to women who have very low grade abnorma...
Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs
This study will determine the efficacy of collagen cross linking for progressive keratoconus and ectasia after lasik. It will try and determine which is a more effective treatment: collage...
Corneal Collagen Cross-linking With Hypotonic Riboflavin in Corneas Thinner Than 400 Microns
Corneal ectasia is a relative weakness in the structure of the cornea, which produces a progressive change in its shape which results in visual distortion. It is known that collagen cross...
Videos
Riboflavin - Vitamin B2: For energy, healthy skin and cataract prevention
In this video Dr Meschino explains the importance of Vitamin B2 for energy, skin complexion, cataract prevention and more. Visit @ http://www.meschinohealth....
Medical and Biotech [MESH] Definitions
Riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
Riboflavin Deficiency
A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed)
Riboflavin Synthase
An enzyme that catalyzes the formation of riboflavin from two molecules of 6,7-dimethyl-8-ribityllumazine, utilizing a four-carbon fragment from one molecule which is transferred to the second molecule. EC 2.5.1.9.
Flavin-adenine Dinucleotide
A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Flavin Mononucleotide
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
